KR101277352B1 - 비타민 ｂ1의 전구물질의 제조 방법 - Google Patents

비타민 ｂ1의 전구물질의 제조 방법 Download PDF

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Publication number
KR101277352B1
KR101277352B1 KR1020077017242A KR20077017242A KR101277352B1 KR 101277352 B1 KR101277352 B1 KR 101277352B1 KR 1020077017242 A KR1020077017242 A KR 1020077017242A KR 20077017242 A KR20077017242 A KR 20077017242A KR 101277352 B1 KR101277352 B1 KR 101277352B1
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KR
South Korea
Prior art keywords
gda
analyzed
nfgda
hydrolysis
sodium formate
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1020077017242A
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English (en)
Korean (ko)
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KR20070098888A (ko
Inventor
베르너 본라스
조셀린 피스케서
리사 기라우디
라인하드 카르게
Original Assignee
디에스엠 아이피 어셋츠 비.브이.
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Publication of KR20070098888A publication Critical patent/KR20070098888A/ko
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Publication of KR101277352B1 publication Critical patent/KR101277352B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077017242A 2005-01-28 2006-01-24 비타민 ｂ1의 전구물질의 제조 방법 Expired - Lifetime KR101277352B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05001859 2005-01-28
EP05001859.7 2005-01-28
PCT/EP2006/000600 WO2006079504A2 (en) 2005-01-28 2006-01-24 Process for the manufacture of a precursor of vitamin b1

Publications (2)

Publication Number Publication Date
KR20070098888A KR20070098888A (ko) 2007-10-05
KR101277352B1 true KR101277352B1 (ko) 2013-06-20

Family

ID=36118080

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077017242A Expired - Lifetime KR101277352B1 (ko) 2005-01-28 2006-01-24 비타민 ｂ1의 전구물질의 제조 방법

Country Status (9)

Country Link
US (1) US9108925B2 (enExample)
EP (1) EP1841745B1 (enExample)
JP (1) JP5191237B2 (enExample)
KR (1) KR101277352B1 (enExample)
CN (1) CN101111484B (enExample)
AT (1) ATE397593T1 (enExample)
DE (1) DE602006001394D1 (enExample)
ES (1) ES2308715T3 (enExample)
WO (1) WO2006079504A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104442A2 (en) * 2006-03-15 2007-09-20 Dsm Ip Assets B.V. Process for the manufacture of a precursor of vitamin b1
WO2010010113A1 (en) * 2008-07-22 2010-01-28 Dsm Ip Assets B.V. Novel synthesis of substituted 4-amino-pyrimidines
CN103896935B (zh) * 2012-12-27 2016-08-10 江西天新药业有限公司 3-[(4-氨基-5-嘧啶基)甲基]-5-(2-羟乙基)-4-甲基噻唑硝酸盐的制备方法
CN104326989B (zh) * 2014-11-26 2016-04-27 江西天新药业有限公司 2-甲基-4-氨基-5-(氨基甲基)嘧啶的制备方法
US9682216B2 (en) 2014-12-05 2017-06-20 Anchor Endovascular, Inc. Anchor device for use with catheters
CN108546249B (zh) * 2018-02-28 2021-10-01 东北制药集团股份有限公司 一种制备双胺嘧啶的方法
CN109467553B (zh) * 2018-12-24 2021-02-12 江苏兄弟维生素有限公司 一种甲酰嘧啶的提纯方法以及维生素b1合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2775592A (en) * 1956-12-25 Z-methyl -
DE2860431D1 (en) * 1977-10-27 1981-02-26 Basf Ag Alpha-aminomethylene-beta-formylaminopropionitrile, process for its preparation and its use in the preparation of 2-methyl-4-amino-5-formylaminomethylpyrimidine
JPS5576084A (en) * 1978-12-01 1980-06-07 Takeda Chem Ind Ltd Method and apparatus for production of vitamin b1 and intermediate thereof
DE10015470A1 (de) * 2000-03-29 2001-10-11 Basf Ag Verfahren zur Herstellung von 2-Methyl-4-amino-5-aminomethyrimidin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Also Published As

Publication number Publication date
DE602006001394D1 (de) 2008-07-17
CN101111484B (zh) 2013-07-24
JP2008528529A (ja) 2008-07-31
WO2006079504A3 (en) 2007-02-15
US9108925B2 (en) 2015-08-18
ATE397593T1 (de) 2008-06-15
US20080242863A1 (en) 2008-10-02
JP5191237B2 (ja) 2013-05-08
ES2308715T3 (es) 2008-12-01
WO2006079504A2 (en) 2006-08-03
EP1841745B1 (en) 2008-06-04
CN101111484A (zh) 2008-01-23
KR20070098888A (ko) 2007-10-05
EP1841745A2 (en) 2007-10-10

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