KR101506593B1 - Ｐｄｇｆ 양친매성 중합체 복합체 - Google Patents

Ｐｄｇｆ 양친매성 중합체 복합체 Download PDF

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Publication number
KR101506593B1
KR101506593B1 KR1020087009706A KR20087009706A KR101506593B1 KR 101506593 B1 KR101506593 B1 KR 101506593B1 KR 1020087009706 A KR1020087009706 A KR 1020087009706A KR 20087009706 A KR20087009706 A KR 20087009706A KR 101506593 B1 KR101506593 B1 KR 101506593B1
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KR
South Korea
Prior art keywords
pdgf
complex
polymer
group
amphipathic polymer
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020087009706A
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English (en)
Korean (ko)
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KR20080080278A (ko
Inventor
기 뒤브레코
라티파 다리-코레이아
호세 코레이아
다비드 뒤라쉐
레미 수라
올리비에 수라
제라르 수라
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아도시아
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020087009706A 2005-09-26 2006-09-26 Ｐｄｇｆ 양친매성 중합체 복합체 Expired - Fee Related KR101506593B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR05/09803 2005-09-26
FR0509803A FR2891149B1 (fr) 2005-09-26 2005-09-26 Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
PCT/IB2006/002666 WO2007034320A2 (fr) 2005-09-26 2006-09-26 Complexe polymere amphiphile-pdgf

Publications (2)

Publication Number Publication Date
KR20080080278A KR20080080278A (ko) 2008-09-03
KR101506593B1 true KR101506593B1 (ko) 2015-03-30

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KR1020087009706A Expired - Fee Related KR101506593B1 (ko) 2005-09-26 2006-09-26 Ｐｄｇｆ 양친매성 중합체 복합체

Country Status (17)

Country Link
US (3) US20090221805A1 (cg-RX-API-DMAC7.html)
EP (2) EP1940448B1 (cg-RX-API-DMAC7.html)
JP (1) JP5438968B2 (cg-RX-API-DMAC7.html)
KR (1) KR101506593B1 (cg-RX-API-DMAC7.html)
CN (3) CN103203023B (cg-RX-API-DMAC7.html)
AU (1) AU2006293613B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0616439A2 (cg-RX-API-DMAC7.html)
CA (1) CA2623529C (cg-RX-API-DMAC7.html)
DK (1) DK1940448T3 (cg-RX-API-DMAC7.html)
ES (1) ES2406229T3 (cg-RX-API-DMAC7.html)
FR (1) FR2891149B1 (cg-RX-API-DMAC7.html)
IL (1) IL190400A (cg-RX-API-DMAC7.html)
PL (1) PL1940448T3 (cg-RX-API-DMAC7.html)
PT (1) PT1940448E (cg-RX-API-DMAC7.html)
RU (1) RU2424824C2 (cg-RX-API-DMAC7.html)
WO (2) WO2007034320A2 (cg-RX-API-DMAC7.html)
ZA (2) ZA200803500B (cg-RX-API-DMAC7.html)

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FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2914305B1 (fr) * 2007-03-29 2009-07-03 Proteins & Peptides Man Dextran fonctionnalise par des amino-acides hydrophobes.
US20120041079A1 (en) * 2006-09-26 2012-02-16 Adocia Dextran functionalized by hydrophobic amino acids
FR2908414B1 (fr) 2006-11-13 2012-01-20 Centre Nat Rech Scient Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
US8247384B2 (en) 2006-11-15 2012-08-21 Coda Therapeutics, Inc. Methods and compositions for wound healing
FR2914191A1 (fr) * 2007-03-29 2008-10-03 Proteins & Peptides Man Composition angiogenique.
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
EP2288370A1 (fr) * 2008-04-14 2011-03-02 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique
FR2934999B1 (fr) * 2008-08-13 2011-07-29 Adocia Polysaccharides fonctionnalises par des derives du tryptophane
EP2349338A2 (fr) * 2008-09-26 2011-08-03 Adocia Complexe constitue d'un polysaccharide et d'une hpb
FR2936800B1 (fr) * 2008-10-06 2010-12-31 Adocia Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
US8426382B2 (en) * 2008-10-06 2013-04-23 Adocia Polysaccharides comprising carboxyl functional groups substituted by a hydrophobic alcohol derivative
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
FR2943538B1 (fr) * 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
FR2958646B1 (fr) * 2010-04-07 2012-05-18 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe.
BR112012019580A2 (pt) * 2010-02-09 2020-08-18 Adocia "polissacarídeos antônicos funcionalizados por pelo menos dois grupos hidrofóbicos carreados por pelo menos um espaçador trivalente
FR2966248B1 (fr) 2010-10-18 2020-05-01 Centre National De La Recherche Scientifique (Cnrs) Procede de fonctionnalisation de surfaces pour la detection d'analytes
WO2012153071A2 (fr) * 2011-05-10 2012-11-15 Adocia Polysaccharides à degré de fonctionnalisation modulable
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
US9084806B2 (en) * 2012-11-12 2015-07-21 Research & Business Foundation Sungkyunkwan University Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
SG10201703742SA (en) * 2012-11-13 2017-06-29 Adocia Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units
US9700599B2 (en) * 2012-11-13 2017-07-11 Adocia Rapid-acting insulin formulation comprising a substituted anionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
CA2958879A1 (en) 2014-08-22 2016-02-25 Auckland Uniservices Limited Channel modulators
FR3025428A1 (fr) * 2014-09-08 2016-03-11 Adocia Composition pharmaceutique stable comprenant du pdgf
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
CN106188649B (zh) * 2016-07-04 2019-06-25 宁波国际材料基因工程研究院有限公司 一种药物缓释载体水凝胶及其制备方法
CN111171174B (zh) * 2020-01-14 2022-02-01 上海图珐医药科技有限公司 葡聚糖衍生物及其制备方法和用于制备药剂的附加剂
CN111253569B (zh) * 2020-02-26 2021-06-01 山东大学 一种聚合物、其制剂及其制备方法和应用

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JPH11512740A (ja) * 1995-10-06 1999-11-02 エチコン・インコーポレーテツド 増殖因子を含むゲル組成物
WO2000076562A1 (fr) * 1999-06-11 2000-12-21 Biodex Biomateriau a base d'un derive de dextrane insolubilise et d'un facteur de croissance

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JPH11512740A (ja) * 1995-10-06 1999-11-02 エチコン・インコーポレーテツド 増殖因子を含むゲル組成物
WO2000076562A1 (fr) * 1999-06-11 2000-12-21 Biodex Biomateriau a base d'un derive de dextrane insolubilise et d'un facteur de croissance

Also Published As

Publication number Publication date
AU2006293613A1 (en) 2007-03-29
US20070254828A1 (en) 2007-11-01
AU2006293613B2 (en) 2012-05-17
ZA200902008B (en) 2010-09-29
CA2623529A1 (fr) 2007-03-29
WO2007034320A3 (fr) 2007-10-04
EP1940448A2 (fr) 2008-07-09
FR2891149B1 (fr) 2007-11-30
EP1940449A2 (fr) 2008-07-09
RU2008116585A (ru) 2009-11-10
RU2424824C2 (ru) 2011-07-27
US8241620B2 (en) 2012-08-14
KR20080080278A (ko) 2008-09-03
IL190400A (en) 2015-08-31
EP1940448B1 (fr) 2013-03-06
US20090221805A1 (en) 2009-09-03
ES2406229T3 (es) 2013-06-06
WO2007034320A2 (fr) 2007-03-29
PL1940448T3 (pl) 2013-08-30
CN103203023B (zh) 2016-06-01
PT1940448E (pt) 2013-04-15
CA2623529C (fr) 2013-12-24
CN103203023A (zh) 2013-07-17
CN101631804B (zh) 2012-11-28
BRPI0616439A2 (pt) 2011-06-21
JP5438968B2 (ja) 2014-03-12
WO2007034321A2 (fr) 2007-03-29
CN101631804A (zh) 2010-01-20
CN101316607A (zh) 2008-12-03
US20110301086A1 (en) 2011-12-08
WO2007034321A3 (fr) 2007-10-04
DK1940448T3 (da) 2013-06-03
ZA200803500B (en) 2012-09-26
JP2009509952A (ja) 2009-03-12
FR2891149A1 (fr) 2007-03-30

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