KR101854879B1 - 염증성 질환의 치료에 사용하기 위한 n-아실에탄올아민에 특이적인 아미다제의 조절용 조성물 및 조절 방법 - Google Patents

염증성 질환의 치료에 사용하기 위한 n-아실에탄올아민에 특이적인 아미다제의 조절용 조성물 및 조절 방법 Download PDF

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KR101854879B1
KR101854879B1 KR1020147025782A KR20147025782A KR101854879B1 KR 101854879 B1 KR101854879 B1 KR 101854879B1 KR 1020147025782 A KR1020147025782 A KR 1020147025782A KR 20147025782 A KR20147025782 A KR 20147025782A KR 101854879 B1 KR101854879 B1 KR 101854879B1
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inflammatory
chronic
pea
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KR20140147819A (ko
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발레 프란체스코 델라
발레 마리아 페데리카 델라
가브리엘레 마르콜론고
마르초 빈첸초 디
살바토레 쿠초크레아
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에피테크 그룹 에스.알.엘.
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
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    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147025782A 2012-02-17 2012-02-17 염증성 질환의 치료에 사용하기 위한 n-아실에탄올아민에 특이적인 아미다제의 조절용 조성물 및 조절 방법 Active KR101854879B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2012/000050 WO2013121449A1 (en) 2012-02-17 2012-02-17 Compositions and methods for the modulation of specific amidases for n-acylethanolamines for use in the therapy of inflammatory diseases

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KR20140147819A KR20140147819A (ko) 2014-12-30
KR101854879B1 true KR101854879B1 (ko) 2018-05-04

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US (1) US9512091B2 (https=)
EP (1) EP2814489B1 (https=)
JP (1) JP5982016B2 (https=)
KR (1) KR101854879B1 (https=)
CN (1) CN104244948B (https=)
AR (1) AR090066A1 (https=)
AU (1) AU2012327209B2 (https=)
BR (1) BR112014020992B1 (https=)
CA (1) CA2864259C (https=)
DK (1) DK2814489T3 (https=)
ES (1) ES2648188T3 (https=)
IN (1) IN2014DN06850A (https=)
PT (1) PT2814489T (https=)
WO (1) WO2013121449A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2772252T3 (es) * 2014-03-21 2020-07-07 Epitech Group S P A Preparaciones oftálmicas, intraarticulares o intravesicales que contienen N-acil-etanolaminas
DK2965765T3 (da) * 2014-07-08 2019-07-22 Epitech Group S P A Anvendelse af adelmidrol til behandling af epiteldysfunktioner
CN108135982A (zh) * 2015-06-16 2018-06-08 默多克儿童研究所 治疗克罗恩病的方法
RU2737893C2 (ru) * 2015-08-11 2020-12-04 Айсью Медсинз Б.В. Пэгилированная липидная наночастица с биоактивным липофильным соединением
EP3520785B1 (en) * 2016-10-09 2024-07-17 Shenzhen Eulikan Biotechnology Co., Ltd. Uses of bacteriostatic agent formula in preparing composition for vaginal use and composition for vaginal use
US10143639B2 (en) * 2017-03-22 2018-12-04 William Robert McDaniel Use of adelmidrol and other topical or oral cannabinomimetic or aliamide mast cell inhibitors to treat dermatoheliosis, seborrheic keratoses, and androgenetic alopecia
PH12018000077B1 (en) * 2017-07-05 2021-07-09 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
SG10201807034XA (en) * 2017-09-05 2019-04-29 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease
EP3574899A1 (en) 2018-05-28 2019-12-04 Université de Bourgogne Oleic acid derivatives, pharmaceutical composition or food composition comprising said oleic acid derivatives, and their uses
FR3098394B1 (fr) * 2019-07-12 2022-07-08 Expanscience Lab Composition comprenant au moins une oxazoline pour inhiber la croissance de levure du genre Malassezia impliquée notamment dans les croûtes de lait
IT202200017820A1 (it) * 2022-08-30 2024-03-01 Unifarco S P A Compressa nutraceutica comprendente palmitoiletanolamide
CN118125936B (zh) * 2022-11-25 2025-10-03 南京清普生物科技有限公司 N-酰基乙醇酰胺衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229020A1 (de) * 1992-09-03 1994-03-10 Henkel Kgaa Verfahren zur Herstellung von þ-Alkanoylaminoalkyl-substituierten quartären Ammoniumsalzen
US20080185332A1 (en) * 2007-02-05 2008-08-07 Dow Global Technologies Inc. Modified polyamide membrane

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2368075A (en) * 1943-09-11 1945-01-23 Commercial Solvents Corp Astringent preparations
US2450806A (en) * 1945-12-07 1948-10-05 Gulf Research Development Co Rust preventive chromium compounds and compositions containing them
US2547493A (en) * 1949-12-01 1951-04-03 Rohm & Haas Imido-esters of diels-alder adducts and process for producing same
US2965459A (en) * 1958-03-03 1960-12-20 Standard Oil Co Gasoline containing borated oxazolines
US3389145A (en) * 1965-10-24 1968-06-18 Katz Jacob Fatty oxazoline surfactants and a process for their preparation
US3648847A (en) * 1969-01-07 1972-03-14 Reichhold Chemicals Inc Filter aid conditioners
US3886128A (en) * 1973-10-15 1975-05-27 Commercial Solvents Corp Oxazoline emulsifier in polymerization of styrene and butadiene
US3920567A (en) 1974-12-27 1975-11-18 Exxon Research Engineering Co Novel oxazoline-alkyl acid phosphate adducts useful as ashless antiwear additives
JPS5283321A (en) * 1975-12-27 1977-07-12 Takeshi Tomiyama Method of manufacturing geranyl farnesyl acetate
US4049819A (en) * 1976-02-09 1977-09-20 Imc Chemical Group, Inc. Method of combatting microorganisms employing substituted oxazolines
US4224172A (en) 1978-12-04 1980-09-23 Mobil Oil Corporation Oil-soluble adducts of benzotriazole and oxazolines and lubricant compositions containing same
US4477384A (en) * 1981-02-20 1984-10-16 The United States Of America As Represented By The Secretary Of Agriculture Preparation of α-substituted acrylic acids
EP0238210A3 (en) 1986-03-14 1989-05-24 Imperial Chemical Industries Plc Solid explosive composition
US4876249A (en) * 1987-01-12 1989-10-24 Rajadhyaksha Vithal J Compositions and method comprising heterocyclic compounds containing two heteroatoms
DE3710516A1 (de) * 1987-03-30 1988-10-20 Henkel Kgaa Verfahren zur herstellung von 2-benzylfettsaeuren
NZ226043A (en) * 1987-09-23 1991-05-28 Ici Australia Operations Explosive composition: ammonium nitrate prills
DE3824982A1 (de) * 1987-11-10 1989-05-18 Henkel Kgaa 2-(11-hydroxy-8-heptadecenyl- oder 11,8- bzw. 11,9-heptadecadienyl)oxazolin, sowie verfahren zur herstellung gegebenenfalls substituierter hoeherer 2-(alkyl- bzw. alkenyl)-oxazoline
JPH0747636B2 (ja) * 1988-12-05 1995-05-24 東レ株式会社 熱可塑性ポリアミド樹脂組成物
DE3914155A1 (de) * 1989-04-28 1990-10-31 Henkel Kgaa Verfahren zur herstellung von 5,6-dihydro-4h-1,3-oxazinen
DE4104789A1 (de) * 1991-02-16 1992-08-20 Henkel Kgaa Cyclische polyiminoether
US5698017A (en) * 1996-09-27 1997-12-16 Xerox Corporation Oxazoline hot melt ink compositions
US6462054B1 (en) * 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
US6706674B2 (en) * 2001-01-17 2004-03-16 The Andrew Jergens Company Nonaqueous hair styling composition and method of use
FR2834216B1 (fr) * 2001-12-27 2004-04-30 Pharmascience Lab Composition cosmetique ou pharmaceutique comprenant au moins une oxazoline pour inhiber la migration des cellules de langerhans, et ses utilisations
BR0314980A (pt) * 2002-10-08 2005-08-09 Scripps Research Inst Inibidores de hidrolase de amida de ácido graxo
FR2885128B1 (fr) 2005-04-27 2007-07-06 Expanscience Laboratoires Sa Composition cosmetique a visee depigmentante ou eclaircissante comprenant au moins une oxazoline, a titre de principe actif depigmentant ou eclaircissant
US20110184026A1 (en) 2008-06-19 2011-07-28 Boger Dale L C4-substituted alpha-keto oxazoles
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229020A1 (de) * 1992-09-03 1994-03-10 Henkel Kgaa Verfahren zur Herstellung von þ-Alkanoylaminoalkyl-substituierten quartären Ammoniumsalzen
US20080185332A1 (en) * 2007-02-05 2008-08-07 Dow Global Technologies Inc. Modified polyamide membrane

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BR112014020992A2 (pt) 2017-06-20
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US9512091B2 (en) 2016-12-06
US20150057269A1 (en) 2015-02-26
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