KR101539470B1 - 키메라 pufa 폴리케타이드 신테이즈 시스템 및 이의 용도 - Google Patents
키메라 pufa 폴리케타이드 신테이즈 시스템 및 이의 용도 Download PDFInfo
- Publication number
- KR101539470B1 KR101539470B1 KR1020097026099A KR20097026099A KR101539470B1 KR 101539470 B1 KR101539470 B1 KR 101539470B1 KR 1020097026099 A KR1020097026099 A KR 1020097026099A KR 20097026099 A KR20097026099 A KR 20097026099A KR 101539470 B1 KR101539470 B1 KR 101539470B1
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- KR
- South Korea
- Prior art keywords
- seq
- pufa pks
- pks system
- domain
- pufa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
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- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Psychiatry (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/749,686 | 2007-05-16 | ||
| US11/749,686 US8003772B2 (en) | 1999-01-14 | 2007-05-16 | Chimeric PUFA polyketide synthase systems and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100020963A KR20100020963A (ko) | 2010-02-23 |
| KR101539470B1 true KR101539470B1 (ko) | 2015-07-24 |
Family
ID=40122412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097026099A Expired - Fee Related KR101539470B1 (ko) | 2007-05-16 | 2008-05-16 | 키메라 pufa 폴리케타이드 신테이즈 시스템 및 이의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8003772B2 (enExample) |
| EP (1) | EP2160470B1 (enExample) |
| JP (1) | JP5551584B2 (enExample) |
| KR (1) | KR101539470B1 (enExample) |
| CN (1) | CN101849014B (enExample) |
| AU (1) | AU2008254837B2 (enExample) |
| BR (1) | BRPI0810302A2 (enExample) |
| CA (1) | CA2687523C (enExample) |
| ES (1) | ES2467918T3 (enExample) |
| IL (1) | IL202131A (enExample) |
| MX (1) | MX2009012395A (enExample) |
| WO (1) | WO2008144473A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| TWI377253B (en) | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| CA3023314C (en) | 2004-04-22 | 2019-12-10 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| MX339812B (es) * | 2006-03-15 | 2016-06-08 | Dsm Ip Assets B V * | Produccion de acido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policetido pufa. |
| AU2007291937B2 (en) | 2006-08-29 | 2014-05-15 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of fatty acids |
| EP2899209A1 (en) | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
| BRPI0913406A2 (pt) | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
| CA3015426C (en) | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| KR101939014B1 (ko) * | 2009-03-16 | 2019-01-15 | 디에스엠 아이피 어셋츠 비.브이. | 라비린툴로바이코타문 미생물에서의 단백질 생산 |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| EP3192871B1 (en) * | 2009-03-19 | 2019-01-23 | DSM IP Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
| EP2481799A4 (en) | 2009-09-24 | 2013-08-07 | Univ Kyushu Nat Univ Corp | METHOD FOR THE TRANSFORMATION OF STRAMENOPILES |
| AU2010343095B2 (en) * | 2009-12-28 | 2017-01-05 | Sanofi Vaccine Technologies, S.A.S. | Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof |
| EP2519636B8 (en) * | 2009-12-28 | 2017-08-09 | DSM IP Assets B.V. | Production of hemagglutinin-neuraminidase protein in microalgae |
| CN103068965A (zh) | 2009-12-28 | 2013-04-24 | Dsmip资产公司 | 在蔗糖上生长的重组破囊壶菌和其组合物、制备方法及用途 |
| CN103260643A (zh) | 2009-12-28 | 2013-08-21 | 梅里亚有限公司 | 重组ndv抗原及其用途 |
| WO2011090730A1 (en) * | 2009-12-28 | 2011-07-28 | Martek Biosciences Corporation | Recombinant thraustochytrids that grow on xylose, and compositions, methods of making, and uses thereof |
| AU2010343305B2 (en) * | 2010-01-19 | 2015-06-11 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| ES2795148T3 (es) | 2010-03-12 | 2020-11-20 | Boehringer Ingelheim Animal Health Usa Inc | Vacunas recombinantes contra el virus de la fiebre aftosa y usos de las mismas |
| US11236351B2 (en) * | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| TW201206473A (en) | 2010-08-03 | 2012-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN103415611B (zh) * | 2010-10-01 | 2016-08-10 | 国立大学法人九州大学 | 原生藻菌的转化方法 |
| WO2012120375A1 (en) * | 2011-03-07 | 2012-09-13 | Ocean Nutrition Canada Limited | Engineering thraustochytrid microorganisms |
| TWI582235B (zh) | 2011-07-21 | 2017-05-11 | Dsm智慧財產有限公司 | 生產二十碳五烯酸之微生物、脂肪酸組成物及其製作方法與用途 |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術 |
| NZ631702A (en) | 2012-06-15 | 2017-01-27 | Grains Res & Dev Corp | Production of long chain polyunsaturated fatty acids in plant cells |
| TW201525136A (zh) * | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌PUFA合成酶於油籽作物中生成ω-3長鏈多不飽和脂肪酸 |
| EP3082405A4 (en) | 2013-12-18 | 2017-12-13 | Commonwealth Scientific and Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
| PH12016502586B1 (en) | 2014-06-27 | 2023-07-19 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| CA2977271A1 (en) | 2015-03-02 | 2016-09-09 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
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Also Published As
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| JP5551584B2 (ja) | 2014-07-16 |
| US20120021470A1 (en) | 2012-01-26 |
| WO2008144473A3 (en) | 2009-01-15 |
| US8003772B2 (en) | 2011-08-23 |
| US8859855B2 (en) | 2014-10-14 |
| CN101849014B (zh) | 2015-08-19 |
| CA2687523C (en) | 2016-09-13 |
| HK1143403A1 (en) | 2010-12-31 |
| KR20100020963A (ko) | 2010-02-23 |
| ES2467918T3 (es) | 2014-06-13 |
| MX2009012395A (es) | 2010-02-10 |
| IL202131A0 (en) | 2010-06-16 |
| AU2008254837B2 (en) | 2013-09-12 |
| EP2160470B1 (en) | 2014-03-05 |
| EP2160470A2 (en) | 2010-03-10 |
| EP2160470A4 (en) | 2012-02-22 |
| JP2010527244A (ja) | 2010-08-12 |
| US8309796B2 (en) | 2012-11-13 |
| CA2687523A1 (en) | 2008-11-27 |
| AU2008254837A1 (en) | 2008-11-27 |
| US20130143281A1 (en) | 2013-06-06 |
| CN101849014A (zh) | 2010-09-29 |
| WO2008144473A2 (en) | 2008-11-27 |
| IL202131A (en) | 2013-09-30 |
| US20080022422A1 (en) | 2008-01-24 |
| BRPI0810302A2 (pt) | 2020-10-06 |
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