KR101508043B1 - 이중특이적 사멸 수용체 아고니스트성 항체 - Google Patents

이중특이적 사멸 수용체 아고니스트성 항체 Download PDF

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KR101508043B1
KR101508043B1 KR1020127007953A KR20127007953A KR101508043B1 KR 101508043 B1 KR101508043 B1 KR 101508043B1 KR 1020127007953 A KR1020127007953 A KR 1020127007953A KR 20127007953 A KR20127007953 A KR 20127007953A KR 101508043 B1 KR101508043 B1 KR 101508043B1
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KR20120056857A (ko
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페터 브륀커
콜러 클라우디아 페라라
잔드라 그라우
실비아 헤르터
크리슈토프 람페르트
에케하르트 뫼쓰너
파블로 우마나
인야 발트하우어
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로슈 글리카트 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020127007953A 2009-09-29 2010-09-27 이중특이적 사멸 수용체 아고니스트성 항체 Expired - Fee Related KR101508043B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09171659.7 2009-09-29
EP09171659 2009-09-29
PCT/EP2010/064209 WO2011039126A1 (en) 2009-09-29 2010-09-27 Bispecific death receptor agonistic antibodies

Publications (2)

Publication Number Publication Date
KR20120056857A KR20120056857A (ko) 2012-06-04
KR101508043B1 true KR101508043B1 (ko) 2015-04-06

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KR1020127007953A Expired - Fee Related KR101508043B1 (ko) 2009-09-29 2010-09-27 이중특이적 사멸 수용체 아고니스트성 항체

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US (1) US9481730B2 (https=)
EP (1) EP2483310B1 (https=)
JP (1) JP5695059B2 (https=)
KR (1) KR101508043B1 (https=)
CN (1) CN102574921B (https=)
AU (1) AU2010303142B2 (https=)
BR (1) BR112012006326A2 (https=)
CA (1) CA2773515C (https=)
CY (1) CY1115639T1 (https=)
DK (1) DK2483310T3 (https=)
ES (1) ES2505269T3 (https=)
HR (1) HRP20141032T1 (https=)
IL (1) IL218437A (https=)
MX (1) MX2012003598A (https=)
PL (1) PL2483310T3 (https=)
PT (1) PT2483310E (https=)
SI (1) SI2483310T1 (https=)
WO (1) WO2011039126A1 (https=)

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PL2483310T3 (pl) 2015-01-30
JP2013505732A (ja) 2013-02-21
HRP20141032T1 (hr) 2015-01-30
ES2505269T3 (es) 2014-10-09
WO2011039126A1 (en) 2011-04-07
MX2012003598A (es) 2012-04-20
US20120184718A1 (en) 2012-07-19
EP2483310A1 (en) 2012-08-08
SI2483310T1 (sl) 2014-12-31
BR112012006326A2 (pt) 2016-11-16
US9481730B2 (en) 2016-11-01
AU2010303142B2 (en) 2013-05-09
DK2483310T3 (da) 2014-09-01
CA2773515A1 (en) 2011-04-07
AU2010303142A1 (en) 2012-03-15
CY1115639T1 (el) 2017-01-04
CN102574921B (zh) 2016-05-04
KR20120056857A (ko) 2012-06-04
IL218437A (en) 2017-04-30
EP2483310B1 (en) 2014-08-13
JP5695059B2 (ja) 2015-04-01
CN102574921A (zh) 2012-07-11
IL218437A0 (en) 2012-04-30
HK1169132A1 (zh) 2013-01-18
PT2483310E (pt) 2014-10-07
CA2773515C (en) 2015-04-28

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