KR101553600B1 - 항균성 퀴놀린 유도체 - Google Patents

항균성 퀴놀린 유도체 Download PDF

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Publication number
KR101553600B1
KR101553600B1 KR1020097013568A KR20097013568A KR101553600B1 KR 101553600 B1 KR101553600 B1 KR 101553600B1 KR 1020097013568 A KR1020097013568 A KR 1020097013568A KR 20097013568 A KR20097013568 A KR 20097013568A KR 101553600 B1 KR101553600 B1 KR 101553600B1
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South Korea
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alkyl
aryl
compound
substituted
het
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Korean (ko)
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KR20090102778A (ko
Inventor
제롬 에밀 조르쥬 길레몽
이스멧 도랑쥬
다비드 프란시스 알랭 랑수와
호세 마누엘 빌랄고르도-소토
이반 르네 페르디난드 시모네
마갈리 매들린 시몬 모떼
코엔라트 요제프 로데윅 마르셀 안드리스
아닐 코울
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얀센 파마슈티카 엔.브이.
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Application filed by 얀센 파마슈티카 엔.브이. filed Critical 얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
KR1020097013568A 2006-12-06 2007-12-04 항균성 퀴놀린 유도체 Expired - Fee Related KR101553600B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125545.1 2006-12-06
EP06125545 2006-12-06

Publications (2)

Publication Number Publication Date
KR20090102778A KR20090102778A (ko) 2009-09-30
KR101553600B1 true KR101553600B1 (ko) 2015-09-16

Family

ID=38048032

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097013568A Expired - Fee Related KR101553600B1 (ko) 2006-12-06 2007-12-04 항균성 퀴놀린 유도체

Country Status (33)

Country Link
US (1) US20100063026A1 (enExample)
EP (1) EP2099761B1 (enExample)
JP (1) JP5466013B2 (enExample)
KR (1) KR101553600B1 (enExample)
CN (1) CN101547906B (enExample)
AP (1) AP2477A (enExample)
AR (1) AR064148A1 (enExample)
AT (1) ATE486061T1 (enExample)
AU (1) AU2007328892B2 (enExample)
BR (1) BRPI0719915A2 (enExample)
CA (1) CA2668558C (enExample)
CL (1) CL2007003518A1 (enExample)
CY (1) CY1112027T1 (enExample)
DE (1) DE602007010182D1 (enExample)
DK (1) DK2099761T3 (enExample)
EA (1) EA016760B1 (enExample)
ES (1) ES2354755T3 (enExample)
HR (1) HRP20110024T1 (enExample)
IL (1) IL199082A (enExample)
JO (1) JO2683B1 (enExample)
ME (1) ME01230B (enExample)
MX (1) MX2009005906A (enExample)
MY (1) MY145940A (enExample)
NO (1) NO341984B1 (enExample)
NZ (1) NZ576862A (enExample)
PL (1) PL2099761T3 (enExample)
PT (1) PT2099761E (enExample)
RS (1) RS51582B (enExample)
SI (1) SI2099761T1 (enExample)
TW (1) TWI487526B (enExample)
UA (1) UA101307C2 (enExample)
WO (1) WO2008068272A2 (enExample)
ZA (1) ZA200903949B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150126737A (ko) * 2006-12-06 2015-11-12 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104254528B (zh) * 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物
US9133167B2 (en) 2012-04-27 2015-09-15 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
WO2023178035A1 (en) 2022-03-14 2023-09-21 Slap Pharmaceuticals Llc Multicyclic compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503411A (ja) * 1996-10-28 2001-03-13 ディパートメント オブ ジ アーミー，ユー．エス．ガバメント 抗生物質耐性感染症の処置のための化合物、組成物および方法
UA86952C2 (uk) * 2004-01-23 2009-06-10 Янссен Фармацевтика Н.В. Похідні хіноліну та їх застосування як мікобактеріальних інгібіторів
CN1910154B (zh) * 2004-01-29 2011-08-17 詹森药业有限公司 用作分枝杆菌抑制剂的喹啉衍生物
ES2306146T3 (es) * 2004-05-28 2008-11-01 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a farmacos.
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
AP2547A (en) * 2005-06-28 2012-12-26 Janssen Pharmaceutica Nv Quinoline derivatives as antibacterial agents
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150126737A (ko) * 2006-12-06 2015-11-12 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체
KR101908350B1 (ko) * 2006-12-06 2018-10-16 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체

Also Published As

Publication number Publication date
NO20092541L (no) 2009-09-02
NO341984B1 (no) 2018-03-05
IL199082A (en) 2014-04-30
CA2668558A1 (en) 2008-06-12
EP2099761A2 (en) 2009-09-16
UA101307C2 (ru) 2013-03-25
CY1112027T1 (el) 2015-11-04
SI2099761T1 (sl) 2011-02-28
EP2099761B1 (en) 2010-10-27
KR20090102778A (ko) 2009-09-30
ZA200903949B (en) 2010-08-25
AU2007328892A1 (en) 2008-06-12
TW200831095A (en) 2008-08-01
HK1137437A1 (en) 2010-07-30
RS51582B (sr) 2011-08-31
PT2099761E (pt) 2011-01-18
AU2007328892B2 (en) 2013-05-16
JP2010511672A (ja) 2010-04-15
JO2683B1 (en) 2013-03-03
TWI487526B (zh) 2015-06-11
DK2099761T3 (da) 2011-02-07
AP2477A (en) 2012-09-27
HRP20110024T1 (hr) 2011-04-30
WO2008068272A3 (en) 2008-07-24
WO2008068272A2 (en) 2008-06-12
CL2007003518A1 (es) 2008-07-11
AR064148A1 (es) 2009-03-18
CA2668558C (en) 2016-06-07
PL2099761T3 (pl) 2011-04-29
DE602007010182D1 (de) 2010-12-09
CN101547906B (zh) 2014-08-06
US20100063026A1 (en) 2010-03-11
CN101547906A (zh) 2009-09-30
EA200970537A1 (ru) 2009-10-30
ATE486061T1 (de) 2010-11-15
AP2009004873A0 (en) 2009-06-30
ES2354755T3 (es) 2011-03-17
MX2009005906A (es) 2009-06-16
BRPI0719915A2 (pt) 2014-03-04
ME01230B (me) 2013-03-20
EA016760B1 (ru) 2012-07-30
JP5466013B2 (ja) 2014-04-09
NZ576862A (en) 2012-01-12
MY145940A (en) 2012-05-31

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