KR101320160B1 - 화학방사선증감제로서의 캄프토테신 유도체 - Google Patents

화학방사선증감제로서의 캄프토테신 유도체 Download PDF

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KR101320160B1
KR101320160B1 KR1020087012095A KR20087012095A KR101320160B1 KR 101320160 B1 KR101320160 B1 KR 101320160B1 KR 1020087012095 A KR1020087012095 A KR 1020087012095A KR 20087012095 A KR20087012095 A KR 20087012095A KR 101320160 B1 KR101320160 B1 KR 101320160B1
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cpt
hydroxy
alkyl
hydrogen
compound
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KR20080086436A (ko
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리-시 양
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카톨릭 헬스케어 웨스트, 두잉 비지니스 애즈 세인트 메리스 메디컬 센터
슈터 웨스트 베이 호스피탈스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087012095A 2005-10-21 2006-10-19 화학방사선증감제로서의 캄프토테신 유도체 Expired - Fee Related KR101320160B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72892405P 2005-10-21 2005-10-21
US60/728,924 2005-10-21
US11/444,150 2006-05-30
US11/444,150 US7875602B2 (en) 2005-10-21 2006-05-30 Camptothecin derivatives as chemoradiosensitizing agents
PCT/US2006/041175 WO2007048002A2 (en) 2005-10-21 2006-10-19 Camptothecin derivatives as chemoradiosensitizing agents

Publications (2)

Publication Number Publication Date
KR20080086436A KR20080086436A (ko) 2008-09-25
KR101320160B1 true KR101320160B1 (ko) 2013-10-23

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US (3) US7875602B2 (enExample)
EP (1) EP1951231B1 (enExample)
JP (1) JP5328357B2 (enExample)
KR (1) KR101320160B1 (enExample)
CN (1) CN101300009B (enExample)
AU (1) AU2006304811C1 (enExample)
CA (1) CA2626032C (enExample)
ES (1) ES2428088T3 (enExample)
NZ (2) NZ567454A (enExample)
TW (1) TWI402270B (enExample)
WO (1) WO2007048002A2 (enExample)

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CN101402640B (zh) * 2008-09-02 2011-06-15 暨南大学 双酯化喜树碱衍生物及其制备方法和应用
DE102009004204A1 (de) * 2009-01-09 2010-07-15 Christian-Albrechts-Universität Zu Kiel Verfahren zur verbesserten Bioaktivierung von Arzneistoffen
US8168648B2 (en) * 2009-03-06 2012-05-01 Taiwan Liposome Co., Ltd. Camptothecin derivatives and uses thereof
WO2010148138A2 (en) * 2009-06-17 2010-12-23 Threshold Pharmaceuticals, Inc. Camptothecin derivatives
US10980798B2 (en) 2011-11-03 2021-04-20 Taiwan Liposome Company, Ltd. Pharmaceutical compositions of hydrophobic camptothecin derivatives
TWI549679B (zh) * 2011-11-03 2016-09-21 台灣微脂體股份有限公司 疏水性喜樹鹼衍生物之醫藥組合物
US20140135357A1 (en) * 2012-11-12 2014-05-15 Taiwan Liposome Company, Ltd. Dose regime for camptothecin derivatives
HK1217092A1 (zh) 2013-02-15 2016-12-23 Kala Pharmaceuticals, Inc. 治疗性化合物及其用途
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9353123B2 (en) 2013-02-20 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
NZ719185A (en) 2013-11-01 2017-11-24 Kala Pharmaceuticals Inc Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2015098963A1 (ja) 2013-12-26 2015-07-02 東亞合成株式会社 カルレティキュリンの発現促進方法および該方法に用いられる合成ペプチド
JP6872713B2 (ja) 2015-05-29 2021-05-19 東亞合成株式会社 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用
CN112759603B (zh) * 2015-10-27 2022-09-09 加州太平洋医疗中心 鬼臼毒素衍生物及其应用
US10087194B2 (en) 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use
CA3036065A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048747A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2021005583A1 (en) 2019-07-11 2021-01-14 Sun Pharma Advanced Research Company Ltd. Camptothecin derivatives with a disulfide moiety and a piperazine moiety
WO2021154746A1 (en) 2020-01-28 2021-08-05 Reflexion Medical, Inc. Joint optimization of radionuclide and external beam radiotherapy

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US20080318873A1 (en) 2008-12-25
WO2007048002A2 (en) 2007-04-26
JP5328357B2 (ja) 2013-10-30
EP1951231B1 (en) 2013-07-31
NZ567454A (en) 2011-07-29
KR20080086436A (ko) 2008-09-25
WO2007048002A3 (en) 2007-09-13
CN101300009B (zh) 2013-04-03
US8779138B2 (en) 2014-07-15
TW200730532A (en) 2007-08-16
US20110184009A1 (en) 2011-07-28
ES2428088T3 (es) 2013-11-05
TWI402270B (zh) 2013-07-21
AU2006304811C1 (en) 2012-11-01
AU2006304811A1 (en) 2007-04-26
NZ593706A (en) 2012-11-30
HK1115321A1 (en) 2008-11-28
EP1951231A2 (en) 2008-08-06
CA2626032C (en) 2011-12-06
US20070093432A1 (en) 2007-04-26
AU2006304811B2 (en) 2012-03-22
CN101300009A (zh) 2008-11-05
JP2009512714A (ja) 2009-03-26
US7875602B2 (en) 2011-01-25
US8563537B2 (en) 2013-10-22
CA2626032A1 (en) 2007-04-26
EP1951231A4 (en) 2010-09-22

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