KR101808398B1 - 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물 - Google Patents

스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물 Download PDF

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KR101808398B1
KR101808398B1 KR1020157031951A KR20157031951A KR101808398B1 KR 101808398 B1 KR101808398 B1 KR 101808398B1 KR 1020157031951 A KR1020157031951 A KR 1020157031951A KR 20157031951 A KR20157031951 A KR 20157031951A KR 101808398 B1 KR101808398 B1 KR 101808398B1
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South Korea
Prior art keywords
clfa
protein
crm
staphylococcus aureus
lyophilized
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KR1020157031951A
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Korean (ko)
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KR20150129071A (ko
Inventor
라크쉬미 칸드케
아키히사 노노야마
타마라 샤퍼 핫쥐
샌딥 니마
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와이어쓰 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
KR1020157031951A 2010-12-22 2011-12-21 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물 Expired - Fee Related KR101808398B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061426476P 2010-12-22 2010-12-22
US61/426,476 2010-12-22
PCT/IB2011/055883 WO2012085872A2 (en) 2010-12-22 2011-12-21 Stable immunogenic compositions of staphylococcus aureus antigens

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137018851A Division KR20130114210A (ko) 2010-12-22 2011-12-21 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물

Publications (2)

Publication Number Publication Date
KR20150129071A KR20150129071A (ko) 2015-11-18
KR101808398B1 true KR101808398B1 (ko) 2017-12-12

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KR1020157031951A Expired - Fee Related KR101808398B1 (ko) 2010-12-22 2011-12-21 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물
KR1020137018851A Ceased KR20130114210A (ko) 2010-12-22 2011-12-21 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물

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Country Status (18)

Country Link
US (1) US20130259896A1 (enExample)
EP (2) EP2654784B1 (enExample)
JP (1) JP6097478B2 (enExample)
KR (2) KR101808398B1 (enExample)
CN (1) CN103826656B (enExample)
AU (1) AU2011346535B2 (enExample)
BR (1) BR112013016153A2 (enExample)
CA (1) CA2819120C (enExample)
DK (2) DK3150222T3 (enExample)
ES (2) ES2769425T3 (enExample)
HU (2) HUE047263T2 (enExample)
IL (1) IL226793B (enExample)
MX (1) MX350170B (enExample)
PL (2) PL3150222T3 (enExample)
PT (2) PT2654784T (enExample)
RU (1) RU2570730C2 (enExample)
SI (2) SI2654784T1 (enExample)
WO (1) WO2012085872A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2730275T3 (es) 2004-09-22 2019-11-11 Glaxosmithkline Biologicals Sa Composición inmunógena para uso en vacunación contra estafilococos
SI2445522T1 (sl) 2009-06-22 2017-10-30 Wyeth Llc Imunogeni sestavki antigenov Staphylococcusa aureusa
EP3461496B1 (en) 2009-06-22 2023-08-23 Wyeth LLC Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
ES2614807T3 (es) * 2010-06-04 2017-06-02 Wyeth Llc Formulaciones vacunales
AU2012266880A1 (en) * 2011-03-16 2013-10-03 Regents Of The University Of Minnesota Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus
GB201310008D0 (en) * 2013-06-05 2013-07-17 Glaxosmithkline Biolog Sa Immunogenic composition for use in therapy
WO2015082571A1 (en) * 2013-12-04 2015-06-11 Glycovaxyn Ag Prevention of staphylococcus aureus infections by glycoprotein vaccines synthesized in escherichia coli
IL310015B1 (en) * 2013-12-31 2025-10-01 Access To Advanced Health Inst Single vial formulation
DK3129001T3 (da) * 2014-04-10 2020-01-20 Asit Biotech S A Hsp-fri fremstilling af allergen
US20200360500A1 (en) * 2017-08-16 2020-11-19 Merck Sharp & Dohme Corp. Pneumococcal conjugate vaccine formulations
GB201802339D0 (en) 2018-02-13 2018-03-28 Glaxosmithkline Biologicals Sa Immunogenic composition
KR102646145B1 (ko) 2018-05-31 2024-03-11 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
KR102058961B1 (ko) 2018-07-28 2019-12-24 주식회사 엑소코바이오 엑소좀의 동결건조 방법
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
BR112022013730A2 (pt) * 2020-01-13 2022-10-11 Aptevo Res & Development Llc Métodos e composições para prevenir a adsorção de proteínas terapêuticas aos componentes do sistema de distribuição de drogas

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158334A1 (en) 2001-07-26 2005-07-21 Mario Contorni Vaccines comprising aluminium adjuvants and histidine
WO2006032472A2 (en) 2004-09-22 2006-03-30 Glaxosmithkline Biologicals S.A. Immunogenic composition for use in vaccination against staphylococcei
WO2007113222A2 (en) * 2006-03-30 2007-10-11 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2007113223A2 (en) 2006-03-30 2007-10-11 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2008057550A2 (en) * 2006-11-07 2008-05-15 Sanofi Pasteur Biologics Co. Stabilization of vaccines by lyophilization

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902506A (en) 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US5078996A (en) 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
IT1253009B (it) 1991-12-31 1995-07-10 Sclavo Ricerca S R L Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini
US5571515A (en) 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6008341A (en) 1994-08-22 1999-12-28 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin S. aureus fibrinogen binding protein gene
BE1008978A5 (fr) 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
JPH11514870A (ja) 1995-10-16 1999-12-21 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規な唾液結合タンパク質
GB9622159D0 (en) 1996-10-24 1996-12-18 Solvay Sociutu Anonyme Polyanionic polymers as adjuvants for mucosal immunization
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
AU1537699A (en) 1997-11-26 1999-06-15 Bioresearch Ireland a division of Eolas - The Irish Science and Technology Agency Extracellular matrix-binding proteins from (staphylococcus aureus)
US6680195B1 (en) 1997-11-26 2004-01-20 Inhibitex, Inc. Extracellular matrix-binding proteins from staphylococcus aureus
WO2000012131A1 (en) * 1998-08-31 2000-03-09 Inhibitex, Inc. Multicomponent vaccines
US6936258B1 (en) 1999-03-19 2005-08-30 Nabi Biopharmaceuticals Staphylococcus antigen and vaccine
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
US7384640B1 (en) 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
RU2413520C2 (ru) 2000-06-08 2011-03-10 Интерселл Аг Вакцинная композиция, содержащая иммуностимулирующие олигодезоксинуклеотиды
AT410635B (de) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
CN1541111A (zh) 2001-06-07 2004-10-27 ���Ͽع����޹�˾ 作为佐剂的霍乱全毒素的突变形式
US7285281B2 (en) 2001-06-07 2007-10-23 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
EP2320233A1 (en) 2001-06-15 2011-05-11 Inhibitex, Inc. Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus
CA2517439C (en) 2003-03-07 2013-07-23 Wyeth Holdings Corporation Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
EP1603950A2 (en) 2003-03-17 2005-12-14 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
GB0606416D0 (en) * 2006-03-30 2006-05-10 Glaxosmithkline Biolog Sa Immunogenic composition
WO2007127668A2 (en) 2006-04-26 2007-11-08 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
MX2010008799A (es) 2008-03-05 2010-09-07 Sanofi Pasteur Proceso para estabilizar una composicion de vacuna que contiene adyuvante.
SI2445522T1 (sl) * 2009-06-22 2017-10-30 Wyeth Llc Imunogeni sestavki antigenov Staphylococcusa aureusa

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158334A1 (en) 2001-07-26 2005-07-21 Mario Contorni Vaccines comprising aluminium adjuvants and histidine
WO2006032472A2 (en) 2004-09-22 2006-03-30 Glaxosmithkline Biologicals S.A. Immunogenic composition for use in vaccination against staphylococcei
WO2007113222A2 (en) * 2006-03-30 2007-10-11 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2007113223A2 (en) 2006-03-30 2007-10-11 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2008057550A2 (en) * 2006-11-07 2008-05-15 Sanofi Pasteur Biologics Co. Stabilization of vaccines by lyophilization

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMBO J. 21(24): 6660-6672(2002.12.16.)*
Vaccine 27(33): 4388-4401(2009.05.28.)*

Also Published As

Publication number Publication date
PT3150222T (pt) 2020-02-03
EP2654784A2 (en) 2013-10-30
EP3150222B1 (en) 2019-11-27
EP2654784B1 (en) 2016-12-07
CN103826656A (zh) 2014-05-28
ES2614815T3 (es) 2017-06-02
CA2819120C (en) 2016-07-05
PL2654784T3 (pl) 2017-08-31
IL226793B (en) 2019-02-28
WO2012085872A2 (en) 2012-06-28
DK3150222T3 (da) 2020-01-27
HK1197370A1 (en) 2015-01-16
JP6097478B2 (ja) 2017-03-15
RU2570730C2 (ru) 2015-12-10
MX350170B (es) 2017-08-28
PL3150222T3 (pl) 2020-05-18
PT2654784T (pt) 2017-02-13
US20130259896A1 (en) 2013-10-03
AU2011346535A1 (en) 2013-06-13
WO2012085872A3 (en) 2012-08-30
ES2769425T3 (es) 2020-06-25
EP3150222A1 (en) 2017-04-05
DK2654784T3 (en) 2017-02-13
KR20150129071A (ko) 2015-11-18
HUE033072T2 (hu) 2017-11-28
SI2654784T1 (sl) 2017-01-31
AU2011346535B2 (en) 2015-09-24
KR20130114210A (ko) 2013-10-16
JP2012136518A (ja) 2012-07-19
CA2819120A1 (en) 2012-06-28
HUE047263T2 (hu) 2020-04-28
MX2013006960A (es) 2013-07-15
BR112013016153A2 (pt) 2017-07-11
RU2013128277A (ru) 2015-01-27
SI3150222T1 (sl) 2020-02-28
CN103826656B (zh) 2015-08-26

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