KR101727085B1 - 과증식성 질환, 자가면역 질환 및 심장 질환을 치료하기 위한 3-퀴뉴클리디논을 포함하는 수용액 - Google Patents

과증식성 질환, 자가면역 질환 및 심장 질환을 치료하기 위한 3-퀴뉴클리디논을 포함하는 수용액 Download PDF

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KR101727085B1
KR101727085B1 KR1020127021595A KR20127021595A KR101727085B1 KR 101727085 B1 KR101727085 B1 KR 101727085B1 KR 1020127021595 A KR1020127021595 A KR 1020127021595A KR 20127021595 A KR20127021595 A KR 20127021595A KR 101727085 B1 KR101727085 B1 KR 101727085B1
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aqueous solution
acid
solution
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present
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KR20120123441A (ko
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스튀르비에른 뷔스트룀
샬로타 릴리에브리스
니누스 카람-렐함
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아프레아 에이비
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Orthopedic Medicine & Surgery (AREA)
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  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127021595A 2010-01-21 2011-01-21 과증식성 질환, 자가면역 질환 및 심장 질환을 치료하기 위한 3-퀴뉴클리디논을 포함하는 수용액 Active KR101727085B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29696410P 2010-01-21 2010-01-21
EP10151326 2010-01-21
EP10151326.5 2010-01-21
US61/296,964 2010-01-21
PCT/EP2011/050854 WO2011089234A2 (en) 2010-01-21 2011-01-21 Method and composition

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KR20120123441A KR20120123441A (ko) 2012-11-08
KR101727085B1 true KR101727085B1 (ko) 2017-04-14

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US (1) US9061016B2 (https=)
EP (1) EP2525796B1 (https=)
JP (2) JP5845193B2 (https=)
KR (1) KR101727085B1 (https=)
CN (2) CN106963759B (https=)
AU (1) AU2011208681B2 (https=)
BR (1) BR112012017994B8 (https=)
CA (1) CA2786824C (https=)
CY (1) CY1117659T1 (https=)
DK (1) DK2525796T3 (https=)
ES (1) ES2578513T3 (https=)
HU (1) HUE028285T2 (https=)
IL (1) IL220318A (https=)
IN (1) IN2012DN05192A (https=)
PH (1) PH12012501402A1 (https=)
PL (1) PL2525796T3 (https=)
PT (1) PT2525796T (https=)
RU (1) RU2571566C2 (https=)
SG (1) SG182537A1 (https=)
SM (1) SMT201600189B (https=)
WO (1) WO2011089234A2 (https=)
ZA (1) ZA201204424B (https=)

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Publication number Priority date Publication date Assignee Title
IN2012DN05192A (https=) * 2010-01-21 2015-10-23 Aprea Ab
CN104860994A (zh) * 2014-02-20 2015-08-26 中国药科大学 3-奎宁环酮类含磷化合物的制备及其医药用途
CN109280056A (zh) * 2017-07-21 2019-01-29 上海时莱生物技术有限公司 手性3-奎宁环酮类化合物、制备方法及用途
EP3762035A4 (en) * 2018-03-09 2022-03-02 Texas Tech University System COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER IN ALT
US20220087987A1 (en) * 2018-12-27 2022-03-24 National Cancer Center A method for treating swi/snf complex-deficient cancers comprising glutathione (gsh) metabolic pathway inhibitor
WO2021053155A1 (en) 2019-09-18 2021-03-25 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein
JP2023514188A (ja) * 2020-02-09 2023-04-05 ニューウェーブ・ファーマスーティカル・インコーポレイテッド 抗がん剤としてのキヌクリジノン系化合物の応用
CN111257458B (zh) * 2020-02-20 2022-07-22 北京鑫开元医药科技有限公司海南分公司 一种3-奎宁环酮盐酸盐的检测方法及应用
WO2021170772A1 (en) 2020-02-26 2021-09-02 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling
WO2021180338A1 (en) 2020-03-09 2021-09-16 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant

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WO2003070250A1 (en) * 2002-02-21 2003-08-28 Aprea Ab Use of low molecular weight compounds for preparing a medicament useful in treating mutant p53 mediated diseases

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WO2002024692A1 (en) 2000-09-20 2002-03-28 Karolinska Innovations Ab 1-azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
RU2226288C2 (ru) 2001-07-10 2004-03-27 ОПТИВА, Инк. Многослойное оптическое покрытие
NZ542212A (en) 2003-03-24 2008-04-30 Aprea Ab Pharmaceutical use of 1-azabicyclo[2.2.2]octanes and a method of testing compounds for the ability of activating inactive WT P53
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JP2007269786A (ja) 2006-03-09 2007-10-18 Daiichi Sankyo Healthcare Co Ltd パンテチン含有経口液剤
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JP2008201778A (ja) * 2007-01-25 2008-09-04 Mochida Pharmaceut Co Ltd バンコマイシン液状製剤
CN101636162A (zh) 2007-03-01 2010-01-27 诺瓦提斯公司 5-(2,4-二羟基-5-异丙基-苯基)-4-(4-吗啉-4-基甲基-苯基)-异唑-3-甲酸乙基酰胺的酸加成盐、水合物和多晶型物以及包含这些形式的制剂
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WO2011089234A2 (en) 2011-07-28
SMT201600189B (it) 2016-08-31
JP2016020356A (ja) 2016-02-04
CN106963759B (zh) 2020-07-07
EP2525796B1 (en) 2016-03-30
CY1117659T1 (el) 2017-05-17
IN2012DN05192A (https=) 2015-10-23
EP2525796A2 (en) 2012-11-28
HUE028285T2 (en) 2016-12-28
AU2011208681A1 (en) 2012-07-05
US9061016B2 (en) 2015-06-23
PT2525796T (pt) 2016-07-11
JP2013518036A (ja) 2013-05-20
IL220318A (en) 2015-10-29
JP5845193B2 (ja) 2016-01-20
BR112012017994B8 (pt) 2020-12-08
RU2012135698A (ru) 2014-02-27
CN102781447B (zh) 2016-11-23
CA2786824C (en) 2018-04-10
CN102781447A (zh) 2012-11-14
SG182537A1 (en) 2012-08-30
CA2786824A1 (en) 2011-07-28
WO2011089234A8 (en) 2012-09-07
RU2571566C2 (ru) 2015-12-20
AU2011208681A8 (en) 2013-01-31
JP6106228B2 (ja) 2017-03-29
CN106963759A (zh) 2017-07-21
BR112012017994B1 (pt) 2020-01-14
US20120289503A1 (en) 2012-11-15
ES2578513T3 (es) 2016-07-27
ZA201204424B (en) 2013-08-28
PH12012501402A1 (en) 2016-07-27
PL2525796T3 (pl) 2016-09-30
KR20120123441A (ko) 2012-11-08
BR112012017994A2 (pt) 2016-05-03
DK2525796T3 (en) 2016-07-04
WO2011089234A3 (en) 2011-10-06
AU2011208681B2 (en) 2014-10-23

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