KR101428116B1 - 아자-벤조푸라닐 화합물 및 사용 방법 - Google Patents
아자-벤조푸라닐 화합물 및 사용 방법 Download PDFInfo
- Publication number
- KR101428116B1 KR101428116B1 KR1020097005786A KR20097005786A KR101428116B1 KR 101428116 B1 KR101428116 B1 KR 101428116B1 KR 1020097005786 A KR1020097005786 A KR 1020097005786A KR 20097005786 A KR20097005786 A KR 20097005786A KR 101428116 B1 KR101428116 B1 KR 101428116B1
- Authority
- KR
- South Korea
- Prior art keywords
- pyridine
- furo
- fluoro
- carboxylic acid
- phenylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCNC(C(OC(C1=**)=**)=C1N(*)*)=O Chemical compound CCNC(C(OC(C1=**)=**)=C1N(*)*)=O 0.000 description 25
- BMIGSRMSSCUMAZ-ZETCQYMHSA-N CC(C)(C)OC(N(CC=C1)[C@@H]1C(O)=O)=O Chemical compound CC(C)(C)OC(N(CC=C1)[C@@H]1C(O)=O)=O BMIGSRMSSCUMAZ-ZETCQYMHSA-N 0.000 description 1
- HMVFITKXZCNKSS-UHFFFAOYSA-N CN(C)CCOC Chemical compound CN(C)CCOC HMVFITKXZCNKSS-UHFFFAOYSA-N 0.000 description 1
- DAHUPKFQCHIVJO-UHFFFAOYSA-N CN(C)CCONC(c([o]c1ccncc11)c1Nc(c(F)c1)ccc1I)=O Chemical compound CN(C)CCONC(c([o]c1ccncc11)c1Nc(c(F)c1)ccc1I)=O DAHUPKFQCHIVJO-UHFFFAOYSA-N 0.000 description 1
- CVBMGGNEUKMUEY-UHFFFAOYSA-N COCC(CNC(c1ncc[nH]1)=O)O Chemical compound COCC(CNC(c1ncc[nH]1)=O)O CVBMGGNEUKMUEY-UHFFFAOYSA-N 0.000 description 1
- IEDFBXYTOVOZFB-UHFFFAOYSA-N COCCCNC(c1nccnc1)=O Chemical compound COCCCNC(c1nccnc1)=O IEDFBXYTOVOZFB-UHFFFAOYSA-N 0.000 description 1
- JFSYLINYOHTYGG-UHFFFAOYSA-N COCCNS(C)(=O)=O Chemical compound COCCNS(C)(=O)=O JFSYLINYOHTYGG-UHFFFAOYSA-N 0.000 description 1
- YIFYAJQIIKEWJQ-UHFFFAOYSA-N CS(NCCON)#[O] Chemical compound CS(NCCON)#[O] YIFYAJQIIKEWJQ-UHFFFAOYSA-N 0.000 description 1
- VGQFOKHFPSTYJY-UHFFFAOYSA-N CSc(cc1)ccc1I Chemical compound CSc(cc1)ccc1I VGQFOKHFPSTYJY-UHFFFAOYSA-N 0.000 description 1
- CTECPRIYINBBIJ-UHFFFAOYSA-N CSc(ccc(C(F)(F)F)c1)c1F Chemical compound CSc(ccc(C(F)(F)F)c1)c1F CTECPRIYINBBIJ-UHFFFAOYSA-N 0.000 description 1
- UVELIRZRGMQOSC-UHFFFAOYSA-N CSc1ccc(C(F)(F)F)cc1Cl Chemical compound CSc1ccc(C(F)(F)F)cc1Cl UVELIRZRGMQOSC-UHFFFAOYSA-N 0.000 description 1
- IRNKYHBUZZWJGM-UHFFFAOYSA-N Cc(c(C(F)(F)F)c1)ccc1I Chemical compound Cc(c(C(F)(F)F)c1)ccc1I IRNKYHBUZZWJGM-UHFFFAOYSA-N 0.000 description 1
- LIFMTDJMLRECMX-UHFFFAOYSA-N Cc(c(Cl)c1)ccc1Br Chemical compound Cc(c(Cl)c1)ccc1Br LIFMTDJMLRECMX-UHFFFAOYSA-N 0.000 description 1
- KKHIHDUDOZKUCU-UHFFFAOYSA-N Cc(c(F)c1)ccc1OC(F)(F)F Chemical compound Cc(c(F)c1)ccc1OC(F)(F)F KKHIHDUDOZKUCU-UHFFFAOYSA-N 0.000 description 1
- HUOUDVNVVVLFSC-UHFFFAOYSA-N Cc(cc(cc1)[Si](C)(C)C)c1S Chemical compound Cc(cc(cc1)[Si](C)(C)C)c1S HUOUDVNVVVLFSC-UHFFFAOYSA-N 0.000 description 1
- JUXFXYQUXNXVAA-UHFFFAOYSA-N Cc(cc1)ccc1OC(F)(F)F Chemical compound Cc(cc1)ccc1OC(F)(F)F JUXFXYQUXNXVAA-UHFFFAOYSA-N 0.000 description 1
- QZLWTFTXGKKCHZ-UHFFFAOYSA-N Cc(ccc(I)c1)c1F Chemical compound Cc(ccc(I)c1)c1F QZLWTFTXGKKCHZ-UHFFFAOYSA-N 0.000 description 1
- HGSGYJWRWHVTMA-UHFFFAOYSA-N Cc(ccc(OC(F)(F)F)c1)c1Cl Chemical compound Cc(ccc(OC(F)(F)F)c1)c1Cl HGSGYJWRWHVTMA-UHFFFAOYSA-N 0.000 description 1
- XEBKPVIIRSQVIC-UHFFFAOYSA-N Cc1cc(C(F)(F)F)ccc1S Chemical compound Cc1cc(C(F)(F)F)ccc1S XEBKPVIIRSQVIC-UHFFFAOYSA-N 0.000 description 1
- LRLRAYMYEXQKID-UHFFFAOYSA-N Cc1ccc(C(F)(F)F)cc1 Chemical compound Cc1ccc(C(F)(F)F)cc1 LRLRAYMYEXQKID-UHFFFAOYSA-N 0.000 description 1
- JAYCCPWHQQRJLI-UHFFFAOYSA-N O=C(c(cccc1)c1C1=O)N1OC1COC(c2ccccc2)OC1 Chemical compound O=C(c(cccc1)c1C1=O)N1OC1COC(c2ccccc2)OC1 JAYCCPWHQQRJLI-UHFFFAOYSA-N 0.000 description 1
- KFCJJPYOSOKYOC-UHFFFAOYSA-N OCC(CONC(c([o]c1ccncc11)c1Nc(c(F)c1)ccc1Br)=O)O Chemical compound OCC(CONC(c([o]c1ccncc11)c1Nc(c(F)c1)ccc1Br)=O)O KFCJJPYOSOKYOC-UHFFFAOYSA-N 0.000 description 1
- OQEBIHBLFRADNM-WISUUJSJSA-N OC[C@H]([C@@H]1O)NC[C@@H]1O Chemical compound OC[C@H]([C@@H]1O)NC[C@@H]1O OQEBIHBLFRADNM-WISUUJSJSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83916106P | 2006-08-21 | 2006-08-21 | |
| US60/839,161 | 2006-08-21 | ||
| US87159106P | 2006-12-22 | 2006-12-22 | |
| US60/871,591 | 2006-12-22 | ||
| US91762307P | 2007-05-11 | 2007-05-11 | |
| US60/917,623 | 2007-05-11 | ||
| US94474107P | 2007-06-18 | 2007-06-18 | |
| US60/944,741 | 2007-06-18 | ||
| PCT/US2007/076344 WO2008024725A1 (en) | 2006-08-21 | 2007-08-20 | Aza-benzofuranyl compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090042332A KR20090042332A (ko) | 2009-04-29 |
| KR101428116B1 true KR101428116B1 (ko) | 2014-08-07 |
Family
ID=38925647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097005786A Expired - Fee Related KR101428116B1 (ko) | 2006-08-21 | 2007-08-20 | 아자-벤조푸라닐 화합물 및 사용 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080085886A1 (enExample) |
| EP (1) | EP2069354B1 (enExample) |
| JP (1) | JP5448818B2 (enExample) |
| KR (1) | KR101428116B1 (enExample) |
| AR (1) | AR062468A1 (enExample) |
| AT (1) | ATE531720T1 (enExample) |
| AU (1) | AU2007286808B2 (enExample) |
| BR (1) | BRPI0714635A2 (enExample) |
| CA (1) | CA2660546A1 (enExample) |
| ES (1) | ES2376771T3 (enExample) |
| IL (1) | IL196956A (enExample) |
| MX (1) | MX2009001878A (enExample) |
| NO (1) | NO20091197L (enExample) |
| PE (1) | PE20080611A1 (enExample) |
| TW (1) | TWI411614B (enExample) |
| WO (1) | WO2008024725A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5349306B2 (ja) * | 2006-08-21 | 2013-11-20 | ジェネンテック， インコーポレイテッド | アザベンゾチオフェニル化合物および使用方法 |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| EP2085390A1 (en) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
| US9084781B2 (en) | 2008-12-10 | 2015-07-21 | Novartis Ag | MEK mutations conferring resistance to MEK inhibitors |
| AU2010237801A1 (en) | 2009-04-14 | 2011-10-20 | Syngenta Participations Ag | Haloalkylsulfonanilide derivative |
| CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
| WO2011106298A1 (en) | 2010-02-25 | 2011-09-01 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
| BR112012022801B8 (pt) | 2010-03-09 | 2019-10-29 | Dana Farber Cancer Inst Inc | método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer |
| US20120157448A1 (en) | 2010-11-22 | 2012-06-21 | Adam Cook | Compounds for treating neurodegenerative diseases |
| WO2012163799A1 (en) | 2011-05-27 | 2012-12-06 | Bayer Intellectual Property Gmbh | Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides |
| AR087405A1 (es) * | 2011-08-01 | 2014-03-19 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| CA2890238A1 (en) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| KR20240110004A (ko) | 2014-03-14 | 2024-07-12 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| SG10202007111TA (en) | 2014-07-15 | 2020-09-29 | Genentech Inc | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| ES2771926T3 (es) | 2014-09-13 | 2020-07-07 | Novartis Ag | Terapias de combinación |
| JP2017535528A (ja) | 2014-10-03 | 2017-11-30 | ノバルティス アーゲー | 組み合わせ治療 |
| US9988452B2 (en) | 2014-10-14 | 2018-06-05 | Novartis Ag | Antibody molecules to PD-L1 and uses thereof |
| EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| WO2017019894A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| CN108025051B (zh) | 2015-07-29 | 2021-12-24 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| HRP20220436T1 (hr) | 2015-11-03 | 2022-05-27 | Janssen Biotech, Inc. | Protutijela koja se specifično vežu na pd-1 i njihove uporabe |
| CN106883270B (zh) | 2015-11-26 | 2019-03-26 | 财团法人工业技术研究院 | 有机金属化合物、包含其的有机发光装置 |
| CA3007671A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
| KR20180134347A (ko) | 2016-04-15 | 2018-12-18 | 제넨테크, 인크. | 암의 진단 및 치료 방법 |
| KR102642411B1 (ko) | 2017-05-19 | 2024-02-28 | 엔플렉션 테라퓨틱스, 인코포레이티드 | 피부병 치료를 위한 피롤로피리딘-아닐린 화합물 |
| ES2913213T3 (es) | 2017-05-19 | 2022-06-01 | Nflection Therapeutics Inc | Compuestos heteroaromáticos de anilina condensados para el tratamiento de trastornos dérmicos |
| US11859252B2 (en) | 2017-09-08 | 2024-01-02 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| MX2020004756A (es) | 2017-11-16 | 2020-08-20 | Novartis Ag | Terapias de combinacion. |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| EP3752200A1 (en) | 2018-02-13 | 2020-12-23 | Vib Vzw | Targeting minimal residual disease in cancer with rxr antagonists |
| SG11202011633SA (en) | 2018-05-24 | 2020-12-30 | Janssen Biotech Inc | Psma binding agents and uses thereof |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| JP7393808B2 (ja) | 2018-11-20 | 2023-12-07 | エヌフレクション セラピューティクス インコーポレイテッド | 皮膚障害の処置のためのナフチリジノン－アニリン化合物 |
| MA55141A (fr) | 2018-11-20 | 2021-09-29 | Nflection Therapeutics Inc | Composés cyanoaryl-aniline pour le traitement d'affections de la peau |
| CN117551073A (zh) | 2018-11-20 | 2024-02-13 | 恩福莱克逊治疗有限公司 | 用于治疗皮肤疾病噻吩基苯胺化合物 |
| AU2019402189B2 (en) | 2018-12-20 | 2023-04-13 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| BR112021015783A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina-2,6-diona e usos dos mesmos |
| CN113329792B (zh) | 2019-02-15 | 2024-06-28 | 诺华股份有限公司 | 取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| BR112021020532A2 (pt) | 2019-04-19 | 2022-03-15 | Janssen Biotech Inc | Métodos para tratamento de câncer de próstata com um anticorpo anti-psma/cd3 |
| AU2020406350A1 (en) | 2019-12-20 | 2022-08-11 | Novartis Ag | Uses of anti-TGF-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
| CA3182346A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
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2007
- 2007-08-20 CA CA002660546A patent/CA2660546A1/en not_active Abandoned
- 2007-08-20 BR BRPI0714635-3A patent/BRPI0714635A2/pt not_active IP Right Cessation
- 2007-08-20 KR KR1020097005786A patent/KR101428116B1/ko not_active Expired - Fee Related
- 2007-08-20 MX MX2009001878A patent/MX2009001878A/es active IP Right Grant
- 2007-08-20 AT AT07814272T patent/ATE531720T1/de active
- 2007-08-20 WO PCT/US2007/076344 patent/WO2008024725A1/en not_active Ceased
- 2007-08-20 EP EP07814272A patent/EP2069354B1/en active Active
- 2007-08-20 JP JP2009525720A patent/JP5448818B2/ja not_active Expired - Fee Related
- 2007-08-20 US US11/894,506 patent/US20080085886A1/en not_active Abandoned
- 2007-08-20 ES ES07814272T patent/ES2376771T3/es active Active
- 2007-08-20 AU AU2007286808A patent/AU2007286808B2/en not_active Ceased
- 2007-08-21 AR ARP070103712A patent/AR062468A1/es unknown
- 2007-08-21 TW TW096130982A patent/TWI411614B/zh not_active IP Right Cessation
- 2007-08-21 PE PE2007001135A patent/PE20080611A1/es not_active Application Discontinuation
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2009
- 2009-02-09 IL IL196956A patent/IL196956A/en not_active IP Right Cessation
- 2009-03-20 NO NO20091197A patent/NO20091197L/no not_active Application Discontinuation
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| WO2005061476A2 (en) * | 2003-12-22 | 2005-07-07 | Basilea Pharmaceutica Ag | Aroylfuranes and aroylthiophenes |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20080611A1 (es) | 2008-07-21 |
| TWI411614B (zh) | 2013-10-11 |
| NO20091197L (no) | 2009-05-20 |
| KR20090042332A (ko) | 2009-04-29 |
| JP5448818B2 (ja) | 2014-03-19 |
| TW200817415A (en) | 2008-04-16 |
| ES2376771T3 (es) | 2012-03-16 |
| MX2009001878A (es) | 2009-03-03 |
| US20080085886A1 (en) | 2008-04-10 |
| WO2008024725A1 (en) | 2008-02-28 |
| AR062468A1 (es) | 2008-11-12 |
| IL196956A0 (en) | 2009-11-18 |
| JP2010501585A (ja) | 2010-01-21 |
| AU2007286808B2 (en) | 2012-12-06 |
| CA2660546A1 (en) | 2008-02-28 |
| IL196956A (en) | 2014-04-30 |
| BRPI0714635A2 (pt) | 2013-06-18 |
| ATE531720T1 (de) | 2011-11-15 |
| AU2007286808A1 (en) | 2008-02-28 |
| EP2069354B1 (en) | 2011-11-02 |
| EP2069354A1 (en) | 2009-06-17 |
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