PT2001876E - Compostos de 8-azabiciclo[3.2.1]octano como antagonistas do receptor opióide mu - Google Patents

Compostos de 8-azabiciclo[3.2.1]octano como antagonistas do receptor opióide mu Download PDF

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Publication number
PT2001876E
PT2001876E PT07752111T PT07752111T PT2001876E PT 2001876 E PT2001876 E PT 2001876E PT 07752111 T PT07752111 T PT 07752111T PT 07752111 T PT07752111 T PT 07752111T PT 2001876 E PT2001876 E PT 2001876E
Authority
PT
Portugal
Prior art keywords
receptor antagonists
opioid receptor
octane compounds
octane
compounds
Prior art date
Application number
PT07752111T
Other languages
English (en)
Inventor
John R Jacobsen
Daisuke Roland Saito
Timothy J Church
Daniel Long
Lan Jiang
Ioanna Stergiades
Priscilla Van Dyke
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2001876(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PT2001876E publication Critical patent/PT2001876E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT07752111T 2006-03-01 2007-02-28 Compostos de 8-azabiciclo[3.2.1]octano como antagonistas do receptor opióide mu PT2001876E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30

Publications (1)

Publication Number Publication Date
PT2001876E true PT2001876E (pt) 2011-08-18

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
PT07752111T PT2001876E (pt) 2006-03-01 2007-02-28 Compostos de 8-azabiciclo[3.2.1]octano como antagonistas do receptor opióide mu

Country Status (25)

Country Link
US (11) US7622508B2 (pt)
EP (1) EP2001876B1 (pt)
JP (2) JP5086280B2 (pt)
KR (1) KR101376479B1 (pt)
AR (1) AR059690A1 (pt)
AT (1) ATE509928T1 (pt)
AU (1) AU2007224213B2 (pt)
BR (1) BRPI0708490B8 (pt)
CA (1) CA2646409C (pt)
CY (1) CY1111747T1 (pt)
DK (1) DK2001876T3 (pt)
HK (1) HK1125935A1 (pt)
HR (1) HRP20110590T1 (pt)
IL (1) IL193690A (pt)
MA (1) MA30284B1 (pt)
MX (1) MX2008011165A (pt)
MY (1) MY145633A (pt)
NZ (1) NZ570764A (pt)
PE (1) PE20071311A1 (pt)
PL (1) PL2001876T3 (pt)
PT (1) PT2001876E (pt)
RU (1) RU2423362C2 (pt)
SI (1) SI2001876T1 (pt)
TW (1) TWI379832B (pt)
WO (1) WO2007103187A2 (pt)

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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
NZ598783A (en) * 2009-09-18 2013-07-26 Adolor Corp Use of opioid receptor antagonist for gastrointestinal tract disorders
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
PE20141002A1 (es) 2010-10-27 2014-08-17 Bayer Ip Gmbh Derivados de heteroarilpiperidina y -piperazina como fungicidas
JP5703009B2 (ja) * 2010-12-16 2015-04-15 住友精化株式会社 スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
KR101848116B1 (ko) 2011-02-01 2018-04-11 바이엘 인텔렉쳐 프로퍼티 게엠베하 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체
WO2013037768A1 (de) 2011-09-15 2013-03-21 Bayer Intellectual Property Gmbh Piperidinpyrazole als fungizide
DK2921495T3 (en) 2011-12-27 2018-07-16 Bayer Ip Gmbh HETEROARYLPIPERIDINE AND PIPERAZINE DERIVATIVES AS FUNGICIDES
CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
SI3277278T1 (sl) * 2015-04-02 2020-04-30 Theravance Biopharma R&D Ip, Llc Kombinacijska odmerna oblika mu-opioidnega receptorskega antagonista in opioidnega sredstva
JP2021512952A (ja) 2018-02-05 2021-05-20 アルカームス・インコーポレイテッド 疼痛の処置のための化合物
KR20230154789A (ko) * 2020-11-06 2023-11-09 액티노젠 메디컬 리미티드 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정

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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2185553B1 (en) 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
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Also Published As

Publication number Publication date
US20230183232A1 (en) 2023-06-15
AU2007224213A1 (en) 2007-09-13
AR059690A1 (es) 2008-04-23
AU2007224213B2 (en) 2012-06-14
US10081626B2 (en) 2018-09-25
RU2008138875A (ru) 2010-04-10
WO2007103187A3 (en) 2007-11-01
SI2001876T1 (sl) 2011-09-30
HK1125935A1 (en) 2009-08-21
US20150291579A1 (en) 2015-10-15
US8664242B2 (en) 2014-03-04
EP2001876A2 (en) 2008-12-17
US20190119267A1 (en) 2019-04-25
PL2001876T3 (pl) 2011-10-31
CA2646409A1 (en) 2007-09-13
US10377751B2 (en) 2019-08-13
US11548887B2 (en) 2023-01-10
ATE509928T1 (de) 2011-06-15
US8263618B2 (en) 2012-09-11
MX2008011165A (es) 2008-09-15
BRPI0708490B8 (pt) 2021-05-25
CA2646409C (en) 2015-11-10
CY1111747T1 (el) 2015-10-07
JP2012211193A (ja) 2012-11-01
US20170349578A1 (en) 2017-12-07
US20190308966A1 (en) 2019-10-10
US20130158060A1 (en) 2013-06-20
EP2001876B1 (en) 2011-05-18
US20070219278A1 (en) 2007-09-20
TWI379832B (en) 2012-12-21
KR101376479B1 (ko) 2014-03-27
DK2001876T3 (da) 2011-08-29
US9663509B2 (en) 2017-05-30
US8927573B2 (en) 2015-01-06
US20160176863A1 (en) 2016-06-23
US10745394B2 (en) 2020-08-18
HRP20110590T1 (hr) 2011-09-30
KR20080100282A (ko) 2008-11-14
US20210024515A1 (en) 2021-01-28
RU2423362C2 (ru) 2011-07-10
US20100035921A1 (en) 2010-02-11
IL193690A (en) 2013-02-28
PE20071311A1 (es) 2007-12-29
NZ570764A (en) 2011-08-26
US9206172B2 (en) 2015-12-08
TW200800981A (en) 2008-01-01
IL193690A0 (en) 2009-08-03
JP2009528371A (ja) 2009-08-06
JP5086280B2 (ja) 2012-11-28
US7622508B2 (en) 2009-11-24
MA30284B1 (fr) 2009-03-02
BRPI0708490A2 (pt) 2011-05-31
US20140288112A1 (en) 2014-09-25
MY145633A (en) 2012-03-15
BRPI0708490B1 (pt) 2019-07-30
WO2007103187A2 (en) 2007-09-13

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