SI2475645T1 - 5-(3,4-dikloro-fenil)-n-(2-hidroksi-cikloheksil)-6(2,2,2-trifluoro- etoksi)-nikotinamid in njegove soli kot sredstva za dvig holesterola hdl - Google Patents

5-(3,4-dikloro-fenil)-n-(2-hidroksi-cikloheksil)-6(2,2,2-trifluoro- etoksi)-nikotinamid in njegove soli kot sredstva za dvig holesterola hdl

Info

Publication number
SI2475645T1
SI2475645T1 SI201030327T SI201030327T SI2475645T1 SI 2475645 T1 SI2475645 T1 SI 2475645T1 SI 201030327 T SI201030327 T SI 201030327T SI 201030327 T SI201030327 T SI 201030327T SI 2475645 T1 SI2475645 T1 SI 2475645T1
Authority
SI
Slovenia
Prior art keywords
nicotinamide
trifluoro
dichloro
ethoxy
cyclohexyl
Prior art date
Application number
SI201030327T
Other languages
English (en)
Inventor
Stephan Roever
Matthew Wright
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of SI2475645T1 publication Critical patent/SI2475645T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201030327T 2009-09-11 2010-09-08 5-(3,4-dikloro-fenil)-n-(2-hidroksi-cikloheksil)-6(2,2,2-trifluoro- etoksi)-nikotinamid in njegove soli kot sredstva za dvig holesterola hdl SI2475645T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09170097 2009-09-11
EP10749873.5A EP2475645B1 (en) 2009-09-11 2010-09-08 5-(3,4-dichloro-phenyl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide and salts thereof as hdl cholesterol raising agents
PCT/EP2010/063136 WO2011029827A1 (en) 2009-09-11 2010-09-08 5- (3, 4-dichloro-phenyl) -n- (2-hydroxy-cyclohexyl) -6- (2,2, 2-trifluoro-ethoxy) -nico tinamide and salts thereof as hdl cholesterol raising agents

Publications (1)

Publication Number Publication Date
SI2475645T1 true SI2475645T1 (sl) 2013-10-30

Family

ID=42830122

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030327T SI2475645T1 (sl) 2009-09-11 2010-09-08 5-(3,4-dikloro-fenil)-n-(2-hidroksi-cikloheksil)-6(2,2,2-trifluoro- etoksi)-nikotinamid in njegove soli kot sredstva za dvig holesterola hdl

Country Status (35)

Country Link
US (1) US8227491B2 (sl)
EP (1) EP2475645B1 (sl)
JP (1) JP5604520B2 (sl)
KR (1) KR101382871B1 (sl)
CN (1) CN102639506B (sl)
AR (2) AR078352A1 (sl)
AU (1) AU2010294277B2 (sl)
BR (1) BR112012005511B8 (sl)
CA (1) CA2771493C (sl)
CL (1) CL2012000611A1 (sl)
CO (1) CO6491033A2 (sl)
CR (1) CR20120089A (sl)
CY (1) CY1114377T1 (sl)
DK (1) DK2475645T3 (sl)
EC (1) ECSP12011723A (sl)
ES (1) ES2423821T3 (sl)
HK (1) HK1172021A1 (sl)
HR (1) HRP20130869T1 (sl)
IL (1) IL217920A (sl)
IN (1) IN2012DN00763A (sl)
MA (1) MA33563B1 (sl)
MX (1) MX2012002254A (sl)
MY (1) MY161103A (sl)
NZ (1) NZ597514A (sl)
PE (1) PE20120863A1 (sl)
PL (1) PL2475645T3 (sl)
PT (1) PT2475645E (sl)
RS (1) RS52987B (sl)
RU (1) RU2541475C2 (sl)
SG (1) SG179035A1 (sl)
SI (1) SI2475645T1 (sl)
TW (1) TWI412363B (sl)
UA (1) UA107088C2 (sl)
WO (1) WO2011029827A1 (sl)
ZA (1) ZA201201599B (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012031817A1 (en) 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US8410107B2 (en) 2010-10-15 2013-04-02 Hoffmann-La Roche Inc. N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
US20120101282A1 (en) * 2010-10-22 2012-04-26 Pascal Dott Process for the preparation of nicotinamide derivatives
US8669254B2 (en) 2010-12-15 2014-03-11 Hoffman-La Roche Inc. Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents
WO2014180741A1 (en) * 2013-05-06 2014-11-13 F. Hoffmann-La Roche Ag Methods of identifying modulators of osbpl7 and the use of such modulators for treatment of diseases associated with osbpl7
US20200085810A1 (en) 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders
US11814354B2 (en) * 2021-09-08 2023-11-14 River 3 Renal Corp. Solid forms

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
RU2404164C2 (ru) 2005-04-06 2010-11-20 Ф.Хоффманн-Ля Рош Аг Производные пиридин-3-карбоксамида в качестве обратных агонистов св1
MX2009003222A (es) 2006-10-04 2009-04-06 Hoffmann La Roche Derivados de 3-piridinocarboxamida y 2-pirazinocarboxamida como agentes elevadores de colesterol de lipoproteina de alta densidad.

Also Published As

Publication number Publication date
PT2475645E (pt) 2013-08-05
CN102639506A (zh) 2012-08-15
BR112012005511A2 (pt) 2016-04-19
BR112012005511B8 (pt) 2021-05-25
CY1114377T1 (el) 2016-08-31
RU2541475C2 (ru) 2015-02-20
MY161103A (en) 2017-04-14
PL2475645T3 (pl) 2013-12-31
MX2012002254A (es) 2012-03-16
EP2475645B1 (en) 2013-07-03
TWI412363B (zh) 2013-10-21
JP2013504534A (ja) 2013-02-07
ES2423821T3 (es) 2013-09-24
CO6491033A2 (es) 2012-07-31
KR101382871B1 (ko) 2014-04-08
UA107088C2 (xx) 2014-11-25
RS52987B (en) 2014-02-28
US20110065759A1 (en) 2011-03-17
AU2010294277B2 (en) 2015-07-09
ECSP12011723A (es) 2012-04-30
WO2011029827A1 (en) 2011-03-17
US8227491B2 (en) 2012-07-24
AU2010294277A1 (en) 2012-02-09
IL217920A0 (en) 2012-03-29
TW201114427A (en) 2011-05-01
DK2475645T3 (da) 2013-07-22
AR114032A2 (es) 2020-07-15
RU2012113924A (ru) 2013-10-20
IN2012DN00763A (sl) 2015-06-26
IL217920A (en) 2015-11-30
CR20120089A (es) 2012-03-22
NZ597514A (en) 2013-10-25
HK1172021A1 (en) 2013-04-12
ZA201201599B (en) 2012-11-28
CL2012000611A1 (es) 2012-09-07
CA2771493C (en) 2017-08-29
PE20120863A1 (es) 2012-07-23
EP2475645A1 (en) 2012-07-18
CA2771493A1 (en) 2011-03-17
CN102639506B (zh) 2014-09-03
JP5604520B2 (ja) 2014-10-08
MA33563B1 (fr) 2012-09-01
HRP20130869T1 (hr) 2013-10-25
AR078352A1 (es) 2011-11-02
KR20120048040A (ko) 2012-05-14
BR112012005511B1 (pt) 2021-03-02
SG179035A1 (en) 2012-04-27

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