KR101076578B1 - 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물 - Google Patents

2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물 Download PDF

Info

Publication number
KR101076578B1
KR101076578B1 KR1020077001519A KR20077001519A KR101076578B1 KR 101076578 B1 KR101076578 B1 KR 101076578B1 KR 1020077001519 A KR1020077001519 A KR 1020077001519A KR 20077001519 A KR20077001519 A KR 20077001519A KR 101076578 B1 KR101076578 B1 KR 101076578B1
Authority
KR
South Korea
Prior art keywords
delete delete
analyte
carrier
ecl
binding partner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020077001519A
Other languages
English (en)
Korean (ko)
Other versions
KR20070049631A (ko
Inventor
알렌 바드
우지암 미아오
Original Assignee
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101076578(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 filed Critical 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
Publication of KR20070049631A publication Critical patent/KR20070049631A/ko
Application granted granted Critical
Publication of KR101076578B1 publication Critical patent/KR101076578B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
KR1020077001519A 2004-06-23 2005-06-23 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물 Expired - Lifetime KR101076578B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58171904P 2004-06-23 2004-06-23
US60/581,719 2004-06-23

Publications (2)

Publication Number Publication Date
KR20070049631A KR20070049631A (ko) 2007-05-11
KR101076578B1 true KR101076578B1 (ko) 2011-10-24

Family

ID=36777656

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077001519A Expired - Lifetime KR101076578B1 (ko) 2004-06-23 2005-06-23 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물

Country Status (8)

Country Link
US (3) US8188243B2 (enExample)
EP (1) EP1787124A2 (enExample)
JP (1) JP5118964B2 (enExample)
KR (1) KR101076578B1 (enExample)
CN (1) CN101057145B (enExample)
AU (1) AU2005326758B2 (enExample)
CA (1) CA2571283C (enExample)
WO (1) WO2006083305A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
AU2005326758B2 (en) 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
KR101603354B1 (ko) * 2008-04-11 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 나노입자 전기발생 화학발광 증폭 방법 및 시스템
EP2294387B1 (en) 2008-05-08 2017-08-23 Board of Regents of the University of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
JP5455878B2 (ja) * 2010-11-30 2014-03-26 シスメックス株式会社 被検物質の電気化学的検出方法
CN102183657B (zh) * 2011-02-24 2014-02-05 南京基蛋生物科技有限公司 一种依赖聚苯乙烯纳米粒大幅度增加化学发光磁酶免疫灵敏度的方法
US20150087526A1 (en) * 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
CN102854183A (zh) * 2012-09-04 2013-01-02 上海师范大学 一种固态电化学发光检测三聚氰胺的方法
GB201218555D0 (en) * 2012-10-16 2012-11-28 Mode Diagnostics Ltd Immunoassay using electrochemical detection
WO2015054287A2 (en) * 2013-10-07 2015-04-16 The University Of Utah Research Foundation Methods and systems for electrochemically detecting or quantifying an analyte
CN106248659A (zh) * 2016-09-14 2016-12-21 燕山大学 一种晶相依赖有机半导体微纳电化学发光传感器及其应用
CN106596972B (zh) * 2016-12-16 2018-08-10 青岛科技大学 一种检测力竭运动小鼠心肌连接蛋白43含量的方法
CN108152275B (zh) * 2017-12-27 2019-07-19 福州大学 一种基于电化学发光体系的透明质酸酶检测方法
US11307206B2 (en) 2018-04-27 2022-04-19 Deutsches Rheuma-Forschungszentrum Berlin Functionalized metal-labeled beads for mass cytometry
CN108827946B (zh) * 2018-04-30 2021-03-02 福建师范大学 一种共用共反应试剂类型的呕吐毒素比率型电致化学发光免疫传感器及其检测方法
CN109651621B (zh) * 2019-01-08 2021-05-14 安徽师范大学 一种锆基金属有机框架复合材料及其制备方法和应用
CN109946289B (zh) * 2019-04-16 2021-06-22 济南大学 一种基于自发光材料Ru@MOF-5检测雌二醇的无标型电致化学发光传感器的制备方法
CN110146692A (zh) * 2019-05-28 2019-08-20 迪瑞医疗科技股份有限公司 一种基于吖啶酯化学发光、链霉亲和素磁珠-生物素放大反应体系及检测试剂盒
WO2021019732A1 (ja) * 2019-07-31 2021-02-04 株式会社日立ハイテク 生体分子分析方法および生体分子分析装置
JP2023544025A (ja) * 2020-09-30 2023-10-19 ザ クリーブランド クリニック ファウンデーション ウイルス及び細菌感染症の迅速検査システム
CN112649605B (zh) * 2020-12-14 2022-11-01 哈尔滨理工大学 一种基于NaBiF4上转换纳米粒子的ECL生物传感器
CN113267629B (zh) * 2021-05-13 2022-06-24 广东优尼德生物科技有限公司 一种抗核抗体谱检测试剂盒及其制备方法
WO2023084369A1 (en) * 2021-11-12 2023-05-19 3M Innovative Properties Company Method of processing polynucleic acids
WO2023084370A1 (en) * 2021-11-12 2023-05-19 3M Innovative Properties Company Solid support comprising ligands suitable for polynucleic acid processing, articles and methods
CN114113051B (zh) * 2021-12-16 2023-06-16 南京信息工程大学 一种psma电致化学发光传感器的制备方法及应用
CN114752374B (zh) * 2022-04-11 2023-02-03 北京艾维镝生物技术有限责任公司 一种均相化学发光免疫检测技术所用微球组合物的制备方法
CN117929497A (zh) * 2024-01-29 2024-04-26 常州大学 基于TbPO4:Ce检测林可霉素的电化学发光适配体传感器及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014139A1 (en) 1991-02-06 1992-08-20 Igen, Inc. Methods and apparatus for improved luminescence assays

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US6271041B1 (en) * 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6881536B1 (en) * 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
WO1987006706A1 (en) 1986-04-30 1987-11-05 Igen, Inc. Electrochemiluminescent assays
US6316607B1 (en) * 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5182016A (en) * 1990-03-22 1993-01-26 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
ZA92804B (en) * 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
US5342774A (en) 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5336596A (en) * 1991-12-23 1994-08-09 Tropix, Inc. Membrane for chemiluminescent blotting applications
US5369036A (en) 1992-07-02 1994-11-29 Becton, Dickinson And Company Enhancement of signal in immunoassays using microparticles which contain different detectable substances
ATE197403T1 (de) 1992-12-22 2000-11-11 Ludwig Inst Cancer Res Methoden zur detektion und behandlung von individuen mit abnormalen hla-a2/tyrosinase- peptidantigenen exprimierenden zellen
US5620886A (en) 1993-03-18 1997-04-15 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
JPH06300763A (ja) * 1993-04-14 1994-10-28 Nippon Telegr & Teleph Corp <Ntt> 蛍光免疫測定用蛍光マイクロビーズ及びその製造方法
US5571711A (en) 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
US5610013A (en) 1993-07-22 1997-03-11 Ludwig Institute For Cancer Research Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors
US5935818A (en) * 1995-02-24 1999-08-10 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
DE69535002T2 (de) * 1994-03-08 2006-12-07 Memorial Sloan-Kettering Cancer Center Rekombinante humanisierte antikörper gegen fb5
US5589334A (en) * 1994-06-03 1996-12-31 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor which is processed to an antigen presented by HLA-B44, and uses thereof
US5599889A (en) * 1994-08-16 1997-02-04 Stoever; Harald D. H. Method of forming polymer microspheres
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
CA2162210A1 (en) * 1994-11-07 1996-05-08 Takumi Kunikiyo Process to form a coated film
WO1996021154A1 (en) * 1995-01-06 1996-07-11 Igen, Inc. Electrogenerated chemiluminescence through enhanced particle luminescence
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US5939526A (en) * 1995-03-21 1999-08-17 Ludwig Institute For Cancer Research Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5821122A (en) * 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
CA2223027A1 (en) * 1995-06-07 1996-12-19 Igen, Inc. Electrochemiluminescent enzyme immunoassay
US5792621A (en) 1995-06-28 1998-08-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters
JP3545524B2 (ja) * 1995-12-28 2004-07-21 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生理活性物質を固定化した導電性磁気ビーズ
US6037124A (en) * 1996-09-27 2000-03-14 Beckman Coulter, Inc. Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof
US6548246B1 (en) * 1997-05-16 2003-04-15 The Regents Of The University Of California Method and probes for the identification of microbial genes specifically induced during host infection
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
WO2000023785A2 (en) * 1998-10-20 2000-04-27 Ljl Biosystems, Inc. Improvements in luminescence assays
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6548264B1 (en) 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US6808939B2 (en) 2001-06-29 2004-10-26 Igen International, Inc. ECL labels having improved non-specific binding properties, methods of using and kits containing the same
AU2002324947B2 (en) 2001-09-10 2007-11-15 Meso Scale Technologies, Llc. Assay buffer, compositions containing the same, and methods of using the same
US20030215845A1 (en) 2002-02-19 2003-11-20 Bille Todd William Selective extraction of DNA from groups of cells
CN100419426C (zh) * 2002-04-22 2008-09-17 佛罗里达州立大学 功能化纳米微粒及其使用方法
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7741033B2 (en) 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
JP4087295B2 (ja) * 2003-06-06 2008-05-21 株式会社サタケ ダイオキシン類の測定方法及び装置
WO2005062982A2 (en) * 2003-12-23 2005-07-14 Xing-Xiang Li Signal amplification methods for analyte detection
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
AU2005326758B2 (en) * 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014139A1 (en) 1991-02-06 1992-08-20 Igen, Inc. Methods and apparatus for improved luminescence assays

Also Published As

Publication number Publication date
CN101057145B (zh) 2014-10-22
JP5118964B2 (ja) 2013-01-16
WO2006083305A3 (en) 2007-04-05
CN101057145A (zh) 2007-10-17
US20120329173A1 (en) 2012-12-27
HK1114173A1 (en) 2008-10-24
KR20070049631A (ko) 2007-05-11
US9442117B2 (en) 2016-09-13
US20150044669A1 (en) 2015-02-12
JP2008504528A (ja) 2008-02-14
US8871917B2 (en) 2014-10-28
CA2571283C (en) 2013-10-22
WO2006083305A8 (en) 2010-04-22
EP1787124A2 (en) 2007-05-23
US8188243B2 (en) 2012-05-29
AU2005326758B2 (en) 2011-07-14
CA2571283A1 (en) 2006-08-10
AU2005326758A1 (en) 2006-08-10
WO2006083305A2 (en) 2006-08-10
US20060078912A1 (en) 2006-04-13
BRPI0512611A (pt) 2008-03-25

Similar Documents

Publication Publication Date Title
KR101076578B1 (ko) 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
Zhao et al. Ultrasensitive electrochemical aptasensor for thrombin based on the amplification of aptamer–AuNPs–HRP conjugates
Li et al. Aptamer-quantum dots conjugates-based ultrasensitive competitive electrochemical cytosensor for the detection of tumor cell
EP2186910A2 (en) Methods and compositions for improved luminescence assays using microparticles
IE69371B1 (en) Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
JP2012242394A (ja) 標的物質検出用キット及びこれを利用した標的物質検出方法
WO2010107058A1 (ja) 標的物質の検出方法
Zhai et al. A label-free genetic biosensor for diabetes based on AuNPs decorated ITO with electrochemiluminescent signaling
WO2011100669A2 (en) Lable-free multiplexing bioassays using fluorescent conjugated polymers and barcoded nanoparticles
Ye et al. Screen-printed electrode-based biosensors modified with functional nucleic acid probes and their applications in this pandemic age: a review
JP5427879B2 (ja) 蛍光ナノ粒子複合体自体、そのような複合体を調製する方法、及び生体分子に親和性を有する迅速な診断システムにおける使用
Wang et al. Aptamer-based silver nanosensor for multiple protein detection
KR100848106B1 (ko) 앱타머를 포함하는 폴리다이아세틸렌 센서칩 및 그제조방법
Zheng et al. Study on an electrochemical biosensor for thrombin recognition based on aptamers and nano particles
JP2004538460A (ja) 高分子生体ポリマーを固着するための装置を少なくとも1つ用いた、高分子生体ポリマーを検出するためのバイオセンサー、および、高分子生体ポリマーの検出方法
HK1114173B (en) Methods and compositions for the detection of biological molecules using a two particle complex
JP2009136238A (ja) 遺伝子検出方法
BRPI0512611B1 (pt) Método, kit e composição para detectar um ácido nucleico ou proteína em uma amostra
JP2007232675A (ja) 遺伝子検出方法
JP2007304091A (ja) 遺伝子検出方法
Bognár Synthetic Receptors and Labels for Chemical Sensing
JP2007232676A (ja) 遺伝子検出方法
WANG et al. Amplified Biosensing Strategies for the Detection of Biologically Related Molecules with Silica Nanoparticles and Conjugated Polyelectrolytes
Cheng Aptamer-based biosensors for protein biomarkers
JP2006345834A (ja) 遺伝子検出方法、及び標識プローブ

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20070122

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20080805

Comment text: Request for Examination of Application

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20081205

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20101021

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20110831

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20111018

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20111018

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20140929

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20140929

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20160929

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20160929

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20170929

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20170929

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20180928

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20180928

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20190924

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20190924

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20210929

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20230921

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20240925

Start annual number: 14

End annual number: 14