HK1218886A1 - 用於治療胰腺炎和胰腺功能不全的胰酶組合物和方法 - Google Patents

用於治療胰腺炎和胰腺功能不全的胰酶組合物和方法

Info

Publication number
HK1218886A1
HK1218886A1 HK16107000.5A HK16107000A HK1218886A1 HK 1218886 A1 HK1218886 A1 HK 1218886A1 HK 16107000 A HK16107000 A HK 16107000A HK 1218886 A1 HK1218886 A1 HK 1218886A1
Authority
HK
Hong Kong
Prior art keywords
pancreatic
enzyme compositions
treating pancreatitis
insufficiency
pancreatic insufficiency
Prior art date
Application number
HK16107000.5A
Other languages
English (en)
Inventor
戈皮．
．文卡特施
斯蒂芬．佩雷特
露絲．泰洛夫-艾克德特
康斯坦蒂諾．艾弗西米奧普羅斯
Original Assignee
Aptalis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43730817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1218886(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptalis Pharma Ltd filed Critical Aptalis Pharma Ltd
Publication of HK1218886A1 publication Critical patent/HK1218886A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK16107000.5A 2009-09-17 2016-06-17 用於治療胰腺炎和胰腺功能不全的胰酶組合物和方法 HK1218886A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24346709P 2009-09-17 2009-09-17

Publications (1)

Publication Number Publication Date
HK1218886A1 true HK1218886A1 (zh) 2017-03-17

Family

ID=43730817

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107000.5A HK1218886A1 (zh) 2009-09-17 2016-06-17 用於治療胰腺炎和胰腺功能不全的胰酶組合物和方法

Country Status (23)

Country Link
US (2) US8784884B2 (zh)
EP (1) EP2477645B1 (zh)
JP (1) JP5877399B2 (zh)
KR (1) KR101771752B1 (zh)
CN (2) CN102630164B (zh)
AR (1) AR078291A1 (zh)
AU (1) AU2010295494B2 (zh)
BR (1) BR112012005837A8 (zh)
CA (1) CA2774269C (zh)
CL (1) CL2012000658A1 (zh)
CO (1) CO6531419A2 (zh)
ES (1) ES2690661T3 (zh)
HK (1) HK1218886A1 (zh)
IL (2) IL218656A (zh)
MX (1) MX2012003214A (zh)
MY (1) MY161843A (zh)
NZ (1) NZ599143A (zh)
RU (1) RU2570376C2 (zh)
SA (1) SA110310695B1 (zh)
TW (2) TW201639545A (zh)
UY (1) UY32896A (zh)
WO (1) WO2011035079A1 (zh)
ZA (1) ZA201202761B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8246950B2 (en) 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
RS53587B1 (en) * 2010-10-01 2015-02-27 Aptalis Pharma Limited ENTERICALLY LOWER PANCRELIPASE FORMULATIONS
EP2741766B1 (en) * 2011-08-08 2015-10-07 Aptalis Pharma Limited Method for dissolution testing of solid compositions containing digestive enzymes
WO2015020943A2 (en) 2013-08-09 2015-02-12 Aptalis Pharma Ltd. Digestive enzyme composition suitable for enteral administration
WO2015193730A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts
FR3079146B1 (fr) * 2018-03-23 2020-04-17 Karim Ioualalen Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive.
US20230138700A1 (en) * 2020-03-30 2023-05-04 Jai WALL Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4447412A (en) * 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US5578304A (en) 1992-06-22 1996-11-26 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5260074A (en) 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5302400A (en) 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
AU1729297A (en) 1996-02-09 1997-08-28 Quadrant Holdings Cambridge Limited Solid formulations containing trehalose
US5750104A (en) 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
CN1156308C (zh) * 2002-04-19 2004-07-07 北京世诺医药科技有限公司 多酶组合胶囊
US20040121010A1 (en) * 2002-10-25 2004-06-24 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
EP1596838A2 (en) 2003-02-11 2005-11-23 Torrent Pharmaceuticals Ltd Once a day orally administered pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic agent
AU2004285558A1 (en) * 2003-10-29 2005-05-12 Altus Pharmaceuticals Inc. Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain
US7387793B2 (en) 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
US7470435B2 (en) 2003-11-17 2008-12-30 Andrx Pharmaceuticals, Llc Extended release venlafaxine formulation
PT1729797E (pt) 2004-03-22 2008-12-17 Solvay Pharm Gmbh Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos
AU2005247061A1 (en) * 2004-05-24 2005-12-08 Novozymes A/S Enzymes for pharmaceutical use
JP4908420B2 (ja) * 2004-10-14 2012-04-04 アルタス ファーマシューティカルズ インコーポレイテッド 膵機能不全を治療するための、リパーゼ、プロテアーゼおよびアミラーゼを含有する組成物
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
MX2007015472A (es) * 2005-06-24 2008-04-17 Novozymes As Lipasas para uso farmaceutico.
US20070025977A1 (en) 2005-07-21 2007-02-01 Mulberg Andrew E Method of treating steatorrhea in infants
PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US8071089B2 (en) * 2005-11-01 2011-12-06 Bio-Cat, Inc. Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
CA2655665A1 (en) * 2006-05-26 2007-12-06 Nestec S.A. Methods of use and nutritional compositions of touchi extract
US20080199448A1 (en) * 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
US20090117180A1 (en) * 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
US8246950B2 (en) 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
US20110171294A1 (en) 2008-09-30 2011-07-14 Dsm Ip Assets B.V. Enzyme composition and application thereof in the treatment of pancreatic insufficiency

Also Published As

Publication number Publication date
AR078291A1 (es) 2011-10-26
IL218656A (en) 2017-12-31
ZA201202761B (en) 2012-12-27
US20160051472A9 (en) 2016-02-25
BR112012005837A8 (pt) 2017-10-10
JP2013505255A (ja) 2013-02-14
KR101771752B1 (ko) 2017-08-25
US20140287035A1 (en) 2014-09-25
SA110310695B1 (ar) 2014-11-26
IL245875A0 (en) 2016-07-31
WO2011035079A1 (en) 2011-03-24
TWI572372B (zh) 2017-03-01
US8784884B2 (en) 2014-07-22
EP2477645A1 (en) 2012-07-25
CN102630164B (zh) 2015-09-16
RU2570376C2 (ru) 2015-12-10
IL218656A0 (en) 2012-05-31
TW201113052A (en) 2011-04-16
JP5877399B2 (ja) 2016-03-08
UY32896A (es) 2011-02-28
EP2477645A4 (en) 2014-06-25
CN102630164A (zh) 2012-08-08
AU2010295494A1 (en) 2012-03-29
RU2012113253A (ru) 2013-10-27
AU2010295494B2 (en) 2014-09-25
CO6531419A2 (es) 2012-09-28
CA2774269C (en) 2017-03-21
US20110064799A1 (en) 2011-03-17
CL2012000658A1 (es) 2012-09-28
KR20120100915A (ko) 2012-09-12
MX2012003214A (es) 2012-08-01
TW201639545A (zh) 2016-11-16
CN105214073A (zh) 2016-01-06
CA2774269A1 (en) 2011-03-24
NZ599143A (en) 2014-05-30
MY161843A (en) 2017-05-15
ES2690661T3 (es) 2018-11-21
EP2477645B1 (en) 2018-08-15
BR112012005837A2 (pt) 2017-05-30

Similar Documents

Publication Publication Date Title
HK1218886A1 (zh) 用於治療胰腺炎和胰腺功能不全的胰酶組合物和方法
IL239918A0 (en) Preparations for the treatment of colitis
HK1210223A1 (zh) 用於抑制基因表達的組合物及其用途
HK1217900A1 (zh) 用於預防或治療眼科病症的方法和組合物
HK1190088A1 (zh) 胰腺的消化的酶製備
EP2513334A4 (en) DICER SUBSTRATE AGENTS AND METHODS FOR SPECIFIC INHIBITION OF GENE EXPRESSION
EP2462230A4 (en) METHOD AND COMPOSITIONS FOR TARGETED GENE MODIFICATION
HK1159155A1 (en) Enzymatic textile bleaching compositions and methods of use thereof
EP2361089A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALTERED FUNCTION OF -SYNUCLEINE
EP2271218A4 (en) USE AND COMPOSITION FOR THE TREATMENT OF DEMENTIA
EP2497482A4 (en) COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF INFLUENZA AVIRUSED INDUCED DISEASES
EP2442655A4 (en) COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
HK1158522A1 (en) Composition and method for treatment of mrsa
IL210097A0 (en) Compositions and methods for treating unfluenza
EP2504428A4 (en) METHOD AND COMPOSITIONS FOR TREATING OXALATE-MEDIATED SUFFERING
EP2575825A4 (en) COMPOSITIONS AND METHODS FOR TREATING DEPRESSION
EP2429584A4 (en) TREATMENT PROCEDURE AND COMPOSITIONS
HK1162058A1 (zh) 鞣製方法和鞣製組合物
IL215932A0 (en) Compositions and methods for treating burns
EP2490536A4 (en) COMPOSITION AND METHOD
EP2291284A4 (en) COMPOSITIONS FOR TREATING MATERIALS AND TREATMENT METHOD THEREFOR
PL2504026T3 (pl) Kompozycja zawierająca połączenie co najmniej jednego enzymu proteolitycznego i co najmniej jednego enzymu lipolitycznego do zastosowania w celu zapobiegania syntezie triglicerydów
HK1250484A1 (zh) 用於治療胰腺炎的吉卡賓和衍生物
EP2512504A4 (en) COMPOSITION AND THERAPEUTIC METHOD
EP2393506A4 (en) METHODS AND COMPOSITIONS FOR TREATING NEUROPATHIES