KR101771752B1 - 췌장 효소 조성물 및 췌장염 및 췌장 기능 부전을 치료하기 위하 방법 - Google Patents

췌장 효소 조성물 및 췌장염 및 췌장 기능 부전을 치료하기 위하 방법 Download PDF

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Publication number
KR101771752B1
KR101771752B1 KR1020127009516A KR20127009516A KR101771752B1 KR 101771752 B1 KR101771752 B1 KR 101771752B1 KR 1020127009516 A KR1020127009516 A KR 1020127009516A KR 20127009516 A KR20127009516 A KR 20127009516A KR 101771752 B1 KR101771752 B1 KR 101771752B1
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South Korea
Prior art keywords
beads
coated
lipase
digestive enzyme
protease
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Expired - Fee Related
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KR1020127009516A
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English (en)
Korean (ko)
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KR20120100915A (ko
Inventor
고피 엠. 벤카테쉬
스테픈 페레트
루쓰 티에로페케르트
콘스탄티노 에프티미오폴로스
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앨러간 파마슈티컬스 인터내셔널 리미티드
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Assigned to 앨러간 테라퓨틱스 엘엘씨 reassignment 앨러간 테라퓨틱스 엘엘씨 권리의 전부이전등록 Assignors: 앨러간 파마슈티컬스 인터내셔널 리미티드
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020127009516A 2009-09-17 2010-09-17 췌장 효소 조성물 및 췌장염 및 췌장 기능 부전을 치료하기 위하 방법 Expired - Fee Related KR101771752B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24346709P 2009-09-17 2009-09-17
US61/243,467 2009-09-17
PCT/US2010/049203 WO2011035079A1 (en) 2009-09-17 2010-09-17 Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency

Publications (2)

Publication Number Publication Date
KR20120100915A KR20120100915A (ko) 2012-09-12
KR101771752B1 true KR101771752B1 (ko) 2017-08-25

Family

ID=43730817

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127009516A Expired - Fee Related KR101771752B1 (ko) 2009-09-17 2010-09-17 췌장 효소 조성물 및 췌장염 및 췌장 기능 부전을 치료하기 위하 방법

Country Status (23)

Country Link
US (2) US8784884B2 (https=)
EP (1) EP2477645B1 (https=)
JP (1) JP5877399B2 (https=)
KR (1) KR101771752B1 (https=)
CN (2) CN102630164B (https=)
AR (1) AR078291A1 (https=)
AU (1) AU2010295494B2 (https=)
BR (1) BR112012005837A8 (https=)
CA (1) CA2774269C (https=)
CL (1) CL2012000658A1 (https=)
CO (1) CO6531419A2 (https=)
ES (1) ES2690661T3 (https=)
HK (1) HK1218886A1 (https=)
IL (2) IL218656A (https=)
MX (1) MX2012003214A (https=)
MY (1) MY161843A (https=)
NZ (1) NZ599143A (https=)
RU (1) RU2570376C2 (https=)
SA (1) SA110310695B1 (https=)
TW (2) TW201639545A (https=)
UY (1) UY32896A (https=)
WO (1) WO2011035079A1 (https=)
ZA (1) ZA201202761B (https=)

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* Cited by examiner, † Cited by third party
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IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
JP5966202B2 (ja) 2007-02-20 2016-08-10 アラガン ファーマシューティカルズ インターナショナル リミテッド 安定な消化酵素組成物
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
ES2657673T3 (es) * 2010-10-01 2018-03-06 Aptalis Pharma Limited Formulaciones recubiertas entéricas de pancrelipasa, de baja intensidad
CA2843556A1 (en) * 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
CA2920844A1 (en) 2013-08-09 2015-02-12 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
FR3079146B1 (fr) * 2018-03-23 2020-04-17 Karim Ioualalen Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive.
US20230138700A1 (en) * 2020-03-30 2023-05-04 Jai WALL Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy

Citations (1)

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WO2008102264A2 (en) * 2007-02-20 2008-08-28 Eurand Pharmaceuticals Limited Stable digestive enzyme compositions

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US5260074A (en) 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5302400A (en) 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
US5578304A (en) 1992-06-22 1996-11-26 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
JP2000505801A (ja) 1996-02-09 2000-05-16 クアドラント・ホールディングズ・ケンブリッジ・リミテッド トレハロースを含む固形製剤
US5750104A (en) 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
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CN1156308C (zh) * 2002-04-19 2004-07-07 北京世诺医药科技有限公司 多酶组合胶囊
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Also Published As

Publication number Publication date
MX2012003214A (es) 2012-08-01
BR112012005837A2 (pt) 2017-05-30
TW201639545A (zh) 2016-11-16
HK1218886A1 (zh) 2017-03-17
CN102630164A (zh) 2012-08-08
JP5877399B2 (ja) 2016-03-08
ZA201202761B (en) 2012-12-27
KR20120100915A (ko) 2012-09-12
UY32896A (es) 2011-02-28
TWI572372B (zh) 2017-03-01
CO6531419A2 (es) 2012-09-28
SA110310695B1 (ar) 2014-11-26
RU2570376C2 (ru) 2015-12-10
TW201113052A (en) 2011-04-16
JP2013505255A (ja) 2013-02-14
EP2477645A4 (en) 2014-06-25
RU2012113253A (ru) 2013-10-27
CA2774269A1 (en) 2011-03-24
EP2477645A1 (en) 2012-07-25
IL218656A0 (en) 2012-05-31
CL2012000658A1 (es) 2012-09-28
CN102630164B (zh) 2015-09-16
IL218656A (en) 2017-12-31
ES2690661T3 (es) 2018-11-21
US8784884B2 (en) 2014-07-22
CA2774269C (en) 2017-03-21
US20140287035A1 (en) 2014-09-25
WO2011035079A1 (en) 2011-03-24
CN105214073A (zh) 2016-01-06
AR078291A1 (es) 2011-10-26
NZ599143A (en) 2014-05-30
EP2477645B1 (en) 2018-08-15
AU2010295494B2 (en) 2014-09-25
BR112012005837A8 (pt) 2017-10-10
US20110064799A1 (en) 2011-03-17
US20160051472A9 (en) 2016-02-25
IL245875A0 (en) 2016-07-31
AU2010295494A1 (en) 2012-03-29
MY161843A (en) 2017-05-15

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