KR100819574B1 - 찰콘 쿠마린 - Google Patents

찰콘 쿠마린 Download PDF

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Publication number
KR100819574B1
KR100819574B1 KR1020027002799A KR20027002799A KR100819574B1 KR 100819574 B1 KR100819574 B1 KR 100819574B1 KR 1020027002799 A KR1020027002799 A KR 1020027002799A KR 20027002799 A KR20027002799 A KR 20027002799A KR 100819574 B1 KR100819574 B1 KR 100819574B1
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KR
South Korea
Prior art keywords
compound
methyl
group
coumarin
propen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020027002799A
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English (en)
Korean (ko)
Other versions
KR20020030800A (ko
Inventor
봄바르델리에지오
발렌티피에로
Original Assignee
인데나 에스피아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인데나 에스피아 filed Critical 인데나 에스피아
Publication of KR20020030800A publication Critical patent/KR20020030800A/ko
Application granted granted Critical
Publication of KR100819574B1 publication Critical patent/KR100819574B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Glass Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020027002799A 1999-09-03 2000-08-28 찰콘 쿠마린 Expired - Fee Related KR100819574B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9920908.2 1999-09-03
GBGB9920908.2A GB9920908D0 (en) 1999-09-03 1999-09-03 Chalcone coumarins

Publications (2)

Publication Number Publication Date
KR20020030800A KR20020030800A (ko) 2002-04-25
KR100819574B1 true KR100819574B1 (ko) 2008-04-04

Family

ID=10860344

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002799A Expired - Fee Related KR100819574B1 (ko) 1999-09-03 2000-08-28 찰콘 쿠마린

Country Status (22)

Country Link
US (1) US6767916B2 (https=)
EP (1) EP1212311B1 (https=)
JP (1) JP2003508523A (https=)
KR (1) KR100819574B1 (https=)
CN (1) CN1142927C (https=)
AT (1) ATE235480T1 (https=)
AU (1) AU775083B2 (https=)
CA (1) CA2382112A1 (https=)
CZ (1) CZ2002786A3 (https=)
DE (1) DE60001850T2 (https=)
DK (1) DK1212311T3 (https=)
ES (1) ES2191643T3 (https=)
GB (1) GB9920908D0 (https=)
HK (1) HK1043997B (https=)
HU (1) HUP0202581A3 (https=)
NO (1) NO20021048L (https=)
PL (1) PL353245A1 (https=)
PT (1) PT1212311E (https=)
RU (1) RU2266291C2 (https=)
SE (1) SE1212311T5 (https=)
SK (1) SK3102002A3 (https=)
WO (1) WO2001017984A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030229136A1 (en) 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US7638554B2 (en) 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US8067461B2 (en) 2005-06-08 2011-11-29 Temple University-Of The Commonwealth System Of Higher Education 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
CN101041646B (zh) * 2007-04-30 2011-07-20 浙江大学 含氮查耳酮衍生物的制备方法和用途
CN101121706B (zh) * 2007-09-18 2010-11-24 南京中瑞药业有限公司 一种香豆素衍生物及其制备方法和用途
WO2009060835A1 (ja) * 2007-11-05 2009-05-14 Kyoto University 新規ユビキリン結合性小分子
US8815940B2 (en) 2010-08-05 2014-08-26 Council Of Scientific & Industrial Research Coumarin-chalcones as anticancer agents
EP2721003B1 (en) 2011-06-15 2018-01-03 The United States of America, as Represented by The Secretary, Department of Health and Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer
CN103420990B (zh) * 2012-05-23 2016-04-20 复旦大学 7-氧、硫或氮杂取代香豆素及其衍生物和用途
CN102731457A (zh) * 2012-06-25 2012-10-17 西南石油大学 一种水溶性荧光示踪聚合物及其制备方法
RU2760006C1 (ru) 2017-11-16 2021-11-22 Дзе Инститьют оф Кансер Рисерч: Ройал Кансер Хоспитал Производное кумарина для лечения или профилактики расстройства пролиферации клеток
CN109293616B (zh) * 2018-09-29 2022-06-21 贵州大学 一种含香豆素查尔酮类衍生物、其制备方法及应用
WO2021047783A1 (en) 2019-09-13 2021-03-18 The Institute Of Cancer Research: Royal Cancer Hospital Vs-6063 in combination with ch5126766 for the treatment of cancer
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor
PL448929A1 (pl) * 2024-06-21 2025-12-22 Instytut Chemii Organicznej Polskiej Akademii Nauk Nowe (kumaryno-7-amino)-acetamidy oraz ich zastosowania

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387956A1 (fr) * 1977-04-20 1978-11-17 Unicler Derives de la pyridine et leur preparation
US5399561A (en) * 1989-09-19 1995-03-21 Allergan, Inc. Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity
WO1991017749A1 (en) * 1990-05-17 1991-11-28 Baylor College Of Medicine Growth inhibitors and methods of treating cancer and cell proliferative diseases
IT1271301B (it) 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) * 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity

Also Published As

Publication number Publication date
AU7648800A (en) 2001-04-10
PL353245A1 (en) 2003-11-03
HUP0202581A3 (en) 2003-07-28
EP1212311B1 (en) 2003-03-26
DE60001850D1 (de) 2003-04-30
GB9920908D0 (en) 1999-11-10
US6767916B2 (en) 2004-07-27
EP1212311A1 (en) 2002-06-12
CN1371370A (zh) 2002-09-25
JP2003508523A (ja) 2003-03-04
DE60001850T2 (de) 2003-12-11
AU775083B2 (en) 2004-07-15
HK1043997B (en) 2003-08-15
NO20021048L (no) 2002-05-03
CZ2002786A3 (cs) 2002-06-12
US20020161036A1 (en) 2002-10-31
CA2382112A1 (en) 2001-03-15
ATE235480T1 (de) 2003-04-15
ES2191643T3 (es) 2003-09-16
RU2266291C2 (ru) 2005-12-20
DK1212311T3 (da) 2003-06-23
WO2001017984A1 (en) 2001-03-15
CN1142927C (zh) 2004-03-24
KR20020030800A (ko) 2002-04-25
NO20021048D0 (no) 2002-03-01
HUP0202581A2 (hu) 2002-11-28
SE1212311T5 (https=) 2003-06-10
HK1043997A1 (en) 2002-10-04
SE1212311T3 (https=) 2003-05-06
PT1212311E (pt) 2003-08-29
RU2002108567A (ru) 2004-01-10
SK3102002A3 (en) 2003-10-07

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