KR102055499B1 - Perfume composition for decreasing relative theta wave and relative alpha wave of brainwave containing essential oil of Chrysanthemum indicum L and use thereof - Google Patents

Abstract

In the present invention, the fragrance composition, which contains the essential oil of persimmon flower as an active ingredient, reduces the relative theta wave in the brain wave and increases the relative alpha wave, thereby providing a fragrance composition exhibiting the effect of improving concentration through psychological stability and positive brain activity.
The fragrance composition according to the present invention can be used as a fragrance composition such as conventional perfumes and fragrances, as well as used in aromatherapy for relieving tension, relieving stress, enhancing psychological stability and concentration, and for cosmetic compositions and health hygiene products. It can be used as a flavoring ingredient. The fragrance composition, cosmetic composition and health hygiene product according to the present invention contains the fragrance composition of the present invention and at the same time have a chrysanthemum fragrance, and when inhaling the fragrance emitted from them, it increases the relative alpha wave in the brain waves and reduces the relative theta wave to stabilize the mind and body It can have the effect of improving positive brain activity and concentration.

Description

Perfume composition for decreasing relative theta wave and relative alpha wave of brainwave containing essential oil of Chrysanthemum indicum L and use according to the EEG containing persimmon flower essential oil as an active ingredient }

The present invention relates to a fragrance composition and its use to reduce the relative theta wave and increase the relative alpha wave in the EEG comprising persimmon flower essential oil as an active ingredient, more specifically comprising an essential oil extracted from persimmon flower as an active ingredient, It relates to a perfume composition and its use which is effective in improving psychological stability and concentration by reducing relative theta waves and increasing the relative alpha waves in the brain waves when inhaled.

Anxiety is a condition of psychological tension when you are in a difficult environment. If the anxiety persists, it may indicate psychological maladjustment such as insomnia, depression, or panic disorder, or may cause physical diseases such as heart disease, gastric ulcer, and high blood pressure. Appropriate tension can be a vital energy for life, boosting life and increasing productivity, but excessive tension can lead to psychological anxiety, which can lead to various diseases and difficulty in daily life due to poor concentration.

In the neuronal cells that make up the human cerebral cortex, microscopic electrical activity is constantly occurring. EEG is a measure of the potential variation on the scalp through tissues, skulls, and scalp that cover the surface of the cerebral cortex. In order to measure EEG, electrodes are placed on the scalp, and electrical signals generated from the brain are input to the electroencephalogram to record the potential over time. The result is called an electroencephalogram or electroencephalogram (EEG). EEG has the advantage of being able to record fluctuations in brain activity that change from time to time and in time and space, and have the advantage of being able to measure brain function simply and non-invasively and continuously, such as brain activity records, disease diagnosis, sleep studies, and psychotherapy. It is widely used and known in cognitive science, medicine and pharmacy.

EEG is a delta wave (0.5 ~ 3Hz), theta wave (4 ~ 7Hz), alpha wave (8 ~ 13Hz), beta (14 ~ 30Hz) depending on the frequency range. , Gamma (gamma) (30Hz or more), delta wave occurs during sleep, theta wave is a brain wave that passes when you fall asleep mainly appears in the dormant or dull state or hypnotic state, alpha wave is relaxed mind and body It is the most common brain wave when it feels comfortable. Beta wave is shown when doing general work or conscious action. It is activated when there is mental activity such as information processing. Gamma wave comes from extreme arousal and excitement.

Gamguk ( Chrysanthemum indicum L) is a perennial herb that blooms dark yellow flowers in wild mountains throughout the country from September to October. Persimmon flowers have been consumed as tea, and it has antipyretic, detoxification, analgesic, anti-inflammatory and antioxidant effects. Have been used (Patent Nos. 10-2017-0019829 and 10-2009-0112133).

When inhaling plant essential oils, volatile aromatic compounds contained in essential oils pass through the nasal cavity to reach the olfactory epithelium, and olfactory neurons in the olfactory epithelium detect this and transmit electrical signals to the brain. It is known that unique brain waves are generated every time.

Accordingly, interest in fragrance (aroma) therapy using plant essential oils is increasing, and the utilization of various fields, such as cosmetics, cosmetics, and health hygiene products, is highly demanded to discover functional plant essential oils.

As a result of continuing research to meet the demands of the prior art, the present inventors found that the essential oil extracted from persimmon flowers decreased the relative theta wave and the relative alpha wave in the brain wave when inhaled, thereby improving the concentration through psychological stability and positive brain activity. It was confirmed that the present invention has the functionality to complete the present invention.

Accordingly, an object of the present invention is to provide a fragrance composition containing the essential oil of persimmon flower as an active ingredient, the relative theta wave is reduced in the brain wave and the relative alpha wave is increased to exert the effect of improving concentration through psychological stability and positive brain activity.

It is also an object of the present invention to provide a use of the perfume composition in the field of cosmetics, cosmetics and hygiene.

In order to achieve the above object, the present invention provides a perfume composition comprising the essential oil of persimmon flower.

In the present invention, "persimmon flower" means petals and / or buds of persimmon, and the persimmon flower is dried and used in the shade.

In the present invention, the persimmon flower essential oil can be obtained by extracting the petals and / or buds of persimmon soup by the Absolute extraction method combining the volatile solvent extraction and ethanol extraction.

Specifically, the persimmon flower essential oil of the present invention may be prepared by an extraction method comprising the following steps:

Iv) added to hexane of 10-30 volume times the weight of persimmon flower, immersed for 1 to 3 days at room temperature and extracted first

Ii) The primary extract was filtered and concentrated under reduced pressure to obtain concrete.

Iv) dissolve in ethanol of 1 to 3 times the weight of concrete, and extract it for 2 to 6 hours at -10 to 5 ° C.

Iii) Centrifugation of the secondary extract to separate the supernatant and concentrated under reduced pressure to obtain Absolute oil.

The 'concrete' refers to a state in which a solvent is volatilized and a flower and a fragrance substance are dissolved together.

1,8-cineol, Camphor, β-phellandrene (β-) having the structural formula shown in Table 1 below as the main fragrance component of the essential oil of the persimmon flower extracted according to the present invention Phellandrene), α-Terpinene, 1-methyl-3-1-methylethyl benzene, 1,1,7-trimethyl-2,2,1 Heptene-2-ol (1,7,7-Trimethyl-2,2,1-heptan-2-ol), Azulene, Campen, Bonyl acetate, β-oxymen (β-Ocimene), α-Copaene, Tetradecane, Caryophyllene, Germacrene D, β-Farnesene, β- Β-Selinene, β-Sesquiphellandrene, Aroma dendrene, β-Bisabolene and the like.

1,8-Cineole Camphor Camphene β-Phellandrene

Germacrene d 1,7,7-Trimethyl-2,2,1-heptan-2-ol Caryophyllene β-Ocimene

Bornyl acetate β-Farnesene β-Sesquiphellandrene β-Selinene

Perfume composition comprising the essential oil of persimmon flower according to the present invention, while releasing the scent of the natural chrysanthemum, while reducing the absolute value of the whole brain wave, increase the relative alpha wave in the brain wave and decrease the relative theta wave, In addition, it has the ability to improve concentration by enabling positive brain activity (Test Example 2, Table 3).

In addition, the fragrance composition comprising the essential oil of persimmon flower according to the present invention exhibits a relaxation effect in the reduction of systolic blood pressure and heart rate in humans (Test Example 3).

According to another object of the present invention, the use of the fragrance composition comprising the essential oil of the persimmon flower as an active ingredient according to the present invention, that is, as a fragrance component, such as perfume composition, cosmetic composition, health hygiene, etc. To be used.

Perfumes according to the present invention may further comprise one or more of the fragrance ingredients that can be commonly used with the persimmon essential oil of the present invention. Flavoring ingredients that can be used commonly include α-pinene, limonene, menthol, phenylethyl alcohol, styralyl acetate, eugenol, rose oxide, linarol, benzaldehyde, muscone, methyl dihydrojasmonate, cis-jasmon, di Hydrojasmon, γ-undecalactone, hexylcinnamic acid aldehyde, jasmal, heliobuke, and the like, but are not particularly limited thereto.

The incense according to the present invention may further include components such as wood, bark and yellow lacquer, which are commonly included in the preparation of incense, together with the persimmon flower essential oil of the present invention.

The blending amount of the persimmon flower essential oil of the present invention in the fragrance composition varies depending on the type and purpose of the fragrance composition formulated, but is preferably used in an amount of about 0.01 to 10% by weight.

The cosmetic composition according to the present invention may include the perfume composition in an amount of 0.01 to 5% by weight based on the total weight of the cosmetic composition, and can be adjusted within the above range according to the characteristics of the cosmetic composition.

In the present invention, the formulation of the cosmetic composition, lotion, lotion, essence, cream, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base, body lotion, body cream, body oil, body essence, ointment, gel , Creams, patches and sprays.

Health hygiene products that can be used to contain the fragrance composition of the present invention is a shampoo, rinse, kohlong, hair tonic, hair cream, pomade, indoor fragrance, soap, dishwashing detergent, laundry detergent, softener, disinfectant detergent, odor removal Detergents, toothpaste, mouse wash and toilet paper.

Perfume composition comprising the essential oil of persimmon flower according to the present invention, in addition to releasing the scent of the natural chrysanthemum, the absolute value of the total brain waves during inhalation decreases, increase the relative alpha wave in the brain waves and decrease the relative theta wave to relax the mind and body ( In addition to its ability to enhance concentration by enabling positive brain activity, it can be used as a normal perfume and incense, as well as in aromatherapy for stress relief, stress relief, psychological stability and concentration. have.

Perfume composition according to the present invention can be used as a perfume component in the cosmetic composition and health hygiene products.

Perfumes, fragrances, cosmetic compositions, and health hygiene products according to the present invention contain the fragrance composition of the present invention, while releasing the scent of the natural chrysanthemum, while increasing the relative alpha wave among the brain waves when inhaling the fragrance emitted from them, and the relative theta wave. It can reduce the effects of mental and physical stability, positive brain activity and concentration.

In addition, the fragrance composition of the present invention can also be used for yawning buds and unflowered buds that are not used as a tea in the manufacture of the country can contribute to the high value added of resources and increase in farm income.

1 is a chromatogram analyzed by gas chromatography of the persimmon oil essential oil according to the present invention.
Figure 2 is a graph showing the relative ratio of brain waves before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
3 is an EEG map showing changes in theta wave before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
Figure 4 is an electroencephalogram map showing the change in alpha wave before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
5 is an electroencephalogram map showing changes in beta waves before and after inhalation of the fragrance of a pharmaceutical composition according to the present invention.
6 is an electroencephalogram map showing changes in gamma waves before and after inhalation of the fragrance of a pharmaceutical composition according to the present invention.
7 is an EEG map showing changes in theta wave relative ratio before and after inhalation of the fragrance composition of the present invention.
8 is an electroencephalogram map showing a change in alpha wave relative ratio before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
9 is an electroencephalogram map showing changes in beta-wave relative ratios before and after inhalation of the perfume composition of the present invention.
10 is an EEG map showing a change in gamma wave relative ratio before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
11 is a graph showing the change in systolic blood pressure before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
12 is a graph showing changes in diastolic blood pressure before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
13 is a graph showing the change in heart rate before and after inhalation of the fragrance of the pharmaceutical composition according to the present invention.
Figure 14 shows a chromatogram (254 nm) of persimmon flower extract using UPLC-PDA as a control.

The invention is explained in more detail by the following examples. These examples are intended to illustrate the invention and the scope of the invention should not be limited by them.

Example

Preparation Example: Manufacture of Persimmon Flower Essential Oil

Gam-guk is grown by harvesting the species (Jeju) owned by the Institute of Medicinal Resources, Gyeongsangnam-do Agricultural Research Institute, located in Hamyang-gun, Gyeongnam, and dried for 10 to 15 days in the shade. It was.

To 500 g of crushed persimmon flower, 5L of hexane (10 times the weight of the flower) is added, followed by immersion for 2 days at room temperature, followed by primary extraction, and filtering impurities using a filter paper (TOYO, Filter Paper NO.2) and rotating the filtrate. Concrete was obtained by rotating under reduced pressure at 20 ° C. using a concentrator (EYELA, N1200B). 1L of ethanol was added to the concrete to completely dissolve it, and the mixture was extracted for 2 hours in a refrigerator (-10 ° C) for 5 hours. The extract was centrifuged (7000rpm, 10 to 20 minutes), and the supernatant was again heated at 20 ° C in a rotary concentrator. Concentration was carried out under reduced pressure while maintaining below to obtain a fragrance composition of Absolute oil (essential oil), which was stored in a refrigerator for analysis of the following test example.

The extraction efficiency of Absolute oil was about 2.2 to 3%.

Test Example 1 Analysis of Flavor Components in Essential Oil of Persimmon Flower

After diluting 20 times the persimmon flower essential oil (Absolut oil) obtained in the above preparation example with ethyl ether, 1 μl was injected into a gas chromatography-mass spectrometer (Agilent 7890A GC with 7693 auto sampler) to inject the components into SPME. Analyzed by law. The column type of gas chromatography was Agilent DB-5MS cappiary, 0.25 µm, and the inlet temperature was 250 ° C. The oven temperature was maintained at 40 ° C. for 5 minutes, the temperature was raised to 3 ° C. per minute to 150 ° C., and then maintained for 5 minutes, and the temperature was maintained at 7 ° C. per minute to 220 ° C. and maintained for 5 minutes. Helium (1 ml / min) was used as the carrier gas, and the ion source temperature of the mass selective detector was 200 ° C and the quadrapole temperature was 150 ° C. The automated sampler used an 7697A Headspace sampler and had an oven temperature of 80 ° C, a loop temperature of 90 ° C and a transferline temperature of 100 ° C.

Component analysis was performed by using GC-MS to obtain the mass spectrum of each component, and then searching through the library search data system of GC-MS.

As described above, the chromatogram analyzed by gas chromatography of persimmon flower essential oil of the present invention is shown in FIG. 1, and the main volatile components contained in the essential oil of persimmon flower through GC analysis are shown in Table 2.

Volatile Flavor Compounds Retention time (min) Retention
index Content (ug / mL) 1,8-Cineole 16.35 1063 66.18 ± 80.59 1,7,7-Trimethyl-2,2,1-heptan-2-ol 20.60 1203 45.19 ± 2.05 Camphene 13.58 977 3.88 ± 0.64 β-Phellandrene 15.42 1033 4.35 ± 2.95 α-Terpinene 15.81 1046 4.53 ± 1.32 1-Methyl-3-1-methylethyl benzene 16.06 1054 6.73 ± 5.08 β-Ocimene 16.75 1075 60.77 ± 84.63 Camphor 20.10 1187 621.08 ± 18.51 Azulene 21.01 1219 4.81 ± 0.05 Bornyl acetate 23.77 1320 86.99 ± 17.21 α-Copaene 26.05 1408 4.20 ± 0.94 Tetradecane 26.44 1424 20.07 ± 4.16 Caryophyllene 27.24 1457 36.18 ± 8.46 Germacrene d 27.40 1463 117.43 ± 16.62 β-Farnesene 28.01 1488 38.33 ± 9.49 Aroma dendrene 28.40 1503 3.32 ± 3.66 β-Selinene 28.56 1510 26.05 ± 5.36 α-Farnesene 29.11 1534 4.73 ± 2.06 β-Bisabolene 29.20 1538 3.76 ± 0.74 β-Sesquiphellandrene 29.61 1555 24.89 ± 4.34

As shown in Table 2, the main volatile fragrance components of the fragrance composition of the present invention are 1,8-cineol, 1,8-Cineole, Camphor, β-Phellandrene, α- Terpinene, α-Terpinene, 1-methyl-3-1-methylethyl benzene, 1,1,7-trimethyl-2,2,1-heptene-2- All (1,7,7-Trimethyl-2,2,1-heptan-2 -ol), Azulene, Camphene, Bonyl Acetate, β-Ocimene , α-Copaene, tetratradecane, Caryophyllene, Germacrene D, β-Farnesene, β-celinene (β- Selinene), β-Sesquiphellandrene, β-Sesquiphellandrene, Aroma dendrene and β-Bisabolene. Especially 1,8-cineol (66.18 ug / mL), camphor (621.08 ug / mL), 1,1,7-trimethyl-2,2,1-hepten-2-ol (45.19 ug / mL), carbonyl acetate (86.99 ug / mL), β-oxymen (60.77 ug / mL), and germanium di (117.43 ug / mL).

Test Example 2 EEG Change Assay by Inhalation of Perfume Composition

In order to test the physiological and psychological effects of the perfume composition of the persimmon flower essential oil according to the present invention prepared in the preparation example, the change of EEG following the inhalation of the perfume composition of the present invention was measured.

<Test method>

The test subjects were 12 adult men and women who had no history of mental illness and had no continuous medication and nose surgery, and refrained from excessive exercise or excessive alcohol intake on the day before the experiment. Avoid smoking, drinks, drugs, and gum.

The experiment was carried out in the olfactory laboratory, and there are intake and exhaust facilities for the purpose of reducing compliance with the smell, and sound insulation is installed to maximize the participants' participation in the experiment and to exclude the influence of the external environment during the experiment. . The internal temperature, humidity, and illuminance were kept constant during the experiment. After the experiment was completed for one condition, the test subject was allowed to rest sufficiently that there was no influence on fragrance and fatigue, and the experiment was performed after ventilating the inside of the laboratory.

Electroencephalograms were measured using an electroencephalogram (EEG) measuring electrode at the frontal lobe, parietal lobe, temporal lobe, and occipital lobe in accordance with International Standard 10-20 Electrode Placement Method. The resistance value between each measurement site was set to 10㏀ or less, and the sampling rate was set to 512 Hz.

When measuring EEG, the subject was provided with the composition 10 channel system for 3 minutes at a distance of 1 ~ 2 cm below the nose, and inhaled for 3 minutes, and the EEG was measured before and during incense.

The measured EEG is analyzed by the power spectrum by FFT method, and then EEG is the absolute value of theta wave, alpha wave, beta wave, gamma wave, relative theta wave, relative alpha wave, relative beta wave and relative gamma wave according to frequency band. The values were obtained and shown in Table 3 and FIG. 2, respectively, using the EEG Mapping program (3D) to map the EEG over time while injecting the fragrance. 3 to 10 show map pictures showing changes in EEG and changes in relative ratios.

Each EEG was analyzed relative to normalized sensitivity by normalizing the EEG values of each fragrance condition to the unscented condition.

Unit (μV) ² Absolute theta Absolute alpha Absolute beta Absolute Gamma Wave Before inhalation 4,436 ± 123 214 ± 113 134 ± 28 50 ± 11 After inhalation 107 ± 15 88 ± 13 93 ± 4.2 43 ± 3

<Test result>

Looking at the absolute value change of theta wave, alpha wave, beta wave, and gamma wave before and after inhalation of the fragrance composition according to the present invention as shown in Table 3, the absolute value of all the EEG is reduced, the trend of such decrease The overall level of brain activity has changed to a stable or efficient activity. Therefore, it can be seen that the perfume composition of the present invention has a function of relaxing the activity of the brain as a whole.

Figure 2 is a graph showing the relative ratio of the EEG before and after the inhalation of the perfume composition of the present invention, the relative theta wave after the inhalation and the relative alpha wave increased compared to before the inhalation. 3 to 10 are brainwave maps showing the results of changes in respective brain waves and relative ratios of the fragrance of the fragrance composition according to the present invention before and after inhalation, the same as the results of FIG.

In general, theta waves occur mainly in a dormant, dull, or hypnotic state. A decrease in relative theta waves can help to improve concentration by bringing positive brain activity. Alpha waves are the most common brain waves when the mind and body are relaxed and relaxed, and the relative alpha waves increase helps psychological relaxation / stabilization, given that they are typically weakened during an excited state or during cognitive activity. .

Therefore, after the inhalation of the fragrance of the pharmaceutical composition according to the present invention, the propensity of EEG of the test subjects is reduced in the content of total EEG, the brain activity is relaxed, the psychological stability is stabilized by the increase of the alpha wave in the relative ratio, and the concentration through positive brain activity by the decrease of theta wave. It can be seen that the improvement effect is experienced.

Test Example 3 Changes in blood pressure and heart rate according to inhalation of the perfume composition

In Test Example 2, the systolic blood pressure, diastolic blood pressure, and heart rate were measured before and after aroma inhalation of the fragrance composition of the present invention in the same test subjects under the same test conditions, respectively. Shown in 13.

11 and 12, the systolic blood pressure was lower in all 12 subjects after inhalation than before the inhalation of the perfume composition of the present invention, the diastolic blood pressure did not show a significant change.

As shown in FIG. 13, in the heart rate, 8 out of 12 test subjects had decreased number of heartbeats after inhalation of the perfume composition of the present invention.

According to the results as described above it can be seen that the perfume composition of the present invention lowers the systolic blood pressure and decreases the number of heart beats, causing a mental relaxation state to make the test subject feel comfortable and stable.

As an example of various uses of the fragrance composition of the present invention was prepared incense and cosmetics (cream).

Formulation Example 1: Incense

Incense fragrance containing the fragrance composition of the present invention as shown in Table 4 below was prepared according to a conventional manufacturing method.

The materials were powdered by about 200 mesh, stirred for 30 minutes at a speed of 40 rpm through a stirrer, mixed and kneaded, and then put into a molding machine and extruded in a molding mold having a diameter of 3 mm. After first drying with only the temperature set at 18 ° C., the second time was dried by the second drying so that the moisture content of the incense was about 15% at 20 to 22 ° C. during the 3rd to 5th days.

ingredient weight% Persimmon Flower Essential Oil 5 Persimmon petals 50 Yellow 5 Teak 5 Pine wood 5 pine cone 5 Brain 5 Elm tree 10 Tooth extract One water Remainder

Formulation example  2: cream

As shown in Table 5 below, a cream containing the perfume composition of the present invention was prepared according to a conventional method.

ingredient weight% Persimmon Flower Essential Oil  One Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 PEG60 Cured Castor Oil 2 Liquid paraffin 10 Squalane 5 Caprylic / Capric Triglycerides 5 glycerin 5 Butylene glycol 6 Purified water Remainder

Control : Organic solvent  By extraction Persimmon flower  extract

After cooling reflux for 24 hours using 20 mL of methanol as an organic solvent to 2 g of pulverized persimmon flower as in the preparation example, 10 mg of the extract was dissolved in 1 mL of methanol for HPLC to prepare a concentration of 100,000 ppm, which was 0.2 UPLC-PDA was analyzed by filtration with a mm filter and the result is chromatogram (254 nm) shown in FIG. 14.

As can be seen in Figure 14, the persimmon flower extract extracted with the organic solvent was not properly separated aromatic compounds. The organic solvent extract of persimmon flower seems to contain mainly secondary metabolites of persimmon rather than aromatic compounds.

Claims (8)

Perfume composition containing persimmon oil essential oil as an active ingredient, which reduces the absolute value of the whole brain wave, reduces the relative theta wave in the brain wave and increases the relative alpha wave,
The persimmon flower essential oil is obtained by extracting at least one selected from the group consisting of petals and buds of persimmon soup by the absolute extraction method combining volatile solvent extraction and ethanol extraction,
1,8-Cineole, Camphor, β-Phellandrene, α-Terpinene, 1-methyl-3-1 1-Methyl-3-1-methylethyl benzene, 1,1,7-trimethyl-2,2,1-heptene-2-ol (1,7,7-Trimethyl-2,2,1 -heptan-2-ol, Azulene, Campen, Bonyl acetate, β-Ocimene, α-Copaene, Tetetracane ), Caryophyllene, Germacrene D, β-Farnesene, β-Selinene, β-Sesquiphellandrene, Aroma dendrene (Aroma dendrene), and β-bisabolene (β-Bisabolene) characterized in that the fragrance composition.
delete According to claim 1, wherein the persimmon oil essential oil
Iv) added to hexane of 10-30 volume times the weight of persimmon flower, immersed for 1 to 3 days at room temperature, and extracted first
Ii) The primary extract was filtered and concentrated under reduced pressure to obtain concrete.
Iv) the concrete is dissolved in 1 ~ 3 volume of ethanol and extracted for 2 hours at -10 ~ 5 ℃ for 2 hours, and
Iii) a pharmaceutical composition, characterized in that the secondary extract is centrifuged to separate the supernatant and concentrated under reduced pressure to obtain Absolute oil.
delete The fragrance composition of claim 1, wherein the fragrance composition has a function of improving psychological stability and concentration.
Cosmetic composition comprising a fragrance composition according to claim 1,
The cosmetic composition is a perfume composition, characterized in that the perfume or fragrance formulation.
Cosmetic composition comprising a fragrance composition according to claim 1,
The cosmetic composition includes a lotion, lotion, essence, cream, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base, body lotion, body cream, body oil, body essence, ointment, gel, cream, patch and Cosmetic composition, characterized in that any one selected from the group consisting of a spray.
A health hygiene product comprising a fragrance composition according to claim 1,
The health hygiene product is composed of shampoo, rinse, cologne, hair tonic, hair cream, pomade, indoor fragrance, soap, dishwashing detergent, laundry detergent, softener, disinfectant detergent, deodorant detergent, toothpaste, mouse wash and toilet paper. Health hygiene product, characterized in that any one of the formulation selected from the group.

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