KR100857759B1 - Ｃｅｔｐ 억제제의 약제학적 조성물 - Google Patents

Ｃｅｔｐ 억제제의 약제학적 조성물 Download PDF

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Publication number
KR100857759B1
KR100857759B1 KR1020057017449A KR20057017449A KR100857759B1 KR 100857759 B1 KR100857759 B1 KR 100857759B1 KR 1020057017449 A KR1020057017449 A KR 1020057017449A KR 20057017449 A KR20057017449 A KR 20057017449A KR 100857759 B1 KR100857759 B1 KR 100857759B1
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South Korea
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group
phenyl
compound
groups
transfer protein
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Expired - Lifetime
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KR1020057017449A
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Korean (ko)
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KR20050110019A (ko
Inventor
마사키 스나미
다카노리 세리가노
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니뽄 다바코 산교 가부시키가이샤
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Application filed by 니뽄 다바코 산교 가부시키가이샤 filed Critical 니뽄 다바코 산교 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
KR1020057017449A 2003-03-17 2004-03-17 Ｃｅｔｐ 억제제의 약제학적 조성물 Expired - Lifetime KR100857759B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US45529303P 2003-03-17 2003-03-17
US60/455,293 2003-03-17
US46052103P 2003-04-04 2003-04-04
US60/460,521 2003-04-04
US47720203P 2003-06-10 2003-06-10
US60/477,202 2003-06-10
US49364903P 2003-08-08 2003-08-08
US60/493,649 2003-08-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020087000175A Division KR20080008440A (ko) 2003-03-17 2004-03-17 Ｃｅｔｐ 억제제의 약제학적 조성물

Publications (2)

Publication Number Publication Date
KR20050110019A KR20050110019A (ko) 2005-11-22
KR100857759B1 true KR100857759B1 (ko) 2008-09-09

Family

ID=33033290

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057017449A Expired - Lifetime KR100857759B1 (ko) 2003-03-17 2004-03-17 Ｃｅｔｐ 억제제의 약제학적 조성물
KR1020087000175A Withdrawn KR20080008440A (ko) 2003-03-17 2004-03-17 Ｃｅｔｐ 억제제의 약제학적 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020087000175A Withdrawn KR20080008440A (ko) 2003-03-17 2004-03-17 Ｃｅｔｐ 억제제의 약제학적 조성물

Country Status (20)

Country Link
US (2) US20040225018A1 (enExample)
EP (2) EP2289507A1 (enExample)
JP (2) JP5546715B2 (enExample)
KR (2) KR100857759B1 (enExample)
AT (1) ATE534381T1 (enExample)
AU (1) AU2004222434B2 (enExample)
BR (1) BRPI0408466B8 (enExample)
CA (1) CA2519432C (enExample)
CO (1) CO5640101A2 (enExample)
CY (1) CY1112324T1 (enExample)
DK (1) DK1603553T3 (enExample)
ES (1) ES2377121T3 (enExample)
IL (1) IL170749A (enExample)
MX (1) MXPA05009848A (enExample)
NO (1) NO336891B1 (enExample)
NZ (1) NZ542852A (enExample)
PL (1) PL1603553T3 (enExample)
PT (1) PT1603553E (enExample)
SI (1) SI1603553T1 (enExample)
WO (1) WO2004082593A2 (enExample)

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US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7186735B2 (en) * 2002-08-07 2007-03-06 Sanofi-Aventis Deutschland Gmbh Acylated arylcycloalkylamines and their use as pharmaceuticals
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2004220548A1 (en) 2003-03-07 2004-09-23 The Trustees Of Columbia University, In The City Of New York Type 1 ryanodine receptor-based methods
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US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
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US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
BRPI0707584A2 (pt) 2006-02-09 2011-05-10 Merck & Co Inc composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica
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PE20140018A1 (es) 2010-11-04 2014-01-31 Hoffmann La Roche Una composicion que comprende 2-metilpropanotioato de s-[2-([[1-(2-etilbutil)ciclohexil]-carbonil]amino)fenilo] y croscarmelosa sodica
WO2012076443A1 (en) 2010-12-08 2012-06-14 F. Hoffmann-La Roche Ag Liposomal formulation of dalcetrapib
BR112013021030A2 (pt) * 2011-02-17 2016-10-11 Hoffmann La Roche processo para cristalização controlada de um ingrediente farmacêutico ativo a partir de estado líquido super-refrigerado por extrusão por fusão a quente
JP6539661B2 (ja) * 2013-12-19 2019-07-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 眼疾患の処置において使用するためのｃｅｔｐモデュレーター
BR112021002387A2 (pt) * 2018-08-09 2021-05-11 Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch métodos para retardo de ocorrência de diabetes tipo 2 de início recente e para redução da progressão e tratamento de diabetes tipo 2
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AU2004222434A1 (en) 2004-09-30
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ATE534381T1 (de) 2011-12-15
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US20040225018A1 (en) 2004-11-11
WO2004082593A3 (en) 2005-02-24
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