KR101678254B1 - 동맥경화증과 같은 심혈관 장애의 치료용 피크노제놀 또는 포도씨와 같은 프로안토시아니딘 및 병풀의 조합 - Google Patents

동맥경화증과 같은 심혈관 장애의 치료용 피크노제놀 또는 포도씨와 같은 프로안토시아니딘 및 병풀의 조합 Download PDF

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KR101678254B1
KR101678254B1 KR1020127006415A KR20127006415A KR101678254B1 KR 101678254 B1 KR101678254 B1 KR 101678254B1 KR 1020127006415 A KR1020127006415 A KR 1020127006415A KR 20127006415 A KR20127006415 A KR 20127006415A KR 101678254 B1 KR101678254 B1 KR 101678254B1
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extract
formulation
proanthocyanidin
pycnogenol
proanthocyanidins
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KR20120103758A (ko
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지아니 벨카로
캐롤리나 부르키
빅터 페라리
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호르파그 리서치 아이피 (피와이씨) 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A61K36/5777—Theobroma, e.g. cocao or cocoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020127006415A 2009-08-12 2010-08-11 동맥경화증과 같은 심혈관 장애의 치료용 피크노제놀 또는 포도씨와 같은 프로안토시아니딘 및 병풀의 조합 Active KR101678254B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009006525 2009-08-12
IBPCT/IB2009/006525 2009-08-12
PCT/IB2010/053637 WO2011018763A1 (en) 2009-08-12 2010-08-11 Combination of proantocycidins such as pycnogenol or grape seeds and centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis

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KR20120103758A KR20120103758A (ko) 2012-09-19
KR101678254B1 true KR101678254B1 (ko) 2016-11-21

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KR1020127006415A Active KR101678254B1 (ko) 2009-08-12 2010-08-11 동맥경화증과 같은 심혈관 장애의 치료용 피크노제놀 또는 포도씨와 같은 프로안토시아니딘 및 병풀의 조합

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US (1) US9308230B2 (enExample)
EP (1) EP2464348B1 (enExample)
JP (1) JP5711231B2 (enExample)
KR (1) KR101678254B1 (enExample)
CN (1) CN102573834B (enExample)
AU (1) AU2010283453B2 (enExample)
BR (1) BR112012002935A2 (enExample)
CA (1) CA2769764C (enExample)
CL (1) CL2012000347A1 (enExample)
DK (1) DK2464348T3 (enExample)
ES (1) ES2426314T3 (enExample)
MX (1) MX2012001111A (enExample)
MY (1) MY162572A (enExample)
PH (1) PH12012500291A1 (enExample)
RU (1) RU2570733C2 (enExample)
SG (1) SG178203A1 (enExample)
WO (1) WO2011018763A1 (enExample)
ZA (1) ZA201200755B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103027908A (zh) * 2012-11-19 2013-04-10 何晓涛 Aphanamixoid A在制备治疗动脉粥样硬化药物中的应用
EP2829277A1 (en) 2013-07-26 2015-01-28 Natac Biotech, S.L. Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease
WO2015184101A1 (en) * 2014-05-29 2015-12-03 Jaguar Animal Health, Inc. Methods of treating diarrhea in neonatal and young non-human animals
WO2015184109A1 (en) * 2014-05-29 2015-12-03 Jaguar Animal Health, Inc. Methods of treating diarrhea in adult non-human animals
WO2016046375A1 (en) * 2014-09-25 2016-03-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders
WO2016138118A1 (en) * 2015-02-26 2016-09-01 Jaguar Animal Health, Inc. Use of croton- or calophyllum-derived proanthocyanidin polymers or botanical extracts in combination with rifaximin for the treatment of diarrhea in non-human animals
GB201801986D0 (en) * 2018-02-07 2018-03-28 Ip Science Ltd Anthocyanins and used thereof
US10849948B2 (en) 2019-04-16 2020-12-01 The Procter & Gamble Company Supplement for menopause

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JP2000325039A (ja) 1999-05-24 2000-11-28 Kikkoman Corp 抗動脈硬化症食品
JP2004532273A (ja) 2001-06-05 2004-10-21 インデナ エッセ ピ ア 限局性の（ｌｏｃａｌｉｚｅｄ）脂肪症（ａｄｉｐｏｓｉｔｙ）およびセルライト（ｃｅｌｌｕｌｉｔｅ）の治療のための医薬用および／または化粧品用組成物
JP2005023032A (ja) 2003-07-03 2005-01-27 Toyo Shinyaku:Kk 動脈硬化予防剤
JP2006028074A (ja) 2004-07-15 2006-02-02 Shield Lab:Kk 血小板凝集抑制組成物

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FR1427100A (fr) 1964-12-14 1966-02-04 Ile De Rech Pharma Et Therapeu Procédé pour l'obtention d'hydroxyflavanne-3-4-diols
BE897965A (fr) * 1983-10-11 1984-01-30 Bago Sa Labor Composition therapeutique exercant une activite anti-agglomeration des plaquettes
US5720956A (en) 1996-04-10 1998-02-24 Rohdewald; Peter Method of controlling the reactivity of human blood platelets by oral administration of the extract of the maritime pine (pycnogenol)
ATE292469T1 (de) * 1999-09-10 2005-04-15 Ceteris Holding B V Amsterdam Ein antioxyrierungsmittel auf basis von pflanzenextrakten zur behandlung von kreislaufs- und fettsuchtproblemen
JP3260134B2 (ja) 1999-10-08 2002-02-25 信孝 鈴木 月経困難症、子宮内膜症の治療薬
JP3495712B2 (ja) 2001-02-19 2004-02-09 株式会社ファンケル 食品組成物
ITGE20020026A1 (it) 2002-03-25 2003-09-25 Segre Silvia Perella Composto da impiegare nel trattamento scleroterapico,nell'insufficienza venosa e nelle alterazioni del microcircolo.
ES2280665T3 (es) 2003-10-18 2007-09-16 Cognis Ip Management Gmbh Preparacion para la ingestion oral.
JP2005237203A (ja) * 2004-02-24 2005-09-08 Haba Laboratories Inc ：喫煙によって生ずるｄｎａ酸化損傷を抑制するに有効な食品組成物
EP1740196B1 (en) * 2004-03-23 2015-08-26 Lifeline Nutraceuticals Corporation Compositions and method for alleviating inflammation and oxidative stress in a mammal
JP5139629B2 (ja) * 2005-06-28 2013-02-06 江崎グリコ株式会社 ＴＮＦ−αおよび一酸化窒素産生抑制剤
WO2007084648A2 (en) 2006-01-20 2007-07-26 Mars, Incorporated Mixed 4→6 procyanidin dimers and their use
US20070265211A1 (en) 2006-05-12 2007-11-15 Matthias Rath Novel composition and method effective in inhibiting the atherogenic process
KR100846292B1 (ko) 2007-07-20 2008-07-16 인타글리오주식회사 비수계 분산형 클렌징밤 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000325039A (ja) 1999-05-24 2000-11-28 Kikkoman Corp 抗動脈硬化症食品
JP2004532273A (ja) 2001-06-05 2004-10-21 インデナ エッセ ピ ア 限局性の（ｌｏｃａｌｉｚｅｄ）脂肪症（ａｄｉｐｏｓｉｔｙ）およびセルライト（ｃｅｌｌｕｌｉｔｅ）の治療のための医薬用および／または化粧品用組成物
JP2005023032A (ja) 2003-07-03 2005-01-27 Toyo Shinyaku:Kk 動脈硬化予防剤
JP2006028074A (ja) 2004-07-15 2006-02-02 Shield Lab:Kk 血小板凝集抑制組成物

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US20120164244A1 (en) 2012-06-28
MY162572A (en) 2017-06-30
MX2012001111A (es) 2012-06-01
CN102573834A (zh) 2012-07-11
PH12012500291A1 (en) 2016-10-12
RU2570733C2 (ru) 2015-12-10
WO2011018763A1 (en) 2011-02-17
CN102573834B (zh) 2015-04-29
SG178203A1 (en) 2012-03-29
AU2010283453B2 (en) 2014-10-09
JP5711231B2 (ja) 2015-04-30
WO2011018763A8 (en) 2012-03-15
CL2012000347A1 (es) 2013-09-23
ZA201200755B (en) 2012-09-26
AU2010283453A1 (en) 2012-02-23
US9308230B2 (en) 2016-04-12
ES2426314T3 (es) 2013-10-22
CA2769764C (en) 2017-04-18
BR112012002935A2 (pt) 2016-04-05
DK2464348T3 (da) 2013-07-29
AU2010283453A8 (en) 2012-06-07
RU2012104215A (ru) 2013-09-20
EP2464348B1 (en) 2013-06-19
EP2464348A1 (en) 2012-06-20
KR20120103758A (ko) 2012-09-19
CA2769764A1 (en) 2011-02-17
JP2013501774A (ja) 2013-01-17

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