KR100819576B1 - 신규 찰콘 화합물 - Google Patents

신규 찰콘 화합물 Download PDF

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Publication number
KR100819576B1
KR100819576B1 KR1020027002798A KR20027002798A KR100819576B1 KR 100819576 B1 KR100819576 B1 KR 100819576B1 KR 1020027002798 A KR1020027002798 A KR 1020027002798A KR 20027002798 A KR20027002798 A KR 20027002798A KR 100819576 B1 KR100819576 B1 KR 100819576B1
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KR
South Korea
Prior art keywords
phenyl
compound
methyl
group
propen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020027002798A
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English (en)
Korean (ko)
Other versions
KR20020031598A (ko
Inventor
봄바르델리에지오
발렌티피에로
Original Assignee
인데나 에스피아
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Publication date
Application filed by 인데나 에스피아 filed Critical 인데나 에스피아
Publication of KR20020031598A publication Critical patent/KR20020031598A/ko
Application granted granted Critical
Publication of KR100819576B1 publication Critical patent/KR100819576B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020027002798A 1999-09-03 2000-08-28 신규 찰콘 화합물 Expired - Fee Related KR100819576B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9920910.8A GB9920910D0 (en) 1999-09-03 1999-09-03 Novel chalcones
GB9920910.8 1999-09-03

Publications (2)

Publication Number Publication Date
KR20020031598A KR20020031598A (ko) 2002-05-02
KR100819576B1 true KR100819576B1 (ko) 2008-04-22

Family

ID=10860346

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002798A Expired - Fee Related KR100819576B1 (ko) 1999-09-03 2000-08-28 신규 찰콘 화합물

Country Status (21)

Country Link
US (1) US6620842B2 (enExample)
EP (1) EP1212315B1 (enExample)
JP (1) JP2003508527A (enExample)
KR (1) KR100819576B1 (enExample)
CN (1) CN1177843C (enExample)
AT (1) ATE235483T1 (enExample)
AU (1) AU776226B2 (enExample)
CA (1) CA2382130A1 (enExample)
CZ (1) CZ2002787A3 (enExample)
DE (1) DE60001851T2 (enExample)
DK (1) DK1212315T3 (enExample)
ES (1) ES2193106T3 (enExample)
GB (1) GB9920910D0 (enExample)
HK (1) HK1043999B (enExample)
HU (1) HUP0202579A3 (enExample)
NO (1) NO20021049L (enExample)
PL (1) PL353064A1 (enExample)
PT (1) PT1212315E (enExample)
RU (1) RU2252938C2 (enExample)
SK (1) SK3112002A3 (enExample)
WO (1) WO2001017988A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101052816B1 (ko) 2002-04-17 2011-07-29 스미스 클라인 비참 코포레이션 화합물, 조성물 및 방법
US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
JP2005533119A (ja) 2002-07-17 2005-11-04 サイトキネティクス・インコーポレーテッド 化合物、組成物、及び方法
US6864264B1 (en) 2002-08-20 2005-03-08 Gloria L. Anderson 1-adamantyl chalcones for the treatment of proliferative disorders
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
CN104169267B (zh) * 2012-03-01 2017-03-01 香港理工大学 含炔烃的类黄酮、含叠氮化物的类黄酮和含三唑的类黄酮作为调节剂用于癌症的多药耐药

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI912995A0 (fi) * 1988-12-21 1991-06-19 Upjohn Co Atiaterosklerotiska och antirombotiska 1-benzopyran-4-oner och 2-amino-1,3-benzoxazin-4-oner.
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) * 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity

Also Published As

Publication number Publication date
SK3112002A3 (en) 2003-10-07
EP1212315B1 (en) 2003-03-26
CZ2002787A3 (cs) 2002-06-12
KR20020031598A (ko) 2002-05-02
HUP0202579A3 (en) 2003-07-28
GB9920910D0 (en) 1999-11-10
NO20021049L (no) 2002-05-03
CN1371372A (zh) 2002-09-25
PT1212315E (pt) 2003-08-29
AU7510900A (en) 2001-04-10
JP2003508527A (ja) 2003-03-04
DE60001851T2 (de) 2003-12-11
CN1177843C (zh) 2004-12-01
HK1043999A1 (en) 2002-10-04
RU2252938C2 (ru) 2005-05-27
HUP0202579A2 (hu) 2002-11-28
NO20021049D0 (no) 2002-03-01
US20030055056A1 (en) 2003-03-20
PL353064A1 (en) 2003-10-06
WO2001017988A1 (en) 2001-03-15
ES2193106T3 (es) 2003-11-01
US6620842B2 (en) 2003-09-16
HK1043999B (en) 2003-08-15
AU776226B2 (en) 2004-09-02
CA2382130A1 (en) 2001-03-15
DK1212315T3 (da) 2003-06-23
DE60001851D1 (de) 2003-04-30
ATE235483T1 (de) 2003-04-15
EP1212315A1 (en) 2002-06-12

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