KR101220245B1 - 성장인자에 결합하는 융합 단백질 - Google Patents
성장인자에 결합하는 융합 단백질 Download PDFInfo
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- KR101220245B1 KR101220245B1 KR1020097020284A KR20097020284A KR101220245B1 KR 101220245 B1 KR101220245 B1 KR 101220245B1 KR 1020097020284 A KR1020097020284 A KR 1020097020284A KR 20097020284 A KR20097020284 A KR 20097020284A KR 101220245 B1 KR101220245 B1 KR 101220245B1
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20220038062A (ko) * | 2019-12-06 | 2022-03-25 | 리제너론 파아마슈티컬스, 인크. | 항-vegf 단백질 조성물 및 이를 생산하는 방법 |
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| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| GEP20156390B (en) | 2008-01-03 | 2015-11-10 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| GB0903325D0 (en) * | 2009-02-26 | 2009-04-08 | Univ Aberdeen | Antibody molecules |
| BRPI1014089A2 (pt) | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
| DK2417156T3 (en) | 2009-04-07 | 2015-03-02 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CA2781519A1 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
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| CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| JP5764677B2 (ja) | 2011-02-28 | 2015-08-19 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原結合タンパク質 |
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| CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
| JP2014531424A (ja) | 2011-08-31 | 2014-11-27 | インディ モレキュラー，インコーポレイテッド | Ｖｅｇｆ−特異的捕捉剤、組成物、並びに使用及び製造方法 |
| WO2013119966A2 (en) | 2012-02-10 | 2013-08-15 | Genentech, Inc. | Single-chain antibodies and other heteromultimers |
| RU2639287C2 (ru) | 2012-06-27 | 2017-12-20 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения |
| KR20150030744A (ko) | 2012-06-27 | 2015-03-20 | 에프. 호프만-라 로슈 아게 | 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도 |
| SG11201408538PA (en) | 2012-07-13 | 2015-02-27 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| GB201223053D0 (en) | 2012-12-20 | 2013-02-06 | Medical Res Council | Receptor |
| EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| KR102060187B1 (ko) * | 2013-07-19 | 2019-12-27 | 삼성전자주식회사 | Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도 |
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| RU2016115866A (ru) | 2013-10-11 | 2017-11-16 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи |
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| KR101844596B1 (ko) * | 2014-03-18 | 2018-04-05 | 한국과학기술원 | 당화 vegf 디코이 수용체 융합 단백질을 포함하는 안질환 치료용 조성물 |
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| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
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| US10654922B2 (en) * | 2016-05-13 | 2020-05-19 | Askgene Pharma Inc. | Angiopoietin 2, VEGF dual antagonists |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
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| US10894824B2 (en) * | 2018-09-24 | 2021-01-19 | Aerpio Pharmaceuticals, Inc. | Multispecific antibodies that target HPTP-β (VE-PTP) and VEGF |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| KR102426802B1 (ko) * | 2019-12-23 | 2022-07-28 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질을 포함하는 신생혈관형성 관련 질환의 예방 및 치료를 위한 약학조성물 |
| CN115803009A (zh) | 2020-05-08 | 2023-03-14 | 瑞泽恩制药公司 | 用于治疗眼病和癌症的vegf阱和微阱及方法 |
| KR20230163462A (ko) * | 2021-03-31 | 2023-11-30 | 항저우 엑제제네시스 바이오 엘티디. | Vegf 및 안지오포이에틴을 표적화하는 융합 분자 및 이의 용도 |
| EP4386009A4 (en) * | 2021-08-09 | 2025-05-14 | Yuanpu Biotechnology (Wuhan) Co., Ltd. | BISPECIFIC FUSION POLYPEPTIDE AND USE THEREOF |
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| CN114262683B (zh) * | 2022-03-01 | 2022-06-17 | 中国科学院动物研究所 | 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用 |
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| WO2003020906A2 (en) * | 2001-08-31 | 2003-03-13 | Abmaxis, Inc. | Multivalent protein conjugate with multiple ligand-binding domains of receptors |
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| US5169939A (en) * | 1985-05-21 | 1992-12-08 | Massachusetts Institute Of Technology & Pres. & Fellows Of Harvard College | Chimeric antibodies |
| US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
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| US6521424B2 (en) * | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
| ATE406914T1 (de) * | 2000-02-10 | 2008-09-15 | Massachusetts Eye & Ear Infirm | Photodynamische therapie zur behandlung von augenerkrankungen |
| PL359653A1 (en) * | 2000-06-23 | 2004-08-23 | Schering Aktiengesellschaft | Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii) |
| US7081443B2 (en) * | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
| US7700318B2 (en) * | 2004-08-25 | 2010-04-20 | Amprotein Corporation | Chimeric polypeptide and use thereof |
| JP2008515970A (ja) | 2004-10-12 | 2008-05-15 | アンプロテイン コーポレイション | キメラタンパク質 |
| US20060234347A1 (en) | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| US10259860B2 (en) * | 2007-02-27 | 2019-04-16 | Aprogen Inc. | Fusion proteins binding to VEGF and angiopoietin |
| KR102060187B1 (ko) * | 2013-07-19 | 2019-12-27 | 삼성전자주식회사 | Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도 |
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| WO2003020906A2 (en) * | 2001-08-31 | 2003-03-13 | Abmaxis, Inc. | Multivalent protein conjugate with multiple ligand-binding domains of receptors |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220038062A (ko) * | 2019-12-06 | 2022-03-25 | 리제너론 파아마슈티컬스, 인크. | 항-vegf 단백질 조성물 및 이를 생산하는 방법 |
| KR102860764B1 (ko) | 2019-12-06 | 2025-09-19 | 리제너론 파아마슈티컬스, 인크. | 항-vegf 단백질 조성물 및 이를 생산하는 방법 |
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| JP5952847B2 (ja) | 2016-07-13 |
| CA2679658A1 (en) | 2008-11-06 |
| WO2008132568A3 (en) | 2008-12-31 |
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| CN108546301B (zh) | 2021-09-07 |
| WO2008132568A2 (en) | 2008-11-06 |
| KR20100005202A (ko) | 2010-01-14 |
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| CN101679988A (zh) | 2010-03-24 |
| AU2008243928B2 (en) | 2012-08-09 |
| US20080242587A1 (en) | 2008-10-02 |
| IL200593A0 (en) | 2011-08-01 |
| IL200593B (en) | 2020-08-31 |
| JP5564268B2 (ja) | 2014-07-30 |
| JP2014138602A (ja) | 2014-07-31 |
| DK2126092T3 (en) | 2018-10-22 |
| CN101679988B (zh) | 2018-05-11 |
| CN108546301A (zh) | 2018-09-18 |
| AU2008243928A1 (en) | 2008-11-06 |
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