KR101167335B1 - 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 - Google Patents

니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 Download PDF

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Publication number
KR101167335B1
KR101167335B1 KR1020067010566A KR20067010566A KR101167335B1 KR 101167335 B1 KR101167335 B1 KR 101167335B1 KR 1020067010566 A KR1020067010566 A KR 1020067010566A KR 20067010566 A KR20067010566 A KR 20067010566A KR 101167335 B1 KR101167335 B1 KR 101167335B1
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South Korea
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delete delete
amino
compound
ethyl
carbonyl
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Expired - Fee Related
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KR1020067010566A
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Korean (ko)
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KR20070006677A (ko
Inventor
윌리암 알렉산더 덴니
그래햄 존 애트웰
샹진 양
윌리암 로버트 윌슨
아담 보른 패터슨
누알라 안 헬스비
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오클랜드 유니서비시즈 리미티드
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Priority claimed from NZ529249A external-priority patent/NZ529249A/en
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Publication of KR20070006677A publication Critical patent/KR20070006677A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Radiation-Therapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020067010566A 2003-10-31 2004-10-29 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도 Expired - Fee Related KR101167335B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ529249 2003-10-31
NZ529249A NZ529249A (en) 2003-10-31 2003-10-31 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic
NZ535618 2004-09-28
NZ53561804 2004-09-28
PCT/NZ2004/000275 WO2005042471A1 (en) 2003-10-31 2004-10-29 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents

Publications (2)

Publication Number Publication Date
KR20070006677A KR20070006677A (ko) 2007-01-11
KR101167335B1 true KR101167335B1 (ko) 2012-07-19

Family

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Family Applications (1)

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KR1020067010566A Expired - Fee Related KR101167335B1 (ko) 2003-10-31 2004-10-29 니트로페닐 머스타드, 니트로페닐아지리딘 알코올 및 이에상응하는 포스페이트, 및 타겟화된 세포독성제로서의이들의 용도

Country Status (10)

Country Link
US (2) US7629332B2 (https=)
EP (1) EP1680394A4 (https=)
JP (1) JP4760712B2 (https=)
KR (1) KR101167335B1 (https=)
AU (1) AU2004285831B2 (https=)
BR (1) BRPI0416085A (https=)
CA (1) CA2544335A1 (https=)
IL (1) IL175000A0 (https=)
RU (1) RU2372324C2 (https=)
WO (1) WO2005042471A1 (https=)

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US7629332B2 (en) * 2003-10-31 2009-12-08 Auckland Uniservices Limited Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents
NZ549659A (en) * 2006-09-04 2008-12-24 Auckland Uniservices Ltd Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom
WO2008033039A1 (en) * 2006-09-11 2008-03-20 Adam Vorn Patterson Cancer treatment
NZ549831A (en) * 2006-09-11 2009-03-31 Auckland Uniservices Ltd Combination of docetaxel and a nitrophenyl phosphate derivative for the treatment of cancer
WO2008033041A1 (en) * 2006-09-11 2008-03-20 Auckland Uniservices Limited Cancer treatment
EP2114157B1 (en) 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
WO2009140553A2 (en) * 2008-05-15 2009-11-19 Threshold Pharmaceuticals, Inc. Hypoxia activated drugs of nitrogen mustard alkylators
WO2010044685A1 (en) * 2008-10-17 2010-04-22 Auckland Uniservices Limited Nitrophenyl mustard alcohols, their corresponding phosphates and their use as targeted cytotoxic agents
JP5765634B2 (ja) 2008-10-21 2015-08-19 スレッシュホールド ファーマシューティカルズ， インコーポレイテッド 低酸素活性化型プロドラッグを用いるがんの処置
CN101723932B (zh) 2008-10-31 2013-11-20 北京以岭生物工程技术有限公司 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途
WO2012009288A2 (en) 2010-07-12 2012-01-19 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer
US10357577B2 (en) 2010-07-16 2019-07-23 Auckland Uniservices Limited Bacterial nitroreductase enzymes and methods relating thereto
CN104039328B (zh) * 2011-11-11 2018-10-09 米伦纽姆医药公司 对蛋白酶体抑制剂的反应的生物标记
WO2013096687A1 (en) 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
WO2014007650A1 (en) * 2011-12-23 2014-01-09 Auckland Uniservices Limited Compounds and methods for selective imaging and/or ablation
US10202408B2 (en) 2012-08-23 2019-02-12 Health Innovation Ventures B.V. Prodrugs and methods of use thereof
CN105051004B (zh) * 2012-08-23 2017-12-05 健康创新企业私人有限责任公司 新型前体药物及其使用方法
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US20160158253A1 (en) 2013-07-26 2016-06-09 Threshold Pharmaceuticals, Inc. Treatment of pancreatic cancer with a combination of a hypoxia-activated prodrug and a taxane
WO2016210175A1 (en) 2015-06-24 2016-12-29 Threshold Pharmaceuticals, Inc. Aziridine containing dna alkylating agents
US10348685B2 (en) * 2016-04-29 2019-07-09 Nicira, Inc. Priority allocation for distributed service rules
CN108571241B (zh) * 2017-03-14 2021-08-17 福特环球技术公司 用于推按式闩锁类型车辆抽屉的惯性锁系统
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy
WO2019190331A1 (en) * 2018-03-29 2019-10-03 Achilles Medical Limited Prodrug compounds activated by akr1c3 and their use for treating hyperproliferative disorders
WO2019229195A1 (en) * 2018-05-30 2019-12-05 Convert Pharmaceuticals S.A. Prodrugs and medical uses thereof

Citations (1)

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WO1993011099A1 (en) * 1991-11-28 1993-06-10 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as antitumor agents

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GB9819472D0 (en) * 1998-09-07 1998-10-28 Cancer Soc Auckland Div Nz Inc Novel nitrophenylaziridine compounds and their use as prodrugs
WO2003022274A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 2-aroylimidazole compounds for treating cancer
NZ521851A (en) * 2002-10-08 2005-02-25 Auckland Uniservices Ltd Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy
US7629332B2 (en) * 2003-10-31 2009-12-08 Auckland Uniservices Limited Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1993011099A1 (en) * 1991-11-28 1993-06-10 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as antitumor agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry, vol.39(13), pp.2518-2528(Web. 1996.06.21.)*
Journal of Medicinal Chemistry, vol.40(8), pp.1270-1275(Web. 1997.04.11.)*

Also Published As

Publication number Publication date
US20070032455A1 (en) 2007-02-08
IL175000A0 (en) 2006-08-20
EP1680394A1 (en) 2006-07-19
RU2372324C2 (ru) 2009-11-10
JP4760712B2 (ja) 2011-08-31
JP2007509928A (ja) 2007-04-19
US7629332B2 (en) 2009-12-08
AU2004285831B2 (en) 2011-09-15
AU2004285831A1 (en) 2005-05-12
US20100010094A1 (en) 2010-01-14
CA2544335A1 (en) 2005-05-12
RU2006118785A (ru) 2007-12-10
WO2005042471A1 (en) 2005-05-12
KR20070006677A (ko) 2007-01-11
BRPI0416085A (pt) 2007-01-02
EP1680394A4 (en) 2006-10-11

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