KR101742329B1 - 인간 간 세포가 이식된 마우스 - Google Patents
인간 간 세포가 이식된 마우스 Download PDFInfo
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| WO2013145331A1 (ja) * | 2012-03-27 | 2013-10-03 | 株式会社トランスジェニック | ヒト化マウス |
| JP5976380B2 (ja) * | 2012-04-27 | 2016-08-23 | 公益財団法人東京都医学総合研究所 | ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス |
| CN103690997B (zh) * | 2013-12-05 | 2016-06-29 | 南方医科大学珠江医院 | 用于制备去细胞肝脏支架的试剂盒及其使用方法 |
| JP6566464B2 (ja) * | 2014-10-24 | 2019-08-28 | 国立大学法人広島大学 | 急性重症肝炎モデル非ヒト動物の作製方法、劇症肝炎治療薬のスクリーニング方法およびｂ型劇症肝炎治療薬 |
| FI3850946T3 (fi) * | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni |
| CN107709550A (zh) * | 2015-06-18 | 2018-02-16 | 转基因股份有限公司 | 脏器人源化小鼠 |
| CN108504624A (zh) * | 2018-04-08 | 2018-09-07 | 深圳市体内生物医药科技有限公司 | 一种免疫缺陷小鼠模型的新应用 |
| CN116121302A (zh) * | 2018-09-27 | 2023-05-16 | 公益财团法人实验动物中央研究所 | 免疫缺陷小鼠 |
| JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| EP3777528A4 (en) * | 2018-12-14 | 2022-01-26 | Central Institute For Experimental Animals | NON-HUMAN VERTEBRATE TRANSPLANTED WITH HUMAN HEPATOCYTES AND METHOD FOR THE PRODUCTION THEREOF |
| CN109735485B (zh) * | 2019-01-29 | 2021-04-16 | 深圳市拓普生物科技有限公司 | 人源化肝脏动物模型及其构建方法和应用 |
| CN110823655A (zh) * | 2019-11-06 | 2020-02-21 | 南通大学 | 一种激光显微切割获取抗体标记组织单细胞的方法 |
| JP7136509B2 (ja) * | 2019-12-27 | 2022-09-13 | 学校法人高崎健康福祉大学 | 肝細胞培養膜、それを備えた薬物輸送能評価キット、及び薬物輸送能評価方法 |
| CN116103379A (zh) * | 2023-01-18 | 2023-05-12 | 广东医科大学附属医院 | 一种动物体内人源细胞的检测方法及用途 |
| JP7471704B1 (ja) | 2023-08-17 | 2024-04-22 | 協和ステンレス株式会社 | ステンレスタンク用電解研磨装置、およびステンレスタンクの電解研磨方法 |
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| WO2001032009A1 (en) * | 1999-11-02 | 2001-05-10 | The University Of Connecticut | Propagation of human hepatocytes in non-human animals |
| WO2003080821A1 (fr) | 2002-03-25 | 2003-10-02 | Japan Science And Technology Agency | Procede assurant la proliferation des hepatocytes humains et procede d'obtention d'hepatocytes humains |
| JP3753321B2 (ja) * | 2000-12-01 | 2006-03-08 | 財団法人実験動物中央研究所 | 異種細胞の生着、分化および増殖に適したマウスの作出方法、該方法により作出されたマウスならびにそのマウスの用途 |
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| US6509514B1 (en) * | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
| CN1189076C (zh) * | 2002-06-15 | 2005-02-16 | 浙江大学 | 一种筛选抗丙型肝炎病毒药物的方法 |
| CN100540660C (zh) * | 2004-08-27 | 2009-09-16 | 上海交通大学附属儿童医院 | 一种转基因小鼠肝病动物模型、其制备方法及应用 |
| CN1732942A (zh) * | 2005-08-08 | 2006-02-15 | 湖北科益药业股份有限公司 | 更昔洛韦在制备治疗肿瘤药物中的应用 |
| WO2008151283A1 (en) * | 2007-06-05 | 2008-12-11 | Oregon Health & Science University | Method of expanding human hepatocytes in vivo |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001032009A1 (en) * | 1999-11-02 | 2001-05-10 | The University Of Connecticut | Propagation of human hepatocytes in non-human animals |
| JP3753321B2 (ja) * | 2000-12-01 | 2006-03-08 | 財団法人実験動物中央研究所 | 異種細胞の生着、分化および増殖に適したマウスの作出方法、該方法により作出されたマウスならびにそのマウスの用途 |
| WO2003080821A1 (fr) | 2002-03-25 | 2003-10-02 | Japan Science And Technology Agency | Procede assurant la proliferation des hepatocytes humains et procede d'obtention d'hepatocytes humains |
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| Blood 2002 vol.100 no.9 pp.3175-3182* |
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| JP5073836B2 (ja) | 2012-11-14 |
| JPWO2010082385A1 (ja) | 2012-06-28 |
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