HK1216096A1 - 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥 - Google Patents

具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥

Info

Publication number
HK1216096A1
HK1216096A1 HK16104109.2A HK16104109A HK1216096A1 HK 1216096 A1 HK1216096 A1 HK 1216096A1 HK 16104109 A HK16104109 A HK 16104109A HK 1216096 A1 HK1216096 A1 HK 1216096A1
Authority
HK
Hong Kong
Prior art keywords
mustards
positively charged
related compounds
skin penetration
charged water
Prior art date
Application number
HK16104109.2A
Other languages
English (en)
Inventor
于崇曦
徐麗娜
Original Assignee
Yu Chongxi
Techfields Biochem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yu Chongxi, Techfields Biochem Co Ltd filed Critical Yu Chongxi
Publication of HK1216096A1 publication Critical patent/HK1216096A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK16104109.2A 2006-10-03 2016-04-11 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥 HK1216096A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2006/053619 WO2008041059A1 (en) 2006-10-03 2006-10-03 Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates
CN200680056000.7A CN101511774B (zh) 2006-10-03 2006-10-03 具有快速皮肤穿透速度的带正电荷的水溶性的芥子气类化合物及其相关化合物的前药

Publications (1)

Publication Number Publication Date
HK1216096A1 true HK1216096A1 (zh) 2016-10-14

Family

ID=39268129

Family Applications (3)

Application Number Title Priority Date Filing Date
HK10100931.0A HK1137415A1 (zh) 2006-10-03 2010-01-28 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子氣類化合物及其相關化合物的前藥
HK15103662.4A HK1203188A1 (zh) 2006-10-03 2015-04-15 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥
HK16104109.2A HK1216096A1 (zh) 2006-10-03 2016-04-11 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK10100931.0A HK1137415A1 (zh) 2006-10-03 2010-01-28 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子氣類化合物及其相關化合物的前藥
HK15103662.4A HK1203188A1 (zh) 2006-10-03 2015-04-15 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥

Country Status (5)

Country Link
US (3) US10189774B2 (zh)
EP (2) EP2077991B1 (zh)
CN (1) CN101511774B (zh)
HK (3) HK1137415A1 (zh)
WO (1) WO2008041059A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
JP2010529101A (ja) 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
MX362949B (es) 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.
CN107929743B (zh) 2012-01-18 2023-09-01 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
CA2917145C (en) 2013-03-15 2023-10-24 Techfields Pharma Co., Ltd. Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases
CN108627380B (zh) * 2017-03-15 2020-10-20 中国人民解放军军事医学科学院毒物药物研究所 去除或减少有毒物质的方法以及检测有毒物质的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091552A (en) 1986-06-30 1992-02-25 Board Of Regents, The University Of Texas System Novel antitumor aldophosphamide analogs
US5773435A (en) 1987-08-04 1998-06-30 Bristol-Myers Squibb Company Prodrugs for β-lactamase and uses thereof
JP2721414B2 (ja) 1988-09-06 1998-03-04 フアーマシア・アンド・アツプジヨン・アー・ベー 縁内障または眼圧亢進の治療のためのプロスタグランジン誘導体
JPH08510469A (ja) 1993-05-25 1996-11-05 オークランド ユニサービシーズ リミテッド ニトロベンジルマスタード四級塩およびその低酸素選択性細胞毒剤としての利用
JP3805365B2 (ja) * 1994-12-23 2006-08-02 シンジェンタ リミテッド 化合物
GB9501052D0 (en) 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
US5659061A (en) 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
US6137003A (en) * 1998-10-28 2000-10-24 Shionogi Bioresearch Bis (haloethyl) aminobenzene derivatives
GB9907414D0 (en) 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
FR2795412B1 (fr) * 1999-06-23 2001-07-13 Adir Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20020004065A1 (en) * 2000-01-20 2002-01-10 David Kanios Compositions and methods to effect the release profile in the transdermal administration of active agents
GB0102239D0 (en) 2001-01-29 2001-03-14 Cancer Res Ventures Ltd Methods of chemical synthisis

Also Published As

Publication number Publication date
US20230097823A1 (en) 2023-03-30
EP2077991B1 (en) 2014-02-26
EP2077991A4 (en) 2011-11-16
CN101511774A (zh) 2009-08-19
HK1203188A1 (zh) 2015-10-23
CN101511774B (zh) 2015-05-13
US20190233367A1 (en) 2019-08-01
US10189774B2 (en) 2019-01-29
US11479527B2 (en) 2022-10-25
US20100069336A1 (en) 2010-03-18
EP2792670A1 (en) 2014-10-22
EP2077991A1 (en) 2009-07-15
HK1137415A1 (zh) 2010-07-30
WO2008041059A1 (en) 2008-04-10

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