KR101376479B1 - 뮤 오피오이드 수용체 안타고니스트인 ８­아자비시클로［３．２．１］옥탄 화합물 - Google Patents

뮤 오피오이드 수용체 안타고니스트인 ８­아자비시클로［３．２．１］옥탄 화합물 Download PDF

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KR101376479B1
KR101376479B1 KR1020087024027A KR20087024027A KR101376479B1 KR 101376479 B1 KR101376479 B1 KR 101376479B1 KR 1020087024027 A KR1020087024027 A KR 1020087024027A KR 20087024027 A KR20087024027 A KR 20087024027A KR 101376479 B1 KR101376479 B1 KR 101376479B1
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endo
azabicyclo
oct
ethyl
benzamide
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KR20080100282A (ko
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다니엘 롱
티모시 제이. 쳐치
존 알. 야콥센
란 지앙
다이스케 롤랜드 사이토
이오안나 스터지아데스
다이크 프리실라 반
션 달지엘
레티샤 프레자
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세라밴스 인코포레이티드
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Assigned to 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 reassignment 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 권리의 전부이전등록 Assignors: 세라밴스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087024027A 2006-03-01 2007-02-28 뮤 오피오이드 수용체 안타고니스트인 ８­아자비시클로［３．２．１］옥탄 화합물 Active KR101376479B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US60/777,962 2006-03-01
US84102806P 2006-08-30 2006-08-30
US60/841,028 2006-08-30
PCT/US2007/005388 WO2007103187A2 (en) 2006-03-01 2007-02-28 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Publications (2)

Publication Number Publication Date
KR20080100282A KR20080100282A (ko) 2008-11-14
KR101376479B1 true KR101376479B1 (ko) 2014-03-27

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ID=38436795

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KR1020087024027A Active KR101376479B1 (ko) 2006-03-01 2007-02-28 뮤 오피오이드 수용체 안타고니스트인 ８­아자비시클로［３．２．１］옥탄 화합물

Country Status (24)

Country Link
US (11) US7622508B2 (https=)
EP (1) EP2001876B1 (https=)
JP (2) JP5086280B2 (https=)
KR (1) KR101376479B1 (https=)
AR (1) AR059690A1 (https=)
AT (1) ATE509928T1 (https=)
AU (1) AU2007224213B2 (https=)
BR (1) BRPI0708490B8 (https=)
CA (1) CA2646409C (https=)
CY (1) CY1111747T1 (https=)
DK (1) DK2001876T3 (https=)
HR (1) HRP20110590T1 (https=)
IL (1) IL193690A (https=)
MA (1) MA30284B1 (https=)
MX (1) MX2008011165A (https=)
MY (1) MY145633A (https=)
NZ (1) NZ570764A (https=)
PE (1) PE20071311A1 (https=)
PL (1) PL2001876T3 (https=)
PT (1) PT2001876E (https=)
RU (1) RU2423362C2 (https=)
SI (1) SI2001876T1 (https=)
TW (1) TWI379832B (https=)
WO (1) WO2007103187A2 (https=)

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MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2390195T3 (es) * 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
CA2774021A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
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KR101848116B1 (ko) 2011-02-01 2018-04-11 바이엘 인텔렉쳐 프로퍼티 게엠베하 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체
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HK1247105A1 (zh) 2015-04-02 2018-09-21 Theravance Biopharma R&D Ip, Llc Mu类鸦片受体拮抗剂与类鸦片药剂的组合剂型
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KR20230154789A (ko) * 2020-11-06 2023-11-09 액티노젠 메디컬 리미티드 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정

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TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
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ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten

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AR059690A1 (es) 2008-04-23
WO2007103187A3 (en) 2007-11-01
US8927573B2 (en) 2015-01-06
EP2001876B1 (en) 2011-05-18
US20070219278A1 (en) 2007-09-20
CA2646409C (en) 2015-11-10
DK2001876T3 (da) 2011-08-29
NZ570764A (en) 2011-08-26
US20190308966A1 (en) 2019-10-10
JP5086280B2 (ja) 2012-11-28
PL2001876T3 (pl) 2011-10-31
BRPI0708490B1 (pt) 2019-07-30
RU2008138875A (ru) 2010-04-10
US8263618B2 (en) 2012-09-11
JP2009528371A (ja) 2009-08-06
US20100035921A1 (en) 2010-02-11
AU2007224213B2 (en) 2012-06-14
US10745394B2 (en) 2020-08-18
US20230183232A1 (en) 2023-06-15
US20150291579A1 (en) 2015-10-15
HRP20110590T1 (hr) 2011-09-30
EP2001876A2 (en) 2008-12-17
IL193690A (en) 2013-02-28
IL193690A0 (en) 2009-08-03
US20160176863A1 (en) 2016-06-23
US7622508B2 (en) 2009-11-24
CA2646409A1 (en) 2007-09-13
ATE509928T1 (de) 2011-06-15
US10081626B2 (en) 2018-09-25
BRPI0708490A2 (pt) 2011-05-31
US10377751B2 (en) 2019-08-13
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
HK1125935A1 (en) 2009-08-21
TWI379832B (en) 2012-12-21
TW200800981A (en) 2008-01-01
MY145633A (en) 2012-03-15
US9206172B2 (en) 2015-12-08
US11548887B2 (en) 2023-01-10
US8664242B2 (en) 2014-03-04
US20190119267A1 (en) 2019-04-25
JP2012211193A (ja) 2012-11-01
MA30284B1 (fr) 2009-03-02
WO2007103187A2 (en) 2007-09-13
SI2001876T1 (sl) 2011-09-30
BRPI0708490B8 (pt) 2021-05-25
US20130158060A1 (en) 2013-06-20
RU2423362C2 (ru) 2011-07-10
US20210024515A1 (en) 2021-01-28
US20140288112A1 (en) 2014-09-25
US20170349578A1 (en) 2017-12-07
AU2007224213A1 (en) 2007-09-13
US9663509B2 (en) 2017-05-30
PE20071311A1 (es) 2007-12-29
CY1111747T1 (el) 2015-10-07
MX2008011165A (es) 2008-09-15

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