KR101717795B1 - 그람 양성 감염 치료를 위한 신규 항박테리아제 - Google Patents

그람 양성 감염 치료를 위한 신규 항박테리아제 Download PDF

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Publication number
KR101717795B1
KR101717795B1 KR1020117017003A KR20117017003A KR101717795B1 KR 101717795 B1 KR101717795 B1 KR 101717795B1 KR 1020117017003 A KR1020117017003 A KR 1020117017003A KR 20117017003 A KR20117017003 A KR 20117017003A KR 101717795 B1 KR101717795 B1 KR 101717795B1
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South Korea
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compound
compounds
acid
methyl
formula
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KR1020117017003A
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English (en)
Korean (ko)
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KR20110114592A (ko
Inventor
안드레 리 피어슨
체스터 에이 3세 멧칼프
징 리
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머크 샤프 앤드 돔 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020117017003A 2008-12-22 2009-12-18 그람 양성 감염 치료를 위한 신규 항박테리아제 Expired - Fee Related KR101717795B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13987508P 2008-12-22 2008-12-22
US61/139,875 2008-12-22
PCT/US2009/068747 WO2010075215A1 (en) 2008-12-22 2009-12-18 Novel antibacterial agents for the treatment of gram positive infections

Publications (2)

Publication Number Publication Date
KR20110114592A KR20110114592A (ko) 2011-10-19
KR101717795B1 true KR101717795B1 (ko) 2017-03-17

Family

ID=41718893

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117017003A Expired - Fee Related KR101717795B1 (ko) 2008-12-22 2009-12-18 그람 양성 감염 치료를 위한 신규 항박테리아제

Country Status (26)

Country Link
US (3) US8507647B2 (https=)
EP (2) EP2379580B1 (https=)
JP (1) JP5670914B2 (https=)
KR (1) KR101717795B1 (https=)
CN (1) CN102325787B (https=)
AR (1) AR074833A1 (https=)
AU (1) AU2009330245C1 (https=)
BR (1) BRPI0923567A2 (https=)
CA (1) CA2747965C (https=)
CY (1) CY1114883T1 (https=)
DK (1) DK2379580T3 (https=)
ES (1) ES2442167T3 (https=)
HR (1) HRP20131170T1 (https=)
IL (1) IL213638A0 (https=)
MX (1) MX2011006803A (https=)
NZ (1) NZ594019A (https=)
PL (1) PL2379580T3 (https=)
PT (1) PT2379580E (https=)
RS (1) RS53152B (https=)
RU (1) RU2512396C2 (https=)
SG (1) SG172299A1 (https=)
SI (1) SI2379580T1 (https=)
SM (1) SMT201400037B (https=)
TW (1) TWI444198B (https=)
WO (1) WO2010075215A1 (https=)
ZA (1) ZA201104693B (https=)

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Publication number Priority date Publication date Assignee Title
RU2013157188A (ru) * 2011-05-26 2015-07-10 Кьюбист Фармасьютикалз, Инк. Композиции св-183,315 и относящиеся к ним способы
US10377699B2 (en) * 2013-11-06 2019-08-13 The University Of Hong Kong Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
WO2015172047A1 (en) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Cyclic peptide compounds and related methods, salts and compositions
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
ES2791319T3 (es) * 2016-04-22 2020-11-03 Astrazeneca Ab Inhibidores de MCL1 macrocíclicos para tratar el cáncer
US10098890B2 (en) 2016-10-29 2018-10-16 Cipla Limited Stable carfilzomib formulations
IT201600127655A1 (it) * 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US10526343B2 (en) 2018-03-26 2020-01-07 University Of Sharjah Heterocyclic systems and pharmaceutical applications thereof
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044272A2 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents

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US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
USRE32455E (en) 1978-10-16 1987-07-07 Eli Lilly And Company A-21978 antibiotics and process for their production
USRE32333E (en) 1978-10-16 1987-01-20 Eli Lilly And Company A-21978 Antibiotics and process for their production
EP0087953B1 (en) 1982-02-27 1988-04-27 Beecham Group Plc Antibacterial 1-normon-2-yl-heterocyclic compounds
US4396543A (en) * 1982-05-21 1983-08-02 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
USRE32310E (en) 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4399067A (en) * 1982-05-21 1983-08-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4482487A (en) * 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
USRE32311E (en) 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production
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ZA883887B (en) * 1987-06-10 1990-02-28 Lilly Co Eli Chromatographic purification process
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ES2089133T3 (es) * 1990-06-07 1996-10-01 Lilly Co Eli Desacilasa de lipopeptidos.
AU7497594A (en) 1993-08-13 1995-03-14 Smithkline Beecham Plc Derivatives of monic acids a and c having antibacterial, antimycoplasmatical, antifungal and herbicidal activity
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE69739532D1 (de) 1996-03-08 2009-09-24 Astellas Pharma Inc Prozess für die deacylierung von zyklischen lipopeptiden.
DE19807972A1 (de) * 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
PL203689B1 (pl) 1998-09-25 2009-11-30 Cubist Pharmaceuticals Zastosowanie daptomycyny
EP1279057B1 (en) 1999-11-03 2013-03-20 The Whitaker LLC Optoelectric module for multi-fiber arrays
MXPA02006028A (es) 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
WO2001044274A1 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
US20060014674A1 (en) * 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
RU2348647C2 (ru) 2001-08-06 2009-03-10 Кьюбист Фармасьютикалз, Инк Новые депсипептиды и способы их получения
WO2006110185A2 (en) 2004-11-12 2006-10-19 Cubist Pharmaceuticals, Inc. Antiinfective lipopeptides

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Publication number Priority date Publication date Assignee Title
WO2001044272A2 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents

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Also Published As

Publication number Publication date
US8507647B2 (en) 2013-08-13
CA2747965A1 (en) 2010-07-01
RU2011130278A (ru) 2013-01-27
AR074833A1 (es) 2011-02-16
RU2512396C2 (ru) 2014-04-10
EP2674437A1 (en) 2013-12-18
SG172299A1 (en) 2011-07-28
EP2379580B1 (en) 2013-10-23
RS53152B (sr) 2014-06-30
AU2009330245A1 (en) 2011-08-04
JP2012513467A (ja) 2012-06-14
WO2010075215A1 (en) 2010-07-01
TWI444198B (zh) 2014-07-11
NZ594019A (en) 2013-08-30
HK1161886A1 (en) 2012-08-10
KR20110114592A (ko) 2011-10-19
HRP20131170T1 (hr) 2014-01-03
BRPI0923567A2 (pt) 2016-09-27
SMT201400037B (it) 2014-05-07
US20140073558A1 (en) 2014-03-13
US20150337013A1 (en) 2015-11-26
JP5670914B2 (ja) 2015-02-18
CY1114883T1 (el) 2016-12-14
EP2379580A1 (en) 2011-10-26
ZA201104693B (en) 2013-01-30
CN102325787B (zh) 2014-05-28
CN102325787A (zh) 2012-01-18
PL2379580T3 (pl) 2014-05-30
MX2011006803A (es) 2011-09-06
DK2379580T3 (da) 2014-01-20
US20100184649A1 (en) 2010-07-22
SI2379580T1 (sl) 2014-02-28
PT2379580E (pt) 2014-01-20
IL213638A0 (en) 2011-07-31
ES2442167T3 (es) 2014-02-10
TW201028161A (en) 2010-08-01
AU2009330245B2 (en) 2013-05-02
CA2747965C (en) 2017-06-27
AU2009330245C1 (en) 2013-09-26

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