JPH01254629A - Agent for raising consciousness level - Google Patents
Agent for raising consciousness levelInfo
- Publication number
- JPH01254629A JPH01254629A JP63083714A JP8371488A JPH01254629A JP H01254629 A JPH01254629 A JP H01254629A JP 63083714 A JP63083714 A JP 63083714A JP 8371488 A JP8371488 A JP 8371488A JP H01254629 A JPH01254629 A JP H01254629A
- Authority
- JP
- Japan
- Prior art keywords
- fraction
- lemon
- fragrance
- consciousness
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 235000019501 Lemon oil Nutrition 0.000 claims abstract description 8
- 239000010501 lemon oil Substances 0.000 claims abstract description 8
- 238000005292 vacuum distillation Methods 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 abstract description 29
- 239000002304 perfume Substances 0.000 abstract description 10
- 241000207199 Citrus Species 0.000 abstract description 5
- 235000020971 citrus fruits Nutrition 0.000 abstract description 5
- 230000003213 activating effect Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 25
- 235000005979 Citrus limon Nutrition 0.000 description 24
- 244000131522 Citrus pyriformis Species 0.000 description 24
- 239000000341 volatile oil Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000000344 soap Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000004821 distillation Methods 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 4
- 238000000222 aromatherapy Methods 0.000 description 4
- 239000012437 perfumed product Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- UJQGVDNQDFTTLZ-VNHYZAJKSA-N 2-[(2r,4ar,8as)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid Chemical compound C1CCC(=C)[C@@H]2C[C@H](C(=C)C(O)=O)CC[C@]21C UJQGVDNQDFTTLZ-VNHYZAJKSA-N 0.000 description 2
- 244000166675 Cymbopogon nardus Species 0.000 description 2
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000032140 Sleepiness Diseases 0.000 description 2
- 206010041349 Somnolence Diseases 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 2
- 240000001519 Verbena officinalis Species 0.000 description 2
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 2
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 2
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 2
- 239000002386 air freshener Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004622 sleep time Effects 0.000 description 2
- 230000037321 sleepiness Effects 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- QXRKIZKJLNNMNC-UHFFFAOYSA-N 11,13-Dihydrocostic acid Natural products CC(C1CCC2(C)CCCC(=C)C2C1)C(=O)O QXRKIZKJLNNMNC-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- SGZOYHLQNUSAIL-UHFFFAOYSA-N Ioscostussaeure Natural products C1C(C(=C)C(O)=O)CCC2(C)CCCC(C)=C21 SGZOYHLQNUSAIL-UHFFFAOYSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 102000012547 Olfactory receptors Human genes 0.000 description 1
- 108050002069 Olfactory receptors Proteins 0.000 description 1
- 241001310492 Pectis angustifolia Species 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- UTXMCYDEIZPGME-UHFFFAOYSA-N beta-Isocostic acid Natural products C1CC(C(=C)C(O)=O)CC2C(C)=CCCC21C UTXMCYDEIZPGME-UHFFFAOYSA-N 0.000 description 1
- UJQGVDNQDFTTLZ-UHFFFAOYSA-N beta-costic acid Natural products C1CCC(=C)C2CC(C(=C)C(O)=O)CCC21C UJQGVDNQDFTTLZ-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】
[産業上の利用分野]
本発明は、ヒトまたは動物の意識水準を高揚させる、減
圧蒸留により、気圧0.08mmHgの下で、100℃
以前に留出する部分を除いたレモン油分画部を吸入させ
ることにより、ヒトまたは動物の意識水準を高揚させる
組成物に関するものである。Detailed Description of the Invention [Industrial Application Field] The present invention is a method for increasing the level of consciousness of humans or animals by distillation under reduced pressure at 100°C under an atmospheric pressure of 0.08 mmHg.
The present invention relates to a composition for raising the level of consciousness in humans or animals by inhalation of a lemon oil fraction, excluding the previously distilled portion.
[従来の技術]
従来から、香料などの芳香物質を吸入させることにより
心身のコントロールを行う、いわゆるアロマテラピー(
芳香療法)という治療方法が知られている。このアロマ
テラピーの中で用いられてきた香料は古来からの伝承を
もとにした天然精油が中心であり、本発明で問題として
いる「意識水準を高める効果」に関しては、はっか、ユ
ーカリレモン、ベルベナ、シトロネラ、カヤブチ、サル
ビア、タイム、クローブ、ローズマリー、ヒソツブ、ベ
ージル等の精油が効果が高いとされている(奥1)冶「
アロマテラピー展望」香料; No、 140(198
3) pp、19−26 )
またP、Rove s t iらの研究グループは、レ
モン、オレンジ、ベルベナ、シトロネラ、イランイラン
等の単品精油あるいはサンダルウツド、バッチユリ−、
ジャスミン、クローブを基本とした混合物をエアゾール
を用いて心理的抑圧に悩む神経症患者に吸入投与したと
ころ興奮剤をあたえた時のような効果が得られたとして
いる。(S、P、CAug475−4781973)
しかしながら、これらの効果は、主観的かつ定性的なも
ので、有効性の点で必ずしも満足し得ないものである。[Prior Art] Traditionally, so-called aromatherapy (
A treatment method called aroma therapy is known. The fragrances that have been used in aromatherapy are mainly natural essential oils based on ancient traditions, and with regard to the ``effect of raising the level of consciousness'' that is the issue of the present invention, mint, eucalyptus lemon, verbena, etc. Essential oils such as , citronella, cypress, salvia, thyme, clove, rosemary, mysotsubu, and basil are said to be highly effective (Oku 1)
Aromatherapy Outlook” Fragrance; No. 140 (198
3) pp, 19-26) In addition, the research group of P. Rovesti et al. has used single essential oils such as lemon, orange, verbena, citronella, and ylang-ylang, or sandalwood, batch lily,
When a mixture based on jasmine and cloves was inhaled using an aerosol to neurotic patients suffering from psychological depression, it was said to have an effect similar to that of a stimulant. (S, P, CAug475-4781973) However, these effects are subjective and qualitative, and are not necessarily satisfactory in terms of effectiveness.
また上記の精油は、強い香りを持つものが多く、調香に
より調合香料を作成する場合に全体の香りに影響を与え
てしまうことから、香りの強度及び嗜好性と効果発現の
有効量とのバランスについても必ずしも満足しえないも
のであった。上記の効果精油の中で、レモン精油は、柑
橘系の精油の中で最も重要な香料であり、日本の消費者
についての嗜好性も高く、製品香料に汎用されるもので
あるが、特有のシトラス香の強度が非常につよいもので
あった。In addition, many of the essential oils mentioned above have a strong scent, and when creating a blended fragrance by perfumery, it will affect the overall scent. The balance was also not necessarily satisfactory. Among the above-mentioned effective essential oils, lemon essential oil is the most important fragrance among citrus essential oils, has a high preference among Japanese consumers, and is commonly used as a product fragrance. The intensity of the citrus scent was very strong.
[発明が解決しようとする課題]
本発明者は上記事情に鑑み、香りの強度が比較的緩和で
あり、真に意識水jp、を高揚させる効果に優れたレモ
ン精油を得るべく鋭意研究を重ねた結果、0.08mm
Hgの減圧下で行う蒸留により、100℃以前に流出す
る部分を除いたレモン分画部が、レモンの特有香がかな
り微弱になっているにもかかわらず、吸入により強力な
意識水準を高揚させる効果を有するという全く新規な事
実を見出し、この知見に基づいて本発明を完成するに至
つた。[Problems to be Solved by the Invention] In view of the above circumstances, the present inventor has conducted extensive research in order to obtain lemon essential oil that has a relatively mild aroma intensity and is highly effective in truly raising the consciousness water. As a result, 0.08mm
Due to the distillation of Hg under reduced pressure, the lemon fraction, excluding the part that flows out before 100℃, has a very faint characteristic lemon scent, but when inhaled it strongly raises the level of consciousness. We have discovered a completely new fact that the present invention has an effect, and have completed the present invention based on this knowledge.
[8題を解決するための手段]
すなわち本発明は、減圧蒸留により、気圧0゜08mm
Hgの下で蒸留分画し、100℃以前に留出する部分を
除いたレモン油分画部(以下、°。[Means for solving the 8 problems] That is, the present invention uses vacuum distillation to reduce the atmospheric pressure to 0°08 mm.
The lemon oil fraction (hereinafter referred to as °) is obtained by distillation under Hg and excluding the part distilled out at temperatures below 100°C.
レモン活性分画部パと略す。)を有効成分として配合し
たことを特徴とするヒトまたは動物の意識水準を高揚さ
せる組成物である。Lemon active fraction is abbreviated as PA. ) as an active ingredient, this is a composition that raises the level of consciousness of humans or animals.
ここで言う意識水準を高揚させる効果とは、ヒトまたは
動物が日常生活で経験する眠け、疲労感惰気などの意識
水準の低下による生理心理的状態から開放し、気分を爽
快にするとともに精神活動を活発化さ笹る効果を指すも
のである。The effect of raising the level of consciousness referred to here refers to the effect of raising the level of consciousness, which relieves the physiological and psychological states caused by a decrease in the level of consciousness, such as sleepiness, fatigue, and lethargy that humans and animals experience in their daily lives. This refers to the effect of activating activities.
また、組成物とは、”レモン活性分画部”が有効量吸入
され、嗅覚受容体を刺激もしくは経気道的に体内に吸収
されることにより効果が発現するものを指し、香水、コ
ロン、室内芳香剤、などのフレグランス製品の他、石鹸
、歯磨などの化粧料、医薬品なども包括するものである
。In addition, the composition refers to a composition in which an effective amount of the "lemon active fraction" is inhaled to stimulate olfactory receptors or to be absorbed into the body through the respiratory tract. In addition to fragrance products such as air fresheners, it also includes cosmetics such as soaps and toothpaste, and pharmaceuticals.
以下本発明について詳しく説明する。The present invention will be explained in detail below.
本発明における”レモン活性分画部”は、公知の物質で
あり、レモン油を気圧0.08mmHgの下で蒸留分画
し、100℃以前に留出する部分を除いたバレリアン油
分画部で、レモン精油の高沸点成分の混合物である。The "lemon active fraction" in the present invention is a known substance, and is a valerian oil fraction obtained by distilling and fractionating lemon oil under an atmospheric pressure of 0.08 mmHg and excluding the part that distills out at temperatures below 100°C. It is a mixture of high boiling point components of lemon essential oil.
レモン油分画部については、標準商業品種の、Lemo
n Naardenlzed S oll(クエ
スト社)の分画部が本発明に用いられるが、米国量、欧
州産等全てのレモン油のどのような成分組成を持つもの
の分画部でも用いることが出来る。For the lemon oil fraction, the standard commercial variety Lemo
Although a fractionating portion of Naardenlzed Soll (Quest Inc.) is used in the present invention, a fractionating portion of any component composition of all lemon oils, such as those produced in the United States and Europe, can also be used.
さらに天然のレモン果皮から蒸留、抽出等の方法で得ら
れた精油の分画部を本発明に用いることが出来る。Furthermore, a fraction of essential oil obtained from natural lemon peel by methods such as distillation and extraction can be used in the present invention.
従って、レモン(Ci trus l imon。Therefore, lemon (Ci trus l imon).
及びその亜種)の果皮から水蒸気蒸留、抽出など種々の
手段により得られた香料混合物を減圧蒸留することによ
って、効果分画部を得ることも出来る。The effective fraction can also be obtained by distilling under reduced pressure a flavor mixture obtained from the pericarp of the fruit (and its subspecies) by various means such as steam distillation and extraction.
”レモン活性分画部パは減圧蒸留以外にも常圧蒸留、カ
ラムクロマトグラフィー、GC分取等の方法で得ること
が出来るが、工業的な観点からは減圧蒸留が望ましいと
考えられる。 これらの”レモン活性分画部”は、単独
または゛レモン活性分画部”と混合可能な様々な媒体(
例えばエタノール、調香料、賦香製品)との混合組成物
として用いられる。``Lemon active fraction can be obtained by other methods than vacuum distillation, such as atmospheric distillation, column chromatography, and GC preparative separation, but vacuum distillation is considered preferable from an industrial standpoint. The "lemon active fraction" can be used alone or in various media that can be mixed with the "lemon active fraction" (
For example, it is used as a mixed composition with ethanol, flavoring agents, perfumed products).
媒体に調合香料を用いる場合は、調合香料全体の香りは
個々の成分の香りが寄与することとなるが、前述の通り
゛レモン活性分画部”は微弱な柑橘系の芳香を有するか
ら調合香料全体の芳香のバランスに悪影響を与えない。When a blended fragrance is used as a medium, the fragrance of the individual ingredients will contribute to the overall scent of the blended fragrance, but as mentioned above, the ``lemon active fraction'' has a weak citrus aroma, so it is difficult to use the blended fragrance. Does not adversely affect the overall aromatic balance.
この点から″レモン活性分画部°゛の使用量はかなり自
由度が高く”レモン活性分画部”を重量比で1%以以上
台香料に配合しても全体の香調のバランスをそこなうこ
となく意識高揚効果を発現させることができる。From this point of view, the amount of ``lemon active fraction'' to be used is quite flexible, and even if more than 1% by weight of ``lemon active fraction'' is added to the fragrance, the balance of the overall fragrance will be impaired. It is possible to produce a consciousness-raising effect without any stress.
さらに意識高揚効果を顕著に発現させるという観点から
見た場合°°レモン活性分画部゛°を重量比で5%から
50%の範囲で調合香料中に配合することが出来る。Furthermore, from the viewpoint of significantly producing a consciousness-enhancing effect, the lemon active fraction can be incorporated in a blended fragrance in a weight ratio of 5% to 50%.
また、媒体として”レモン活性分画部”単独または上に
記載した”レモン活性分画部”を含有する香料組成物を
エチルアルコールと混合し、オーデコロンとして用いる
ことも出来る。Furthermore, the "lemon active fraction" alone or the fragrance composition containing the "lemon active fraction" described above can be mixed with ethyl alcohol and used as an eau de cologne.
また゛°レモン活性分画部”単独、または上に記載した
”レモン活性分画部°”を含有する香料組成物を用いて
、担体としての賦香製品に賦香することもできる。その
ような賦香製品としては、フレグランス、室内芳香剤、
クリーム、乳液化粧パウダー、ボディローション、デオ
ドラントスティック、歯磨、頭髪製品、エアゾール製品
などがある。It is also possible to use the "lemon active fraction" alone or a fragrance composition containing the "lemon active fraction" described above to flavor a perfumed product as a carrier. Scented products include fragrances, room air fresheners,
Products include creams, emulsion makeup powders, body lotions, deodorant sticks, toothpastes, hair products, and aerosol products.
ざらに゛°レモン活性分画部°゛を有効成分とする吸入
医薬品としても用いることが出来る。It can also be used as an inhalation drug containing Zarani's active fraction of lemon as an active ingredient.
[薬理効果]
1、マウスに対する麻酔薬作用時間延長効果(1)実験
方法
ICR系雄性マウス(6〜7週齢、体重80〜35g)
に、下記の被験物質を含む空気流(1〜2mgの被験物
質を含む空気を毎分21供給)を4時間吸入させた群と
、物質を吸入させない群のベンドパルビタール睡眠時間
(55mg/kglffj注)の差を比較した。[Pharmacological effects] 1. Effect of prolonging the anesthetic action time on mice (1) Experimental method ICR male mice (6-7 weeks old, weight 80-35 g)
Bendoparbital sleep time (55 mg/kg lffj Note) Differences were compared.
(2)被験物質
物質A:Lemon naardenized S
o i l(クエスト社より入手)
物質B:”レモン活性分画部”
(以下余白)
実験結果を表、1に示す。(2) Test substance A: Lemon naardenized S
o i l (obtained from Quest Inc.) Substance B: "Lemon active fraction" (the following margins) The experimental results are shown in Table 1.
吸入群の平均睡眠時間が延長したことを示、負のものは
短縮したことを示す。Indicates that the average sleep time of the inhalation group was extended; negative values indicate that it was shortened.
[投与方法、投与量]
本発明は吸入による投与を特徴とするものであり経口投
与、皮下注射、筋肉注射などによる興奮剤とはとは異な
り、健常人に対して与えた場合に興奮剤よりも緩和な意
識鎮静効果を期待するものであるから上に述べた°°レ
モン活性分画部°゛をアルコールあるいは香料などを含
む組成物の一部として、または賦香製品に用いられた香
料の組成物の一部として与えることが望ましい。[Administration Method and Dose] The present invention is characterized by administration by inhalation, and unlike stimulants administered orally, subcutaneously, or intramuscularly, it is more effective than stimulants when given to healthy individuals. Because it is expected to have a mild sedative effect, the above-mentioned lemon active fraction can be used as part of a composition containing alcohol or fragrance, or as part of a fragrance used in perfumed products. Preferably, it is given as part of a composition.
本発明の意識を高揚させる吸入剤の効果は年齢個人差、
性別、心身試態などに影響されるので、場合によっては
下記範囲外量を投与する場合も生ずるが、一般に健常人
を対象とする場合”レモン活性分画部°゛を0.1%か
ら5%含む賦香製品から揮散する香気により”レモン活
性分画部°゛を有効量一定時間あるいは継続的に吸入投
与することが好ましい。The effects of the inhaler that increases consciousness according to the present invention vary depending on age,
It is affected by gender, physical and mental conditions, etc., so in some cases it may be necessary to administer a dose outside the range shown below, but in general, when administering to healthy subjects, the amount of ``lemon active fraction'' is 0.1% to 5%. It is preferable to administer an effective amount of "lemon active fraction" by inhalation over a certain period of time or continuously, based on the aroma volatilized from a perfumed product containing %.
[実施例]
つぎに実施例および比較例をあげて、本発明を具体的に
明らかにする。本発明はこれにより限定されるものでは
ない。配合量は重量%である。[Examples] Next, examples and comparative examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The blending amount is in weight%.
実施例1 香水及びオーデコロン
標準商業品種のパ活性物質°゛を重量濃度で、それぞれ
5%、10%15%、20%加えた柑橘系の香りをもつ
フレグランス用調合香′l!4を95%の水性アルコー
ルに重量濃度で3%になるように溶解し、オーデコロン
を調製する。また同じ調合香料を95%水性アルコール
に重量濃度で20%になるように溶解して香水とする。Example 1 Perfume and Eau de Cologne A fragrance preparation with a citrus aroma containing 5%, 10%, 15%, and 20% by weight of perfuming active substances of standard commercial varieties, respectively. Eau de cologne is prepared by dissolving 4 in 95% aqueous alcohol to a weight concentration of 3%. Further, the same blended fragrance is dissolved in 95% aqueous alcohol to a weight concentration of 20% to prepare a perfume.
これらのオーデコロンは香気吸入により人間の意識水準
を高揚させる効果を持つ。These colognes have the effect of raising a person's level of consciousness by inhaling their scent.
実施例2 室内用エアスプレー 以下の処方によりエアゾールに充填した。Example 2 Indoor air spray The aerosol was filled according to the following formulation.
°゛レモン活性分画部゛°を15%含む調香料(以下、
効果調香料Aと略す。) 5工チルアルコール95
% 56スバン 85
2ツイン 81
1プロペラント 3にれ
らのエアゾールは香気吸入により、人間の意識水準を高
揚させる効果を持つ。Perfume containing 15% of lemon active fraction (hereinafter referred to as
It is abbreviated as effect fragrance A. ) 5-ethyl alcohol 95
% 56 Subang 85
2 twin 81
1. Propellant 3. These aerosols have the effect of raising the level of human consciousness by inhaling the aroma.
実施例3 石鹸
(1)石鹸素地 95.0(
2)効果調査料A5.0
(3)色素 適量製法
(2)及び(3)を石けん素地に添加後9機械練り、あ
るいは枠線りして石けんを製造した。Example 3 Soap (1) Soap base 95.0 (
2) Effect test material A5.0 (3) Pigment After adding appropriate amounts of manufacturing methods (2) and (3) to the soap base, soap was manufactured by kneading with a machine or forming a border for 9 times.
これらの石鹸は使用時の香気吸入により人間の意識水準
を高揚させる効果を持つ。These soaps have the effect of raising a person's level of consciousness by inhaling their fragrance when used.
実施例4 シャンプー
(1)アルキル硫酸トリエタノールアミン塩 15.0
(2)ヤシ#J肋酸モノエタノールアミド 5.0
(3)エチレングリコールモノステアレート2.0(4
)防腐剤 適量(5)色
素 適量(6)効果調
香mA3.0
(7)精製水 残余製法
(1)〜(6)を(7)中に撹拌溶解しシャンプーを得
た。Example 4 Shampoo (1) Alkyl sulfate triethanolamine salt 15.0
(2) Palm #J costic acid monoethanolamide 5.0
(3) Ethylene glycol monostearate 2.0 (4
) Preservative: Appropriate amount (5) Pigment: Appropriate amount (6) Effect Perfume mA 3.0 (7) Purified water Residual manufacturing methods (1) to (6) were dissolved in (7) with stirring to obtain a shampoo.
これらのシャンプーは使用時の香気吸入により人間の意
識水準を高揚させる効果を持つ。These shampoos have the effect of raising a person's level of consciousness by inhaling their fragrance when used.
実施例5 ヘアリンス
(1)塩化アルキル
トリメチルアンモニウム 3.0(2)セチルア
ルコール 1.0(3)防腐剤
0.1(4)グリセリン
5.0(5)効果調香:RA
O,4(6)色素
適量(7)POE(8モル)ス
テアリルエーテル 0.6(8)精製水
残余製法
(1)〜(8)を80℃にて混合溶解し、室温まで放冷
してヘアリンスを得た。Example 5 Hair rinse (1) Alkyltrimethylammonium chloride 3.0 (2) Cetyl alcohol 1.0 (3) Preservative
0.1(4) Glycerin
5.0 (5) Effect perfume: RA
O,4(6) dye
Appropriate amount (7) POE (8 mol) Stearyl ether 0.6 (8) Purified water
The remaining production methods (1) to (8) were mixed and dissolved at 80°C, and the mixture was allowed to cool to room temperature to obtain a hair rinse.
これらのヘアリンスは使用時の香気吸入により人間の意
識水準を高揚させる効果を持つ。These hair rinses have the effect of raising a person's level of consciousness by inhaling their fragrance when used.
実施例6 バスパウダー
(1)タルク 80.0
(2)効果香料組成物 20.0
(効果調査料A、流動パラフィン、C20)製法
(1)、(2)を混合撹拌してバスパウダーを得た。Example 6 Bath powder (1) Talc 80.0
(2) Effective fragrance composition 20.0
(Effect Investigation Material A, Liquid Paraffin, C20) Production Methods (1) and (2) were mixed and stirred to obtain a bath powder.
これらのバスパウダーは、使用時の香気吸入により人間
の意識水準を高揚させる効果を持つ。These bath powders have the effect of raising a person's level of consciousness by inhaling their aroma when used.
実施例7 線香水
(1)効果香料組成物 90.0(
効果調香’MA、ワセリン、5:4)(2)トリミリス
チン酸グリセリン 8.0(3)香料
2.0製法
(1)〜(3)を混合撹拌して線香水を得た。Example 7 String perfume (1) Effective fragrance composition 90.0 (
Effect perfume 'MA, Vaseline, 5:4) (2) Glycerin trimyristate 8.0 (3) Fragrance
2.0 Manufacturing method (1) to (3) were mixed and stirred to obtain a line perfume.
これらの線香水は、使用時の香気吸入により人間の意識
水準を高揚させる効果を持つ。These line perfumes have the effect of raising a person's level of consciousness by inhaling their scent when used.
[発明の効果]
本発明は、ヒトまたは動物が日常生活で経験する眠け、
疲労感惰気などの意識水準の低下による生理心理的状態
から開放し、気分を爽快にするとともに精神活動を活発
化させるなどの意識水準を高揚させる効果を有するもの
である。[Effects of the Invention] The present invention can reduce sleepiness that humans or animals experience in their daily lives.
It relieves physiological and psychological conditions caused by a decrease in the level of consciousness, such as fatigue and lethargy, and has the effect of refreshing the mood and raising the level of consciousness by activating mental activity.
特許出順人 樺式会社資生堂Patent issuer Kaba style company Shiseido
Claims (1)
以前に留出する部分を除いたレモン油分画部を有効成分
として配合したことを特長とする、ヒトまたは動物の意
識水準を高揚させる組成物。100℃ under an atmospheric pressure of 0.08 mmHg by vacuum distillation
A composition for raising the level of consciousness of humans or animals, characterized in that it contains as an active ingredient a lemon oil fraction from which the previously distilled part has been removed.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63083714A JP2614484B2 (en) | 1988-04-05 | 1988-04-05 | Indoor air freshener with the effect of raising awareness level |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63083714A JP2614484B2 (en) | 1988-04-05 | 1988-04-05 | Indoor air freshener with the effect of raising awareness level |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH01254629A true JPH01254629A (en) | 1989-10-11 |
JP2614484B2 JP2614484B2 (en) | 1997-05-28 |
Family
ID=13810172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63083714A Expired - Fee Related JP2614484B2 (en) | 1988-04-05 | 1988-04-05 | Indoor air freshener with the effect of raising awareness level |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2614484B2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741481A (en) * | 1994-07-27 | 1998-04-21 | Picken, Jr.; Henry M. | Cosmetics containing citrus water distillate |
US5853730A (en) * | 1996-08-22 | 1998-12-29 | Picken, Jr.; Henry M. | Cleaning solution using citrus water distillate |
WO2002053151A1 (en) * | 2001-08-08 | 2002-07-11 | Shiseido Company, Ltd. | Perfume compositions |
WO2002030377A3 (en) * | 2000-10-09 | 2002-07-18 | Karen Croissant | Product for cleaning teeth and/or the mouth |
EP1066824A3 (en) * | 1999-07-09 | 2003-05-14 | Shiseido Company Limited | Stimulative agent and stimulative perfume composition |
JP2010507712A (en) * | 2003-07-07 | 2010-03-11 | ジボダン ネーデルランド サービシーズ ビー.ヴイ. | Fragrance composition |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5670096A (en) * | 1979-11-12 | 1981-06-11 | Takasago Perfumery Co Ltd | Manufacture of lemon oil having no phototoxicity |
JPS58127797A (en) * | 1982-01-25 | 1983-07-29 | 小林香料株式会社 | Purification of bergamot oil |
JPS598391A (en) * | 1982-07-05 | 1984-01-17 | 日本電気株式会社 | Solder plate for mounting planarly |
JPS5968399A (en) * | 1982-10-13 | 1984-04-18 | 株式会社 小林コ−セ− | Manufacture of low sensitive low irritant jasmine oil |
JPS606993A (en) * | 1983-05-11 | 1985-01-14 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | Word processing system |
JPS606992A (en) * | 1983-06-27 | 1985-01-14 | 株式会社日立製作所 | Display unit |
JPS6017479A (en) * | 1983-07-09 | 1985-01-29 | キヤノン株式会社 | Electric circuit substrate |
JPS6019955A (en) * | 1983-07-01 | 1985-02-01 | ロ−ベルト・ボツシユ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | Fuel injection pump for internal combustion engine |
JPS6191297A (en) * | 1984-10-12 | 1986-05-09 | カネボウ株式会社 | Production of iran oil excellent in flavor and low in sensitivity |
JPS6284194A (en) * | 1985-10-08 | 1987-04-17 | カネボウ株式会社 | Production of iranian oil excellent in flavor and low in sensitivity |
JPS62275199A (en) * | 1986-05-22 | 1987-11-30 | 長谷川香料株式会社 | Non-phototoxic orange flower essential oil |
-
1988
- 1988-04-05 JP JP63083714A patent/JP2614484B2/en not_active Expired - Fee Related
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5670096A (en) * | 1979-11-12 | 1981-06-11 | Takasago Perfumery Co Ltd | Manufacture of lemon oil having no phototoxicity |
JPS58127797A (en) * | 1982-01-25 | 1983-07-29 | 小林香料株式会社 | Purification of bergamot oil |
JPS598391A (en) * | 1982-07-05 | 1984-01-17 | 日本電気株式会社 | Solder plate for mounting planarly |
JPS5968399A (en) * | 1982-10-13 | 1984-04-18 | 株式会社 小林コ−セ− | Manufacture of low sensitive low irritant jasmine oil |
JPS606993A (en) * | 1983-05-11 | 1985-01-14 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | Word processing system |
JPS606992A (en) * | 1983-06-27 | 1985-01-14 | 株式会社日立製作所 | Display unit |
JPS6019955A (en) * | 1983-07-01 | 1985-02-01 | ロ−ベルト・ボツシユ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | Fuel injection pump for internal combustion engine |
JPS6017479A (en) * | 1983-07-09 | 1985-01-29 | キヤノン株式会社 | Electric circuit substrate |
JPS6191297A (en) * | 1984-10-12 | 1986-05-09 | カネボウ株式会社 | Production of iran oil excellent in flavor and low in sensitivity |
JPS6284194A (en) * | 1985-10-08 | 1987-04-17 | カネボウ株式会社 | Production of iranian oil excellent in flavor and low in sensitivity |
JPS62275199A (en) * | 1986-05-22 | 1987-11-30 | 長谷川香料株式会社 | Non-phototoxic orange flower essential oil |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741481A (en) * | 1994-07-27 | 1998-04-21 | Picken, Jr.; Henry M. | Cosmetics containing citrus water distillate |
US5853730A (en) * | 1996-08-22 | 1998-12-29 | Picken, Jr.; Henry M. | Cleaning solution using citrus water distillate |
EP1066824A3 (en) * | 1999-07-09 | 2003-05-14 | Shiseido Company Limited | Stimulative agent and stimulative perfume composition |
US6835709B2 (en) | 1999-07-09 | 2004-12-28 | Shiseido Co., Ltd. | Stimulative agent and stimulative perfume composition |
WO2002030377A3 (en) * | 2000-10-09 | 2002-07-18 | Karen Croissant | Product for cleaning teeth and/or the mouth |
WO2002053151A1 (en) * | 2001-08-08 | 2002-07-11 | Shiseido Company, Ltd. | Perfume compositions |
EP1941870A2 (en) | 2001-08-08 | 2008-07-09 | Shiseido Co., Ltd. | Perfume Composition comprising perilla aldehyde |
JP2010507712A (en) * | 2003-07-07 | 2010-03-11 | ジボダン ネーデルランド サービシーズ ビー.ヴイ. | Fragrance composition |
Also Published As
Publication number | Publication date |
---|---|
JP2614484B2 (en) | 1997-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1941870B1 (en) | Perfume Composition comprising perilla aldehyde | |
JP2003119490A (en) | Psychosedative perfume composition | |
JPH0523245B2 (en) | ||
JP5053472B2 (en) | Fragrance composition | |
KR102055499B1 (en) | Perfume composition for decreasing relative theta wave and relative alpha wave of brainwave containing essential oil of Chrysanthemum indicum L and use thereof | |
JP2652552B2 (en) | Composition for inhalation administration to calm the consciousness level | |
JPH01254629A (en) | Agent for raising consciousness level | |
JP3590274B2 (en) | Sedative for vaporizing inhalation and sedative fragrance composition containing the same as an active ingredient | |
JP2007197334A (en) | Composition for autonomic nerve regulator, sleep improving agent or stress relaxant | |
WO2020004182A1 (en) | Sleep-enhancing agent | |
JP5019016B2 (en) | Sleep improver and fragrance preparation | |
CA2357106A1 (en) | Aromatherapeutic environmental system | |
JP2009051770A (en) | Appetite suppressant composition | |
JP2676543B2 (en) | Awareness lowering agent | |
JP4547193B2 (en) | Fragrance composition | |
JP5306159B2 (en) | Method for imparting mental enhancement effect in fragrance composition | |
JPH11343497A (en) | Cosmetic | |
CN105496857A (en) | Lemon flavor toilet water | |
JPS63250315A (en) | Composition for promoting level of consciousness | |
JP3659665B2 (en) | Idea promoter | |
JP2007008862A (en) | Dhea production promoter, beautification method and method for using dhea production promoter | |
JP5127104B2 (en) | Fragrance composition and scented product for enhancing convenience | |
JP5478679B2 (en) | Fragrance composition and scented product for enhancing convenience | |
JP2801027B2 (en) | Immune function enhancer | |
JP6283579B2 (en) | Fatigue suppressant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |