KR101732751B1 - Ｒｅｌ-ｎ-［6-［(2ｒ,6ｓ)-2,6-디메틸-4-모르폴리닐］-3-피리디닐］-2-메틸-4'-(트리플루오로메톡시)-［1,1'-비페닐］-3-카르복스아미드를 포함한 국소 제약 조성물 - Google Patents

Ｒｅｌ-ｎ-［6-［(2ｒ,6ｓ)-2,6-디메틸-4-모르폴리닐］-3-피리디닐］-2-메틸-4'-(트리플루오로메톡시)-［1,1'-비페닐］-3-카르복스아미드를 포함한 국소 제약 조성물 Download PDF

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KR101732751B1
KR101732751B1 KR1020127004353A KR20127004353A KR101732751B1 KR 101732751 B1 KR101732751 B1 KR 101732751B1 KR 1020127004353 A KR1020127004353 A KR 1020127004353A KR 20127004353 A KR20127004353 A KR 20127004353A KR 101732751 B1 KR101732751 B1 KR 101732751B1
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skin
trifluoromethoxy
methyl
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KR20120097482A (ko
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안드레아스 프릿쯔
카리느 꼬르셀르
멜린다 에니코 그루베사
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노파르티스 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127004353A 2009-07-21 2010-07-20 Ｒｅｌ-ｎ-［6-［(2ｒ,6ｓ)-2,6-디메틸-4-모르폴리닐］-3-피리디닐］-2-메틸-4'-(트리플루오로메톡시)-［1,1'-비페닐］-3-카르복스아미드를 포함한 국소 제약 조성물 Active KR101732751B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22714109P 2009-07-21 2009-07-21
US61/227,141 2009-07-21
US29588410P 2010-01-18 2010-01-18
US61/295,884 2010-01-18
PCT/EP2010/060470 WO2011009852A2 (en) 2009-07-21 2010-07-20 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
KR20120097482A KR20120097482A (ko) 2012-09-04
KR101732751B1 true KR101732751B1 (ko) 2017-05-04

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KR1020127004353A Active KR101732751B1 (ko) 2009-07-21 2010-07-20 Ｒｅｌ-ｎ-［6-［(2ｒ,6ｓ)-2,6-디메틸-4-모르폴리닐］-3-피리디닐］-2-메틸-4'-(트리플루오로메톡시)-［1,1'-비페닐］-3-카르복스아미드를 포함한 국소 제약 조성물

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Country Link
US (1) US8722672B2 (https=)
EP (1) EP2456422B1 (https=)
JP (2) JP6106434B2 (https=)
KR (1) KR101732751B1 (https=)
CN (2) CN103893184B (https=)
AR (1) AR077490A1 (https=)
AU (1) AU2010275240A1 (https=)
BR (1) BR112012001340B1 (https=)
CA (1) CA2768457C (https=)
ES (1) ES2576740T3 (https=)
HK (1) HK1199217A1 (https=)
IN (1) IN2012DN00239A (https=)
MX (1) MX2012000954A (https=)
RU (1) RU2589699C2 (https=)
TW (1) TW201107314A (https=)
WO (1) WO2011009852A2 (https=)

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TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
SG194800A1 (en) * 2011-06-02 2013-12-30 Novartis Ag Biomarkers for hedgehog inhibitor therapy
MX353017B (es) 2011-09-28 2017-12-18 Titan Wood Ltd Paneles de fibras de densidad media.
AU2014220339B2 (en) * 2013-02-25 2016-12-01 Sun Pharmaceutical Industries Limited Oral formulation and suspension of an oncology drug
US10266523B2 (en) 2015-03-30 2019-04-23 Crystal Pharmatech Co., Ltd. Crystaline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-Methyl-4′-(trifluoromethoxy) [1,1′-biphenyl]-3-Methanamide monophosphate, and process of preparation thereof
PL3302428T3 (pl) 2015-06-04 2026-04-13 Sol-Gel Technologies Ltd. Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie
CN105330658B (zh) * 2015-12-09 2017-09-19 苏州明锐医药科技有限公司 索尼吉布的制备方法
CN112773805B (zh) * 2019-11-11 2024-05-10 中国科学院脑科学与智能技术卓越创新中心 缺血性脑损伤的新型治疗药物

Citations (1)

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WO2008154259A1 (en) * 2007-06-07 2008-12-18 Irm Llc Biphenylcarboxamide derivatives as hedgehog pathway modulators

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US4082881A (en) * 1976-12-23 1978-04-04 E. R. Squibb & Sons, Inc. Topical and other type pharmaceutical formulations containing isosorbide carrier
US5216011A (en) * 1989-09-01 1993-06-01 Bristol-Myers Squibb Co. Stable solutions of mitomycin c
IT1265001B1 (it) * 1993-12-16 1996-10-17 Zambon Spa Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico
DE4405898A1 (de) * 1994-02-18 1995-08-24 Schering Ag Transdermale therapeutische Systeme enthaltend Sexualsteroide
FR2719475B1 (fr) * 1994-05-05 1996-06-07 Oreal Composition cosmétique et/ou dermatologique à gélifiant polymérique cationique, ses utilisations notamment pour la dépigmentation de la peau.
US6765001B2 (en) * 2001-12-21 2004-07-20 Medicis Pharmaceutical Corporation Compositions and methods for enhancing corticosteroid delivery
RU2207124C1 (ru) * 2002-04-24 2003-06-27 Закрытое акционерное общество "Брынцалов-А" Крем "брамизил" противогрибкового действия
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
DE102006014454B3 (de) 2006-03-29 2007-11-08 Hoffmann, Frank Stanzvorrichtung mit Zuführeinrichtung
UA93548C2 (uk) * 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
CN101445508B (zh) * 2008-11-21 2011-08-31 南京威尔化工有限公司 异山梨醇二甲醚的合成方法

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2008154259A1 (en) * 2007-06-07 2008-12-18 Irm Llc Biphenylcarboxamide derivatives as hedgehog pathway modulators

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Publication number Publication date
JP6106434B2 (ja) 2017-03-29
CN103893184A (zh) 2014-07-02
EP2456422B1 (en) 2016-03-16
RU2012105752A (ru) 2013-08-27
MX2012000954A (es) 2012-02-28
WO2011009852A2 (en) 2011-01-27
CN103893184B (zh) 2016-03-02
AR077490A1 (es) 2011-08-31
CA2768457A1 (en) 2011-01-27
BR112012001340A2 (pt) 2016-03-15
CA2768457C (en) 2018-01-23
AU2010275240A1 (en) 2012-02-02
KR20120097482A (ko) 2012-09-04
US8722672B2 (en) 2014-05-13
IN2012DN00239A (https=) 2015-05-01
RU2589699C2 (ru) 2016-07-10
EP2456422A2 (en) 2012-05-30
BR112012001340B1 (pt) 2021-08-03
CN102481249A (zh) 2012-05-30
ES2576740T3 (es) 2016-07-11
HK1199217A1 (en) 2015-06-26
JP2015199753A (ja) 2015-11-12
TW201107314A (en) 2011-03-01
WO2011009852A3 (en) 2012-01-19
JP2012533598A (ja) 2012-12-27
US20120122866A1 (en) 2012-05-17

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