SI2001876T1 - 8-azabiciklo(3.2.1)oktanske spojine kot antagonisti mu-opioidnega receptorja - Google Patents

8-azabiciklo(3.2.1)oktanske spojine kot antagonisti mu-opioidnega receptorja

Info

Publication number
SI2001876T1
SI2001876T1 SI200730691T SI200730691T SI2001876T1 SI 2001876 T1 SI2001876 T1 SI 2001876T1 SI 200730691 T SI200730691 T SI 200730691T SI 200730691 T SI200730691 T SI 200730691T SI 2001876 T1 SI2001876 T1 SI 2001876T1
Authority
SI
Slovenia
Prior art keywords
receptor antagonists
opioid receptor
octane compounds
octane
compounds
Prior art date
Application number
SI200730691T
Other languages
English (en)
Inventor
Daniel Long
Timothy J Church
John R Jacobsen
Lan Jiang
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla Van
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2001876(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of SI2001876T1 publication Critical patent/SI2001876T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
SI200730691T 2006-03-01 2007-02-28 8-azabiciklo(3.2.1)oktanske spojine kot antagonisti mu-opioidnega receptorja SI2001876T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30
EP07752111A EP2001876B1 (en) 2006-03-01 2007-02-28 8-azabicycloý3.2.1¨octane compounds as mu opioid receptor antagonists
PCT/US2007/005388 WO2007103187A2 (en) 2006-03-01 2007-02-28 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Publications (1)

Publication Number Publication Date
SI2001876T1 true SI2001876T1 (sl) 2011-09-30

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730691T SI2001876T1 (sl) 2006-03-01 2007-02-28 8-azabiciklo(3.2.1)oktanske spojine kot antagonisti mu-opioidnega receptorja

Country Status (25)

Country Link
US (11) US7622508B2 (sl)
EP (1) EP2001876B1 (sl)
JP (2) JP5086280B2 (sl)
KR (1) KR101376479B1 (sl)
AR (1) AR059690A1 (sl)
AT (1) ATE509928T1 (sl)
AU (1) AU2007224213B2 (sl)
BR (1) BRPI0708490B8 (sl)
CA (1) CA2646409C (sl)
CY (1) CY1111747T1 (sl)
DK (1) DK2001876T3 (sl)
HK (1) HK1125935A1 (sl)
HR (1) HRP20110590T1 (sl)
IL (1) IL193690A (sl)
MA (1) MA30284B1 (sl)
MX (1) MX2008011165A (sl)
MY (1) MY145633A (sl)
NZ (1) NZ570764A (sl)
PE (1) PE20071311A1 (sl)
PL (1) PL2001876T3 (sl)
PT (1) PT2001876E (sl)
RU (1) RU2423362C2 (sl)
SI (1) SI2001876T1 (sl)
TW (1) TWI379832B (sl)
WO (1) WO2007103187A2 (sl)

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MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009029253A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
CA2774021A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
BR112013010497B1 (pt) 2010-10-27 2018-07-17 Bayer Intellectual Property Gmbh derivados de heteroaril - piperidina e - piperazina enquanto fungicidas, composição os compreendendo, bem como processo para a produção de composições para controle de fungos fitopatogênicos nocivos e método para controle de fungos fitopatogênicos nocivos
JP5703009B2 (ja) * 2010-12-16 2015-04-15 住友精化株式会社 スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
CN104987330B (zh) 2011-02-01 2019-04-05 拜耳知识产权有限责任公司 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物
BR112014005989B1 (pt) 2011-09-15 2019-11-05 Bayer Ip Gmbh compostos fungicidas piperidina-pirazoles, seus usos, método e composição para controlar fungos fitopatogênicos prejudiciais, e método para produzir composições
AR089415A1 (es) 2011-12-27 2014-08-20 Bayer Ip Gmbh Derivados de heteroarilpiperidina y de heteroarilpiperazina como funguicidas
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
RS60074B1 (sr) * 2015-04-02 2020-05-29 Theravance Biopharma R&D Ip Llc Kombinovani oblik doze antagonista mu opioidnog receptora i opioidni agens
EP3749667A1 (en) 2018-02-05 2020-12-16 Alkermes, Inc. Compounds for the treatment of pain
EP4240740A1 (en) * 2020-11-06 2023-09-13 Actinogen Medical Limited Process for preparing heterocyclic methanone compounds and aza-bicyclo intermediates thereof

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TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ATE502939T1 (de) 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
EP2185553B1 (en) 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029253A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Also Published As

Publication number Publication date
WO2007103187A2 (en) 2007-09-13
US8263618B2 (en) 2012-09-11
NZ570764A (en) 2011-08-26
US20170349578A1 (en) 2017-12-07
HK1125935A1 (en) 2009-08-21
ATE509928T1 (de) 2011-06-15
US20140288112A1 (en) 2014-09-25
CA2646409A1 (en) 2007-09-13
PE20071311A1 (es) 2007-12-29
US20100035921A1 (en) 2010-02-11
JP2012211193A (ja) 2012-11-01
EP2001876A2 (en) 2008-12-17
AR059690A1 (es) 2008-04-23
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
RU2423362C2 (ru) 2011-07-10
US20190308966A1 (en) 2019-10-10
TW200800981A (en) 2008-01-01
US9663509B2 (en) 2017-05-30
US10745394B2 (en) 2020-08-18
US20210024515A1 (en) 2021-01-28
US20160176863A1 (en) 2016-06-23
US20190119267A1 (en) 2019-04-25
HRP20110590T1 (hr) 2011-09-30
US8664242B2 (en) 2014-03-04
TWI379832B (en) 2012-12-21
BRPI0708490B1 (pt) 2019-07-30
US20230183232A1 (en) 2023-06-15
US10081626B2 (en) 2018-09-25
RU2008138875A (ru) 2010-04-10
US20130158060A1 (en) 2013-06-20
IL193690A0 (en) 2009-08-03
EP2001876B1 (en) 2011-05-18
JP5086280B2 (ja) 2012-11-28
DK2001876T3 (da) 2011-08-29
MY145633A (en) 2012-03-15
CA2646409C (en) 2015-11-10
AU2007224213A1 (en) 2007-09-13
US20070219278A1 (en) 2007-09-20
BRPI0708490A2 (pt) 2011-05-31
PL2001876T3 (pl) 2011-10-31
IL193690A (en) 2013-02-28
MA30284B1 (fr) 2009-03-02
US11548887B2 (en) 2023-01-10
MX2008011165A (es) 2008-09-15
US8927573B2 (en) 2015-01-06
US10377751B2 (en) 2019-08-13
AU2007224213B2 (en) 2012-06-14
US7622508B2 (en) 2009-11-24
US20150291579A1 (en) 2015-10-15
KR101376479B1 (ko) 2014-03-27
JP2009528371A (ja) 2009-08-06
CY1111747T1 (el) 2015-10-07
BRPI0708490B8 (pt) 2021-05-25
US9206172B2 (en) 2015-12-08
WO2007103187A3 (en) 2007-11-01

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