KR101667822B1 - 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 - Google Patents

오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 Download PDF

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KR101667822B1
KR101667822B1 KR1020107025018A KR20107025018A KR101667822B1 KR 101667822 B1 KR101667822 B1 KR 101667822B1 KR 1020107025018 A KR1020107025018 A KR 1020107025018A KR 20107025018 A KR20107025018 A KR 20107025018A KR 101667822 B1 KR101667822 B1 KR 101667822B1
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KR20100132067A (ko
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싱 팡 시에
모한 셀바라 쿠마
츠안 쉬
수-잉 우
유-쉥 차오
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내셔날 헬스 리서치 인스티튜트
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020107025018A 2008-04-30 2009-04-22 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 Active KR101667822B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4906308P 2008-04-30 2008-04-30
US61/049,063 2008-04-30
PCT/US2009/041382 WO2009134658A2 (en) 2008-04-30 2009-04-22 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors

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KR20100132067A KR20100132067A (ko) 2010-12-16
KR101667822B1 true KR101667822B1 (ko) 2016-10-19

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KR1020107025018A Active KR101667822B1 (ko) 2008-04-30 2009-04-22 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물

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Country Link
US (1) US8138194B2 (https=)
EP (1) EP2276346B1 (https=)
JP (1) JP5502072B2 (https=)
KR (1) KR101667822B1 (https=)
CN (1) CN102014627B (https=)
AU (1) AU2009241469B2 (https=)
CA (1) CA2722220C (https=)
DK (1) DK2276346T3 (https=)
ES (1) ES2616255T3 (https=)
PL (1) PL2276346T3 (https=)
TW (1) TWI363627B (https=)
WO (1) WO2009134658A2 (https=)

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CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
JP2016514087A (ja) 2013-02-01 2016-05-19 バイエル・ファルマ・アクティエンゲゼルシャフト 置換チエノピリミジンおよびその薬学的使用
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RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
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FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106243124B (zh) * 2016-07-29 2018-03-09 湖北民族学院 一种噻吩并嘧啶脲类化合物及其制备方法和应用
TW201811795A (zh) 2016-08-24 2018-04-01 美商亞闊股份有限公司 胺基-吡咯并嘧啶酮化合物及其用途
CN106810512B (zh) * 2017-01-18 2019-09-10 江苏省中医药研究院 Idh2突变体抑制剂及其用途
AU2018317828A1 (en) * 2017-08-15 2020-04-02 AbbVie Deutschland GmbH & Co. KG Macrocyclic MCL-1 inhibitors and methods of use
TW201920193A (zh) * 2017-08-15 2019-06-01 美商艾伯維有限公司 大環mel-1抑制劑以及使用方法
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Also Published As

Publication number Publication date
PL2276346T3 (pl) 2017-07-31
EP2276346A4 (en) 2011-08-24
US20090275533A1 (en) 2009-11-05
WO2009134658A3 (en) 2009-12-30
AU2009241469B2 (en) 2015-05-07
JP2011522789A (ja) 2011-08-04
HK1151694A1 (en) 2012-02-10
KR20100132067A (ko) 2010-12-16
CN102014627B (zh) 2014-10-29
DK2276346T3 (en) 2017-02-27
AU2009241469A1 (en) 2009-11-05
CA2722220C (en) 2016-06-07
JP5502072B2 (ja) 2014-05-28
WO2009134658A2 (en) 2009-11-05
CA2722220A1 (en) 2009-11-05
TW200948365A (en) 2009-12-01
EP2276346A2 (en) 2011-01-26
CN102014627A (zh) 2011-04-13
ES2616255T3 (es) 2017-06-12
TWI363627B (en) 2012-05-11
EP2276346B1 (en) 2016-11-23
US8138194B2 (en) 2012-03-20

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