JPS63250315A - Composition for promoting level of consciousness - Google Patents

Abstract

PURPOSE:To obtain the titled composition having excellent raising effects on level of consciousness and low strength of fragrance, by blending blended perfume with a specific terpene alcohol compound. CONSTITUTION:Blended perfume is mixed with one or more compounds selected from phytol shown by formula I, isophytol shown by formula II, which are known as perfume components in jasmine, geranylgeraniol shown by formula III and geranyllinalool shown by formula IV, analog compounds thereof, as an active ingredient. the compounds are almost odorless themselves. Since addition of >=1wt.% of the compound to blended perfume hardly affects fragrance of total perfume and 5-50wt.% of the compound is added to blended perfume to manifest raising effects on consciousness.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention is directed to the treatment of humans or animals by inhaling diterpene alcohol compounds such as phytol, isophytol, geranylgeraniol, and geranyl linalool, which increase the level of consciousness of humans or animals. The present invention relates to a composition that increases the level of consciousness of animals.

[Prior Art] Traditionally, so-called aromatherapy (
A treatment method called aroma therapy is known. The fragrances that have been used in aromatherapy are mainly natural essential oils based on ancient traditions, and with regard to the ``effect of raising the level of consciousness'' that is the issue of the present invention, fragrances such as eucalyptus, lemon, and , verbena, citronella, cypress, salvia, thyme, clove, rosemary, cypress,
Essential oils such as basil are said to be highly effective (Oku 1) Osamu "Aromatherapy Perspective"Fragrance; No. 140 (1983)
) pp, 19-26).

In addition, the research group led by P. Rovest I et al.
When a mixture based on , jasmine, and cloves was inhaled using an aerosol and administered to neurotic patients suffering from psychological depression, it was said to have an effect similar to that of a stimulant. (s,p,cAug 475-478197
3) However, these effects are subjective and qualitative, and their effectiveness is not necessarily satisfactory.

In addition, many of the essential oils mentioned above have a strong scent, and when creating a blended fragrance based on research, it will affect the overall scent, so it is important to balance the strength and palatability of the scent with the effective amount to achieve the effect. However, it was not always satisfactory.

[Problems to be Solved by the Invention] In view of the above circumstances, the inventor of the present invention has conducted intensive research to obtain a substance with a low fragrance intensity and an excellent effect of truly raising the level of consciousness. The known ingredients phytol and isophytol, as well as similar compounds geranylgeraniol and geranyl linalool, are completely odorless, yet have a powerful effect on raising the level of consciousness when inhaled. We have discovered this fact and have completed the present invention based on this knowledge.

[Means for Solving the Problems] That is, the present invention is characterized in that one or more diterpene alcohol compounds selected from phytol, isophytol, geranylgeraniol, and geranyl linalool are blended as active ingredients. It is a composition that increases the level of consciousness of humans or animals.

The effect of raising the level of consciousness referred to here refers to the effect of raising the level of consciousness, which relieves the physiological and psychological states caused by a decrease in the level of consciousness, such as sleepiness, fatigue, and inertia that humans and animals experience in their daily lives. This refers to the effect of increasing activity.

In addition, the composition refers to a diterpene alcohol compound that is inhaled in an effective amount and produces an effect by stimulating olfactory receptors or being absorbed into the body through the respiratory tract.
It includes fragrance products such as perfumes, colognes, and room air fresheners, as well as cosmetics such as soaps and toothpaste, and pharmaceuticals.

The present invention will be explained in detail below.

The diterpene alcohol compounds in the present invention are known substances, including phytol represented by the following structural formula 1,
Examples include isophytol represented by Structural Formula 2, geranylgeraniol represented by Structural Formula 8, and geranyl linalool represented by Structural Formula 4.

(hereinafter referred to as all white) 1] Shishi-1''2 Regarding phytol, standard commercial varieties of cis/trans mixture and 100% trans form of phytol are used in the present invention, but the cis:trans ratio is from 100:1 to 100%. Those having various mixing ratios up to 1:100 can be used. Similarly, commercially available isophytol, geranylgeraniol, and geranyl linalool can be used in the present invention, but any stereoisomeric structure can be used. I can do it.

Furthermore, naturally occurring or synthetically obtained phytol, isophytol, geranylgeraniol, and geranyl linalool can be used in the present invention.

Therefore, phytol or isophytol can be isolated from natural essential oils such as alfalfa and jasmine by various means such as distillation and column fractionation.For example, farnesol can be hydrogenated to form hexahydro-farnesol, and then bromide and After that, ethyl
It can also be synthesized by condensation saponification with sodio-acetate to form a ketone body, acetylene condensation reaction with this to form isophytol, and further reaction to form phytol through rearrangement.

These diterpene alcohol compounds are used alone or as a mixed composition with various media (for example, organic solvents, oils, blended fragrances, and perfumed products) that can be mixed with the diterpene alcohol compounds.

When a blended fragrance is used as a medium, the scent of the individual ingredients contributes to the overall scent of the blend, but as mentioned above, these diterpene alcohol compounds themselves are almost odorless, so they do not contribute to the overall scent of the blend. has almost no effect.

From this point of view, the amount of diterpene alcohol compounds to be used has a high degree of freedom, and even if 1% or more by weight of diterpene alcohol compounds is added to a blended fragrance, a consciousness-raising effect can be achieved without changing the overall scent of the fragrance. can.

Furthermore, from the perspective of significantly producing a consciousness-enhancing effect, the weight ratio of diterpene alcohol compounds is 5%.
% to 50% in the blended fragrance.

It can also be used as an eau de cologne using ethyl alcohol as a medium. In this case as well, the diterpene alcohol compound can be incorporated alone or in combination with the above-mentioned perfume preparations.

In addition, by incorporating diterpene alcohol-based compounds alone or in combination with blended fragrances into products using other vehicles, we can create products such as fragrances, room air fresheners, creams, emulsions, cosmetic powders, body lotions, deodorant sticks, and toothpastes. , hair products, aerosol products, etc. In this case, the amount of the diterpene alcohol compound ranges from 0.3% by weight to 50% by weight.
Used in a range of % by weight.

Furthermore, it can also be used as an inhalation drug containing a diterpene alcohol compound as an active ingredient.

Next, an experiment on the consciousness-enhancing effect of each diterpene alcohol compound and its results will be described.

[Pharmacological effects] 1. Mice (1) Experimental method ICR male mice (6-7 weeks old, weight 30-35 g)
Bendoparbital sleep time (55 mg/min) of the group that was inhaled for 4 hours with an air flow containing the test substance listed below (2 L/min of air containing 1 to 2 mg of the test substance) and the group that was not inhaled with the test substance. kg intraperitoneally) was compared.

(2) Test substance Substance A Nidoran Suphytol Substance B: phytol (cis and trans mixture of the above substances) Substance C: Isophytol Substance D = Geranylgeraniol Substance E: Geranyllinalool The experimental results are shown in Table 1.

Table 1 (Note) A positive sign for average sleep time indicates that the average sleep time of the test substance inhalation group was extended, and a negative sign indicates that it was shortened.

[Administration method, administration ffi] The present invention is characterized by administration by inhalation, and unlike stimulants administered by oral administration, subcutaneous injection, intramuscular injection, etc., stimulants are administered to healthy individuals. Since it is expected to have a milder consciousness-raising effect than the above, the diterpene alcohol-based compound mentioned above can be used as part of a composition containing alcohol or fragrance, or in a fragrance composition used in a perfumed product. It is preferable to give it as a part.

The effects of the consciousness-enhancing inhaler of the present invention are affected by age, individual differences, gender, physical and mental conditions, etc., so in some cases doses outside the ranges listed below may be administered, but in general it is intended for healthy people. If the diterpene alcohol compound is 0
．． It is preferable to inhale and administer the aroma volatilized from a perfumed product containing 1% to 5% over a certain period of time or continuously.

[Examples] Next, examples will be given to clarify the present invention more specifically. The present invention is not limited thereby.

The blending amount is in weight%.

Example 1 Eau de cologne and perfume standard commercial variety phytol in citrus blend fragrance at 30%
After addition, it was diluted to 3% with 95% ethyl alcohol to make eau de cologne.

Furthermore, 5%, 10%, and 20% colognes were created using the same method.

Further, a perfume was obtained by diluting the same blended fragrance in which 30% phytol was added to a citrus blended fragrance to 20% in 95% ethyl alcohol.

These colognes had the effect of raising the level of consciousness of humans or animals when inhaled.

Example 2 Indoor air spray An indoor air spray was created with the following formulation.

(Weight%) Isophytol 0.75 Citrus blend fragrance 4.2595% Ethyl alcohol 56.00 Span 85
2゜OO twin 81
1.00 Example 3 Soap (wt%)
(1) Soap base 95.0 (2
) Phytol 2.5 (3
) Preparation tube N 2.5 Manufacturing method Soap was manufactured by adding (2), (3) and (4) to the soap base of (1) and then kneading it in a machine for 9 minutes or forming a frame.

Example 4 Shampoo (wt%) (1)
Alkyl sulfate triethanolamine [15,0(2)
Coconut fatty acid monoethanolamide
5.0(3) Ethylene glycol monostearate 2.
0(4) Isophytol 0.9(
5) Mixed fragrance 2.1 (6) Preservative appropriate amount (7) Pigment
Shampoo was obtained by stirring and dissolving appropriate amounts of manufacturing methods (1) to (7) in (8).

Example 5 Hair rinse (weight X) (1)
Alkyltrimethylammonium chloride 3.0 (2) Cetyl alcohol 1.0 (3
) Preservative 0.1 (4)
Glycerin 5,0 (5) Geranylgeraniol 0.2 (6) Mixed fragrance
0.2(7) Pigment
Appropriate amount (8) POE (8 mol) stearyl ether o, e Production methods (1) to (9) were mixed and dissolved at 80°C and allowed to cool to room temperature to obtain a hair rinse.

Example 6 Bath powder (wt%) (1) Talc 80 (2) Geranyl linalool 1 (3) M tube IJ42 Production methods (1) to (4) were mixed and stirred to obtain bath powder.

Example 7 String perfume (weight 2) (1)
Geranyl linalool 20(2) Mixed fragrance 30(3) Vaseline
40(4) Glycerin trimyristate 8 Production methods (1) to (5) were mixed and stirred to obtain a string perfume.

These line perfumes have the effect of raising a person's level of consciousness by inhaling their scent when used.

Claims (1)

[Claims] phytol, isophytol, geranylgeraniol,
A composition for raising the level of consciousness of humans or animals, characterized in that it contains one or more diterpene alcohol compounds selected from geranyl linalool as an active ingredient.