KR100738165B1 - 헤테로방향족 카르복사미드 유도체 및 ｉｋｋ-2 효소억제제로서의 용도 - Google Patents

헤테로방향족 카르복사미드 유도체 및 ｉｋｋ-2 효소억제제로서의 용도 Download PDF

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Publication number
KR100738165B1
KR100738165B1 KR1020027010124A KR20027010124A KR100738165B1 KR 100738165 B1 KR100738165 B1 KR 100738165B1 KR 1020027010124 A KR1020027010124 A KR 1020027010124A KR 20027010124 A KR20027010124 A KR 20027010124A KR 100738165 B1 KR100738165 B1 KR 100738165B1
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KR
South Korea
Prior art keywords
amino
aminocarbonyl
thiophenecarboxamide
phenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020027010124A
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English (en)
Korean (ko)
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KR20030005183A (ko
Inventor
앤드류 백스터
스테판 브라흐
알란 파울
크레이그 존스톤
토마스 맥키날리
Original Assignee
아스트라제네카 아베
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Publication of KR20030005183A publication Critical patent/KR20030005183A/ko
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Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020027010124A 2000-02-12 2001-02-07 헤테로방향족 카르복사미드 유도체 및 ｉｋｋ-2 효소억제제로서의 용도 Expired - Fee Related KR100738165B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0003154.2A GB0003154D0 (en) 2000-02-12 2000-02-12 Novel compounds
GB0003154.2 2000-02-12
PCT/SE2001/000248 WO2001058890A1 (en) 2000-02-12 2001-02-07 Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2

Publications (2)

Publication Number Publication Date
KR20030005183A KR20030005183A (ko) 2003-01-17
KR100738165B1 true KR100738165B1 (ko) 2007-07-10

Family

ID=9885396

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027010124A Expired - Fee Related KR100738165B1 (ko) 2000-02-12 2001-02-07 헤테로방향족 카르복사미드 유도체 및 ｉｋｋ-2 효소억제제로서의 용도

Country Status (21)

Country Link
US (2) US7358376B2 (enExample)
EP (1) EP1261600B1 (enExample)
JP (1) JP4812999B2 (enExample)
KR (1) KR100738165B1 (enExample)
CN (1) CN1243747C (enExample)
AT (1) ATE266019T1 (enExample)
AU (1) AU781047B2 (enExample)
BR (1) BR0108143A (enExample)
CA (1) CA2396824C (enExample)
DE (1) DE60103132T2 (enExample)
DK (1) DK1261600T3 (enExample)
ES (1) ES2218376T3 (enExample)
GB (1) GB0003154D0 (enExample)
IL (2) IL150482A0 (enExample)
MX (1) MXPA02007734A (enExample)
NO (1) NO327741B1 (enExample)
NZ (1) NZ519947A (enExample)
PT (1) PT1261600E (enExample)
TR (1) TR200401962T4 (enExample)
WO (1) WO2001058890A1 (enExample)
ZA (1) ZA200205300B (enExample)

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Also Published As

Publication number Publication date
PT1261600E (pt) 2004-08-31
NO20023786L (no) 2002-09-23
CN1425012A (zh) 2003-06-18
DE60103132D1 (de) 2004-06-09
US7358376B2 (en) 2008-04-15
US20090181962A1 (en) 2009-07-16
IL150482A (en) 2006-08-01
NO327741B1 (no) 2009-09-14
ZA200205300B (en) 2003-10-02
AU3070501A (en) 2001-08-20
CA2396824A1 (en) 2001-08-16
EP1261600B1 (en) 2004-05-06
CN1243747C (zh) 2006-03-01
ATE266019T1 (de) 2004-05-15
DK1261600T3 (da) 2004-08-16
NO20023786D0 (no) 2002-08-09
KR20030005183A (ko) 2003-01-17
WO2001058890A1 (en) 2001-08-16
CA2396824C (en) 2010-11-16
GB0003154D0 (en) 2000-04-05
BR0108143A (pt) 2003-01-21
NZ519947A (en) 2004-05-28
US20020107252A1 (en) 2002-08-08
DE60103132T2 (de) 2005-05-12
JP4812999B2 (ja) 2011-11-09
MXPA02007734A (es) 2002-10-11
TR200401962T4 (tr) 2004-09-21
EP1261600A1 (en) 2002-12-04
IL150482A0 (en) 2002-12-01
JP2003522766A (ja) 2003-07-29
ES2218376T3 (es) 2004-11-16
AU781047B2 (en) 2005-05-05

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