JP5170577B2 - 炎症障害の治療のためにバラの実および他の活性剤を含んでなる組成物 - Google Patents
炎症障害の治療のためにバラの実および他の活性剤を含んでなる組成物 Download PDFInfo
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- JP5170577B2 JP5170577B2 JP2009519834A JP2009519834A JP5170577B2 JP 5170577 B2 JP5170577 B2 JP 5170577B2 JP 2009519834 A JP2009519834 A JP 2009519834A JP 2009519834 A JP2009519834 A JP 2009519834A JP 5170577 B2 JP5170577 B2 JP 5170577B2
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Description
・リグスチリド:0.5mgから500mgおよび/または
・ヒドロキシチロソール:0.2mgから500mg
・ホノキオールおよび/またはマグノロール:好ましくは、マグノリア樹皮エキスの形態で各々0.2mgから500mgおよび/または
・ゲニステイン:0.2mgから1000mgおよび/または
・カルドールジエン(XII)および/またはカルドールトリエン(XIII):好ましくは、カシューフルーツエキス(カシューナッツ(Anacardium occidentale))の形態で各々0.2mgから1000mgおよび/または
・甘草フォエチダ(Glycyrrhiza foetida)または式(III)から(XI)までから選択される1種または数種の化合物:好ましくは、甘草フォエチダ(Glycyrrhiza foetida)のエキスの形態で各々0.5mg〜1000mg、
から選択される少なくとも1種の成分を含んでなる。
a)バラの実が十分に熟したら、バラの実を収穫し、
b)収穫されたバラの実を小片に刻み、
c)刻んだバラの実を多くて5重量%の含水量に乾燥し、
d)任意に、乾燥および刻んだバラの実は、異物を取り除く分離ステップを通過させ、
e)任意に、果肉および種子を分離することができ、別個に抽出することができ、
f)残存する物質を粉砕機で、1mm未満の粒径に粉砕する。
組成物は関節の健康を維持し、および/または改善し、関節の剛直を予防し、関節の運動性を促進し、しなやかなおよび/または柔軟性のある関節を提供し、関節を滑らかにし、関節炎の痛みを軽減し、関節問題を減らし、関節ケアを提供し、関節の減損を治療または予防し、関節の完全性を提供し、関節損傷の進行を遅らせるかまたは予防し、関節機能を維持し、関節の健康および機能を促進し、活動的な個人に対して関節の健康および運動性を自然に維持し、関節の活動的な柔軟性を維持し、関節の柔軟性を促進し、関節の運動性を促進する。
・軟骨再生剤および維持剤としての本発明による組成物の使用
・関節健康の維持のための本発明による組成物の使用
・関節軟骨の維持および再生のための(組成物の製造のための)本発明による組成物の使用
・本発明による組成物の有効量を、このような再生および/または維持を必要とする哺乳動物に投与することを含んでなる、哺乳動物における(関節)軟骨の再生および/または維持のための方法、
である。
以下の実施例において、「(A)群」は、以下の化合物群として定義される:リグスチリド、オレウロペインアグリコン(II)、チロソール、ヒドロキシチロソール、マグノリアオフィシナリス(Magnolia officinalis)樹皮からのエキス、マグノロール、ホノキオール、ゲニステイン、メチルスルホニルメタン、SAMe、コラーゲン加水分解物、コラーゲン、アスコルビルホスフェート、リコペン、ルテイン、ゼアキサンチン、β−クリプトキサンチン、デビルスクロー、乳タンパク質濃縮物、可溶性ケラチン、セロリ種子エキス、セチル化脂肪酸、カルニチン、チモキノン、2−ヒドロキシ−4−メトキシ−3−(2−ヒドロキシ−3−メチル−3−ブテニル)−6−(2−フェニルエチル)−安息香酸(III)、アモルフルチンB(IV)、アモルフルチンA(V)、2−ヒドロキシ−4−メトキシ−3−(3−メチル−2−ブテニル)−6−ペンチル−安息香酸(VI)、カンナビゲロール酸モノメチルエーテル(VII)、2−ヒドロキシ−4−メトキシ−3−(2−ヒドロキシ−3−メチル−3−ブテニル)−6−ペンチル−安息香酸(VIII)、3−メトキシ−2−(3−メチル−2−ブテニル)−5−(2−フェニルエチル)−フェノール(IX)、式(X)の化合物および2−ヒドロキシ−4−メトキシ−5−(2−ヒドロキシ−3−メチル−3−ブテニル)−6−(2−フェニルエチル)−安息香酸(XI)、カルドールジエン(XII)、カルドールトリエン(XIII)、カシューフルーツエキス、ボスウェリア酸、カルノシン酸、ウルソール酸、セイヨウトチノキエキス、ジオスメチン、トリプタントリン、ジオスゲニン、クルクミンおよび誘導体、甘草フォエチダ(Glycyrrhiza foetida)および白ヤナギ樹皮エキス。
バラの実およびリグスチリド、ヒドロキシチロソール、マグノロール、ならびにゲニステインの抗炎症効果は、酸化窒素および/または炎症誘発性プロスタグランジン(PG)類の合成阻害を測定することによって活性化マクロファージにおいて評価した。PGE2は、炎症過程において重要な役割を果たし、一方、酸化窒素(NO)は、種々の形態の関節炎、胃腸疾患および代謝症候群を含む種々の慢性炎症疾患における炎症の証明となる。
軟ゼラチンカプセルは従来の手法により調製し、700mgの乾燥バラの実濃縮物ならびに50mgの上記に定義された(A)群から選択された少なくとも1種の化合物(例えば、ヒドロキシチロソール)の用量を提供する。好適な毎日の用量は1個から8個のカプセルである。
硬ゼラチンカプセルは従来の手法により調製し、650mgのバラの実ならびに100mgの上記に定義された(A)群から選択された少なくとも1種の成分(例えば、マグノリア樹皮エキス)の用量を提供する。好適な毎日の用量は1個から5個のカプセルである。
充填剤:適量の乳糖またはセルロースまたはセルロース誘導体、
潤滑剤:必要ならばステアリン酸マグネシウム(0.5%)である。
錠剤は従来の手法により調製し、1錠剤当り100mgのバラの実の活性成分ならびに上記に定義された(A)群から選択された少なくとも1種の成分、100mgの(例えば)リグスチリド、賦形剤として500mgの微結晶性セルロース、二酸化シリコーン(SiO2)、ステアリン酸マグネシウム、クロスポビドンNF(崩壊剤である)を提供する。
ベータ−カロテン10%CWSで着色され、バラの実および上記に定義された(A)群から選択される少なくとも1種の成分を有するオレンジジュースドリンクは以下のとおり調製することができる:
−攪拌しながら水中の安息香酸ナトリウムを溶解する
−攪拌を続け、糖シロップ、アスコルビン酸、クエン酸、ペクチン溶液、ジュース化合物を次々に加える。高スピードミキサーは使用しない
−ビン詰めシロップを(炭酸)水で1リットルの飲料に希釈する
−ジュース濃縮液に脱イオン水を加え、緩やかに攪拌してジュース濃縮液を水和させる。
−油性風味料およびベータ−カロテン10%CWS原液を加え、ロータ−ステータ−ホモジナイザー中で予備乳化する。
−高圧ホモジナイザー中、200バールでホモジナイズする。
A)部およびB)部を攪拌しながら85℃に加熱する。均質になったら、攪拌しながらA)部にB)部を加える。攪拌しながら約45℃に冷却する。C)部を加える。11000rpmでホモジナイズして小粒径を得る。攪拌しながら周囲温度に冷却する。次いでD)部を加える。
A)部およびB)部を攪拌しながら85℃に加熱する。均質になったら、攪拌しながらA)部にB)部を加える。攪拌しながら周囲温度に冷却してC)部を加える。ホモジナイズして小粒径を得る。
A)部およびB)部を攪拌しながら85℃に加熱する。均質になったら、攪拌しながらA)部にB)部を加える。攪拌しながら周囲温度に冷却してC)部を加える。ホモジナイズして小粒径を得る。
A)部およびB)部を攪拌しながら85℃に加熱する。均質になったら、攪拌しながらA)部にB)部を加える。攪拌しながら周囲温度に冷却してC)部を加える。ホモジナイズして小粒径を得る。
部分1の全ての成分を加え、均質な溶液が得られるまで激しく混合する。酢酸によりpHを6.5に調整する。
部分1を85℃まで加熱し;また部分2を85℃まで加熱する。双方とも同じ温度を有したら、激しくホモジナイズしながら部分1に部分2を加える。攪拌しながら生成物を35℃に冷却する。ここで部分3を加えて再度激しくホモジナイズする。一般に、乳濁液を生成させ真空を用いることが推奨される。
A)部、B)部およびC)部を攪拌しながら85℃に加熱する。均質になったら、攪拌しながらA)部にB)部およびC)部を加える。攪拌しながら周囲温度に冷却してD)部およびE)部を加える。ホモジナイズして小粒径を得る。
市販の乾燥ドッグフード(ヒルズペットニュートリション社(Hill’s Pet Nutrition GmbH)、Liebigstrasse2−20、D−22113により供給されたヒルズサイエンス(Hill’s Science)のイヌ用飼料「Canine Maintenance dry」)に、乾燥バラの実濃縮物の重量を基準にして、体重1kg当り200mgから1gのバラの実、および0.1mgから3mgのゲニステイン(DSMニュートリショナル・プロダクツにより供給された)の毎日の用量を対象に投与するのに十分な量で、バラの実およびゲニステインの水溶液でスプレーする。さらにDSMニュートリショナル・プロダクツAGからのL−アスコルビン酸−モノホスフェート(ROVIMIX(登録商標)STAY−C(登録商標)35)、ビタミンEおよびベータ−カロテンを、最終フード組成物中に30mgのROVIMIX(登録商標)STAY−C(登録商標)35/kg、300mgのIUビタミンE/kgおよび280mgのベータ−カロテン/kgを提供するのに十分な量で組み込んでから混合物全体を押出す。約90重量%の乾燥物質を含有するようにこのフード組成物を乾燥する。
市販の湿性キャットフード(ヒルズペットニュートリション社、Liebigstrasse2−20、D−22113により供給されたヒルズサイエンスのネコ用飼料「Feline Maintenance wet」)を、乾燥バラの実の重量を基準にして体重1kg当り200mgから1gのバラの実および体重1kg当り0.1mgから3mgのゲニステインの毎日の用量を対象に投与するのに十分な量で、バラの実およびゲニステインの水溶液と混合する。さらにDSMニュートリショナル・プロダクツAGからのL−アスコルビン酸−モノホスフェート(ROVIMIX(登録商標)STAY−C(登録商標)35)、ビタミンEおよびベータ−カロテンを、最終フード組成物中に30mgのROVIMIX(登録商標)STAY−C(登録商標)35/kg、300mgのIUビタミンE/kgおよび280mgのベータ−カロテン/kgを提供するのに十分な量で組み込んでから混合物全体を押出す。約90重量%の乾燥物質を含有するようにこのフード組成物を乾燥する。
Claims (4)
- バラの実およびリグスチリドを含む、炎症性障害の治療、共治療もしくは予防、関節健康の維持、または、関節障害の治療、共治療もしくは予防のための薬剤。
- 炎症性障害の治療、共治療または予防を目的とした薬物の製造のための、バラの実およびリグスチリドを含む組成物の使用。
- 前記炎症性障害が関節炎である請求項2に記載の使用。
- 前記炎症性障害が皮膚の炎症である請求項3に記載の使用。
Applications Claiming Priority (3)
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EP06014642 | 2006-07-14 | ||
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PCT/EP2007/006201 WO2008006589A2 (en) | 2006-07-14 | 2007-07-12 | Compositions comprising rosehip and other active agents for the treatment of inflammatory disorders |
Publications (2)
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JP5170577B2 true JP5170577B2 (ja) | 2013-03-27 |
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EP (1) | EP2049134A2 (ja) |
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Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008006581A2 (en) * | 2006-07-14 | 2008-01-17 | Dsm Ip Assets B.V. | Compositions and use thereof for the treatment, co-treatment or prevention of imflammatory disorders |
ES2597104T3 (es) | 2007-04-19 | 2017-01-13 | Mary Kay, Inc. | Composiciones que contienen extracto de magnolia |
EP2070524A1 (en) * | 2007-12-11 | 2009-06-17 | DSM IP Assets B.V. | Compositions comprising Magnolol and/or Honokiol and glucosamine and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
EP2070525A1 (en) * | 2007-12-11 | 2009-06-17 | DSM IP Assets B.V. | Compositions comprising Magnolol and/or Honokiol and chondroitin and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
EP2070523B1 (en) * | 2007-12-11 | 2010-08-18 | DSM IP Assets B.V. | Composition comprising Magnolol and Honokiol in synergistic amount |
EP2224939B1 (de) * | 2007-12-21 | 2015-03-18 | Finzelberg GmbH & Co. KG | Zubereitungen mit hagebuttenextrakten sowie verfahren zur herstellung von hagebuttenextrakten |
NZ567712A (en) * | 2008-04-24 | 2010-11-26 | Fonterra Cooperative Group Ltd | Compositions and methods for maintaining bone health or reducing bone loss |
WO2009135880A1 (de) | 2008-05-06 | 2009-11-12 | Finzelberg Gmbh & Co. Kg | Zistrosenextrakt mit angereicherten sekundären pflanzeninhaltsstoffen |
FR2935084B1 (fr) * | 2008-08-19 | 2011-05-06 | Pancosma Sa Pour L Ind Des Produits Biochimiques | Additif pour l'alimentation animale et son procede de preparation |
DE102009030351A1 (de) * | 2009-06-22 | 2010-12-23 | Gelita Ag | Zusammensetzung zur Behandlung von degenerativen Gelenkerkrankungen |
EP2613762B1 (en) | 2010-09-10 | 2018-10-17 | Mary Kay, Inc. | Topical skin care formulations comprising jaboticaba fruit pulp |
WO2012067641A2 (en) * | 2010-11-17 | 2012-05-24 | Nestec S.A. | Methods and compositions for preventing and treating osteoarthritis |
US9180155B2 (en) * | 2010-11-29 | 2015-11-10 | Bio Nexus, Ltd | Compositions from Nigella sativa |
CN102258191B (zh) * | 2010-12-23 | 2012-12-19 | 天津天狮生物发展有限公司 | 预防慢性炎症的抗氧化保健食品及制备方法 |
IE20110008A1 (en) * | 2011-01-12 | 2012-08-01 | Patrick Thomas Prendergast | Compositions for alleviating:- stress, anxiety, depression and aiding with weight loss |
BR112013018397A2 (pt) * | 2011-01-18 | 2016-10-11 | Equine Nutriceuticals Llc | suplemento equino nutricional |
KR20180132958A (ko) * | 2011-03-04 | 2018-12-12 | 라이온 가부시키가이샤 | 성장 호르몬 분비 촉진제 |
PL2872135T3 (pl) * | 2012-07-06 | 2017-04-28 | Orkla Health A/S | Sposób wytwarzania proszku z owoców róży |
CA3056759C (en) | 2016-03-22 | 2024-01-23 | Avicenna Nutraceutical, Llc | Hydrolyzed collagen compositions and methods of making thereof |
FR3067593B1 (fr) * | 2017-06-20 | 2019-12-20 | Jean-Noel Thorel | Utilisation d'extraits de plantes pour le traitement dermatocosmetique des etats inflammatoires lies a une surproduction de il-17 |
EP3728061A4 (en) * | 2017-12-21 | 2021-09-08 | Pepsico Inc | MULTI-INGREDIENT POP-UP DRINK CAPSULE FOR PREPARING A DRINK |
US11700869B2 (en) * | 2018-06-27 | 2023-07-18 | Pepsico, Inc. | Mouthfeel enhancing composition |
CA3110952A1 (en) * | 2018-08-31 | 2020-03-05 | Innophos, Inc. | Botanical antioxidants |
WO2020046478A1 (en) * | 2018-08-31 | 2020-03-05 | Innophos, Inc. | Botanical modulator of metabolic disorders |
CN112703007B (zh) * | 2018-08-31 | 2023-03-24 | 伊诺弗斯公司 | 抗炎植物提取物 |
CN109395055A (zh) * | 2019-01-07 | 2019-03-01 | 琪庆生物医药(上海)有限公司 | 一种具有修复关节软组织损伤作用的组合物及其制备方法 |
CN111529480A (zh) * | 2020-06-18 | 2020-08-14 | 广东景兴健康护理实业股份有限公司 | 一种丝素蛋白美肌配方及其制备方法 |
CN113661992B (zh) * | 2021-08-25 | 2022-08-23 | 河南农业大学 | 藁本内酯及含其的植物精油在防治花生白绢病方面的应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59101478A (ja) * | 1982-11-29 | 1984-06-12 | Sunstar Inc | リグスチライドを安定に配合した水系組成物 |
LU86703A1 (fr) | 1986-12-08 | 1988-07-14 | Oreal | Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b |
FR2636338B1 (fr) | 1988-09-09 | 1990-11-23 | Rhone Poulenc Chimie | Diorganopolysiloxane a fonction benzalmalonate |
FR2658075B1 (fr) | 1990-02-14 | 1992-05-07 | Oreal | Composition cosmetique filtrante photostable contenant un filtre uv-a et un beta,beta-diphenylacrylate ou alpha-cyano-beta,beta-diphenylacrylate d'alkyle. |
EP0500233A2 (en) | 1991-02-14 | 1992-08-26 | National Semiconductor Corporation | Bipolar transistor structure & BICMOS IC fabrication process |
GB9110123D0 (en) | 1991-05-10 | 1991-07-03 | Dow Corning | Organosilicon compounds their preparation and use |
JP2839778B2 (ja) * | 1991-12-10 | 1998-12-16 | 恒雄 難波 | センキュウエキス中精油成分の薬物皮膚透過促進効果を利用した浴湯剤 |
ES2170116T3 (es) | 1994-10-14 | 2002-08-01 | Hoffmann La Roche | Composiciones de filtrado de luz cosmeticas fotoestables. |
US6033649A (en) | 1995-12-18 | 2000-03-07 | Roche Vitamins Inc. | Light screening agents |
US6069170A (en) | 1997-08-05 | 2000-05-30 | Roche Vitamins Inc. | Light screening compounds and compositions |
FR2768621B1 (fr) | 1997-09-22 | 2000-04-07 | Oreal | Utilisation d'un extrait d'au moins un vegetal de la famille des rosacees |
US5904924A (en) * | 1997-11-04 | 1999-05-18 | Oncologics, Inc. | Green nutritional powder composition |
US6024960A (en) * | 1998-04-17 | 2000-02-15 | Otto Torbjorn Hansen And Marianne Hansen | Rose-hip formulations as anti-inflammatory natural medicine for alleviating/reducing symptoms associated with inflammation and arthritis |
DE19917906A1 (de) | 1999-04-20 | 2000-10-26 | Basf Ag | Verwendung von aminosubstituierten Hydroxybenzophenonen als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen |
WO2001076579A1 (en) * | 2000-04-06 | 2001-10-18 | Perricone Nicholas V | Treatment of skin damage using olive oil polyphenols |
WO2001085188A2 (en) * | 2000-05-05 | 2001-11-15 | Bioniche Life Sciences Inc. | Use of echinacea as a hematinic agent |
US6485752B1 (en) | 2000-10-23 | 2002-11-26 | Otto Torbjorn Hansen | Composition and method for alleviating joint pain and stiffness |
JP2002226322A (ja) * | 2001-01-31 | 2002-08-14 | Masumi Kinoshita | 化粧品原料及び皮膚用化粧品 |
JP2002265995A (ja) * | 2001-03-08 | 2002-09-18 | Shizuko Watanabe | 石 鹸 |
GB0202853D0 (en) | 2002-02-07 | 2002-03-27 | Dow Corning | Encapsulation process and encapsulated compositions |
JPWO2004016236A1 (ja) * | 2002-08-14 | 2005-12-02 | 株式会社ファンケル | 化粧料 |
JP2004113141A (ja) * | 2002-09-26 | 2004-04-15 | Daawinzu:Kk | Msm含有の健康食品 |
US20050043253A1 (en) * | 2003-08-19 | 2005-02-24 | Cook Bradley R. | Use of wound healing compositions for prevention of infections and allergies |
WO2005025586A1 (en) * | 2003-09-12 | 2005-03-24 | Access Business Group International Llc | Cytokine modulators and related method of use |
KR20060121887A (ko) * | 2003-09-23 | 2006-11-29 | 디에스엠 아이피 어셋츠 비.브이. | 진성 당뇨병의 치료 및 예방용 조성물 |
WO2005080341A1 (en) | 2004-02-13 | 2005-09-01 | Dsm Ip Assets B.V. | Ionic uv-a sunscreens and compositions containing them |
US20060140885A1 (en) * | 2004-12-29 | 2006-06-29 | Abdul Gaffar | Method of reducing oral tissue inflammation using magnolia extract |
EP1937250B1 (en) * | 2005-05-24 | 2011-10-19 | DSM IP Assets B.V. | Ligustilide derivatives for the treatment of inflammatory disorders |
US20070196296A1 (en) * | 2005-12-13 | 2007-08-23 | Rosemarie Osborne | Personal care compositions |
WO2007112996A2 (en) * | 2006-03-31 | 2007-10-11 | Dsm Ip Assets B.V. | Novel use of compounds and combinations of compunds for improving the physical appearance |
-
2007
- 2007-07-12 US US12/373,617 patent/US20100055218A1/en not_active Abandoned
- 2007-07-12 KR KR1020097002869A patent/KR20090033470A/ko not_active Application Discontinuation
- 2007-07-12 WO PCT/EP2007/006201 patent/WO2008006589A2/en active Application Filing
- 2007-07-12 JP JP2009519834A patent/JP5170577B2/ja not_active Expired - Fee Related
- 2007-07-12 EP EP07786033A patent/EP2049134A2/en not_active Withdrawn
- 2007-07-12 CN CN2007800343480A patent/CN101516386B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101516386A (zh) | 2009-08-26 |
WO2008006589A3 (en) | 2008-02-28 |
CN101516386B (zh) | 2013-05-15 |
JP2010500965A (ja) | 2010-01-14 |
KR20090033470A (ko) | 2009-04-03 |
WO2008006589A2 (en) | 2008-01-17 |
EP2049134A2 (en) | 2009-04-22 |
US20100055218A1 (en) | 2010-03-04 |
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