KR101445458B1 - １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 - Google Patents
１Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 Download PDFInfo
- Publication number
- KR101445458B1 KR101445458B1 KR1020127000098A KR20127000098A KR101445458B1 KR 101445458 B1 KR101445458 B1 KR 101445458B1 KR 1020127000098 A KR1020127000098 A KR 1020127000098A KR 20127000098 A KR20127000098 A KR 20127000098A KR 101445458 B1 KR101445458 B1 KR 101445458B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- quinolin
- dihydro
- imidazo
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *c(c(I=N)c1)c(*)c(nc2*)c1c(*)c2[N+]([O-])=O Chemical compound *c(c(I=N)c1)c(*)c(nc2*)c1c(*)c2[N+]([O-])=O 0.000 description 29
- YRTIPZUNGYBTAI-UHFFFAOYSA-O CC(C(C[NH2+]C)C1=Cc2c(cc(cc3)-c(cn4)ccc4OCC[O](Cc4ccccc4)=C)c3ncc2N(C)C1=O)=N Chemical compound CC(C(C[NH2+]C)C1=Cc2c(cc(cc3)-c(cn4)ccc4OCC[O](Cc4ccccc4)=C)c3ncc2N(C)C1=O)=N YRTIPZUNGYBTAI-UHFFFAOYSA-O 0.000 description 1
- VOMUOHJLYTYKLU-UHFFFAOYSA-O CC(C(N(c1c(cc(cc2)-c(cc3)cnc3-[n]3nccc3)c2ncc1N1C)C1=O)=C=[NH2+])=N Chemical compound CC(C(N(c1c(cc(cc2)-c(cc3)cnc3-[n]3nccc3)c2ncc1N1C)C1=O)=C=[NH2+])=N VOMUOHJLYTYKLU-UHFFFAOYSA-O 0.000 description 1
- LDNRGBSBPGMGPI-UHFFFAOYSA-O CC(C(N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1)C1=O)=C[NH2+]C)NC Chemical compound CC(C(N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1)C1=O)=C[NH2+]C)NC LDNRGBSBPGMGPI-UHFFFAOYSA-O 0.000 description 1
- YWRBLSYOLXMZGA-UHFFFAOYSA-N CC1(C)OB(c2c[n](CCOC3OCCCC3)nc2)OC1(C)C Chemical compound CC1(C)OB(c2c[n](CCOC3OCCCC3)nc2)OC1(C)C YWRBLSYOLXMZGA-UHFFFAOYSA-N 0.000 description 1
- UMNHNYSMUMUXMG-UHFFFAOYSA-N CC1(C)OB(c2ccc(N3CCC3)nc2)OC1(C)C Chemical compound CC1(C)OB(c2ccc(N3CCC3)nc2)OC1(C)C UMNHNYSMUMUXMG-UHFFFAOYSA-N 0.000 description 1
- MDQFPCPLPMLWQE-UHFFFAOYSA-O CCC(CC)CC1=C(C)NCC(c(ccc2ncc3N4C)cc2c3N(C(C(C)=N)=C[NH2+]C)C4=O)=C1 Chemical compound CCC(CC)CC1=C(C)NCC(c(ccc2ncc3N4C)cc2c3N(C(C(C)=N)=C[NH2+]C)C4=O)=C1 MDQFPCPLPMLWQE-UHFFFAOYSA-O 0.000 description 1
- IPRBGSHKJYVKMQ-UHFFFAOYSA-N CCC(CC1)N=C(C)C1N(c(c(cc(cc1)-c2cncc(OC3CCC3)c2)c1nc1)c1N1C)C1=O Chemical compound CCC(CC1)N=C(C)C1N(c(c(cc(cc1)-c2cncc(OC3CCC3)c2)c1nc1)c1N1C)C1=O IPRBGSHKJYVKMQ-UHFFFAOYSA-N 0.000 description 1
- ZIRKWXVVWHTKJA-UHFFFAOYSA-O CCN(C)C(C[NH2+]C=C(C(C)=N)N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1C)C1=O)=O Chemical compound CCN(C)C(C[NH2+]C=C(C(C)=N)N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1C)C1=O)=O ZIRKWXVVWHTKJA-UHFFFAOYSA-O 0.000 description 1
- QZWGMFPVRXMGNO-UHFFFAOYSA-N CCNC(c1cc(S2OC(C)(C)C(C)(C)O2)cnc1NC)=O Chemical compound CCNC(c1cc(S2OC(C)(C)C(C)(C)O2)cnc1NC)=O QZWGMFPVRXMGNO-UHFFFAOYSA-N 0.000 description 1
- IUAYLJIEHYDJLS-UHFFFAOYSA-O CCOc1cncc(-c(ccc2ncc3N4C)cc2c3N(C(C[NH2+]C)C(C)=N)C4=O)c1 Chemical compound CCOc1cncc(-c(ccc2ncc3N4C)cc2c3N(C(C[NH2+]C)C(C)=N)C4=O)c1 IUAYLJIEHYDJLS-UHFFFAOYSA-O 0.000 description 1
- GRFCJZIHPOHZAL-UHFFFAOYSA-O CC[NH2+]C=C(C(C)=N)N(c(c(cc(cc1)-c(cc2OCC)ccc2OCC)c1nc1)c1N1C)C1=O Chemical compound CC[NH2+]C=C(C(C)=N)N(c(c(cc(cc1)-c(cc2OCC)ccc2OCC)c1nc1)c1N1C)C1=O GRFCJZIHPOHZAL-UHFFFAOYSA-O 0.000 description 1
- AHOJCZFQXZGFMZ-UHFFFAOYSA-O C[NH2+]C=C(C(Cl)=N)N(c1c(cc(C2C=NC(OC)=C(COC)C2)cc2)c2ncc1N1C)C1=O Chemical compound C[NH2+]C=C(C(Cl)=N)N(c1c(cc(C2C=NC(OC)=C(COC)C2)cc2)c2ncc1N1C)C1=O AHOJCZFQXZGFMZ-UHFFFAOYSA-O 0.000 description 1
- DOAAPYLUVPPLPI-UHFFFAOYSA-N Cc1n[n](C)c(N(c(c2nc(-c3ccc(C)c(OC)c3)ccc2nc2)c2N2C)C2=O)c1 Chemical compound Cc1n[n](C)c(N(c(c2nc(-c3ccc(C)c(OC)c3)ccc2nc2)c2N2C)C2=O)c1 DOAAPYLUVPPLPI-UHFFFAOYSA-N 0.000 description 1
- PFEQWFLEEJGWPM-UHFFFAOYSA-N Cc1n[n](C)cc1N(C1c2cc(-c3cccc(S(N4CCCC4)=O)c3)ccc2N=CC1N1C)C1=O Chemical compound Cc1n[n](C)cc1N(C1c2cc(-c3cccc(S(N4CCCC4)=O)c3)ccc2N=CC1N1C)C1=O PFEQWFLEEJGWPM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18414109P | 2009-06-04 | 2009-06-04 | |
| US61/184,141 | 2009-06-04 | ||
| PCT/EP2010/057719 WO2010139731A1 (en) | 2009-06-04 | 2010-06-02 | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120034710A KR20120034710A (ko) | 2012-04-12 |
| KR101445458B1 true KR101445458B1 (ko) | 2014-10-07 |
Family
ID=42697442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127000098A Expired - Fee Related KR101445458B1 (ko) | 2009-06-04 | 2010-06-02 | １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8476294B2 (https=) |
| EP (1) | EP2438064A1 (https=) |
| JP (1) | JP5596137B2 (https=) |
| KR (1) | KR101445458B1 (https=) |
| CN (1) | CN102574845B (https=) |
| AR (1) | AR076949A1 (https=) |
| AU (1) | AU2010255727B2 (https=) |
| BR (1) | BRPI1010621A2 (https=) |
| CA (1) | CA2763821A1 (https=) |
| CL (1) | CL2011003052A1 (https=) |
| CO (1) | CO6470887A2 (https=) |
| CR (1) | CR20110608A (https=) |
| CU (1) | CU24064B1 (https=) |
| DO (1) | DOP2011000373A (https=) |
| EA (1) | EA020715B1 (https=) |
| EC (1) | ECSP11011500A (https=) |
| GE (1) | GEP20156267B (https=) |
| IL (1) | IL216452A0 (https=) |
| MA (1) | MA33332B1 (https=) |
| MX (1) | MX2011012943A (https=) |
| NI (1) | NI201100209A (https=) |
| NZ (1) | NZ596487A (https=) |
| PE (1) | PE20120224A1 (https=) |
| SG (1) | SG176572A1 (https=) |
| TN (1) | TN2011000626A1 (https=) |
| TW (1) | TWI464168B (https=) |
| UA (1) | UA106074C2 (https=) |
| UY (1) | UY32682A (https=) |
| WO (1) | WO2010139731A1 (https=) |
| ZA (1) | ZA201108439B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010035744A1 (de) * | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| JP2014504286A (ja) * | 2010-12-06 | 2014-02-20 | ピラマル エンタープライジーズ リミテッド | 置換イミダゾキノリン誘導体 |
| JO3003B1 (ar) | 2011-01-14 | 2016-09-05 | Lilly Co Eli | مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor |
| WO2013071698A1 (zh) | 2011-11-17 | 2013-05-23 | 山东轩竹医药科技有限公司 | 三环类PI3K和/或mTOR抑制剂 |
| WO2014141118A1 (en) * | 2013-03-14 | 2014-09-18 | Piramal Enterprises Limited | Imidazo[4,5-c]quinoline derivatives and uses thereof |
| BR112015025686B1 (pt) | 2013-04-15 | 2020-10-27 | Fmc Corporation | composto, composições fungicidas e método para o controle das doenças dos vegetais |
| JP6576929B2 (ja) * | 2013-09-11 | 2019-09-18 | メルク パテント ゲーエムベーハー | ヘテロ環化合物 |
| US9745321B2 (en) | 2013-09-30 | 2017-08-29 | Shanghai Yingli Pharmaceutical Co., Ltd | Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof |
| JP6606428B2 (ja) * | 2013-10-11 | 2019-11-13 | 国立大学法人 東京医科歯科大学 | 脊髄小脳変性症を予防又は治療するための薬剤 |
| CN104447740B (zh) | 2013-11-20 | 2017-02-22 | 北京富龙康泰生物技术有限公司 | 咪唑酮类衍生物、其药物组合物和用途 |
| NO2714752T3 (https=) | 2014-05-08 | 2018-04-21 | ||
| JP6195684B2 (ja) | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| PL3560924T3 (pl) * | 2015-04-02 | 2021-10-11 | Merck Patent Gmbh | Imidazolonylochinoliny i ich zastosowanie jako inhibitorów kinazy atm |
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519568D0 (en) * | 2015-11-05 | 2015-12-23 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| BR112019007594A2 (pt) | 2016-10-13 | 2019-07-02 | Loyola University Of Chicago | método para bloquear a transmissão do parasita da malária |
| CN110072521B (zh) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | 包含t型钙通道阻断剂的药物组合 |
| MA47409A (fr) | 2017-02-06 | 2019-12-11 | Idorsia Pharmaceuticals Ltd | Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| EP3728228A1 (en) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| CN115151253B (zh) * | 2019-09-23 | 2025-04-15 | 南京征祥医药有限公司 | 磷酸二酯酶抑制剂及用途 |
| ES2974742T3 (es) | 2020-09-21 | 2024-07-01 | Wei Zhong | Compuestos de 1-(3,3-difluoropiperidin-4-il)-imidazo[4,5-c]quinolin-2-ona sustituidos con capacidad de penetración en la barrera hematoencefálica |
| CN115136336A (zh) * | 2021-01-26 | 2022-09-30 | 京东方科技集团股份有限公司 | 量子点发光器件、显示装置和制作方法 |
| CN116768928A (zh) * | 2023-06-15 | 2023-09-19 | 上海毕臣生化科技有限公司 | 一种3-叔丁基-5-硼酸酯基吡啶的合成方法 |
| CN117384154A (zh) * | 2023-09-04 | 2024-01-12 | 广州医科大学 | 一种吡咯并喹啉酮化合物、合成方法及其应用 |
Citations (1)
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|---|---|---|---|---|
| WO2003097641A2 (en) * | 2002-05-21 | 2003-11-27 | Novartis Ag | 1h-imidazo[4,5-c] quinoline derivatives in the treatment of protein kinase dependent diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004014969D1 (de) | 2003-11-21 | 2008-08-21 | Novartis Ag | 1h-imidazochinolinderivate als proteinkinaseinhibitoren |
| AR046845A1 (es) * | 2003-11-21 | 2005-12-28 | Novartis Ag | Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas |
| US20080213308A1 (en) | 2004-09-14 | 2008-09-04 | Nicholas Valiante | Imidazoquinoline Compounds |
| GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| KR20080083270A (ko) | 2005-11-04 | 2008-09-17 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 하이드록시 및 알콕시 치환된 1에이치 이미다조퀴놀린 및방법 |
| RS53335B (sr) | 2006-11-20 | 2014-10-31 | Novartis Ag | Kristalna monotozilatna so 2-metil-2-[4-(3-metil-2-okso-8-hinolin-3-il-2,3-dihidro-imidazo[4,5-c]hinolin-1-il)-fenil]-propionitrila |
| US9370508B2 (en) * | 2007-02-20 | 2016-06-21 | Novartis Ag | Imidazoquinolines as dual lipid kinase and mTOR inhibitors |
| JP2010534219A (ja) * | 2007-07-24 | 2010-11-04 | ノバルティス アーゲー | Ｅｇｆｒ依存性疾患またはｅｇｆｒファミリーメンバーを標的とする薬剤に対して耐性を獲得した疾患の処置のための、イミダゾキノリンの使用 |
| US20090082387A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched nvp-bez234 |
| BRPI0909082A2 (pt) | 2008-03-26 | 2019-02-26 | Novartis Ag | imidazoquinolinas e derivados de pirimidina como moduladores potentes de processos angiogênicos acionados por vegf |
| EP2303890A4 (en) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | INHIBITORS OF PHOSPHATIDYLINOSITE-3-KINASE |
| WO2010038165A1 (en) * | 2008-09-30 | 2010-04-08 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
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|---|---|---|---|---|
| WO2003097641A2 (en) * | 2002-05-21 | 2003-11-27 | Novartis Ag | 1h-imidazo[4,5-c] quinoline derivatives in the treatment of protein kinase dependent diseases |
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