KR101855611B1 - (r,s)-니코틴의 제조 방법 - Google Patents

(r,s)-니코틴의 제조 방법 Download PDF

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Publication number
KR101855611B1
KR101855611B1 KR1020167033978A KR20167033978A KR101855611B1 KR 101855611 B1 KR101855611 B1 KR 101855611B1 KR 1020167033978 A KR1020167033978 A KR 1020167033978A KR 20167033978 A KR20167033978 A KR 20167033978A KR 101855611 B1 KR101855611 B1 KR 101855611B1
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KR
South Korea
Prior art keywords
mixture
solvent
nicotine
rti
reaction
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KR1020167033978A
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English (en)
Korean (ko)
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KR20170054327A (ko
Inventor
마이클 아놀드
Original Assignee
넥스트 제너레이션 랩스, 엘엘씨
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Application filed by 넥스트 제너레이션 랩스, 엘엘씨 filed Critical 넥스트 제너레이션 랩스, 엘엘씨
Publication of KR20170054327A publication Critical patent/KR20170054327A/ko
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Publication of KR101855611B1 publication Critical patent/KR101855611B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • Y10S514/813—

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167033978A 2014-10-22 2015-10-22 (r,s)-니코틴의 제조 방법 KR101855611B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462067196P 2014-10-22 2014-10-22
US62/067,196 2014-10-22
PCT/US2015/057017 WO2016065209A2 (en) 2014-10-22 2015-10-22 Process for the preparation of (r,s)-nicotine

Publications (2)

Publication Number Publication Date
KR20170054327A KR20170054327A (ko) 2017-05-17
KR101855611B1 true KR101855611B1 (ko) 2018-05-04

Family

ID=55761749

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167033978A KR101855611B1 (ko) 2014-10-22 2015-10-22 (r,s)-니코틴의 제조 방법

Country Status (6)

Country Link
US (1) US9556142B2 (zh)
EP (1) EP3209653B1 (zh)
KR (1) KR101855611B1 (zh)
CN (2) CN107406411B (zh)
AU (1) AU2015335770B2 (zh)
WO (1) WO2016065209A2 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180111822A (ko) * 2015-12-30 2018-10-11 넥스트 제너레이션 랩스, 엘엘씨 합성 니코틴을 포함하는 니코틴 대체 요법 물질
RS62759B1 (sr) 2017-12-22 2022-01-31 Siegfried Ag Jednofazni postupak za pripremu racemskog nikotina reakcijom etil nikotinata sa n-vinilpirolidonom u prisustvu natrijum etanolata ili kalijum etanolata ili njihovih smeša
US11279685B2 (en) 2017-12-22 2022-03-22 Siegfried Ag Enantiomeric separation of racemic nicotine by addition of an O,O″-disubstituted tartaric acid enantiomer
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US10952460B2 (en) 2018-11-05 2021-03-23 Blesst Boyz LLC Composition for a tobacco-free chew and method of manufacturing same
HUE051799T2 (hu) * 2018-11-16 2021-03-29 Zanoprima Lifesciences Ltd Eljárás (S)-nikotin elõállítására myosmine vegyületbõl
US10913962B2 (en) * 2018-11-16 2021-02-09 Zanoprima Lifesciences Limited Process of making (S)-nicotine
CN110256403B (zh) * 2019-07-02 2020-06-19 深圳市馨艺坊生物科技有限公司 一种人工合成尼古丁的制备方法
CN110357853B (zh) * 2019-08-05 2020-07-10 济南悟通生物科技有限公司 (r,s-)尼古丁的合成方法
JP7148756B2 (ja) 2019-09-12 2022-10-05 キャブベイシス・リミテッド・ライアビリティ・カンパニー 喫煙製品およびヴェポライザー用物品および製剤
WO2021127986A1 (zh) * 2019-12-24 2021-07-01 深圳雾芯科技有限公司 一种制备尼古丁的方法
CN113373188B (zh) * 2020-03-10 2024-02-20 重庆博腾制药科技股份有限公司 一种(s)-尼古丁的合成方法
CN113527187B (zh) 2020-04-22 2023-12-26 凯特立斯（深圳）科技有限公司 一种尼古丁的不对称制备方法
CN112125883A (zh) * 2020-10-22 2020-12-25 东莞市鸿馥生物科技有限公司 一种消旋烟碱的合成方法
CN114437025B (zh) * 2020-11-05 2023-08-25 上海零诺生物科技有限公司 消旋6-甲基烟碱及其制备方法、以及应用
US20220154231A1 (en) * 2020-11-18 2022-05-19 Shandong Jincheng Pharmaceutical Chemical Co., Ltd Methods for preparing nicotine and intermediates thereof
CN112409327A (zh) * 2020-11-18 2021-02-26 山东金城医药化工有限公司 一种高光学纯度烟碱的制备方法
CN112795603B (zh) * 2020-12-14 2022-06-24 山东金城医药化工有限公司 一种制备(s)-2-(3-吡啶)-吡咯烷的方法
CN112745294B (zh) * 2020-12-30 2022-02-22 山东金城柯瑞化学有限公司 (r,s-)尼古丁的合成方法
CN112876461B (zh) * 2021-01-20 2022-12-30 上海零诺生物科技有限公司 尼古丁及其中间体的制备方法
CN113087697A (zh) * 2021-04-12 2021-07-09 深圳市优绿信生物科技有限公司 一种尼古丁的合成方法
CN114644614B (zh) * 2021-04-21 2023-03-28 黄冈中有生物科技有限公司 一种左旋烟碱的制备方法
CN115260088A (zh) * 2021-04-30 2022-11-01 武汉中有药业有限公司 烟碱及其中间体的制备方法
CN113406231B (zh) * 2021-06-18 2023-06-09 云南民族大学 一种次生物碱含量低的烟碱及其应用
CN115927216A (zh) * 2021-08-10 2023-04-07 深圳瑞德林生物技术有限公司 一种s-尼古丁的制备方法
CN113788815A (zh) * 2021-09-27 2021-12-14 成昌梅 一种烟碱中间体的合成制备方法
EP4332098A1 (en) 2022-08-31 2024-03-06 Siegfried AG Chiral synthesis of nornicotine and nicotine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102633773A (zh) 2011-02-14 2012-08-15 迪维斯实验室有限公司 一种(r,s)-烟碱的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304191D0 (en) * 1993-03-02 1993-04-21 Ciba Geigy Ag Process for the preparation of aqueous nicotinaldehyde
AU5319700A (en) * 1999-06-02 2000-12-18 S. Mbua Ngale Efange Nicotine receptor ligands
AU2002322562A1 (en) * 2001-07-19 2003-03-03 Medical College Of Georgia Research Institute Novel analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
AU2003293039C1 (en) * 2003-11-17 2010-08-12 North Carolina State University Regiospecific synthesis of nicotine derivatives
US8378111B2 (en) * 2011-02-02 2013-02-19 Divi's Laboratories, Ltd. Process for the resolution of (R,S)-nicotine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102633773A (zh) 2011-02-14 2012-08-15 迪维斯实验室有限公司 一种(r,s)-烟碱的制备方法
US20120209006A1 (en) * 2011-02-14 2012-08-16 Divi's Laboratories Limited Process for the preparation of (r,s)-nicotine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Acta Chem. Scand. B 30(1976), 93

Also Published As

Publication number Publication date
US20160115150A1 (en) 2016-04-28
US9556142B2 (en) 2017-01-31
AU2015335770A1 (en) 2017-06-08
CN113149958A (zh) 2021-07-23
WO2016065209A3 (en) 2016-09-01
WO2016065209A2 (en) 2016-04-28
KR20170054327A (ko) 2017-05-17
EP3209653B1 (en) 2021-06-09
EP3209653A2 (en) 2017-08-30
EP3209653A4 (en) 2018-06-06
CN107406411B (zh) 2021-04-09
AU2015335770B2 (en) 2019-03-14
CN107406411A (zh) 2017-11-28

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