AU776226B2 - Novel chalcones - Google Patents

Novel chalcones Download PDF

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Publication number
AU776226B2
AU776226B2 AU75109/00A AU7510900A AU776226B2 AU 776226 B2 AU776226 B2 AU 776226B2 AU 75109/00 A AU75109/00 A AU 75109/00A AU 7510900 A AU7510900 A AU 7510900A AU 776226 B2 AU776226 B2 AU 776226B2
Authority
AU
Australia
Prior art keywords
group
ring atoms
substituted
unsubstituted
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU75109/00A
Other languages
English (en)
Other versions
AU7510900A (en
Inventor
Ezio Bombardelli
Piero Valenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of AU7510900A publication Critical patent/AU7510900A/en
Application granted granted Critical
Publication of AU776226B2 publication Critical patent/AU776226B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU75109/00A 1999-09-03 2000-08-28 Novel chalcones Ceased AU776226B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9920910 1999-09-03
GBGB9920910.8A GB9920910D0 (en) 1999-09-03 1999-09-03 Novel chalcones
PCT/EP2000/008366 WO2001017988A1 (en) 1999-09-03 2000-08-28 Novel chalcones

Publications (2)

Publication Number Publication Date
AU7510900A AU7510900A (en) 2001-04-10
AU776226B2 true AU776226B2 (en) 2004-09-02

Family

ID=10860346

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75109/00A Ceased AU776226B2 (en) 1999-09-03 2000-08-28 Novel chalcones

Country Status (21)

Country Link
US (1) US6620842B2 (enExample)
EP (1) EP1212315B1 (enExample)
JP (1) JP2003508527A (enExample)
KR (1) KR100819576B1 (enExample)
CN (1) CN1177843C (enExample)
AT (1) ATE235483T1 (enExample)
AU (1) AU776226B2 (enExample)
CA (1) CA2382130A1 (enExample)
CZ (1) CZ2002787A3 (enExample)
DE (1) DE60001851T2 (enExample)
DK (1) DK1212315T3 (enExample)
ES (1) ES2193106T3 (enExample)
GB (1) GB9920910D0 (enExample)
HK (1) HK1043999B (enExample)
HU (1) HUP0202579A3 (enExample)
NO (1) NO20021049L (enExample)
PL (1) PL353064A1 (enExample)
PT (1) PT1212315E (enExample)
RU (1) RU2252938C2 (enExample)
SK (1) SK3112002A3 (enExample)
WO (1) WO2001017988A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4664597B2 (ja) 2002-04-17 2011-04-06 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
ATE423110T1 (de) 2002-07-17 2009-03-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
US6864264B1 (en) * 2002-08-20 2005-03-08 Gloria L. Anderson 1-adamantyl chalcones for the treatment of proliferative disorders
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
WO2013127361A1 (en) 2012-03-01 2013-09-06 The Hong Kong Polytechnic University Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459983A1 (en) * 1988-12-21 1991-12-11 PHARMACIA & UPJOHN COMPANY Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5023341A (en) * 1989-09-19 1991-06-11 Allergan, Inc. Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Also Published As

Publication number Publication date
AU7510900A (en) 2001-04-10
SK3112002A3 (en) 2003-10-07
KR20020031598A (ko) 2002-05-02
CZ2002787A3 (cs) 2002-06-12
ES2193106T3 (es) 2003-11-01
DE60001851D1 (de) 2003-04-30
US6620842B2 (en) 2003-09-16
HK1043999B (en) 2003-08-15
KR100819576B1 (ko) 2008-04-22
ATE235483T1 (de) 2003-04-15
JP2003508527A (ja) 2003-03-04
WO2001017988A1 (en) 2001-03-15
PT1212315E (pt) 2003-08-29
CN1177843C (zh) 2004-12-01
PL353064A1 (en) 2003-10-06
DE60001851T2 (de) 2003-12-11
HUP0202579A3 (en) 2003-07-28
GB9920910D0 (en) 1999-11-10
EP1212315A1 (en) 2002-06-12
RU2252938C2 (ru) 2005-05-27
NO20021049L (no) 2002-05-03
HUP0202579A2 (hu) 2002-11-28
EP1212315B1 (en) 2003-03-26
US20030055056A1 (en) 2003-03-20
HK1043999A1 (en) 2002-10-04
NO20021049D0 (no) 2002-03-01
CN1371372A (zh) 2002-09-25
CA2382130A1 (en) 2001-03-15
DK1212315T3 (da) 2003-06-23

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