KR101612655B1 - 신규한 코팅된 방출 제어형 활성 약물 담체 - Google Patents

신규한 코팅된 방출 제어형 활성 약물 담체 Download PDF

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KR101612655B1
KR101612655B1 KR1020147015774A KR20147015774A KR101612655B1 KR 101612655 B1 KR101612655 B1 KR 101612655B1 KR 1020147015774 A KR1020147015774 A KR 1020147015774A KR 20147015774 A KR20147015774 A KR 20147015774A KR 101612655 B1 KR101612655 B1 KR 101612655B1
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Prior art keywords
calcium carbonate
active drug
reacted
carrier according
carrier
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KR20140091054A (ko
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패트릭 슈바르젠트루버
마이유타 니콜 디
조아힘 쇼엘코프
캐서린 진 리쥐웨이
패트릭 에이 씨 가네
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옴야 인터내셔널 아게
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Priority claimed from EP11188597.6A external-priority patent/EP2591772B1/en
Application filed by 옴야 인터내셔널 아게 filed Critical 옴야 인터내셔널 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
KR1020147015774A 2011-11-10 2012-11-08 신규한 코팅된 방출 제어형 활성 약물 담체 Active KR101612655B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11188597.6A EP2591772B1 (en) 2011-11-10 2011-11-10 New coated controlled release active agent carriers
EP11188597.6 2011-11-10
US201161559253P 2011-11-14 2011-11-14
US61/559,253 2011-11-14
PCT/EP2012/072161 WO2013068478A1 (en) 2011-11-10 2012-11-08 New coated controlled release active agent carriers

Publications (2)

Publication Number Publication Date
KR20140091054A KR20140091054A (ko) 2014-07-18
KR101612655B1 true KR101612655B1 (ko) 2016-04-14

Family

ID=47143128

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147015774A Active KR101612655B1 (ko) 2011-11-10 2012-11-08 신규한 코팅된 방출 제어형 활성 약물 담체

Country Status (25)

Country Link
US (1) US9579291B2 (https=)
EP (1) EP2747752B1 (https=)
KR (1) KR101612655B1 (https=)
CN (1) CN103957893B (https=)
AU (1) AU2012334082B2 (https=)
BR (1) BR112014011310B1 (https=)
CA (1) CA2851069C (https=)
CL (1) CL2014001172A1 (https=)
CO (1) CO6940430A2 (https=)
DK (1) DK2747752T3 (https=)
ES (1) ES2553091T3 (https=)
IL (1) IL231959A0 (https=)
IN (1) IN2014MN00843A (https=)
MX (1) MX346884B (https=)
MY (1) MY168425A (https=)
PH (1) PH12014500750A1 (https=)
PL (1) PL2747752T3 (https=)
PT (1) PT2747752E (https=)
RU (2) RU2018123688A (https=)
SG (1) SG11201401350WA (https=)
SI (1) SI2747752T1 (https=)
SM (1) SMT201600010B (https=)
TW (1) TWI625129B (https=)
WO (1) WO2013068478A1 (https=)
ZA (1) ZA201403611B (https=)

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ES2536836T3 (es) 2012-10-12 2015-05-29 Omya International Ag Formulación de medicamento gastrorretentivo y sistemas de liberación y su método de preparación usando carbonato de calcio transformado en funcional
JP2016514095A (ja) * 2013-02-15 2016-05-19 ウェルマーク インターナショナルＷｅｌｌｍａｒｋ Ｉｎｔｅｒｎａｔｉｏｎａｌ 無機飼料を介する製剤
TR201815327T4 (tr) * 2015-06-10 2018-11-21 Omya Int Ag Anti-blokaj maddesi olarak yüzeyi tepkimeye girmiş kalsiyum karbonat kullanımı.
EP3176222A1 (en) * 2015-12-01 2017-06-07 Omya International AG Method for the production of granules comprising surface-reacted calcium carbonate
EP3426706A1 (en) 2016-03-08 2019-01-16 Living Proof, Inc. Long lasting cosmetic compositions
EP3275947A1 (en) * 2016-07-25 2018-01-31 Omya International AG Surface-reacted calcium carbonate with functional cations
EP3400810A1 (en) * 2017-05-11 2018-11-14 Omya International AG Surface-reacted calcium carbonate in food
CN107258776A (zh) * 2017-06-29 2017-10-20 山东大农药业有限公司 一种缓释农药颗粒剂及其制备方法
CA3074845A1 (en) 2017-09-13 2019-03-21 Living Proof, Inc. Color protectant compositions
EP3681920B1 (en) 2017-09-13 2025-06-25 Living Proof, Inc. Long lasting cosmetic compositions
US11510877B2 (en) 2017-10-10 2022-11-29 Capsugel Belgium Nv Gelling multiparticulates
AU2018370210B2 (en) 2017-11-20 2024-09-26 Living Proof, Inc. Properties for achieving long-lasting cosmetic performance
EP3520798A1 (en) * 2018-01-31 2019-08-07 Omya International AG Use of functionalized calcium carbonate as active ingredient
EP3784711A1 (en) 2018-04-27 2021-03-03 Living Proof, Inc. Long lasting cosmetic compositions
EP3598105A1 (en) 2018-07-20 2020-01-22 Omya International AG Method for detecting phosphate and/or sulphate salts on the surface of a substrate or within a substrate, use of a lwir detecting device and a lwir imaging system
WO2020091456A1 (ko) * 2018-10-31 2020-05-07 ㈜아모레퍼시픽 바이오 폴리머를 포함하는 코어-쉘 네트워크 구조체 및 이를 포함하는 조성물
KR102739456B1 (ko) * 2018-10-31 2024-12-09 (주)아모레퍼시픽 바이오 폴리머를 포함하는 코어-쉘 네트워크 구조체 및 이를 포함하는 조성물
US20220105047A1 (en) * 2019-01-16 2022-04-07 Research Cooperation Foundation Of Yeungnam University Microcapsule composition using alginate gel, and method for producing same
KR102936013B1 (ko) 2019-12-03 2026-03-10 (주)아모레퍼시픽 바이오 폴리머를 포함하는 효능물질 전달체
CN111436426B (zh) * 2020-05-11 2022-04-08 北京首创股份有限公司 供水管道输水用二次加氯胶囊及其制备方法
EP3928859A1 (en) * 2020-06-23 2021-12-29 Omya International AG Surface-reacted calcium carbonate in a process for the production of a loaded microcapsule
AR123009A1 (es) 2020-07-20 2022-10-19 Omya Int Ag Agente estabilizante para composición probiótica
WO2025132417A1 (en) 2023-12-19 2025-06-26 Omya International Ag Granular material comprising a carboxymethylcellulose binder
WO2025207519A1 (en) * 2024-03-23 2025-10-02 Texas Tech University System Biocompatible and biodegradable polymer nanodiscs as lipoprotein-mimicking nanocarriers with high stability and long circulation time for drug delivery

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US4657784A (en) 1986-03-10 1987-04-14 Ecolab Inc. Process for encapsulating particles with at least two coating layers having different melting points
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PT2264109E (pt) 2009-06-15 2012-05-09 Omya Development Ag Processo de preparação de carbonato de cálcio com superfície tratada por reacção e sua utilização

Also Published As

Publication number Publication date
BR112014011310A2 (pt) 2017-05-09
EP2747752A1 (en) 2014-07-02
CA2851069A1 (en) 2013-05-16
RU2665382C1 (ru) 2018-08-29
CN103957893A (zh) 2014-07-30
MY168425A (en) 2018-11-09
RU2018123688A3 (https=) 2022-01-24
NZ623515A (en) 2016-09-30
CO6940430A2 (es) 2014-05-09
MX2014005466A (es) 2014-08-22
ES2553091T3 (es) 2015-12-04
BR112014011310B1 (pt) 2022-04-12
CL2014001172A1 (es) 2014-09-12
KR20140091054A (ko) 2014-07-18
PL2747752T3 (pl) 2016-04-29
WO2013068478A1 (en) 2013-05-16
US9579291B2 (en) 2017-02-28
TW201328709A (zh) 2013-07-16
ZA201403611B (en) 2015-07-29
RU2018123688A (ru) 2019-03-07
IN2014MN00843A (https=) 2015-07-03
SG11201401350WA (en) 2014-05-29
IL231959A0 (en) 2014-05-28
SI2747752T1 (sl) 2015-12-31
SMT201600010B (it) 2016-02-25
DK2747752T3 (en) 2016-01-18
CN103957893B (zh) 2017-08-15
AU2012334082A1 (en) 2014-04-24
AU2012334082B2 (en) 2015-10-29
TWI625129B (zh) 2018-06-01
CA2851069C (en) 2016-05-31
MX346884B (es) 2017-04-05
PH12014500750A1 (en) 2014-05-12
EP2747752B1 (en) 2015-10-07
PT2747752E (pt) 2016-02-08
US20140248340A1 (en) 2014-09-04

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