KR102060958B1 - Tropical passion flower aroma composition for enhancing concentration of human brain and uses thereof - Google Patents

Abstract

The present invention relates to a fragrance composition for improving concentration, health functional food and a cosmetic composition for improving concentration by including the fragrance composition, a fragrance mixture producing method having a concentration enhancing effect, and a fragrance mixture having a concentration enhancing effect produced by the method. The fragrance composition of the present invention has a concentration enhancing effect by inducing an increase in relative beta power spectrum (RB) in a right prefrontal lobe, a right frontal lobe, a central frontal lobe, and a right occipital lobe, an increase in relative gamma power spectrum (RG) in a right frontal lobe, a central frontal lobe, a right occipital lobe, and a left occipital lobe, an increase in relative high beta power spectrum (RHB) in a right prefrontal lobe, a right frontal lobe, a central frontal lobe, a central parietal lobe, and a right occipital lobe, an increase in the ratio of SMR-mid beta to theta power spectrum (RSMT) in a right occipital lobe, an increase in spectral edge frequency 50% (SEF50) in a right prefrontal lobe, a right frontal lobe, a central frontal lobe, a central parietal lobe, a left temporal lobe, and a right occipital lobe, an increase in spectral edge frequency 90% (SEF90) in a right frontal lobe, a central frontal lobe, and a right occipital lobe, and an increase in spectral edge frequency 50% of alpha spectrum band (ASEF) in a right prefrontal lobe, a right frontal lobe, a central frontal lobe, a left temporal lobe, a central parietal lobe, and a right temporal lobe. The present invention is produced by including 0.8-1.2 wt% of cis-3-Hexenol, 5.5-6.5 wt% of ethyl linalool, 5-6 wt% of benzyl acetate, 7.5-8.5 wt% of florol, and other components based on the total weight of the fragrance mixture.

Description

Tropical Passion Flower Aroma Composition for Enhancing Concentration of Human Brain and Uses

The present invention relates to a fragrance composition for increasing concentration, a health functional food and cosmetic composition for increasing concentration, including the fragrance composition, and a method for producing a fragrance mixture having a concentration increasing effect, and a fragrance mixture having a concentration increasing effect prepared by the above method. will be.

Perfume is a ethanol-diluted product of essential oils, a volatile fragrance compound, which is divided into natural and synthetic flavors. Natural flavors are divided into animal flavors obtained from animals and plant flavors obtained from plants. Animal flavors include ambergris from the sperm whale, musk from the musk deer, vivette from the musk cat, and castorium from the beaver, but these days are not used well. Plant flavors can be obtained by distilling, extracting and compressing the flowers, leaves, fruits, seeds, resins, roots and stems of about 1,500 kinds of plants, but they are low in purity and have a high odor change during extraction and distillation. The strength and quality change varies greatly depending on the region, harvest time, and post-harvest storage methods, and about 200 species are currently on the market due to large supply uncertainties.

Organic synthetic fragrances can be obtained through organic synthesis in laboratories, which are highly preferred in the perfume industry because they are more pure than natural fragrances, are inexpensive to use, stable, have a long shelf life, are high in concentration and have no problems with seasonal supply. . Representative examples of the organic synthetic fragrances include aldehydes used in Chanel No. 5.

Each fragrance represents each unique and unique fragrance, which is called fragrance or knot. Flavors are generally citrus, floral, green, fruity, aldehyde, oriental, spicy, woody, psypre, after It is represented by fogere, marine, and gurumand. Mixing several flavors changes the flavor of each flavor. Mixing a number of single flavors is called steering, which allows you to create combination flavors with different flavors. Combination fragrances are divided into fragrances and flavors according to their use. Fragrance is based on the content of essential oils, namely fragrance (15-30%), eau de parfum (15-18%), eau de toilette (4-8%) and eau de cologne (3-5%). Are distinguished. In general, when preparing a new fragrance product by mixing the combination fragrance, the top note that appears immediately when sprinkled, the middle note that characterizes the fragrance, and the last note that gives depth and volume to the fragrance should be harmonized.

When humans inhale perfume, electrical signals are generated when the fragrance molecules move along the nasal cavity and bind to olfactory receptors. The electrical signal generated at this time is transmitted to the cerebral cortex along the olfactory tract in the olfactory bulb, thereby activating the brain. Odor molecules contained in fragrances are known to affect the brain of the human brain to change the brain waves and induce physiological and psychological changes.

When the cerebral cortex is activated by a stimulus, a brain wave is generated, which is an electrical signal generated between neurons in the nervous system of the human cerebral cortex.

Attach the electrodes that can amplify cerebral electrical activity to the scalp, record the waveforms, analyze them, and analyze them. EEG, an electrical signal generated by the brain's autonomous activity, is recorded in the brain by recording and observing brain activity. It is used as an indicator of human psychophysiological functions such as arousal, activity, anxiety and stability. EEG is used in cognitive science, medicine, pharmacy, and criminal investigation because it has the advantage of being able to record and measure objectively, non-invasively and continuously.

EEG mainly represents the frequency of 0 ~ 60 Hz and the amplitude of 5 ~ 300 V. Depending on the frequency range, delta wave (0 ~ 4 Hz), theta wave (4 ~ 8 Hz), alpha wave (8 ~ 13 Hz), beta It is divided into wave (13 ~ 30 Hz) and gamma wave (30 ~ 50 Hz). Delta and theta waves are slow waves and appear when you think and act using information from your brain. Beta waves higher than alpha waves are fast waves. In EEG analysis, not only absolute power, but also relative power, which can reduce individual differences such as skull thickness difference, electrical condition of the scalp, and tension, and analyze accurate EEG response.

Korean Registered Patent No.0803998 discloses a dermal fermentation extract, a method of manufacturing the same, and a health functional food. Korean Patent Publication No. 2015-0122983 discloses a cosmetic composition containing peppermint herb, but the concentration of the brain of the present invention Is different from the tropical fashion flower fragrance composition to improve the.

The present invention is derived from the above requirements, the present invention using a natural flavor and synthetic fragrances suitable for a variety of flavor image has a high fashion fashion floral flavor of the consumer's preference, RB, The present invention was completed by confirming that the RG, RHB, RSMT, SEF50, SEF90 and ASEF indices were induced to increase.

In order to solve the above problems, the present invention is cis-3-hexenol (cis-3-Hexenol), ethyl linalool (Ethyl linalool), benzyl acetate (Benzyl acetate), Florol (Florol), phenylethyl alcohol (Phenylethyl alcohol, Floralozone, Iso E Super, dimethyl anthranilate, cis-3-hexenyl salicylate, hedion ), Helional, Bergamot oil, Lemon oil Italy, Peppermint essential oil extract, dermis essential oil extract, Mandarin oil colorless, Grapefruit oil white The present invention provides a fragrance composition for increasing concentration, containing a fragrance mixture mixed with a floral musk base and an isopropyl myristate as an active ingredient.

In addition, the present invention provides a health functional food for increasing concentration comprising the perfume composition.

In addition, the present invention provides a cosmetic composition for increasing concentration comprising the perfume composition.

In addition, the present invention is cis-3-hexenol, ethyl linalool, benzyl acetate, florol, phenylethyl alcohol, floral ozone (Floralozone), Iso E Super, Dimethyl anthranilate, cis-3-hexenyl salicylate, Hedion, Helional ( Helional, Bergamot oil, Lemon oil Italy, Peppermint essential oil extract, Dermis essential oil extract, Mandarin oil colorless, Grapefruit oil white, Floral musk base (floral musk base) and isopropyl myristate (Isopropyl myristate) to provide a method for producing a fragrance mixture having a concentration increase effect, characterized in that prepared by mixing.

The present invention also provides a flavor mixture having a concentration increase effect produced by the above method.

Tropical fashion flower combination fragrance of the present invention has a high preference of the consumer, while RB (relative beta power spectrum), RG (relative gamma power spectrum), RHB (relative high beta power) at various points of the brain spectrum), RSMT indicator (ratio of (SMR ~ mid beta) to theta power spectrum), SEF50 indicator (spectral edge frequency 50%), SEF90 (Spectral edge frequency 90%), ASEF (Spectral edge frequency 50% of alpha spectrum band ), Which can be used to develop a variety of fragrance industry products for consumers who want to improve their concentration.

Figure 1 is a photograph showing the 10-20 international standard electrode attachment method showing the site for attaching the electrode to the human brain for EEG measurement.
Figure 2 is a photograph showing the appearance of measuring the EEG with a cap for the electroencephalogram (EEG) on the brain of the subject.

In order to achieve the object of the present invention, the present invention is cis-3-hexenol, ethyl linalool, benzyl acetate, florol, phenylethyl alcohol (Phenylethyl alcohol), Floralozone, Iso E Super, Dimethyl anthranilate, cis-3-hexenyl salicylate, Hedion (Hedion), Helional, Bergamot oil, Lemon oil Italy, Peppermint essential oil extract, dermis essential oil extract, Mandarin oil colorless, Grapefruit oil white (Grapefruit) It provides a fragrance composition for increasing concentration, containing a perfume mixture of oil white, floral musk base and isopropyl myristate as an active ingredient.

In the fragrance composition of the present invention, the fragrance mixture is preferably 0.8-1.2 wt% cis-3-hexenol, 5.5-6.5 wt% ethyl linalool, benzyl acetate acetate) 5-6 wt%, Florol 7.5-8.5 wt%, Phenylethyl alcohol 4-5 wt%, Floralalozone 0.4-0.6 wt%, Iso E Super ) 5.5-6.5 wt%, dimethyl anthranilate 0.8-1.2 wt%, cis-3-hexenyl salicylate 6-7 wt%, Hedion 7 ~ 8 wt%, Helional 2.2 ~ 2.7 wt%, Bergamot oil 3.5 ~ 4.5 wt%, Lemon oil Italy 8-9 wt%, Peppermint essential oil extract 0.15 ~ 0.25 wt% %, Dermis essential oil extract 0.25 ~ 0.35 wt%, Mandarin oil colorless 1.3 ~ 1.7 wt%, Grapefruit oil white 9-10 wt%, floral musk Device (floral musk base) can be made to 6.5 ~ 8% by weight, and isopropyl myristate (Isopropyl myristate) 18 ~ 22% by weight,

More preferably, 1% by weight of cis-3-hexenol, 6% by weight of ethyl linalool, 5.5% by weight of Benzyl acetate, 8% by weight of Florol , 4.5 wt% Phenylethyl alcohol, 0.5 wt% Floralozone, 6 wt% Iso E Super, 1 wt% Dimethyl anthranilate, cis-3- 6.5% by weight of hexenyl salicylate, 7.5% by weight of Hedion, 2.5% by weight of Helional, 4% by weight of bergamot oil, Lemon oil Italy oil Italy) 8.5% by weight, peppermint essential oil extract 0.2%, dermis essential oil extract 0.3% by weight, Mandarin oil colorless 1.5% by weight, grapefruit oil white 9.5% by weight, floral musk base 7.2% by weight (floral musk base) and 19.8% by weight of isopropyl myristate Lure may be true.

The fragrance composition of the present invention increases the relative beta power spectrum (RB) in the right frontal lobe, right frontal lobe, central frontal lobe, and right occipital lobe, and increases the relative gamma power spectrum (RG) in the right frontal lobe, central frontal lobe, right occipital lobe, and left occipital lobe. RHB increased in the right frontal lobe, right frontal lobe, central frontal lobe, medial parietal lobe, and right occipital lobe and RMT of the right occipital lobe increased in the ratio of (SMR to mid beta) to theta power spectrum. , Increased SEF50 (spectral edge frequency 50%) in the right frontal lobe, right frontal lobe, medial frontal lobe, medial parietal lobe, left temporal lobe and right occipital lobe, and SEF90 (Spectral edge frequency 90%) in the right frontal lobe, medial frontal lobe and right occipital lobe. Increase of Spectral edge frequency 50% of alpha spectrum band in right frontal lobe, right frontal lobe, central frontal lobe, left temporal lobe, medial parietal lobe and right temporal lobe It is characterized by exhibiting an effect of increasing concentration.

RB refers to the proportion of Beta waves in total. Beta waves appear when doing general tasks or conscious actions and are activated when there is mental activity such as information processing. RG is the ratio of Gamma waves in total, and Gamma waves are known to be activated during high cognitive action such as reasoning and judgment. RHB refers to the ratio of high beta waves in total, and high beta waves appear when performing relatively complex inferences or complex information processing activities with high mental load, and RSMT means SMR ~ Mid Beta waves / Theta waves. SEF50 means the specific frequency value where the area up to a certain frequency value occupies 50% of the area for the frequency domain, and SEF90 means the specific frequency where the area up to each particular frequency value occupies 90% of the area for the frequency domain. A value, used to evaluate arousal levels. An increase in ASEF means an increase in the rate of fast alpha waves across the brain waves.

The present invention also provides a health functional food for increasing concentration, comprising the perfume composition of the present invention.

The dietary supplement includes various nutrients, vitamins, minerals (electrolytes), synthetic and natural flavors, colorants and enhancers (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like. Others may contain pulp for the production of natural fruit juices and vegetable drinks. These components can be used independently or in combination.

The dietary supplement of the present invention may contain various flavors or natural carbohydrates as additional ingredients. The natural carbohydrates are glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetening agent, natural sweetening agents such as tautin and stevia extract, synthetic sweetening agents such as saccharin and aspartame, and the like can be used.

The present invention also provides a cosmetic composition for increasing concentration comprising the perfume composition of the present invention.

The cosmetic composition is supple cosmetics, astringent cosmetics, nourishing cosmetics, nourishing lotion, nutrition essence, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base It is preferable to have a formulation selected from the group consisting of body lotion, body cream, body oil, body essence, lotion, ointment, gel, cream, patch and spray, but not limited thereto.

The present invention also provides cis-3-hexenol, ethyl linalool, benzyl acetate, florol, phenylethyl alcohol, and floral ozone. (Floralozone), Iso E Super, Dimethyl anthranilate, cis-3-hexenyl salicylate, Hedion, Helional ( Helional, Bergamot oil, Lemon oil Italy, Peppermint essential oil extract, Dermis essential oil extract, Mandarin oil colorless, Grapefruit oil white, Floral musk base It is prepared by mixing (floral musk base) and isopropyl myristate, increases RB (Relative Beta power spectrum) in the right frontal lobe, right frontal lobe, central frontal lobe, and right frontal lobe, right frontal lobe, central frontal lobe, right Occipital lobe and Increase the relative gamma power spectrum (RG) in the lateral occipital lobe, increase the relative high beta power spectrum (RHB) in the right frontal lobe, right frontal lobe, central frontal lobe, medial parietal lobe, and right occipital lobe, and increase the ratio of RSMT in the right occipital lobe. ~ mid beta) to theta power spectrum, increase SEF50 (spectral edge frequency 50%) in the right frontal lobe, right frontal lobe, medial frontal lobe, medial parietal lobe, left temporal lobe and right occipital lobe, and right frontal lobe, central frontal lobe and right Increases SEF90 (Spectral edge frequency 90%) in the occipital lobe and increases ASEF (Spectral edge frequency 50% of alpha spectrum band) in the right frontal lobe, right frontal lobe, central frontal lobe, left temporal lobe, right parietal lobe and right temporal lobe. It provides a method of preparing a fragrance mixture having an effect of increasing concentration.

The manufacturing method of the perfume mixture having an effect of increasing the concentration of the present invention, more specifically, based on the total weight of the perfume mixture, cis-3- hexenol (cis-3-Hexenol) 0.8 ~ 1.2% by weight, ethyl linalul (Ethyl linalool) 5.5 ~ 6.5 wt%, Benzyl acetate 5-6 wt%, Florol 7.5 ~ 8.5 wt%, Phenylethyl alcohol 4-5 wt%, Floralozone 0.4 ~ 0.6% by weight, 5.5-6.5% by weight Iso E Super, 0.8-1.2% by weight dimethyl anthranilate, cis-3-hexenyl salicylate ) 6 ~ 7 wt%, Hedion 7 ~ 8 wt%, Helional 2.2 ~ 2.7 wt%, Bergamot oil 3.5 ~ 4.5 wt%, Lemon oil Italy 8 ~ 9% by weight, Peppermint essential oil extract 0.15 ~ 0.25% by weight, dermis essential oil extract 0.25 ~ 0.35% by weight, Mandarin oil colorless 1.3-1.7% by weight, grapefruit One white (Grapefruit oil white) 9 ~ 10% by weight, and floral musk base (floral musk base) 6.5 ~ 8 may be prepared by mixing the weight percent of isopropyl myristate (Isopropyl myristate) 18 ~ 22% by weight,

More specifically, based on the total weight of the perfume mixture, 1% by weight of cis-3-Hexenol, 6% by weight of ethyl linalool, 5.5% by weight of benzyl acetate, flo 8 wt% Florol, 4.5 wt% Phenylethyl alcohol, 0.5 wt% Floralozone, 6 wt% Iso E Super, Dimethyl anthranilate 1 Wt%, cis-3-hexenyl salicylate 6.5 wt%, Hedion 7.5 wt%, Helional 2.5 wt%, Bergamot oil 4 wt% %, Lemon oil Italy 8.5%, Peppermint essential oil extract 0.2%, Dermal essential oil extract 0.3%, Mandarin oil colorless 1.5%, Grapefruit oil white 9.5% by weight, 7.2% by weight floral musk base and isopropyl myri stay It may be prepared by mixing 19.8% by weight of sodium (Isopropyl myristate).

The present invention also provides a perfume mixture having a concentration increasing effect produced by the above method.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

Preparation of Fragrance Samples

The fragrance composition of the present invention used to develop the tropical fashion flower fragrance of the present invention is cis-3-hexenol, ethyl linalool, benzyl acetate, florol (Florol), Phenylethyl alcohol, Floralozone, Iso E Super, Dimethyl anthranilate, Cis-3-hexenyl salicylate (cis-3 -hexenyl salicylate, Hedion, Helional, Bergamot oil, Lemon oil Italy, peppermint essential oil extract, dermis essential oil extract, Mandarin oil colorless Grapefruit oil white and Isopropyl myristate purchased samples from a domestic raw material supplier with a clear CAS number. And dermis, peppermint oil was performed using a steam distillation apparatus (EssenLab-Plus, HANIL LABTECH, Korea). 2 L of distilled water was put in the steam generating part of the steam distillation apparatus, 1 kg of the sample was put in the essential oil generating part, and 4 ° C. cooling water was continuously flowed through the cooling tube. Steam was generated while maintaining the temperature of the steam generating part at 100 ° C. for 90 minutes, and the essential oil contained in the sample was condensed in a cooling tube and collected in a distilled water layer and an essential oil layer in a receiver. In order to collect only the essential oil, the essential oil layer was passed through a triangle funnel containing anhydrous sodium sulfate to remove moisture and impurities, and the collected essential oil was stored in a refrigerator at 4 ° C.

Production Example  One. Tropical  fashion flower  Development of fragrance fragrance composition

Tropical fashion flower scent of the present invention uses a variety of citrus spices such as bergamot, lemon, grapefruit, etc. in consideration of the fresh and fresh image based on the smell of ozonic odor of tropical beach sweetness and sea breeze Helional and floral aozone were added, and herb and freshness of peppermint essential oil extracts were added, and dermal essential oil extracts that strengthen citrus were added to make a natural image. Cis-3-Hexenol, Ethyl linalool, Benzyl acetate, Florol, Phenyl to develop compositions with novel tropical fashion flower odors Phenylethyl alcohol, Floralozone, Iso E Super, Dimethyl anthranilate, cis-3-hexenyl salicylate, Hedion, Helional, Bergamot oil, Lemon oil Italy, Peppermint essential oil extract, dermis essential oil extract, Mandarin oil colorless, Grapefruit oil white (Grapefruit oil white), isopropyl myristate (Isopropyl myristate) was mixed as shown in Table 1 to develop five species.

Composition and Composition Ratio for Development of New Tropical Fashion Flower Flavor Fragrance ingredients CAS Combination
Spices
One Combination
Spices
2 Combination
Spices
3 Combination
Spices
4 Combination
Spices
5 One cis-3-Hexenol 928-96-1 0.5 1.0 1.0 1.0 2.0 2 Ethyl linalool 10339-55-6 8.0 6.0 6.0 6.0 4.0 3 Benzyl acetate 140-11-4 6.5 5.5 5.5 5.5 4.5 4 Florol 63500-71-0 5.0 6.0 7.0 8.0 10 5 Phenylethyl alcohol 60-12-8 8.5 7.5 6.5 4.5 2.5 6 Floralozone 67634-15-5 0.2 0.2 0.5 0.5 1.0 7 Iso e super 54464-57-2 9.0 8.0 7.0 6.0 5.0 8 Dimethyl anthranilate 85-91-6 0.5 0.5 0.5 1.0 1.5 9 cis-3-hexenyl salicylate 65405-77-8 12.5 10.5 8.5 6.5 4.5 10 Hedion 24851-98-7 10.5 9.5 8.5 7.5 6.5 11 Helional 1205-17-0 1.5 2.5 2.5 2.5 3.5 12 Bergamot oil 8007-75-8 2.0 3.0 3.0 4.0 5.0 13 Lemon oil italy 8008-56-8 2.5 4.5 6.5 8.5 10.5 14 Peppermint Essential Oil Extract 0.1 0.1 0.1 0.2 0.3 15 Dermis essential oil extract 0.1 0.2 0.2 0.3 0.5 16 Mandarin oil colorless 8008-31-9 0.5 0.5 1.0 1.5 1.5 17 Grapefruit oil white 8016-20-4 12.5 11.5 10.5 9.5 8.5 18 Floral musk base 1 5.2 5.2 5.2 7.2 9.2 19 Isopropyl myristate 110-27-0 14.4 17.8 20 19.8 19.5 Sum 100 100 100 100 100

Example  One. Tropical  fashion flower  Investigate consumer preferences for perfume compositions

Preference of the five combination flavors steered in Preparation Example 1 was soaked in a taste paper (0.5 cm × 13 cm) for 30 general consumers in their 30s and 30, and then incense at 5 cm from the nose. 10 points for the most preferred flavor and 0 for the most unfavorable flavor. The average value was calculated based on the preference result, which is shown in Table 2.

According to a preference survey for five tropical fashion flower fragrance compositions, consumers in their teens and thirties preferred the composition of combination fragrance 4. The lowest preference was Combination Flavor 1 with a preference of 5.6.

Consumer Preference for Five Combination Flavors Consumer preference Combination spices 1 Combination spices 2 Combination spices 3 Combination spices 4 Combination spices 5 medium 5.6 6.6 8.0 9.1 7.8

Example  2. Tropical  fashion Flower  Scent evaluation

The flavor evaluation of the combination perfume 4, which had the highest consumer preference through Example 1, was carried out by four professional panels of Rose of Sharon, a perfume development club of Kangwon National University, which had been trained for more than six months. The fragrance selected in Example 1 was soaked in a sachet (0.5 cm × 5 cm), and then the fragrance was placed at a 5 cm position from the nose of the panel to smell the fragrance, using the fragrance evaluation terminology. It was. Fragrance types used in sensory evaluation are aldehydes, animalic, balsamic, citrus, coniferous, earthy, floral, and fury fruity, green, herbal, medical, minty, marine, mosy, musky, oily, oriental , Powdery, smokey, spicy, sweet and woody, commonly used by the odor evaluation expert group.

Odor Evaluation for Combination Fragrance 4 Scent Type Aldehyde Animalic Balsamic ○ Citrus ○ Coniferous Earthy Floral Fruity ○ Green ○ Herbal Medicinal Minty ○ Marine Musky Oily Oriental Powdery Smoky Spicy Sweet Woody

Example  3. Tropical  fashion flower  Combination spices 4 teeth  Effect on human brain waves

In Example 1, the electroencephalogram (EEG) was measured to know how the combination flavor 4, which had the highest consumer preference, was inhaled upon human brain activity. Electroencephalography was performed on 20 subjects, 10 males and 10 females, in a 32.4 m ² laboratory maintained at a temperature of 23 ° C. and a humidity of 50% without noise.

The EEG measuring instrument used for EEG measurement was Quick-30 Dry EEG Headset (Cognionics, Inc. USA) .The EEG signal measurement of the participants was carried out by Cognionics Cognionics Data Acquisition Software, and EEG data analysis was performed by LAXTHA's data collection equipment and analysis. The program (Telescan) was used. Participants were asked to wear an EEG cap with 29 ground electrodes distributed using the International 10 ~ 20 System, and the ground electrodes were EEG drypad sensors (Cognionics, Inc. USA) on the left and right frontal lobes (Fp1, Fp2). ), Left and right frontal lobes (Af3, Af4, Fc5, Fc6, F3, Fz, F4, F7, F8), left and right temporal lobes (T7, T8, C3, Cz, C4, Cp5, Cp6), left and right Flex Sensors (Cognionics, Inc. USA) were attached to the right parietal lobe (P3, Pz, P4, P7, P8), left and right occipital lobes (Po3, Po4, Po7, Po8, O1, O2). Drypad Sensors were also used to attach the reference electrodes to the left earlobe.

The air bomb outlet was placed 5 cm before the test participant and measured for 120 seconds (2 minutes) each for 60 seconds before the inhalation of the perfume (no stimulation) and the inhalation state (fragrance).

Data processing obtained through EEG measurement was performed by extracting only the EEG signals for a typical 50 seconds among the EEG signals of the experiment participants, followed by a batch processing program, and then using SPSS (SPSS 24.0 version), a statistical analysis software program. A paired T test was performed. In the present embodiment, the types of EEG indicators for data analysis before and during inhalation (non-irritation) and inhalation (fragrance stimulation) of tropical fashion flowers are shown in Table 4, and the meanings of the respective EEG indicators are shown in Table 5. .

Types of EEG Indicators Used in Data Analysis No. Analysis Full name of EEG indicator Wavelength band (Hz) One AT Absolute Theta Power Spectrum 4 ~ 8 2 AA Absolute Alpha Power Spectrum 8-13 3 AB Absolute Beta Power Spectrum 13-30 4 AG Absolute Gamma Power Spectrum 30-50 5 AFA Absolute Fast Alpha Power Spectrum 11-13 6 ASA Absolute Slow Alpha Power Spectrum 8 ~ 11 7 ALB Absolute Low Beta Power Spectrum 12-15 8 AMB Absolute Mid Beta Power Spectrum 15-20 9 AHB Absolute High Beta Power Spectrum 20-30 10 RT Relative Theta Power Spectrum (4-8) / (4-50) 11 RA Relative Alpha Power Spectrum (8-13) / (4-50) 12 RB Relative Beta Power Spectrum (13-30) / (4-50) 13 RG Relative Gamma Power Spectrum (30-50) / (4-50) 14 RFA Relative Fast Alpha Power Spectrum (11-13) / (4-50) 15 RSA Relative Slow Alpha Power Spectrum (8-11) / (4-50) 16 RLB Relative Low Beta Power Spectrum (12-15) / (4-50) 17 RMB Relative Mid Beta Power Spectrum (15-20) / (4-50) 18 RHB Relative High Beta Power Spectrum (20-30) / (4-50) 19 RST Ratio of SMR to Theta (12-15) / (4-8) 20 RMT Ratio of Mid Beta to Theta (15-20) / (4-8) 21 RSMT Ratio of (SMR-Mid Beta) to Theta (12-20) / (4-8) 22 RAHB Ratio of Alpha to High Beta (8-13) / (20-30) 23 SEF50 Spectral Edge Frequency 50% 4-50 24 SEF90 Spectral Edge Frequency 90% 4-50 25 ASEF Spectral Edge Frequency 50% of Alpha Spectrum Band 8-13

Meaning of EEG Indicators Used in Data Analysis No. Analysis meaning One AT Absolute Power of Theta Wave (when meditating, sleepy) 2 AA Alpha wave absolute power (relaxation, stability) 3 AB Absolute power of beta wave (tension, arousal, activity, cognition) 4 AG Absolute Power of Gamma Wave (High Cognition or Anxiety, Excitement) 5 AFA Absolute power of fast alpha waves (comfort and immersion) 6 ASA Absolute power of slow alpha wave (relaxation) 7 ALB Absolute power of low beta wave, also called SMR wave (attention or boundary) 8 AMB Absolute power of Mid beta wave (focus, attention) 9 AHB Absolute power of high beta wave (stress, mental load, tension) 10 RT Proportion of theta waves in total 11 RA Percentage of Alpha Waves in Total 12 RB Percent of Beta Waves in Total 13 RG Of Gamma waves in total 14 RFA Ratio of Fast Alpha Waves in Total 15 RSA The ratio of Slow Alpha waves to the total 16 RLB The ratio of low beta wave in total 17 RMB The ratio of Mid Beta wave to total 18 RHB The ratio of high beta waves in total 19 RST The ratio of Theta waves to SMR waves in total 20 RMT The ratio of theta wave to mid beta wave 21 RSMT SMR ~ Mid Beta wave / Theta wave (EEG concentration indicator) 22 RAHB Alpha wave / High Beta wave (stability and relaxation) 23 SEF50 Median Frequency Brain Activity (EEG) 24 SEF90 Median Frequency Brain Activity (Mental Load, Stress) 25 ASEF Alpha wave SEF50 (comfort: many Fast Alpha waves)

As a result of analyzing the effect of the combination perfume 4, which was the most preferred in Example 1 of the present invention, on human brain waves, RB indicator, RG indicator, RHB indicator, RSMT indicator, SEF50 indicator, SEF90 indicator, ASEF indicator among 25 indicators. Only statistically significant ( p <0.05) is described.

RB (relative beta power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the RB index increased statistically ( p <0.05) at the electrode attachment sites Fp2, Af4, Fz, Fc6 and Po6 (Table 6). ). The RB index is the absolute power ratio of the beta band to the absolute power of the entire frequency domain in the EEG spectrum, which means the relative power spectrum value obtained by dividing the beta wave region (13 to 30 Hz) into the full frequency region (4 to 50 Hz). . Since the RB wave was increased upon inhalation of the combination perfume 4 of the present invention, it was determined that the concentration of the brain was increased.

2.RG (relative gamma power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the RG index was increased in the frontal lobe F8 and Fz, the occipital lobe Po6 and Po3, which are electrode attachment sites (Table 7). The RG index is an absolute power ratio of gamma band to absolute power of the entire frequency domain in the EEG spectrum, and means a spectral value obtained by dividing the gamma wave region (30-50 Hz) into the entire frequency region (4-50 Hz). Gamma wave is one of the fastest waves in the brain, and it is known to be activated when it is emotionally nervous or at high cognitive effects such as reasoning and judgment. Increased RG by inhalation of Combination Fragrance 4 indicates increased brain cognition.

3. RHB (relative high beta power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the RHB index was increased at Fp2, Af4, F8, Fz, F4, Fc6, Cz, Po6, and O2 sites (Table 8). The RHB index is the absolute power ratio of the high beta band to the absolute power of the entire frequency domain in the EEG spectrum. It is a spectral value obtained by dividing the high beta wave region (20 to 30 Hz) into the full frequency region (4 to 50 Hz). . Increasing RHB by inhalation of Combination Fragrance 4 indicates an increase in brain activity, ie tension.

4.RSMT (ratio of (SMR ~ mid beta) to theta power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the RSMT index was increased in the occipital lobe Po6, which is an electrode attachment site (Table 9). The RSMT indicator is the spectral value obtained by dividing the SMR to mid beta wave region (12 to 20 Hz) into the theta wave region (4 to 8 Hz) by the SMR to mid beta / theta ratio in the EEG spectrum. It is used as an EEG concentration index. Increased RSMT indices with inhalation of Combination Fragrance 4 indicates enhanced brain concentration.

5.SEF50 (spectral edge frequency 50%)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the SEF50 index was increased at the Fp2, Af4, F8, Fz, Fc6, Cz, Cp5, and Po6 sites (Table 10). SEF50 indicators can be used to determine workload and arousal status as a baseline for cortical activity on cognitive activity. The frequency ratio of how much the EEG power spectral distribution is biased toward the high frequency compared to the low frequency is expressed as the area ratio for the entire frequency range. The higher the SEF50 value, the higher the frequency component of the power spectral distribution. . Increased SEF50 indices with inhalation of Combination Fragrance 4 indicates enhanced brain activity.

6.SEF90 (Spectral edge frequency 90%)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the SEF90 index was increased in the frontal lobe F8 and Fz and the occipital lobe Po6, which are electrode attachment sites (Table 11). The SEF90 indicator refers to a specific frequency value where the area up to each specific frequency value occupies 90% of the area of the frequency domain, and assesses the cognitive load felt during the task: mental stress levels and excessive mental arousal levels. It is used to Increased SEF90 by inhalation of Combination Fragrance 4 indicates increased brain arousal.

7. Spectral edge frequency 50% of alpha spectrum band (ASEF)

As a result of measuring EEG before and during inhalation of the combination perfume 4 of the present invention, the ASEF index was increased at the electrode attachment sites Fp2, Af4, F8, Fz, F4, Fc6, T7, Cz and C4 (Table 12). The ASEF index is an EEG indicator that shows comfort with alpha wave SEF50, and it is known that alpha wave EEG activity can be confirmed. Increasing ASEF with inhalation of Combination Fragrance 4 indicates an increase in brain comfort.

Claims (8)

delete delete delete delete delete delete 0.8 to 1.2 weight percent cis-3-Hexenol, 5.5 to 6.5 weight percent ethyl linalool, 5 to 6 weight percent benzyl acetate, based on the total weight of the fragrance mixture , 7.5 ~ 8.5 wt% Florol, 4-5 wt% Phenylethyl alcohol, 0.4 ~ 0.6 wt% Floralozone, 5.5 ~ 6.5 wt% Iso E Super, Dimethyl anthranilate 0.8-1.2 wt%, cis-3-hexenyl salicylate 6-7 wt%, Hedion 7-8 wt%, Helio Healal 2.2 ~ 2.7 wt%, Bergamot oil 3.5 ~ 4.5 wt%, Lemon oil Italy 8-9 wt%, Peppermint essential oil extract 0.15 ~ 0.25 wt%, dermis essential oil extract 0.25 ~ 0.35 wt%, Mandarin oil colorless 1.3-1.7 wt%, Grapefruit oil white 9-10 wt%, floral musk base 6.5-8 wt% It is prepared by mixing 18-22% by weight of isopropyl myristate, and increases the RB (Relative Beta power spectrum) in the right frontal lobe, right frontal lobe, central frontal lobe, and right occipital lobe, right frontal lobe, central frontal lobe, and right occipital lobe. And increase the relative gamma power spectrum (RG) in the left occipital lobe, increase the relative high beta power spectrum (RHB) in the right frontal lobe, right frontal lobe, central frontal lobe, medial parietal lobe, and right occipital lobe, and in the right occipital lobe SMR ~ mid beta) to theta power spectrum, increased SEF50 (spectral edge frequency 50%) in the right frontal lobe, right frontal lobe, right frontal lobe, medial parietal lobe, left temporal lobe and right occipital lobe, and right frontal lobe, central frontal lobe and Increase SEF90 (Spectral edge frequency 90%) in the right occipital lobe, right frontal lobe, right frontal lobe, central frontal lobe, left temporal lobe, Method of manufacturing a fragrance mixture having a central parietal and concentration increase effect, comprising a step in the right temporal increase the ASEF (Spectral edge frequency 50% of alpha spectrum band). Fragrance mixture having a concentration increase effect prepared by the method of claim 7.

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