KR101773541B1 - 6-아미노-2-｛［(1ｓ)-1-메틸부틸］옥시｝-9-［5-(1-피페리디닐)-7,9-디하이드로-8ｈ-퓨린-8-온 말레이트 - Google Patents

6-아미노-2-｛［(1ｓ)-1-메틸부틸］옥시｝-9-［5-(1-피페리디닐)-7,9-디하이드로-8ｈ-퓨린-8-온 말레이트 Download PDF

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KR101773541B1
KR101773541B1 KR1020127023687A KR20127023687A KR101773541B1 KR 101773541 B1 KR101773541 B1 KR 101773541B1 KR 1020127023687 A KR1020127023687 A KR 1020127023687A KR 20127023687 A KR20127023687 A KR 20127023687A KR 101773541 B1 KR101773541 B1 KR 101773541B1
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oxy
methylbutyl
piperidinyl
amino
pentyl
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KR20120135408A (ko
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로버트 헤르만 기번
아만다 루카스
스티븐 앤드류 허미티지
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글락소스미스클라인 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
KR1020127023687A 2010-02-10 2011-02-08 6-아미노-2-｛［(1ｓ)-1-메틸부틸］옥시｝-9-［5-(1-피페리디닐)-7,9-디하이드로-8ｈ-퓨린-8-온 말레이트 Expired - Fee Related KR101773541B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30301010P 2010-02-10 2010-02-10
US61/303,010 2010-02-10
PCT/EP2011/051830 WO2011098452A1 (en) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate

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KR20120135408A KR20120135408A (ko) 2012-12-13
KR101773541B1 true KR101773541B1 (ko) 2017-08-31

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EP (1) EP2534149B1 (OSRAM)
JP (1) JP5922587B2 (OSRAM)
KR (1) KR101773541B1 (OSRAM)
CN (1) CN102753553B (OSRAM)
AU (1) AU2011214468B2 (OSRAM)
BR (1) BR112012018904A2 (OSRAM)
CA (1) CA2786973C (OSRAM)
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EA (1) EA021048B1 (OSRAM)
ES (1) ES2525826T3 (OSRAM)
HR (1) HRP20141258T1 (OSRAM)
IL (1) IL220845A (OSRAM)
ME (1) ME01926B (OSRAM)
MX (1) MX2012009316A (OSRAM)
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PT (1) PT2534149E (OSRAM)
RS (1) RS53745B1 (OSRAM)
SG (1) SG182471A1 (OSRAM)
SI (1) SI2534149T1 (OSRAM)
SM (1) SMT201400196B (OSRAM)
WO (1) WO2011098452A1 (OSRAM)
ZA (1) ZA201205995B (OSRAM)

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KR102712879B1 (ko) 2012-07-13 2024-10-04 웨이브 라이프 사이언시스 리미티드 키랄 제어
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
AR092198A1 (es) 2012-08-24 2015-04-08 Glaxosmithkline Llc Derivados de pirazolopirimidinas
CN104780923B (zh) 2012-11-20 2017-03-15 葛兰素史克有限责任公司 干扰素诱导剂化合物
PE20151086A1 (es) 2012-11-20 2015-08-20 Glaxosmithkline Llc COMPUESTOS DERIVADOS DE 5H-PIRROLO-[3,2-d]PIRIMIDIN-4-AMINA 2,6,7 TRISUSTITUIDOS O 2,7 DISUSTITUIDOS COMO INDUCTORES DEL INTERFERON HUMANO
RU2643371C2 (ru) 2012-11-20 2018-02-01 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Новые соединения
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
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JP7109188B2 (ja) * 2014-08-29 2022-07-29 コリウム， インコーポレイテッド 活性剤の送達のための微細構造アレイ
BR112017009648A2 (pt) * 2014-11-13 2017-12-19 Glaxosmithkline Biologicals Sa composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto.
WO2020110584A1 (ja) * 2018-11-28 2020-06-04 株式会社島津製作所 アゾ化合物の分析方法
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WO2008101867A1 (en) 2007-02-19 2008-08-28 Smithkline Beecham Corporation Purine derivatives as immunomodulators
WO2008114008A1 (en) * 2007-03-19 2008-09-25 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
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RS53745B1 (sr) 2015-06-30
AU2011214468A1 (en) 2012-08-09
SI2534149T1 (sl) 2015-02-27
HRP20141258T1 (hr) 2015-02-27
WO2011098452A1 (en) 2011-08-18
CN102753553A (zh) 2012-10-24
US8703754B2 (en) 2014-04-22
CN102753553B (zh) 2016-03-30
KR20120135408A (ko) 2012-12-13
ZA201205995B (en) 2014-01-29
SG182471A1 (en) 2012-08-30
JP2013519645A (ja) 2013-05-30
EA021048B1 (ru) 2015-03-31
CA2786973A1 (en) 2011-08-18
ME01926B (me) 2015-05-20
EP2534149A1 (en) 2012-12-19
DK2534149T3 (da) 2015-01-05
EP2534149B1 (en) 2014-10-15
JP5922587B2 (ja) 2016-05-24
PL2534149T3 (pl) 2015-03-31
EA201290631A1 (ru) 2013-03-29
IL220845A (en) 2016-08-31
AU2011214468B2 (en) 2015-05-28
BR112012018904A2 (pt) 2020-09-01
PT2534149E (pt) 2014-12-23
CA2786973C (en) 2018-04-10
ES2525826T3 (es) 2014-12-30
SMT201400196B (it) 2015-01-15
US20120308609A1 (en) 2012-12-06
MX2012009316A (es) 2012-09-12

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