CU20140046A7 - Derivados de (4- fenilimidazol-2-il) etilamina útiles como moduladores de canal de sodio - Google Patents

Derivados de (4- fenilimidazol-2-il) etilamina útiles como moduladores de canal de sodio

Info

Publication number
CU20140046A7
CU20140046A7 CU2014000046A CU20140046A CU20140046A7 CU 20140046 A7 CU20140046 A7 CU 20140046A7 CU 2014000046 A CU2014000046 A CU 2014000046A CU 20140046 A CU20140046 A CU 20140046A CU 20140046 A7 CU20140046 A7 CU 20140046A7
Authority
CU
Cuba
Prior art keywords
derivatives
useful
phenylimidazol
ethylamine
sodium channel
Prior art date
Application number
CU2014000046A
Other languages
English (en)
Inventor
Sharanjeet Kaur Bagal
Mark Ian Kemp
Duncan Charles Miller
Yoshihisa Murata
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20140046(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CU20140046A7 publication Critical patent/CU20140046A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a derivados imidazol, a su uso en medicina, a composiciones que lo contienen, a procesos para su preparación y a intermediarios utilizados en tales procesos. Más particularmente, la invención se refiere a nuevos moduladores Nav1.8 imidazol de la Fórmula( I): o una sal farmacéuticamente aceptable del mismo, en donde R^1, R^2, R^3, R^4 y R^5 son como se definen en la descrpción. Los moduladores Nav1. 8 son potencialmente útiles en le tratamiento de un amplio margen de trastornos, particularmente dolor.
CU2014000046A 2011-10-26 2014-04-24 Derivados de (4- fenilimidazol-2-il) etilamina útiles como moduladores de canal de sodio CU20140046A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161551628P 2011-10-26 2011-10-26
PCT/IB2012/055610 WO2013061205A2 (en) 2011-10-26 2012-10-15 Chemical compounds

Publications (1)

Publication Number Publication Date
CU20140046A7 true CU20140046A7 (es) 2014-10-02

Family

ID=47278356

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2014000046A CU20140046A7 (es) 2011-10-26 2014-04-24 Derivados de (4- fenilimidazol-2-il) etilamina útiles como moduladores de canal de sodio

Country Status (28)

Country Link
US (1) US9079878B2 (es)
EP (1) EP2771335A2 (es)
JP (1) JP5946538B2 (es)
KR (1) KR101586966B1 (es)
CN (1) CN103906746B (es)
AP (1) AP2014007579A0 (es)
AU (1) AU2012328034B2 (es)
BR (1) BR112014009102A2 (es)
CA (1) CA2850925C (es)
CL (1) CL2014000956A1 (es)
CO (1) CO6940427A2 (es)
CR (1) CR20140185A (es)
CU (1) CU20140046A7 (es)
DO (1) DOP2014000085A (es)
EA (1) EA023375B1 (es)
EC (1) ECSP14013324A (es)
GT (1) GT201400079A (es)
HK (1) HK1198650A1 (es)
IL (1) IL232267A (es)
MD (1) MD20140037A2 (es)
MX (1) MX337469B (es)
NI (1) NI201400031A (es)
PE (1) PE20141682A1 (es)
SG (1) SG11201401032YA (es)
TN (1) TN2014000147A1 (es)
UA (1) UA109220C2 (es)
WO (1) WO2013061205A2 (es)
ZA (1) ZA201402281B (es)

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KR102192572B1 (ko) 2014-06-09 2020-12-18 삼성전자주식회사 광원 모듈의 불량 검사방법, 광원 모듈의 제조 방법 및 광원 모듈 검사장치
JP6779217B2 (ja) * 2014-10-24 2020-11-04 アヴェクタス リミテッド 細胞原形質膜を越える送達方法
US9763955B2 (en) 2015-02-19 2017-09-19 Purdue Pharma L.P. Methods and compositions for decreasing gastric emptying
IS2977B (is) 2015-02-23 2017-07-15 Actavis Group Ptc Ehf. Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni
JP7449646B2 (ja) 2015-12-30 2024-03-14 アヴェクタス リミテッド 細胞および組織への遺伝子編集タンパク質および組成物の、ベクターなしでの送達
AU2017292169B2 (en) 2016-07-06 2021-12-23 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
EP3481857A1 (en) 2016-07-06 2019-05-15 Crispr Therapeutics AG Materials and methods for treatment of pain related disorders
WO2018213426A1 (en) 2017-05-16 2018-11-22 Vertex Pharmaceuticals Incorporated Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
EP3651752A1 (en) 2017-07-11 2020-05-20 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2019157505A1 (en) 2018-02-12 2019-08-15 Vertex Pharmaceuticals Incorporated A method of treating pain
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
US20220110923A1 (en) 2019-01-10 2022-04-14 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020176763A1 (en) 2019-02-27 2020-09-03 Vertex Pharmaceuticals Incorporated Dosage form comprising prodrug of na 1.8 sodium channel inhibitor
WO2020219867A1 (en) 2019-04-25 2020-10-29 Vertex Pharmaceuticals Incorporated Pyridone amide co-crystal compositions for the treatment of pain
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
EP4347584A1 (en) 2021-06-04 2024-04-10 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
WO2022256702A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
CN117794918A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 经取代的四氢呋喃类似物作为钠通道调节剂
JP2024520649A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド （２ｒ，３ｓ，４ｓ，５ｒ）－４－［［３－（３，４－ジフルオロ－２－メトキシ－フェニル）－４，５－ジメチル－５－（トリフルオロメチル）テトラヒドロフラン－２－カルボニル］アミノ］ピリジン－２－カルボキサミドを含む固体剤形及び投与レジメン
EP4347033A1 (en) 2021-06-04 2024-04-10 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
AR126073A1 (es) 2021-06-04 2023-09-06 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofuran carboxamidas como moduladores de canales de sodio
WO2023205465A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20230382910A1 (en) 2022-04-22 2023-11-30 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20230373925A1 (en) 2022-04-22 2023-11-23 Vertex Pharma Heteroaryl compounds for the treatment of pain
WO2023205468A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2023211990A1 (en) 2022-04-25 2023-11-02 Siteone Therapeutics, Inc. Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain

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Also Published As

Publication number Publication date
MX2014004738A (es) 2014-08-01
CA2850925C (en) 2017-01-10
JP5946538B2 (ja) 2016-07-06
DOP2014000085A (es) 2014-08-31
TN2014000147A1 (fr) 2015-09-30
ZA201402281B (en) 2015-11-25
BR112014009102A2 (pt) 2017-04-18
CO6940427A2 (es) 2014-05-09
CL2014000956A1 (es) 2014-07-18
CR20140185A (es) 2014-06-03
AU2012328034A1 (en) 2014-05-15
US20140296313A1 (en) 2014-10-02
KR20140069234A (ko) 2014-06-09
AP2014007579A0 (en) 2014-04-30
PE20141682A1 (es) 2014-11-14
SG11201401032YA (en) 2014-07-30
IL232267A (en) 2016-10-31
CN103906746A (zh) 2014-07-02
JP2014530900A (ja) 2014-11-20
AU2012328034B2 (en) 2015-04-23
HK1198650A1 (en) 2015-05-22
UA109220C2 (uk) 2015-07-27
WO2013061205A3 (en) 2013-06-27
GT201400079A (es) 2015-06-02
NZ623090A (en) 2015-10-30
MX337469B (es) 2016-03-02
WO2013061205A2 (en) 2013-05-02
EA023375B1 (ru) 2016-05-31
US9079878B2 (en) 2015-07-14
EA201490864A1 (ru) 2014-08-29
NI201400031A (es) 2014-10-01
MD20140037A2 (ro) 2014-08-31
IL232267A0 (en) 2014-06-30
CA2850925A1 (en) 2013-05-02
EP2771335A2 (en) 2014-09-03
CN103906746B (zh) 2015-12-09
ECSP14013324A (es) 2014-05-31
WO2013061205A8 (en) 2014-03-27
KR101586966B1 (ko) 2016-01-19

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