JP5118964B2 - ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物 - Google Patents

２粒子複合体を用いた生物学的分子の検出のための方法及び組成物 Download PDF

Info

Publication number
JP5118964B2
JP5118964B2 JP2007518295A JP2007518295A JP5118964B2 JP 5118964 B2 JP5118964 B2 JP 5118964B2 JP 2007518295 A JP2007518295 A JP 2007518295A JP 2007518295 A JP2007518295 A JP 2007518295A JP 5118964 B2 JP5118964 B2 JP 5118964B2
Authority
JP
Japan
Prior art keywords
interest
analyte
linked
ecl
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2007518295A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008504528A (ja
JP2008504528A5 (enExample
Inventor
バード、アレン
ミャオ、ウーチャム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5118964(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Texas System filed Critical University of Texas System
Publication of JP2008504528A publication Critical patent/JP2008504528A/ja
Publication of JP2008504528A5 publication Critical patent/JP2008504528A5/ja
Application granted granted Critical
Publication of JP5118964B2 publication Critical patent/JP5118964B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2007518295A 2004-06-23 2005-06-23 ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物 Expired - Lifetime JP5118964B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58171904P 2004-06-23 2004-06-23
US60/581,719 2004-06-23
PCT/US2005/022388 WO2006083305A2 (en) 2004-06-23 2005-06-23 Methods and compositions for the detection of biological molecules using a two particle complex

Publications (3)

Publication Number Publication Date
JP2008504528A JP2008504528A (ja) 2008-02-14
JP2008504528A5 JP2008504528A5 (enExample) 2008-07-17
JP5118964B2 true JP5118964B2 (ja) 2013-01-16

Family

ID=36777656

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007518295A Expired - Lifetime JP5118964B2 (ja) 2004-06-23 2005-06-23 ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物

Country Status (8)

Country Link
US (3) US8188243B2 (enExample)
EP (1) EP1787124A2 (enExample)
JP (1) JP5118964B2 (enExample)
KR (1) KR101076578B1 (enExample)
CN (1) CN101057145B (enExample)
AU (1) AU2005326758B2 (enExample)
CA (1) CA2571283C (enExample)
WO (1) WO2006083305A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
AU2005326758B2 (en) 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
KR101603354B1 (ko) * 2008-04-11 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 나노입자 전기발생 화학발광 증폭 방법 및 시스템
EP2294387B1 (en) 2008-05-08 2017-08-23 Board of Regents of the University of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
JP5455878B2 (ja) * 2010-11-30 2014-03-26 シスメックス株式会社 被検物質の電気化学的検出方法
CN102183657B (zh) * 2011-02-24 2014-02-05 南京基蛋生物科技有限公司 一种依赖聚苯乙烯纳米粒大幅度增加化学发光磁酶免疫灵敏度的方法
US20150087526A1 (en) * 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
CN102854183A (zh) * 2012-09-04 2013-01-02 上海师范大学 一种固态电化学发光检测三聚氰胺的方法
GB201218555D0 (en) * 2012-10-16 2012-11-28 Mode Diagnostics Ltd Immunoassay using electrochemical detection
WO2015054287A2 (en) * 2013-10-07 2015-04-16 The University Of Utah Research Foundation Methods and systems for electrochemically detecting or quantifying an analyte
CN106248659A (zh) * 2016-09-14 2016-12-21 燕山大学 一种晶相依赖有机半导体微纳电化学发光传感器及其应用
CN106596972B (zh) * 2016-12-16 2018-08-10 青岛科技大学 一种检测力竭运动小鼠心肌连接蛋白43含量的方法
CN108152275B (zh) * 2017-12-27 2019-07-19 福州大学 一种基于电化学发光体系的透明质酸酶检测方法
US11307206B2 (en) 2018-04-27 2022-04-19 Deutsches Rheuma-Forschungszentrum Berlin Functionalized metal-labeled beads for mass cytometry
CN108827946B (zh) * 2018-04-30 2021-03-02 福建师范大学 一种共用共反应试剂类型的呕吐毒素比率型电致化学发光免疫传感器及其检测方法
CN109651621B (zh) * 2019-01-08 2021-05-14 安徽师范大学 一种锆基金属有机框架复合材料及其制备方法和应用
CN109946289B (zh) * 2019-04-16 2021-06-22 济南大学 一种基于自发光材料Ru@MOF-5检测雌二醇的无标型电致化学发光传感器的制备方法
CN110146692A (zh) * 2019-05-28 2019-08-20 迪瑞医疗科技股份有限公司 一种基于吖啶酯化学发光、链霉亲和素磁珠-生物素放大反应体系及检测试剂盒
WO2021019732A1 (ja) * 2019-07-31 2021-02-04 株式会社日立ハイテク 生体分子分析方法および生体分子分析装置
JP2023544025A (ja) * 2020-09-30 2023-10-19 ザ クリーブランド クリニック ファウンデーション ウイルス及び細菌感染症の迅速検査システム
CN112649605B (zh) * 2020-12-14 2022-11-01 哈尔滨理工大学 一种基于NaBiF4上转换纳米粒子的ECL生物传感器
CN113267629B (zh) * 2021-05-13 2022-06-24 广东优尼德生物科技有限公司 一种抗核抗体谱检测试剂盒及其制备方法
WO2023084369A1 (en) * 2021-11-12 2023-05-19 3M Innovative Properties Company Method of processing polynucleic acids
WO2023084370A1 (en) * 2021-11-12 2023-05-19 3M Innovative Properties Company Solid support comprising ligands suitable for polynucleic acid processing, articles and methods
CN114113051B (zh) * 2021-12-16 2023-06-16 南京信息工程大学 一种psma电致化学发光传感器的制备方法及应用
CN114752374B (zh) * 2022-04-11 2023-02-03 北京艾维镝生物技术有限责任公司 一种均相化学发光免疫检测技术所用微球组合物的制备方法
CN117929497A (zh) * 2024-01-29 2024-04-26 常州大学 基于TbPO4:Ce检测林可霉素的电化学发光适配体传感器及其制备方法和应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US6271041B1 (en) * 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6881536B1 (en) * 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
WO1987006706A1 (en) 1986-04-30 1987-11-05 Igen, Inc. Electrochemiluminescent assays
US6316607B1 (en) * 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5182016A (en) * 1990-03-22 1993-01-26 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
IL100867A (en) 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
ZA92804B (en) * 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
US5342774A (en) 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5336596A (en) * 1991-12-23 1994-08-09 Tropix, Inc. Membrane for chemiluminescent blotting applications
US5369036A (en) 1992-07-02 1994-11-29 Becton, Dickinson And Company Enhancement of signal in immunoassays using microparticles which contain different detectable substances
ATE197403T1 (de) 1992-12-22 2000-11-11 Ludwig Inst Cancer Res Methoden zur detektion und behandlung von individuen mit abnormalen hla-a2/tyrosinase- peptidantigenen exprimierenden zellen
US5620886A (en) 1993-03-18 1997-04-15 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
JPH06300763A (ja) * 1993-04-14 1994-10-28 Nippon Telegr & Teleph Corp <Ntt> 蛍光免疫測定用蛍光マイクロビーズ及びその製造方法
US5571711A (en) 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
US5610013A (en) 1993-07-22 1997-03-11 Ludwig Institute For Cancer Research Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors
US5935818A (en) * 1995-02-24 1999-08-10 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
DE69535002T2 (de) * 1994-03-08 2006-12-07 Memorial Sloan-Kettering Cancer Center Rekombinante humanisierte antikörper gegen fb5
US5589334A (en) * 1994-06-03 1996-12-31 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor which is processed to an antigen presented by HLA-B44, and uses thereof
US5599889A (en) * 1994-08-16 1997-02-04 Stoever; Harald D. H. Method of forming polymer microspheres
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
CA2162210A1 (en) * 1994-11-07 1996-05-08 Takumi Kunikiyo Process to form a coated film
WO1996021154A1 (en) * 1995-01-06 1996-07-11 Igen, Inc. Electrogenerated chemiluminescence through enhanced particle luminescence
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US5939526A (en) * 1995-03-21 1999-08-17 Ludwig Institute For Cancer Research Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5821122A (en) * 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
CA2223027A1 (en) * 1995-06-07 1996-12-19 Igen, Inc. Electrochemiluminescent enzyme immunoassay
US5792621A (en) 1995-06-28 1998-08-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters
JP3545524B2 (ja) * 1995-12-28 2004-07-21 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生理活性物質を固定化した導電性磁気ビーズ
US6037124A (en) * 1996-09-27 2000-03-14 Beckman Coulter, Inc. Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof
US6548246B1 (en) * 1997-05-16 2003-04-15 The Regents Of The University Of California Method and probes for the identification of microbial genes specifically induced during host infection
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
WO2000023785A2 (en) * 1998-10-20 2000-04-27 Ljl Biosystems, Inc. Improvements in luminescence assays
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6548264B1 (en) 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US6808939B2 (en) 2001-06-29 2004-10-26 Igen International, Inc. ECL labels having improved non-specific binding properties, methods of using and kits containing the same
AU2002324947B2 (en) 2001-09-10 2007-11-15 Meso Scale Technologies, Llc. Assay buffer, compositions containing the same, and methods of using the same
US20030215845A1 (en) 2002-02-19 2003-11-20 Bille Todd William Selective extraction of DNA from groups of cells
CN100419426C (zh) * 2002-04-22 2008-09-17 佛罗里达州立大学 功能化纳米微粒及其使用方法
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7741033B2 (en) 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
JP4087295B2 (ja) * 2003-06-06 2008-05-21 株式会社サタケ ダイオキシン類の測定方法及び装置
WO2005062982A2 (en) * 2003-12-23 2005-07-14 Xing-Xiang Li Signal amplification methods for analyte detection
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
AU2005326758B2 (en) * 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex

Also Published As

Publication number Publication date
CN101057145B (zh) 2014-10-22
WO2006083305A3 (en) 2007-04-05
CN101057145A (zh) 2007-10-17
US20120329173A1 (en) 2012-12-27
HK1114173A1 (en) 2008-10-24
KR20070049631A (ko) 2007-05-11
US9442117B2 (en) 2016-09-13
US20150044669A1 (en) 2015-02-12
JP2008504528A (ja) 2008-02-14
KR101076578B1 (ko) 2011-10-24
US8871917B2 (en) 2014-10-28
CA2571283C (en) 2013-10-22
WO2006083305A8 (en) 2010-04-22
EP1787124A2 (en) 2007-05-23
US8188243B2 (en) 2012-05-29
AU2005326758B2 (en) 2011-07-14
CA2571283A1 (en) 2006-08-10
AU2005326758A1 (en) 2006-08-10
WO2006083305A2 (en) 2006-08-10
US20060078912A1 (en) 2006-04-13
BRPI0512611A (pt) 2008-03-25

Similar Documents

Publication Publication Date Title
JP5118964B2 (ja) ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物
JP4146239B2 (ja) オリゴヌクレオチド修飾粒子をベースとするバイオバーコード
Li et al. Aptamer-quantum dots conjugates-based ultrasensitive competitive electrochemical cytosensor for the detection of tumor cell
Li et al. Graphene functionalized porous Au-paper based electrochemiluminescence device for detection of DNA using luminescent silver nanoparticles coated calcium carbonate/carboxymethyl chitosan hybrid microspheres as labels
JP2012242394A (ja) 標的物質検出用キット及びこれを利用した標的物質検出方法
EP2186910A2 (en) Methods and compositions for improved luminescence assays using microparticles
IE69371B1 (en) Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
JP2002542794A (ja) 標識担持標的を検出するための単層および電極ならびにその使用方法
CN101027314A (zh) 用于分析物电化学检测的介体修饰的氧化还原生物分子
Liu et al. Electrochemiluminescent biosensor with DNA link for selective detection of human IgG based on steric hindrance
Wang et al. Label/immobilization-free Cas12a-based electrochemiluminescence biosensor for sensitive DNA detection
Wang et al. Aptamer-based silver nanosensor for multiple protein detection
Zheng et al. Study on an electrochemical biosensor for thrombin recognition based on aptamers and nano particles
HK1114173B (en) Methods and compositions for the detection of biological molecules using a two particle complex
JP2004538460A (ja) 高分子生体ポリマーを固着するための装置を少なくとも１つ用いた、高分子生体ポリマーを検出するためのバイオセンサー、および、高分子生体ポリマーの検出方法
BRPI0512611B1 (pt) Método, kit e composição para detectar um ácido nucleico ou proteína em uma amostra
JP2007232675A (ja) 遺伝子検出方法
US20250341518A1 (en) Magnetic microgel beads, methods of making and uses thereof
Bognár Synthetic Receptors and Labels for Chemical Sensing
JP2007232676A (ja) 遺伝子検出方法
KR20250094677A (ko) 표적 핵산 검출용 키트 및 방법
WANG et al. Amplified Biosensing Strategies for the Detection of Biologically Related Molecules with Silica Nanoparticles and Conjugated Polyelectrolytes
Cheng Aptamer-based biosensors for protein biomarkers
JP2009247330A (ja) 遺伝子検出方法
JP2006345834A (ja) 遺伝子検出方法、及び標識プローブ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080523

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080523

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20081119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20081119

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20090109

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20101008

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101019

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110105

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110125

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110218

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110311

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110315

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110418

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120116

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120220

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20121016

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20121022

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 5118964

Country of ref document: JP

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151026

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term