MA33563B1 - 5-(3,4-dichloro-phényl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-éthoxy)-nicotinamide et ses sels utilisés comme agents augmentant le cholestérol hdl - Google Patents
5-(3,4-dichloro-phényl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-éthoxy)-nicotinamide et ses sels utilisés comme agents augmentant le cholestérol hdlInfo
- Publication number
- MA33563B1 MA33563B1 MA34662A MA34662A MA33563B1 MA 33563 B1 MA33563 B1 MA 33563B1 MA 34662 A MA34662 A MA 34662A MA 34662 A MA34662 A MA 34662A MA 33563 B1 MA33563 B1 MA 33563B1
- Authority
- MA
- Morocco
- Prior art keywords
- hdl cholesterol
- trichloroetoxy
- nectanamide
- dichlorophenyl
- cyclohexyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Cette invention concerne un composé représenté par tous les isomères de la formule et ses sels pharmaceutiquement acceptables, leur fabrication, les compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments dans le traitement et/ou la prophylaxie des maladies pouvant être traitées par des agents augmentant le cholestérol hdl, notamment la dyslipémie, l'athérosclérose et les maladies cardiovasculaires.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09170097 | 2009-09-11 | ||
PCT/EP2010/063136 WO2011029827A1 (fr) | 2009-09-11 | 2010-09-08 | 5-(3,4-dichloro-phényl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-éthoxy)-nicotinamide et ses sels utilisés comme agents augmentant le cholestérol hdl |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33563B1 true MA33563B1 (fr) | 2012-09-01 |
Family
ID=42830122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34662A MA33563B1 (fr) | 2009-09-11 | 2012-03-05 | 5-(3,4-dichloro-phényl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-éthoxy)-nicotinamide et ses sels utilisés comme agents augmentant le cholestérol hdl |
Country Status (35)
Country | Link |
---|---|
US (1) | US8227491B2 (fr) |
EP (1) | EP2475645B1 (fr) |
JP (1) | JP5604520B2 (fr) |
KR (1) | KR101382871B1 (fr) |
CN (1) | CN102639506B (fr) |
AR (2) | AR078352A1 (fr) |
AU (1) | AU2010294277B2 (fr) |
BR (1) | BR112012005511B8 (fr) |
CA (1) | CA2771493C (fr) |
CL (1) | CL2012000611A1 (fr) |
CO (1) | CO6491033A2 (fr) |
CR (1) | CR20120089A (fr) |
CY (1) | CY1114377T1 (fr) |
DK (1) | DK2475645T3 (fr) |
EC (1) | ECSP12011723A (fr) |
ES (1) | ES2423821T3 (fr) |
HK (1) | HK1172021A1 (fr) |
HR (1) | HRP20130869T1 (fr) |
IL (1) | IL217920A (fr) |
IN (1) | IN2012DN00763A (fr) |
MA (1) | MA33563B1 (fr) |
MX (1) | MX2012002254A (fr) |
MY (1) | MY161103A (fr) |
NZ (1) | NZ597514A (fr) |
PE (1) | PE20120863A1 (fr) |
PL (1) | PL2475645T3 (fr) |
PT (1) | PT2475645E (fr) |
RS (1) | RS52987B (fr) |
RU (1) | RU2541475C2 (fr) |
SG (1) | SG179035A1 (fr) |
SI (1) | SI2475645T1 (fr) |
TW (1) | TWI412363B (fr) |
UA (1) | UA107088C2 (fr) |
WO (1) | WO2011029827A1 (fr) |
ZA (1) | ZA201201599B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012031817A1 (fr) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Détermination des niveaux de protéine abca1 dans des cellules |
US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
US20120101282A1 (en) * | 2010-10-22 | 2012-04-26 | Pascal Dott | Process for the preparation of nicotinamide derivatives |
US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
WO2014180741A1 (fr) * | 2013-05-06 | 2014-11-13 | F. Hoffmann-La Roche Ag | Procédés d'identification de modulateurs d'osbpl7 et utilisation de ces modulateurs pour traiter les maladies associées à osbpl7 |
US20200085810A1 (en) | 2018-07-26 | 2020-03-19 | Hoffmann-La Roche Inc. | Compounds for use in treating kidney disorders |
US11814354B2 (en) | 2021-09-08 | 2023-11-14 | River 3 Renal Corp. | Solid forms |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
DK1868999T3 (da) * | 2005-04-06 | 2009-08-17 | Hoffmann La Roche | Pyridin-3-carboxamidderivater som omvendte CB1-agonister |
BRPI0717845A2 (pt) | 2006-10-04 | 2015-06-16 | Hoffmann La Roche | Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos |
-
2010
- 2010-08-09 UA UAA201204339A patent/UA107088C2/ru unknown
- 2010-09-03 US US12/875,196 patent/US8227491B2/en active Active
- 2010-09-08 SI SI201030327T patent/SI2475645T1/sl unknown
- 2010-09-08 ES ES10749873T patent/ES2423821T3/es active Active
- 2010-09-08 PL PL10749873T patent/PL2475645T3/pl unknown
- 2010-09-08 EP EP10749873.5A patent/EP2475645B1/fr active Active
- 2010-09-08 SG SG2012016127A patent/SG179035A1/en unknown
- 2010-09-08 PE PE2012000302A patent/PE20120863A1/es active IP Right Grant
- 2010-09-08 NZ NZ597514A patent/NZ597514A/xx unknown
- 2010-09-08 MY MYPI2012001104A patent/MY161103A/en unknown
- 2010-09-08 DK DK10749873.5T patent/DK2475645T3/da active
- 2010-09-08 KR KR1020127008704A patent/KR101382871B1/ko active IP Right Grant
- 2010-09-08 TW TW099130367A patent/TWI412363B/zh active
- 2010-09-08 IN IN763DEN2012 patent/IN2012DN00763A/en unknown
- 2010-09-08 AU AU2010294277A patent/AU2010294277B2/en active Active
- 2010-09-08 BR BR112012005511A patent/BR112012005511B8/pt active IP Right Grant
- 2010-09-08 JP JP2012528344A patent/JP5604520B2/ja active Active
- 2010-09-08 PT PT107498735T patent/PT2475645E/pt unknown
- 2010-09-08 RS RS20130395A patent/RS52987B/en unknown
- 2010-09-08 CA CA2771493A patent/CA2771493C/fr active Active
- 2010-09-08 CN CN201080039932.7A patent/CN102639506B/zh active Active
- 2010-09-08 RU RU2012113924/04A patent/RU2541475C2/ru active
- 2010-09-08 MX MX2012002254A patent/MX2012002254A/es active IP Right Grant
- 2010-09-08 WO PCT/EP2010/063136 patent/WO2011029827A1/fr active Application Filing
- 2010-09-09 AR ARP100103303A patent/AR078352A1/es not_active Application Discontinuation
-
2012
- 2012-01-12 CO CO12004250A patent/CO6491033A2/es active IP Right Grant
- 2012-02-02 IL IL217920A patent/IL217920A/en active IP Right Grant
- 2012-02-21 CR CR20120089A patent/CR20120089A/es unknown
- 2012-03-02 ZA ZA2012/01599A patent/ZA201201599B/en unknown
- 2012-03-03 EC ECSP12011723 patent/ECSP12011723A/es unknown
- 2012-03-05 MA MA34662A patent/MA33563B1/fr unknown
- 2012-03-08 CL CL2012000611A patent/CL2012000611A1/es unknown
- 2012-12-12 HK HK12112824.3A patent/HK1172021A1/xx unknown
-
2013
- 2013-09-05 CY CY20131100768T patent/CY1114377T1/el unknown
- 2013-09-16 HR HRP20130869AT patent/HRP20130869T1/hr unknown
-
2018
- 2018-11-16 AR ARP180103371A patent/AR114032A2/es unknown
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