MA30284B1 - Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu - Google Patents

Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu

Info

Publication number
MA30284B1
MA30284B1 MA31246A MA31246A MA30284B1 MA 30284 B1 MA30284 B1 MA 30284B1 MA 31246 A MA31246 A MA 31246A MA 31246 A MA31246 A MA 31246A MA 30284 B1 MA30284 B1 MA 30284B1
Authority
MA
Morocco
Prior art keywords
compounds
opioid receptor
azabicyclo
receptor antagonists
octane compounds
Prior art date
Application number
MA31246A
Other languages
English (en)
Inventor
Daniel Long
Timothy J Church
John R Jacobsen
Lan Jiang
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla Van
Sean Dalziel
Leticia Preza
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30284(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MA30284B1 publication Critical patent/MA30284B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne de nouveaux composés de 8-azabicyclo[3.2.1]octane de formule (I) où R1, R2, R3, A et G sont tels que définis dans la description, ou un sel ou solvate pharmaceutiquement acceptable de ceux-ci, lesdits composés étant des antagonistes du récepteur opioïde mu. L'invention décrit également des compositions pharmaceutiques contenant de tels composés, des procédés d'utilisation de tels composés visant à traiter des pathologies associées à l'activité du récepteur opioïde mu, ainsi que des procédés et des intermédiaires utiles pour la préparation de ces composés.
MA31246A 2006-03-01 2008-09-17 Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu MA30284B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30

Publications (1)

Publication Number Publication Date
MA30284B1 true MA30284B1 (fr) 2009-03-02

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31246A MA30284B1 (fr) 2006-03-01 2008-09-17 Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu

Country Status (25)

Country Link
US (11) US7622508B2 (fr)
EP (1) EP2001876B1 (fr)
JP (2) JP5086280B2 (fr)
KR (1) KR101376479B1 (fr)
AR (1) AR059690A1 (fr)
AT (1) ATE509928T1 (fr)
AU (1) AU2007224213B2 (fr)
BR (1) BRPI0708490B8 (fr)
CA (1) CA2646409C (fr)
CY (1) CY1111747T1 (fr)
DK (1) DK2001876T3 (fr)
HK (1) HK1125935A1 (fr)
HR (1) HRP20110590T1 (fr)
IL (1) IL193690A (fr)
MA (1) MA30284B1 (fr)
MX (1) MX2008011165A (fr)
MY (1) MY145633A (fr)
NZ (1) NZ570764A (fr)
PE (1) PE20071311A1 (fr)
PL (1) PL2001876T3 (fr)
PT (1) PT2001876E (fr)
RU (1) RU2423362C2 (fr)
SI (1) SI2001876T1 (fr)
TW (1) TWI379832B (fr)
WO (1) WO2007103187A2 (fr)

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MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
ES2364686T3 (es) * 2007-08-27 2011-09-12 Theravance, Inc. Compuestos de alquil-8-azabiciclo[3.2.1]octano disustituidos como antagonistas del receptor opioide mu.
US7902221B2 (en) * 2007-08-27 2011-03-08 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2465621T3 (es) * 2007-08-27 2014-06-06 Theravance, Inc. Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu
MX342548B (es) * 2009-09-18 2016-10-04 Merck Sharp & Dohme Corp * Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal.
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
EP2423210A1 (fr) 2010-08-25 2012-02-29 Bayer CropScience AG Dérivés d'hétéroarylpipéridine et -pipérazine comme fongicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
CA2815716C (fr) 2010-10-27 2019-06-11 Bayer Intellectual Property Gmbh Heteroarylpiperidine et derives d'heteroarylpiperidine comme fongicide
JP5703009B2 (ja) * 2010-12-16 2015-04-15 住友精化株式会社 スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
MX352307B (es) 2011-02-01 2017-11-17 Bayer Ip Gmbh Derivados de heteroarilpiperidina y -piperazina como fungicidas.
MX355824B (es) 2011-09-15 2018-05-02 Bayer Ip Gmbh Piperidinpirazoles como fungicidas.
ES2695233T3 (es) 2011-12-27 2019-01-02 Bayer Cropscience Ag Derivados de isoxazol
US9192570B2 (en) 2013-12-20 2015-11-24 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
WO2016161069A1 (fr) 2015-04-02 2016-10-06 Theravance Biopharma R&D Ip, Llc Forme galénique combinée d'un antagoniste de récepteur opioïde mu et d'un agent opioïde
US10604489B2 (en) 2018-02-05 2020-03-31 Alkermes, Inc. Compounds for the treatment of pain
US20230416243A1 (en) * 2020-11-06 2023-12-28 Actinogen Medical Limited Process for Preparing Heterocyclic Methanone Compounds and AZA-Bicyclo Intermediates Thereof

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TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
ES2465621T3 (es) 2007-08-27 2014-06-06 Theravance, Inc. Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
US7902221B2 (en) 2007-08-27 2011-03-08 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ES2364686T3 (es) 2007-08-27 2011-09-12 Theravance, Inc. Compuestos de alquil-8-azabiciclo[3.2.1]octano disustituidos como antagonistas del receptor opioide mu.

Also Published As

Publication number Publication date
JP2012211193A (ja) 2012-11-01
AU2007224213A1 (en) 2007-09-13
US20190308966A1 (en) 2019-10-10
SI2001876T1 (sl) 2011-09-30
US8664242B2 (en) 2014-03-04
KR101376479B1 (ko) 2014-03-27
EP2001876B1 (fr) 2011-05-18
US20070219278A1 (en) 2007-09-20
PL2001876T3 (pl) 2011-10-31
US20190119267A1 (en) 2019-04-25
US9663509B2 (en) 2017-05-30
HRP20110590T1 (hr) 2011-09-30
AU2007224213B2 (en) 2012-06-14
US20230183232A1 (en) 2023-06-15
BRPI0708490B8 (pt) 2021-05-25
US8263618B2 (en) 2012-09-11
US20170349578A1 (en) 2017-12-07
BRPI0708490B1 (pt) 2019-07-30
US20130158060A1 (en) 2013-06-20
HK1125935A1 (en) 2009-08-21
WO2007103187A3 (fr) 2007-11-01
MY145633A (en) 2012-03-15
TWI379832B (en) 2012-12-21
PE20071311A1 (es) 2007-12-29
US11548887B2 (en) 2023-01-10
CY1111747T1 (el) 2015-10-07
MX2008011165A (es) 2008-09-15
CA2646409C (fr) 2015-11-10
IL193690A (en) 2013-02-28
JP2009528371A (ja) 2009-08-06
AR059690A1 (es) 2008-04-23
EP2001876A2 (fr) 2008-12-17
US9206172B2 (en) 2015-12-08
US20160176863A1 (en) 2016-06-23
US20140288112A1 (en) 2014-09-25
ATE509928T1 (de) 2011-06-15
RU2423362C2 (ru) 2011-07-10
US8927573B2 (en) 2015-01-06
BRPI0708490A2 (pt) 2011-05-31
RU2008138875A (ru) 2010-04-10
JP5086280B2 (ja) 2012-11-28
US10745394B2 (en) 2020-08-18
NZ570764A (en) 2011-08-26
DK2001876T3 (da) 2011-08-29
US20210024515A1 (en) 2021-01-28
US20100035921A1 (en) 2010-02-11
IL193690A0 (en) 2009-08-03
WO2007103187A2 (fr) 2007-09-13
TW200800981A (en) 2008-01-01
CA2646409A1 (fr) 2007-09-13
US20150291579A1 (en) 2015-10-15
US10377751B2 (en) 2019-08-13
US10081626B2 (en) 2018-09-25
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
US7622508B2 (en) 2009-11-24

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