KR101382871B1 - Ｈｄｌ-콜레스테롤 상승제로서 5-(3,4-다이클로로-페닐)-ｎ-(2-하이드록시-사이클로헥실)-6-(2,2,2-트라이플루오로-에톡시)-니코틴아미드 및 이의 염 - Google Patents

Ｈｄｌ-콜레스테롤 상승제로서 5-(3,4-다이클로로-페닐)-ｎ-(2-하이드록시-사이클로헥실)-6-(2,2,2-트라이플루오로-에톡시)-니코틴아미드 및 이의 염 Download PDF

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KR101382871B1
KR101382871B1 KR1020127008704A KR20127008704A KR101382871B1 KR 101382871 B1 KR101382871 B1 KR 101382871B1 KR 1020127008704 A KR1020127008704 A KR 1020127008704A KR 20127008704 A KR20127008704 A KR 20127008704A KR 101382871 B1 KR101382871 B1 KR 101382871B1
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formula
compound
trifluoro
ethoxy
acid
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KR20120048040A (ko
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스테판 로에베르
매튜 롸이트
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에프. 호프만-라 로슈 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020127008704A 2009-09-11 2010-09-08 Ｈｄｌ-콜레스테롤 상승제로서 5-(3,4-다이클로로-페닐)-ｎ-(2-하이드록시-사이클로헥실)-6-(2,2,2-트라이플루오로-에톡시)-니코틴아미드 및 이의 염 Active KR101382871B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09170097 2009-09-11
EP09170097.1 2009-09-11
PCT/EP2010/063136 WO2011029827A1 (en) 2009-09-11 2010-09-08 5- (3, 4-dichloro-phenyl) -n- (2-hydroxy-cyclohexyl) -6- (2,2, 2-trifluoro-ethoxy) -nico tinamide and salts thereof as hdl cholesterol raising agents

Publications (2)

Publication Number Publication Date
KR20120048040A KR20120048040A (ko) 2012-05-14
KR101382871B1 true KR101382871B1 (ko) 2014-04-08

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KR1020127008704A Active KR101382871B1 (ko) 2009-09-11 2010-09-08 Ｈｄｌ-콜레스테롤 상승제로서 5-(3,4-다이클로로-페닐)-ｎ-(2-하이드록시-사이클로헥실)-6-(2,2,2-트라이플루오로-에톡시)-니코틴아미드 및 이의 염

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Country Link
US (1) US8227491B2 (https=)
EP (1) EP2475645B1 (https=)
JP (1) JP5604520B2 (https=)
KR (1) KR101382871B1 (https=)
CN (1) CN102639506B (https=)
AR (2) AR078352A1 (https=)
AU (1) AU2010294277B2 (https=)
BR (1) BR112012005511B8 (https=)
CA (1) CA2771493C (https=)
CL (1) CL2012000611A1 (https=)
CO (1) CO6491033A2 (https=)
CR (1) CR20120089A (https=)
CY (1) CY1114377T1 (https=)
DK (1) DK2475645T3 (https=)
EC (1) ECSP12011723A (https=)
ES (1) ES2423821T3 (https=)
HR (1) HRP20130869T1 (https=)
IL (1) IL217920A (https=)
IN (1) IN2012DN00763A (https=)
MA (1) MA33563B1 (https=)
MX (1) MX2012002254A (https=)
MY (1) MY161103A (https=)
NZ (1) NZ597514A (https=)
PE (1) PE20120863A1 (https=)
PL (1) PL2475645T3 (https=)
PT (1) PT2475645E (https=)
RS (1) RS52987B (https=)
RU (1) RU2541475C2 (https=)
SG (1) SG179035A1 (https=)
SI (1) SI2475645T1 (https=)
TW (1) TWI412363B (https=)
UA (1) UA107088C2 (https=)
WO (1) WO2011029827A1 (https=)
ZA (1) ZA201201599B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012031817A1 (en) 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US8410107B2 (en) 2010-10-15 2013-04-02 Hoffmann-La Roche Inc. N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
US20120101282A1 (en) * 2010-10-22 2012-04-26 Pascal Dott Process for the preparation of nicotinamide derivatives
US8669254B2 (en) 2010-12-15 2014-03-11 Hoffman-La Roche Inc. Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents
WO2014180741A1 (en) * 2013-05-06 2014-11-13 F. Hoffmann-La Roche Ag Methods of identifying modulators of osbpl7 and the use of such modulators for treatment of diseases associated with osbpl7
US20200085810A1 (en) 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders
US11814354B2 (en) * 2021-09-08 2023-11-14 River 3 Renal Corp. Solid forms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070110122A (ko) * 2005-04-06 2007-11-15 에프. 호프만-라 로슈 아게 Ｃｂ1 역 작용제로서 피리딘-3-카복사마이드 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
KR101107896B1 (ko) 2006-10-04 2012-01-25 에프. 호프만-라 로슈 아게 고 밀도 지단백질(ｈｄｌ)-콜레스테롤 상승제로서 3-피리딘카복스아마이드 및 2-피라진카복스아마이드 유도체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070110122A (ko) * 2005-04-06 2007-11-15 에프. 호프만-라 로슈 아게 Ｃｂ1 역 작용제로서 피리딘-3-카복사마이드 유도체

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ES2423821T3 (es) 2013-09-24
HK1172021A1 (en) 2013-04-12
SI2475645T1 (sl) 2013-10-30
PL2475645T3 (pl) 2013-12-31
IL217920A (en) 2015-11-30
AR078352A1 (es) 2011-11-02
CO6491033A2 (es) 2012-07-31
AU2010294277B2 (en) 2015-07-09
CL2012000611A1 (es) 2012-09-07
NZ597514A (en) 2013-10-25
SG179035A1 (en) 2012-04-27
RU2541475C2 (ru) 2015-02-20
RS52987B (sr) 2014-02-28
ZA201201599B (en) 2012-11-28
TW201114427A (en) 2011-05-01
CY1114377T1 (el) 2016-08-31
JP5604520B2 (ja) 2014-10-08
IN2012DN00763A (https=) 2015-06-26
BR112012005511A2 (pt) 2016-04-19
ECSP12011723A (es) 2012-04-30
CN102639506A (zh) 2012-08-15
CN102639506B (zh) 2014-09-03
DK2475645T3 (da) 2013-07-22
IL217920A0 (en) 2012-03-29
BR112012005511B1 (pt) 2021-03-02
KR20120048040A (ko) 2012-05-14
HRP20130869T1 (hr) 2013-10-25
CR20120089A (es) 2012-03-22
EP2475645B1 (en) 2013-07-03
AR114032A2 (es) 2020-07-15
WO2011029827A1 (en) 2011-03-17
MY161103A (en) 2017-04-14
UA107088C2 (xx) 2014-11-25
MA33563B1 (fr) 2012-09-01
JP2013504534A (ja) 2013-02-07
CA2771493C (en) 2017-08-29
PT2475645E (pt) 2013-08-05
MX2012002254A (es) 2012-03-16
RU2012113924A (ru) 2013-10-20
PE20120863A1 (es) 2012-07-23
EP2475645A1 (en) 2012-07-18
AU2010294277A1 (en) 2012-02-09
US8227491B2 (en) 2012-07-24
TWI412363B (zh) 2013-10-21
US20110065759A1 (en) 2011-03-17
CA2771493A1 (en) 2011-03-17
BR112012005511B8 (pt) 2021-05-25

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