JPH01254629A - Agent for raising consciousness level - Google Patents

Abstract

PURPOSE:To obtain the subject composition useful for relieving from a physiological and psychological state caused by the lowering of the consciousness level, e.g., fatigue feeling or idleness, refreshing the feeling and activating the psychologic action, by using a specific lemon oil fraction obtained by vacuum distillation as an active component. CONSTITUTION:The objective agent contains, as an active component, a lemon oil fraction prepared by removing the fraction distilled out at <=100 deg.C under 0.08mmHg pressure by vacuum distillation,. The fraction has slight citrus fragrance and is applicable without giving influence to the balance of the odor of the whole compound perfume. Preferably, the composition is added to a flavoring product in an amount of 0.1-5% and the active amount of the fraction is inhaled continuously or for a prescribed period by the aid of the fragrance emitted from said product.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention is a method for increasing the level of consciousness of humans or animals by distillation under reduced pressure at 100°C under an atmospheric pressure of 0.08 mmHg.
The present invention relates to a composition for raising the level of consciousness in humans or animals by inhalation of a lemon oil fraction, excluding the previously distilled portion.

[Prior Art] Traditionally, so-called aromatherapy (
A treatment method called aroma therapy is known. The fragrances that have been used in aromatherapy are mainly natural essential oils based on ancient traditions, and with regard to the ``effect of raising the level of consciousness'' that is the issue of the present invention, mint, eucalyptus lemon, verbena, etc. Essential oils such as , citronella, cypress, salvia, thyme, clove, rosemary, mysotsubu, and basil are said to be highly effective (Oku 1)
Aromatherapy Outlook” Fragrance; No. 140 (198
3) pp, 19-26) In addition, the research group of P. Rovesti et al. has used single essential oils such as lemon, orange, verbena, citronella, and ylang-ylang, or sandalwood, batch lily,
When a mixture based on jasmine and cloves was inhaled using an aerosol to neurotic patients suffering from psychological depression, it was said to have an effect similar to that of a stimulant. (S, P, CAug475-4781973) However, these effects are subjective and qualitative, and are not necessarily satisfactory in terms of effectiveness.

In addition, many of the essential oils mentioned above have a strong scent, and when creating a blended fragrance by perfumery, it will affect the overall scent. The balance was also not necessarily satisfactory. Among the above-mentioned effective essential oils, lemon essential oil is the most important fragrance among citrus essential oils, has a high preference among Japanese consumers, and is commonly used as a product fragrance. The intensity of the citrus scent was very strong.

[Problems to be Solved by the Invention] In view of the above circumstances, the present inventor has conducted extensive research in order to obtain lemon essential oil that has a relatively mild aroma intensity and is highly effective in truly raising the consciousness water. As a result, 0.08mm
Due to the distillation of Hg under reduced pressure, the lemon fraction, excluding the part that flows out before 100℃, has a very faint characteristic lemon scent, but when inhaled it strongly raises the level of consciousness. We have discovered a completely new fact that the present invention has an effect, and have completed the present invention based on this knowledge.

[Means for solving the 8 problems] That is, the present invention uses vacuum distillation to reduce the atmospheric pressure to 0°08 mm.
The lemon oil fraction (hereinafter referred to as °) is obtained by distillation under Hg and excluding the part distilled out at temperatures below 100°C.

Lemon active fraction is abbreviated as PA. ) as an active ingredient, this is a composition that raises the level of consciousness of humans or animals.

The effect of raising the level of consciousness referred to here refers to the effect of raising the level of consciousness, which relieves the physiological and psychological states caused by a decrease in the level of consciousness, such as sleepiness, fatigue, and lethargy that humans and animals experience in their daily lives. This refers to the effect of activating activities.

In addition, the composition refers to a composition in which an effective amount of the "lemon active fraction" is inhaled to stimulate olfactory receptors or to be absorbed into the body through the respiratory tract. In addition to fragrance products such as air fresheners, it also includes cosmetics such as soaps and toothpaste, and pharmaceuticals.

The present invention will be explained in detail below.

The "lemon active fraction" in the present invention is a known substance, and is a valerian oil fraction obtained by distilling and fractionating lemon oil under an atmospheric pressure of 0.08 mmHg and excluding the part that distills out at temperatures below 100°C. It is a mixture of high boiling point components of lemon essential oil.

For the lemon oil fraction, the standard commercial variety Lemo
Although a fractionating portion of Naardenlzed Soll (Quest Inc.) is used in the present invention, a fractionating portion of any component composition of all lemon oils, such as those produced in the United States and Europe, can also be used.

Furthermore, a fraction of essential oil obtained from natural lemon peel by methods such as distillation and extraction can be used in the present invention.

Therefore, lemon (Ci trus l imon).

The effective fraction can also be obtained by distilling under reduced pressure a flavor mixture obtained from the pericarp of the fruit (and its subspecies) by various means such as steam distillation and extraction.

``Lemon active fraction can be obtained by other methods than vacuum distillation, such as atmospheric distillation, column chromatography, and GC preparative separation, but vacuum distillation is considered preferable from an industrial standpoint. The "lemon active fraction" can be used alone or in various media that can be mixed with the "lemon active fraction" (
For example, it is used as a mixed composition with ethanol, flavoring agents, perfumed products).

When a blended fragrance is used as a medium, the fragrance of the individual ingredients will contribute to the overall scent of the blended fragrance, but as mentioned above, the ``lemon active fraction'' has a weak citrus aroma, so it is difficult to use the blended fragrance. Does not adversely affect the overall aromatic balance.

From this point of view, the amount of ``lemon active fraction'' to be used is quite flexible, and even if more than 1% by weight of ``lemon active fraction'' is added to the fragrance, the balance of the overall fragrance will be impaired. It is possible to produce a consciousness-raising effect without any stress.

Furthermore, from the viewpoint of significantly producing a consciousness-enhancing effect, the lemon active fraction can be incorporated in a blended fragrance in a weight ratio of 5% to 50%.

Furthermore, the "lemon active fraction" alone or the fragrance composition containing the "lemon active fraction" described above can be mixed with ethyl alcohol and used as an eau de cologne.

It is also possible to use the "lemon active fraction" alone or a fragrance composition containing the "lemon active fraction" described above to flavor a perfumed product as a carrier. Scented products include fragrances, room air fresheners,
Products include creams, emulsion makeup powders, body lotions, deodorant sticks, toothpastes, hair products, and aerosol products.

It can also be used as an inhalation drug containing Zarani's active fraction of lemon as an active ingredient.

[Pharmacological effects] 1. Effect of prolonging the anesthetic action time on mice (1) Experimental method ICR male mice (6-7 weeks old, weight 80-35 g)
Bendoparbital sleep time (55 mg/kg lffj Note) Differences were compared.

(2) Test substance A: Lemon naardenized S
o i l (obtained from Quest Inc.) Substance B: "Lemon active fraction" (the following margins) The experimental results are shown in Table 1.

Indicates that the average sleep time of the inhalation group was extended; negative values indicate that it was shortened.

[Administration Method and Dose] The present invention is characterized by administration by inhalation, and unlike stimulants administered orally, subcutaneously, or intramuscularly, it is more effective than stimulants when given to healthy individuals. Because it is expected to have a mild sedative effect, the above-mentioned lemon active fraction can be used as part of a composition containing alcohol or fragrance, or as part of a fragrance used in perfumed products. Preferably, it is given as part of a composition.

The effects of the inhaler that increases consciousness according to the present invention vary depending on age,
It is affected by gender, physical and mental conditions, etc., so in some cases it may be necessary to administer a dose outside the range shown below, but in general, when administering to healthy subjects, the amount of ``lemon active fraction'' is 0.1% to 5%. It is preferable to administer an effective amount of "lemon active fraction" by inhalation over a certain period of time or continuously, based on the aroma volatilized from a perfumed product containing %.

[Examples] Next, examples and comparative examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The blending amount is in weight%.

Example 1 Perfume and Eau de Cologne A fragrance preparation with a citrus aroma containing 5%, 10%, 15%, and 20% by weight of perfuming active substances of standard commercial varieties, respectively. Eau de cologne is prepared by dissolving 4 in 95% aqueous alcohol to a weight concentration of 3%. Further, the same blended fragrance is dissolved in 95% aqueous alcohol to a weight concentration of 20% to prepare a perfume.

These colognes have the effect of raising a person's level of consciousness by inhaling their scent.

Example 2 Indoor air spray The aerosol was filled according to the following formulation.

Perfume containing 15% of lemon active fraction (hereinafter referred to as
It is abbreviated as effect fragrance A. ) 5-ethyl alcohol 95
% 56 Subang 85
2 twin 81
1. Propellant 3. These aerosols have the effect of raising the level of human consciousness by inhaling the aroma.

Example 3 Soap (1) Soap base 95.0 (
2) Effect test material A5.0 (3) Pigment After adding appropriate amounts of manufacturing methods (2) and (3) to the soap base, soap was manufactured by kneading with a machine or forming a border for 9 times.

These soaps have the effect of raising a person's level of consciousness by inhaling their fragrance when used.

Example 4 Shampoo (1) Alkyl sulfate triethanolamine salt 15.0
(2) Palm #J costic acid monoethanolamide 5.0
(3) Ethylene glycol monostearate 2.0 (4
) Preservative: Appropriate amount (5) Pigment: Appropriate amount (6) Effect Perfume mA 3.0 (7) Purified water Residual manufacturing methods (1) to (6) were dissolved in (7) with stirring to obtain a shampoo.

These shampoos have the effect of raising a person's level of consciousness by inhaling their fragrance when used.

Example 5 Hair rinse (1) Alkyltrimethylammonium chloride 3.0 (2) Cetyl alcohol 1.0 (3) Preservative
0.1(4) Glycerin
5.0 (5) Effect perfume: RA
O,4(6) dye
Appropriate amount (7) POE (8 mol) Stearyl ether 0.6 (8) Purified water
The remaining production methods (1) to (8) were mixed and dissolved at 80°C, and the mixture was allowed to cool to room temperature to obtain a hair rinse.

These hair rinses have the effect of raising a person's level of consciousness by inhaling their fragrance when used.

Example 6 Bath powder (1) Talc 80.0
(2) Effective fragrance composition 20.0
(Effect Investigation Material A, Liquid Paraffin, C20) Production Methods (1) and (2) were mixed and stirred to obtain a bath powder.

These bath powders have the effect of raising a person's level of consciousness by inhaling their aroma when used.

Example 7 String perfume (1) Effective fragrance composition 90.0 (
Effect perfume 'MA, Vaseline, 5:4) (2) Glycerin trimyristate 8.0 (3) Fragrance
2.0 Manufacturing method (1) to (3) were mixed and stirred to obtain a line perfume.

These line perfumes have the effect of raising a person's level of consciousness by inhaling their scent when used.

[Effects of the Invention] The present invention can reduce sleepiness that humans or animals experience in their daily lives.
It relieves physiological and psychological conditions caused by a decrease in the level of consciousness, such as fatigue and lethargy, and has the effect of refreshing the mood and raising the level of consciousness by activating mental activity.

Patent issuer Kaba style company Shiseido

Claims (1)

[Claims] 100℃ under an atmospheric pressure of 0.08 mmHg by vacuum distillation
A composition for raising the level of consciousness of humans or animals, characterized in that it contains as an active ingredient a lemon oil fraction from which the previously distilled part has been removed.