KR101586966B1 - 나트륨 채널 조절제로서 유용한 (4-페닐이미다졸-2-일) 에틸아민 유도체 - Google Patents

나트륨 채널 조절제로서 유용한 (4-페닐이미다졸-2-일) 에틸아민 유도체 Download PDF

Info

Publication number
KR101586966B1
KR101586966B1 KR1020147010826A KR20147010826A KR101586966B1 KR 101586966 B1 KR101586966 B1 KR 101586966B1 KR 1020147010826 A KR1020147010826 A KR 1020147010826A KR 20147010826 A KR20147010826 A KR 20147010826A KR 101586966 B1 KR101586966 B1 KR 101586966B1
Authority
KR
South Korea
Prior art keywords
phenyl
formula
oxetane
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020147010826A
Other languages
English (en)
Korean (ko)
Other versions
KR20140069234A (ko
Inventor
샤란지트 카우르 바갈
마크 이안 켐프
던칸 찰스 밀러
요시히사 뮤라타
Original Assignee
화이자 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101586966(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 화이자 리미티드 filed Critical 화이자 리미티드
Publication of KR20140069234A publication Critical patent/KR20140069234A/ko
Application granted granted Critical
Publication of KR101586966B1 publication Critical patent/KR101586966B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147010826A 2011-10-26 2012-10-15 나트륨 채널 조절제로서 유용한 (4-페닐이미다졸-2-일) 에틸아민 유도체 Expired - Fee Related KR101586966B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161551628P 2011-10-26 2011-10-26
US61/551,628 2011-10-26
PCT/IB2012/055610 WO2013061205A2 (en) 2011-10-26 2012-10-15 Chemical compounds

Publications (2)

Publication Number Publication Date
KR20140069234A KR20140069234A (ko) 2014-06-09
KR101586966B1 true KR101586966B1 (ko) 2016-01-19

Family

ID=47278356

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147010826A Expired - Fee Related KR101586966B1 (ko) 2011-10-26 2012-10-15 나트륨 채널 조절제로서 유용한 (4-페닐이미다졸-2-일) 에틸아민 유도체

Country Status (28)

Country Link
US (1) US9079878B2 (enExample)
EP (1) EP2771335A2 (enExample)
JP (1) JP5946538B2 (enExample)
KR (1) KR101586966B1 (enExample)
CN (1) CN103906746B (enExample)
AP (1) AP2014007579A0 (enExample)
AU (1) AU2012328034B2 (enExample)
BR (1) BR112014009102A2 (enExample)
CA (1) CA2850925C (enExample)
CL (1) CL2014000956A1 (enExample)
CO (1) CO6940427A2 (enExample)
CR (1) CR20140185A (enExample)
CU (1) CU20140046A7 (enExample)
DO (1) DOP2014000085A (enExample)
EA (1) EA023375B1 (enExample)
EC (1) ECSP14013324A (enExample)
GT (1) GT201400079A (enExample)
IL (1) IL232267A (enExample)
MD (1) MD20140037A2 (enExample)
MX (1) MX337469B (enExample)
NI (1) NI201400031A (enExample)
PE (1) PE20141682A1 (enExample)
PH (1) PH12014500919A1 (enExample)
SG (1) SG11201401032YA (enExample)
TN (1) TN2014000147A1 (enExample)
UA (1) UA109220C2 (enExample)
WO (1) WO2013061205A2 (enExample)
ZA (1) ZA201402281B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1199262A1 (en) * 2011-09-14 2015-06-26 Dow Agrosciences Llc Methods and systems for forming boronic acids and intermediates thereof
LT3080134T (lt) 2013-12-13 2018-11-12 Vertex Pharmaceuticals Incorporated Piridono amidų provaistai, naudotini kaip natrio kanalų moduliatoriai
KR102192572B1 (ko) 2014-06-09 2020-12-18 삼성전자주식회사 광원 모듈의 불량 검사방법, 광원 모듈의 제조 방법 및 광원 모듈 검사장치
CN107206015A (zh) * 2014-10-24 2017-09-26 阿维塔斯有限公司 透细胞质膜的传递
BR112017017619A2 (pt) 2015-02-19 2018-05-08 Purdue Pharma Lp métodos e composições para diminuir esvaziamento gástrico
IS2977B (is) 2015-02-23 2017-07-15 Actavis Group Ptc Ehf. Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni
CN116676292A (zh) 2015-12-30 2023-09-01 阿维塔斯有限公司 基因编辑蛋白和组合物向细胞和组织的无载体递送
AU2017292173B2 (en) 2016-07-06 2022-01-13 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
CN110214149B (zh) 2016-07-06 2024-05-14 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
US11358977B2 (en) 2017-05-16 2022-06-14 Vertex Pharmaceuticals Incorporated Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
ES3008911T3 (en) 2017-07-11 2025-03-25 Vertex Pharma Carboxamides as modulators of sodium channels
US20190343817A1 (en) 2018-02-12 2019-11-14 Vertex Pharmaceuticals Incorporated Method of treating pain
MA54076A (fr) 2018-11-02 2022-02-09 Merck Sharp & Dohme 2-amino-n-hétéroaryl-nicotinamides utilisés en tant qu'inhibiteurs de nav1.8
WO2020146612A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2020176763A1 (en) 2019-02-27 2020-09-03 Vertex Pharmaceuticals Incorporated Dosage form comprising prodrug of na 1.8 sodium channel inhibitor
WO2020219867A1 (en) 2019-04-25 2020-10-29 Vertex Pharmaceuticals Incorporated Pyridone amide co-crystal compositions for the treatment of pain
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN117794919A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺类似物作为钠通道调节剂
AU2022285758A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
CN117858875A (zh) 2021-06-04 2024-04-09 沃泰克斯药物股份有限公司 羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂
BR112023025264A2 (pt) 2021-06-04 2024-02-20 Vertex Pharma Formas farmacêuticas sólidas e regimes posológicos compreendendo (2r,3s,4s,5r)-4-[[3- (3,4-difluoro-2-metóxi-fenil)-4,5-dimetil-5-(trifluorometil) tetra-hidrofuran-2-carbonil]amino ]piridina-2-carboxamida
JP2024522292A (ja) 2021-06-04 2024-06-13 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド
CN117813302A (zh) 2021-06-04 2024-04-02 沃泰克斯药物股份有限公司 经取代的四氢呋喃-2-甲酰胺作为钠通道调节剂
PE20251179A1 (es) 2022-04-22 2025-04-23 Vertex Pharma Compuestos de heteroarilo para el tratamiento del dolor
TW202408501A (zh) 2022-04-22 2024-03-01 美商維泰克斯製藥公司 用於治療疼痛之雜芳基化合物
JP2025513454A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
EP4511117A1 (en) 2022-04-22 2025-02-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
JP2025516005A (ja) 2022-04-25 2025-05-23 サイトワン セラピューティクス インコーポレイテッド 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤
CN115656380B (zh) * 2022-11-09 2025-04-01 武汉海特生物创新医药研究有限公司 一种mtv对映异构体的hplc-uv检测方法
KR20250120351A (ko) 2022-12-06 2025-08-08 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 치환된 테트라하이드로푸란 조절제의 합성을 위한 방법
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
TW202535867A (zh) 2023-10-23 2025-09-16 美商維泰克斯製藥公司 用於治療疼痛之鈉通道調節劑及其固體形式的製備方法
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20250186419A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens for treating pain
WO2025160286A1 (en) 2024-01-24 2025-07-31 Siteone Therapeutics, Inc. 2-aryl cycloalkyl and heterocycloalkyl inhibitors of nav1.8 for the treatment of pain
WO2025231324A1 (en) * 2024-05-02 2025-11-06 Genep Inc. Imidazole compounds and their use as sodium channel inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050038087A1 (en) 1999-10-11 2005-02-17 Chabrier De Lassauniere Pierre-Etienne Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US20050234118A1 (en) 2002-07-25 2005-10-20 Dennis Bigg Novel aryllimidazole derivatives, preparation and therapeutic used thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
US7112366B2 (en) 2001-01-05 2006-09-26 The Ohio State University Chemical monolayer and micro-electronic junctions and devices containing same
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
SI1747210T1 (sl) * 2004-05-07 2010-09-30 Warner Lambert Co ali monosubstituirani fenolin in tiofenolni derivati uporabni kot ligandi H
US7456164B2 (en) * 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
CA2584785A1 (en) 2004-10-27 2006-05-04 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of nav1.8
EP1963280B1 (en) * 2005-12-22 2015-10-28 Newron Pharmaceuticals S.p.A. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
CL2008000835A1 (es) 2007-03-23 2008-10-03 Icagen Inc Pfizer Ltd Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm
US20100227872A1 (en) 2007-05-03 2010-09-09 Mark Ian Kemp Pyrazine derivatives
AP2516A (en) 2007-05-03 2012-11-26 Pfizer Ltd 2-Pyridine carboxamide derivatives as sodium channel modulators
WO2009012242A2 (en) 2007-07-13 2009-01-22 Icagen, Inc. Sodium channel inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050038087A1 (en) 1999-10-11 2005-02-17 Chabrier De Lassauniere Pierre-Etienne Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US20050234118A1 (en) 2002-07-25 2005-10-20 Dennis Bigg Novel aryllimidazole derivatives, preparation and therapeutic used thereof

Also Published As

Publication number Publication date
CN103906746A (zh) 2014-07-02
PE20141682A1 (es) 2014-11-14
EP2771335A2 (en) 2014-09-03
CA2850925C (en) 2017-01-10
CO6940427A2 (es) 2014-05-09
GT201400079A (es) 2015-06-02
AU2012328034B2 (en) 2015-04-23
IL232267A (en) 2016-10-31
US9079878B2 (en) 2015-07-14
UA109220C2 (uk) 2015-07-27
CN103906746B (zh) 2015-12-09
US20140296313A1 (en) 2014-10-02
MD20140037A2 (ro) 2014-08-31
PH12014500919A1 (en) 2014-06-09
CR20140185A (es) 2014-06-03
HK1198650A1 (en) 2015-05-22
AU2012328034A1 (en) 2014-05-15
ZA201402281B (en) 2015-11-25
DOP2014000085A (es) 2014-08-31
NI201400031A (es) 2014-10-01
CU20140046A7 (es) 2014-10-02
JP5946538B2 (ja) 2016-07-06
BR112014009102A2 (pt) 2017-04-18
IL232267A0 (en) 2014-06-30
SG11201401032YA (en) 2014-07-30
ECSP14013324A (es) 2014-05-31
WO2013061205A3 (en) 2013-06-27
AP2014007579A0 (en) 2014-04-30
MX337469B (es) 2016-03-02
EA201490864A1 (ru) 2014-08-29
KR20140069234A (ko) 2014-06-09
TN2014000147A1 (fr) 2015-09-30
EA023375B1 (ru) 2016-05-31
WO2013061205A2 (en) 2013-05-02
NZ623090A (en) 2015-10-30
CL2014000956A1 (es) 2014-07-18
CA2850925A1 (en) 2013-05-02
JP2014530900A (ja) 2014-11-20
MX2014004738A (es) 2014-08-01
WO2013061205A8 (en) 2014-03-27

Similar Documents

Publication Publication Date Title
KR101586966B1 (ko) 나트륨 채널 조절제로서 유용한 (4-페닐이미다졸-2-일) 에틸아민 유도체
JP6002785B2 (ja) ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体
JP5860045B2 (ja) 化合物
JP6058023B2 (ja) スルホンアミド誘導体
JP6067031B2 (ja) Ｎ−アミノスルホニルベンズアミド
JP4056081B1 (ja) ピリジン誘導体
JP5872552B2 (ja) 化学化合物
JP2013532185A (ja) 化合物
JP2013532186A (ja) 化合物
JP2013531030A (ja) 電位開口型ナトリウムチャネルの阻害剤としてのｎ−スルホニルベンズアミド
JP2013536165A (ja) 痛みの処置のためのｎａｖ１．７阻害薬としてのスルホンアミド誘導体
JP2009514937A (ja) ピラジン誘導体
JP2009523842A (ja) ナトリウムチャネルモジュレーターとしてのピリジン誘導体
NZ623090B2 (en) (4-phenylimidazol-2-yl)ethylamine derivatives useful as sodium channel modulators
HK1198650B (en) (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
OA16888A (en) (4-phenylimidazol-2-YL) ethylamine derivatives useful as sodium channel modulators

Legal Events

Date Code Title Description
A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20190114

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20190114