NO20091197L - Azabenzofuranylforbindelser og anvendelser derav - Google Patents
Azabenzofuranylforbindelser og anvendelser deravInfo
- Publication number
- NO20091197L NO20091197L NO20091197A NO20091197A NO20091197L NO 20091197 L NO20091197 L NO 20091197L NO 20091197 A NO20091197 A NO 20091197A NO 20091197 A NO20091197 A NO 20091197A NO 20091197 L NO20091197 L NO 20091197L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- treat
- methods
- relates
- azabenzofuranyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Oppfinnelsen vedrører zabenzo-furanylforbindelser med formel (I) med antikreft- og/eller antiinflammatorisk aktivitet, og nærmere bestemt azabenzofuranylforbindelser som inhiberer MEK-kinaseaktivitet. Oppfinnelsen tilveiebringer preparater og fremgangsmåter som kan anvendes til inhibering av unormal cellevekst eller behandling av en hyperproliferativ forstyrrelse, eller behandling av en inflammatorisk sykdom hos et pattedyr. Oppfinnelsen vedrører også fremgangsmåter for anvendelse av forbindelsene til diagnose eller behandling in vitro, in situ og in vivo av pattedyrceller eller ledsagende patologiske tilstander.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83916106P | 2006-08-21 | 2006-08-21 | |
US87159106P | 2006-12-22 | 2006-12-22 | |
US91762307P | 2007-05-11 | 2007-05-11 | |
US94474107P | 2007-06-18 | 2007-06-18 | |
PCT/US2007/076344 WO2008024725A1 (en) | 2006-08-21 | 2007-08-20 | Aza-benzofuranyl compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091197L true NO20091197L (no) | 2009-05-20 |
Family
ID=38925647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091197A NO20091197L (no) | 2006-08-21 | 2009-03-20 | Azabenzofuranylforbindelser og anvendelser derav |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080085886A1 (no) |
EP (1) | EP2069354B1 (no) |
JP (1) | JP5448818B2 (no) |
KR (1) | KR101428116B1 (no) |
AR (1) | AR062468A1 (no) |
AT (1) | ATE531720T1 (no) |
AU (1) | AU2007286808B2 (no) |
BR (1) | BRPI0714635A2 (no) |
CA (1) | CA2660546A1 (no) |
ES (1) | ES2376771T3 (no) |
IL (1) | IL196956A (no) |
MX (1) | MX2009001878A (no) |
NO (1) | NO20091197L (no) |
PE (1) | PE20080611A1 (no) |
TW (1) | TWI411614B (no) |
WO (1) | WO2008024725A1 (no) |
Families Citing this family (50)
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WO2009073620A2 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics | Ido inhibitors |
EP2085390A1 (en) * | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Mek阻害剤に対する耐性を付与するmek突然変異 |
US20120029187A1 (en) | 2009-04-14 | 2012-02-02 | Nissan Chemical Industries, Ltd. | Haloalkylsulfonanilide derivative |
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CA2791247C (en) | 2010-03-09 | 2019-05-14 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
AR083953A1 (es) | 2010-11-22 | 2013-04-10 | Array Biopharma Inc | Compuestos para tratar enfermedades neurodegenerativas |
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US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
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CN116617401A (zh) | 2014-07-15 | 2023-08-22 | 豪夫迈·罗氏有限公司 | 使用pd-1轴结合拮抗剂和mek抑制剂治疗癌症的组合物 |
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AU2016369537B2 (en) | 2015-12-17 | 2024-03-14 | Novartis Ag | Antibody molecules to PD-1 and uses thereof |
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MA49140A (fr) * | 2017-05-19 | 2020-03-25 | Nflection Therapeutics Inc | Composés hétéroaromatiques-aniline fusionnés pour le traitement de troubles dermiques |
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WO2022169780A1 (en) | 2021-02-02 | 2022-08-11 | Les Laboratoires Servier | Selective bcl-xl protac compounds and methods of use |
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FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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-
2007
- 2007-08-20 JP JP2009525720A patent/JP5448818B2/ja not_active Expired - Fee Related
- 2007-08-20 AU AU2007286808A patent/AU2007286808B2/en not_active Ceased
- 2007-08-20 ES ES07814272T patent/ES2376771T3/es active Active
- 2007-08-20 MX MX2009001878A patent/MX2009001878A/es active IP Right Grant
- 2007-08-20 BR BRPI0714635-3A patent/BRPI0714635A2/pt not_active IP Right Cessation
- 2007-08-20 AT AT07814272T patent/ATE531720T1/de active
- 2007-08-20 US US11/894,506 patent/US20080085886A1/en not_active Abandoned
- 2007-08-20 WO PCT/US2007/076344 patent/WO2008024725A1/en active Application Filing
- 2007-08-20 CA CA002660546A patent/CA2660546A1/en not_active Abandoned
- 2007-08-20 EP EP07814272A patent/EP2069354B1/en active Active
- 2007-08-20 KR KR1020097005786A patent/KR101428116B1/ko not_active IP Right Cessation
- 2007-08-21 TW TW096130982A patent/TWI411614B/zh not_active IP Right Cessation
- 2007-08-21 PE PE2007001135A patent/PE20080611A1/es not_active Application Discontinuation
- 2007-08-21 AR ARP070103712A patent/AR062468A1/es unknown
-
2009
- 2009-02-09 IL IL196956A patent/IL196956A/en not_active IP Right Cessation
- 2009-03-20 NO NO20091197A patent/NO20091197L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2007286808A1 (en) | 2008-02-28 |
PE20080611A1 (es) | 2008-07-21 |
AU2007286808B2 (en) | 2012-12-06 |
MX2009001878A (es) | 2009-03-03 |
IL196956A0 (en) | 2009-11-18 |
KR101428116B1 (ko) | 2014-08-07 |
US20080085886A1 (en) | 2008-04-10 |
EP2069354B1 (en) | 2011-11-02 |
ATE531720T1 (de) | 2011-11-15 |
IL196956A (en) | 2014-04-30 |
ES2376771T3 (es) | 2012-03-16 |
JP5448818B2 (ja) | 2014-03-19 |
JP2010501585A (ja) | 2010-01-21 |
KR20090042332A (ko) | 2009-04-29 |
TW200817415A (en) | 2008-04-16 |
EP2069354A1 (en) | 2009-06-17 |
CA2660546A1 (en) | 2008-02-28 |
AR062468A1 (es) | 2008-11-12 |
BRPI0714635A2 (pt) | 2013-06-18 |
TWI411614B (zh) | 2013-10-11 |
WO2008024725A1 (en) | 2008-02-28 |
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