KR101528013B1 - 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 - Google Patents

친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 Download PDF

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KR101528013B1
KR101528013B1 KR1020127008265A KR20127008265A KR101528013B1 KR 101528013 B1 KR101528013 B1 KR 101528013B1 KR 1020127008265 A KR1020127008265 A KR 1020127008265A KR 20127008265 A KR20127008265 A KR 20127008265A KR 101528013 B1 KR101528013 B1 KR 101528013B1
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KR20120060874A (ko
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토마스 유 호퍼
랄프 호세
에케하드 모에스너
파블로 우마나
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로슈 글리카트 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127008265A 2009-08-31 2010-08-27 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 Expired - Fee Related KR101528013B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23850509P 2009-08-31 2009-08-31
US61/238,505 2009-08-31
PCT/EP2010/062527 WO2011023787A1 (en) 2009-08-31 2010-08-27 Affinity-matured humanized anti cea monoclonal antibodies

Publications (2)

Publication Number Publication Date
KR20120060874A KR20120060874A (ko) 2012-06-12
KR101528013B1 true KR101528013B1 (ko) 2015-06-16

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KR1020127008265A Expired - Fee Related KR101528013B1 (ko) 2009-08-31 2010-08-27 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체

Country Status (22)

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US (2) US9068008B2 (cg-RX-API-DMAC7.html)
EP (1) EP2473532B1 (cg-RX-API-DMAC7.html)
JP (1) JP5744872B2 (cg-RX-API-DMAC7.html)
KR (1) KR101528013B1 (cg-RX-API-DMAC7.html)
CN (1) CN102741293B (cg-RX-API-DMAC7.html)
AR (1) AR078111A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010288469A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012003983A2 (cg-RX-API-DMAC7.html)
CA (1) CA2770174A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012000551A1 (cg-RX-API-DMAC7.html)
CO (1) CO6491105A2 (cg-RX-API-DMAC7.html)
CR (1) CR20120087A (cg-RX-API-DMAC7.html)
EC (1) ECSP12011698A (cg-RX-API-DMAC7.html)
IL (1) IL218038A0 (cg-RX-API-DMAC7.html)
MA (1) MA33536B1 (cg-RX-API-DMAC7.html)
MX (1) MX339608B (cg-RX-API-DMAC7.html)
PE (1) PE20121552A1 (cg-RX-API-DMAC7.html)
RU (1) RU2570554C2 (cg-RX-API-DMAC7.html)
SG (1) SG178567A1 (cg-RX-API-DMAC7.html)
TW (1) TW201121994A (cg-RX-API-DMAC7.html)
WO (1) WO2011023787A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201200954B (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
EP2473532A1 (en) 2012-07-11
KR20120060874A (ko) 2012-06-12
EP2473532B1 (en) 2017-06-21
SG178567A1 (en) 2012-04-27
CA2770174A1 (en) 2011-03-03
MX2012002461A (es) 2012-03-14
WO2011023787A1 (en) 2011-03-03
CN102741293B (zh) 2015-04-01
RU2012112340A (ru) 2013-10-10
TW201121994A (en) 2011-07-01
PE20121552A1 (es) 2012-11-26
JP5744872B2 (ja) 2015-07-08
US20160075795A1 (en) 2016-03-17
ECSP12011698A (es) 2012-03-30
HK1176951A1 (en) 2013-08-09
CL2012000551A1 (es) 2012-10-12
US20110104148A1 (en) 2011-05-05
CO6491105A2 (es) 2012-07-31
ZA201200954B (en) 2014-07-30
AU2010288469A1 (en) 2012-03-01
RU2570554C2 (ru) 2015-12-10
AR078111A1 (es) 2011-10-12
US9068008B2 (en) 2015-06-30
CR20120087A (es) 2012-03-22
MA33536B1 (fr) 2012-08-01
JP2013502913A (ja) 2013-01-31
CN102741293A (zh) 2012-10-17
BR112012003983A2 (pt) 2021-09-14
MX339608B (es) 2016-05-31
IL218038A0 (en) 2012-04-30

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