CN1177843C - 新的查耳酮 - Google Patents

新的查耳酮 Download PDF

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Publication number
CN1177843C
CN1177843C CNB008123039A CN00812303A CN1177843C CN 1177843 C CN1177843 C CN 1177843C CN B008123039 A CNB008123039 A CN B008123039A CN 00812303 A CN00812303 A CN 00812303A CN 1177843 C CN1177843 C CN 1177843C
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CN
China
Prior art keywords
phenyl
compound
methyl
propen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008123039A
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English (en)
Chinese (zh)
Other versions
CN1371372A (zh
Inventor
E����ķ�͵���
E·博姆巴德利
P·瓦伦蒂
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Indena SpA
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Indena SpA
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Publication date
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Publication of CN1371372A publication Critical patent/CN1371372A/zh
Application granted granted Critical
Publication of CN1177843C publication Critical patent/CN1177843C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008123039A 1999-09-03 2000-08-28 新的查耳酮 Expired - Fee Related CN1177843C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9920910.8 1999-09-03
GBGB9920910.8A GB9920910D0 (en) 1999-09-03 1999-09-03 Novel chalcones

Publications (2)

Publication Number Publication Date
CN1371372A CN1371372A (zh) 2002-09-25
CN1177843C true CN1177843C (zh) 2004-12-01

Family

ID=10860346

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008123039A Expired - Fee Related CN1177843C (zh) 1999-09-03 2000-08-28 新的查耳酮

Country Status (21)

Country Link
US (1) US6620842B2 (enExample)
EP (1) EP1212315B1 (enExample)
JP (1) JP2003508527A (enExample)
KR (1) KR100819576B1 (enExample)
CN (1) CN1177843C (enExample)
AT (1) ATE235483T1 (enExample)
AU (1) AU776226B2 (enExample)
CA (1) CA2382130A1 (enExample)
CZ (1) CZ2002787A3 (enExample)
DE (1) DE60001851T2 (enExample)
DK (1) DK1212315T3 (enExample)
ES (1) ES2193106T3 (enExample)
GB (1) GB9920910D0 (enExample)
HK (1) HK1043999B (enExample)
HU (1) HUP0202579A3 (enExample)
NO (1) NO20021049L (enExample)
PL (1) PL353064A1 (enExample)
PT (1) PT1212315E (enExample)
RU (1) RU2252938C2 (enExample)
SK (1) SK3112002A3 (enExample)
WO (1) WO2001017988A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4664597B2 (ja) 2002-04-17 2011-04-06 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
ATE423110T1 (de) 2002-07-17 2009-03-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
US6864264B1 (en) * 2002-08-20 2005-03-08 Gloria L. Anderson 1-adamantyl chalcones for the treatment of proliferative disorders
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
WO2013127361A1 (en) 2012-03-01 2013-09-06 The Hong Kong Polytechnic University Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459983A1 (en) * 1988-12-21 1991-12-11 PHARMACIA & UPJOHN COMPANY Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5023341A (en) * 1989-09-19 1991-06-11 Allergan, Inc. Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Also Published As

Publication number Publication date
AU776226B2 (en) 2004-09-02
AU7510900A (en) 2001-04-10
SK3112002A3 (en) 2003-10-07
KR20020031598A (ko) 2002-05-02
CZ2002787A3 (cs) 2002-06-12
ES2193106T3 (es) 2003-11-01
DE60001851D1 (de) 2003-04-30
US6620842B2 (en) 2003-09-16
HK1043999B (en) 2003-08-15
KR100819576B1 (ko) 2008-04-22
ATE235483T1 (de) 2003-04-15
JP2003508527A (ja) 2003-03-04
WO2001017988A1 (en) 2001-03-15
PT1212315E (pt) 2003-08-29
PL353064A1 (en) 2003-10-06
DE60001851T2 (de) 2003-12-11
HUP0202579A3 (en) 2003-07-28
GB9920910D0 (en) 1999-11-10
EP1212315A1 (en) 2002-06-12
RU2252938C2 (ru) 2005-05-27
NO20021049L (no) 2002-05-03
HUP0202579A2 (hu) 2002-11-28
EP1212315B1 (en) 2003-03-26
US20030055056A1 (en) 2003-03-20
HK1043999A1 (en) 2002-10-04
NO20021049D0 (no) 2002-03-01
CN1371372A (zh) 2002-09-25
CA2382130A1 (en) 2001-03-15
DK1212315T3 (da) 2003-06-23

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