CN101111484B - 用于制造维生素b1前体的方法 - Google Patents

用于制造维生素b1前体的方法 Download PDF

Info

Publication number
CN101111484B
CN101111484B CN2006800034976A CN200680003497A CN101111484B CN 101111484 B CN101111484 B CN 101111484B CN 2006800034976 A CN2006800034976 A CN 2006800034976A CN 200680003497 A CN200680003497 A CN 200680003497A CN 101111484 B CN101111484 B CN 101111484B
Authority
CN
China
Prior art keywords
formula
gda
compound
nfgda
methylpyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2006800034976A
Other languages
English (en)
Chinese (zh)
Other versions
CN101111484A (zh
Inventor
维尔纳·邦拉蒂
乔斯莱恩·菲斯柴瑟
莉萨·吉拉蒂
里恩哈德·卡治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN101111484A publication Critical patent/CN101111484A/zh
Application granted granted Critical
Publication of CN101111484B publication Critical patent/CN101111484B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2006800034976A 2005-01-28 2006-01-24 用于制造维生素b1前体的方法 Active CN101111484B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05001859.7 2005-01-28
EP05001859 2005-01-28
PCT/EP2006/000600 WO2006079504A2 (en) 2005-01-28 2006-01-24 Process for the manufacture of a precursor of vitamin b1

Publications (2)

Publication Number Publication Date
CN101111484A CN101111484A (zh) 2008-01-23
CN101111484B true CN101111484B (zh) 2013-07-24

Family

ID=36118080

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800034976A Active CN101111484B (zh) 2005-01-28 2006-01-24 用于制造维生素b1前体的方法

Country Status (9)

Country Link
US (1) US9108925B2 (enExample)
EP (1) EP1841745B1 (enExample)
JP (1) JP5191237B2 (enExample)
KR (1) KR101277352B1 (enExample)
CN (1) CN101111484B (enExample)
AT (1) ATE397593T1 (enExample)
DE (1) DE602006001394D1 (enExample)
ES (1) ES2308715T3 (enExample)
WO (1) WO2006079504A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101627017B (zh) * 2006-03-15 2013-02-27 帝斯曼知识产权资产管理有限公司 用于制造维生素b1前体的方法
JP5618306B2 (ja) * 2008-07-22 2014-11-05 ディーエスエム アイピー アセッツ ビー．ブイ． 置換４−アミノ−ピリミジンの新規合成
CN103896935B (zh) * 2012-12-27 2016-08-10 江西天新药业有限公司 3-[(4-氨基-5-嘧啶基)甲基]-5-(2-羟乙基)-4-甲基噻唑硝酸盐的制备方法
CN104326989B (zh) * 2014-11-26 2016-04-27 江西天新药业有限公司 2-甲基-4-氨基-5-(氨基甲基)嘧啶的制备方法
US9682216B2 (en) 2014-12-05 2017-06-20 Anchor Endovascular, Inc. Anchor device for use with catheters
CN108546249B (zh) * 2018-02-28 2021-10-01 东北制药集团股份有限公司 一种制备双胺嘧啶的方法
CN109467553B (zh) * 2018-12-24 2021-02-12 江苏兄弟维生素有限公司 一种甲酰嘧啶的提纯方法以及维生素b1合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319592A (zh) * 2000-03-29 2001-10-31 Basf公司 制备2－甲基－4－氨基－5－氨基甲基嘧啶的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2775592A (en) * 1956-12-25 Z-methyl -
EP0001760B1 (de) * 1977-10-27 1981-01-07 BASF Aktiengesellschaft Alpha-aminomethylen-beta-formylaminopropionitril, Verfahren zu seiner Herstellung sowie Verwendung zur Herstellung von 2-Methyl-4-amino-5-formylaminomethyl-pyrimidin
JPS5576084A (en) * 1978-12-01 1980-06-07 Takeda Chem Ind Ltd Method and apparatus for production of vitamin b1 and intermediate thereof
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319592A (zh) * 2000-03-29 2001-10-31 Basf公司 制备2－甲基－4－氨基－5－氨基甲基嘧啶的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELVERS B ET AL ELVERS B ET AL."Ullmann＇s Encyclopedia of Industrial Chemistry".ULLMANN＇S ENCYCLOPEDIA OF INDUSTRIAL CHEMISTRY. THORIUM AND THORIUM COMPOUNDS TO VITAMINS,VOL. A27.VOL. A27515-517.
ELVERS B ET AL ELVERS B ET AL."Ullmann＇s Encyclopedia of Industrial Chemistry".ULLMANN＇S ENCYCLOPEDIA OF INDUSTRIAL CHEMISTRY. THORIUM AND THORIUM COMPOUNDS TO VITAMINS,VOL. A27.VOL. A27515-517. *

Also Published As

Publication number Publication date
US9108925B2 (en) 2015-08-18
DE602006001394D1 (de) 2008-07-17
CN101111484A (zh) 2008-01-23
JP5191237B2 (ja) 2013-05-08
KR20070098888A (ko) 2007-10-05
WO2006079504A3 (en) 2007-02-15
ATE397593T1 (de) 2008-06-15
ES2308715T3 (es) 2008-12-01
EP1841745B1 (en) 2008-06-04
US20080242863A1 (en) 2008-10-02
JP2008528529A (ja) 2008-07-31
KR101277352B1 (ko) 2013-06-20
EP1841745A2 (en) 2007-10-10
WO2006079504A2 (en) 2006-08-03

Similar Documents

Publication Publication Date Title
US11952341B2 (en) Method of preparing high chiral purity lactam intermediate and brivaracetam
CA2954167C (en) Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids
CN101111484B (zh) 用于制造维生素b1前体的方法
CN114380741B (zh) 一种2-甲基喹啉类化合物的4号位烷基化衍生物的制备方法
US20080103334A1 (en) Process For Synthesis Of Gabapentin
JP2004527577A (ja) ４−フェニル酪酸の合成
US7355080B2 (en) Method of preparing memantine hydrochloride
CN114174261B (zh) 制备一氧化氮供体型前列腺素类似物的方法
CN101407460A (zh) 三羟基-2-酰基苯乙酸酯及其制备方法与应用
CN106278928B (zh) 一种磷酸奥司他韦异构体杂质的合成方法
JP7623802B2 (ja) ビオチン及びその製造方法、並びに、ビオチン・アミン類塩の製造方法
US20100010230A1 (en) Method for the purification of lansoprazole
JP6275596B2 (ja) テルミサルタンのアンモニウム塩の製造方法
CN114573489B (zh) 一种卡前列素的分离方法
JP5397706B2 (ja) 高純度１−ベンジル−３−アミノピロリジンの製造方法
CN102351805B (zh) 一种5-氨基-1h-四氮唑乙酸的制备、离析与精制方法
CN102574776A (zh) ω-氨基-烷酰胺和ω-氨基-烷硫酰胺的制备方法及该方法的中间体
CN101218215A (zh) 3,4-二氯异噻唑羧酸的制备方法
KR100958678B1 (ko) 시스-디메크로틴산 및 이의 염의 제조방법
US20180111890A1 (en) Process for the Preparation of Ethacrynic Acid
CN119409594A (zh) 一种莫奈太尔重要中间体的合成与精制方法
CN120329180A (zh) 一种纯化环庚酮的方法
WO2002059078A1 (en) PROCESS FOR PRODUCING Z-α-ALKOXYIMINOPHENYLACETIC ACID DERIVATIVE
CN118146111A (zh) 一种奥司他韦酸甲酯的制备方法
RU2196765C2 (ru) Способ выделения и очистки (rr,ss)-2-[(диметиламино)метил]-1-(3-метоксифенил)циклогексанола (трамадола) гидрохлорида

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant