KR101756772B1 - β-Ｃ-아릴 글루코사이드의 제조 방법 - Google Patents

β-Ｃ-아릴 글루코사이드의 제조 방법 Download PDF

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Publication number
KR101756772B1
KR101756772B1 KR1020147015420A KR20147015420A KR101756772B1 KR 101756772 B1 KR101756772 B1 KR 101756772B1 KR 1020147015420 A KR1020147015420 A KR 1020147015420A KR 20147015420 A KR20147015420 A KR 20147015420A KR 101756772 B1 KR101756772 B1 KR 101756772B1
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formula
compound
aryl
group
arylation
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Korean (ko)
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KR20140089427A (ko
Inventor
줄리안 폴 헨스케
첸-웨이 린
핑-유 우
치-눙 시아오
지-슝 랴오
충-유 시아오
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시노팜 타이완 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020147015420A 2011-11-07 2012-11-07 β-Ｃ-아릴 글루코사이드의 제조 방법 Expired - Fee Related KR101756772B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161556780P 2011-11-07 2011-11-07
US61/556,780 2011-11-07
US201261661793P 2012-06-19 2012-06-19
US61/661,793 2012-06-19
PCT/IB2012/002894 WO2013068850A2 (en) 2011-11-07 2012-11-07 PROCESS FOR THE PREPARATION OF β-C-ARYL GLUCOSIDES

Publications (2)

Publication Number Publication Date
KR20140089427A KR20140089427A (ko) 2014-07-14
KR101756772B1 true KR101756772B1 (ko) 2017-07-26

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KR1020147015420A Expired - Fee Related KR101756772B1 (ko) 2011-11-07 2012-11-07 β-Ｃ-아릴 글루코사이드의 제조 방법

Country Status (11)

Country Link
EP (1) EP2776449B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP6144686B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR101756772B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN103974964B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2012335280B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR112014010997A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2854591A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL232418A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014CN04050A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TWI488861B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2013068850A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
CN104557894A (zh) * 2013-10-18 2015-04-29 上海信谊药厂有限公司 坎格列汀晶型及其制备方法
WO2015155739A1 (en) * 2014-04-11 2015-10-15 Scinopharm Taiwan, Ltd. Process for the preparation of beta-c-arylglucosides
CN105017237A (zh) * 2014-04-29 2015-11-04 嘉实（湖南）医药科技有限公司 一种卡格列净的制备工艺
EP2947077A1 (en) 2014-05-19 2015-11-25 LEK Pharmaceuticals d.d. Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides
US10370365B2 (en) 2015-09-16 2019-08-06 Optimus Drugs (P) Limited Process for the preparation of Canagliflozin
CN105294624B (zh) * 2015-11-16 2018-01-12 山东罗欣药业集团股份有限公司 一种达格列净的制备方法
CN105486767B (zh) * 2015-12-03 2018-03-13 上海应用技术学院 一种达格列净及其α‑异构体的分离方法
CN105541815B (zh) * 2015-12-24 2018-07-13 寿光富康制药有限公司 一种卡格列净的制备方法
WO2021176096A1 (en) 2020-03-05 2021-09-10 Krka, D.D., Novo Mesto Pharmaceutical composition comprising sglt2 inhibitor
CN115867538A (zh) 2020-06-05 2023-03-28 新梅斯托克公司 高纯的无定形达格列净的制备

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011064726A1 (en) 2009-11-24 2011-06-03 South African Medical Research Council Method for the synthesis of aspalathin and analogues thereof

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Publication number Priority date Publication date Assignee Title
JPS5872599A (ja) * 1981-10-27 1983-04-30 Kanto Ishi Pharma Co Ltd 複合糖質誘導体
CN101260130A (zh) * 2003-01-03 2008-09-10 布里斯托尔-迈尔斯斯奎布公司 制备c-芳基葡糖苷sglt2抑制剂的方法
AR056195A1 (es) * 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011064726A1 (en) 2009-11-24 2011-06-03 South African Medical Research Council Method for the synthesis of aspalathin and analogues thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Carbohydrate Research, Vol. 342, pp. 913-918 (2007.)

Also Published As

Publication number Publication date
BR112014010997A2 (pt) 2017-06-06
IL232418A0 (en) 2014-06-30
IL232418A (en) 2016-10-31
TWI488861B (zh) 2015-06-21
WO2013068850A3 (en) 2013-08-22
WO2013068850A8 (en) 2013-10-10
AU2012335280A1 (en) 2014-05-22
CN103974964A (zh) 2014-08-06
KR20140089427A (ko) 2014-07-14
TW201335175A (zh) 2013-09-01
CN103974964B (zh) 2016-03-23
JP2014532690A (ja) 2014-12-08
EP2776449B1 (en) 2017-08-02
WO2013068850A2 (en) 2013-05-16
JP6144686B2 (ja) 2017-06-07
CA2854591A1 (en) 2013-05-16
EP2776449A2 (en) 2014-09-17
AU2012335280B2 (en) 2016-09-29
EP2776449A4 (en) 2015-10-07
IN2014CN04050A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-07-10

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